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1. 发明申请

US20070190786A1 SITE-SELECTIVELY MODIFIED MICRO-AND NANOSTRUCTURES AND THE METHODS OF THEIR FABRICATION 有权
标题翻译：站点 - 选择性修改的微米和纳米结构及其制造方法
公开(公告)号：US20070190786A1
公开(公告)日：2007-08-16
申请号：US11623817
申请日：2007-01-17
申请人： Kenji Murao , Kosuke Kuwabara , Masahiko Ogino
发明人： Kenji Murao , Kosuke Kuwabara , Masahiko Ogino
IPC分类号： H01L21/302 , H01L21/461
CPC分类号： B81C1/0046 , B29C43/021 , B29C2043/025 , B81B2201/0214 , B81B2203/0361 , B81C2201/0153 , B82Y10/00 , B82Y15/00 , B82Y40/00 , G03F7/0002
摘要： It is an object of the present invention to provide a method which can easily and selectively modify specific sites on indentations or protrusions of indentation/protrusion structures fabricated by nano-imprinting. Pressing a mold having indentation/protrusion structures onto a polymer substrate comprising at least two layers of different chemical composition exposes the second layer, which has been covered by the outermost layer, in pillars formed as a result of the pressing. Site-specific chemical modification of the pillars can be achieved by formulating a desired chemical composition for the second layer beforehand, or by chemical modification of the exposed second layer cross-sections in the pillars.
摘要翻译：本发明的一个目的是提供一种方法，其可以容易且选择性地改变通过纳米压印制造的压痕/突起结构的凹陷或凸起上的特定部位。将具有凹陷/突起结构的模具压到包含至少两层不同化学组成的聚合物基材上，将由最外层覆盖的第二层暴露在由压制形成的柱中。可以通过预先为第二层配制所需的化学组合物，或者通过化学修饰柱中暴露的第二层横截面来实现柱的特定位点的化学修饰。

2. 发明授权

US07887723B2 Site-selectively modified micro-and nanostructures and the methods of their fabrication 有权
标题翻译：位点选择性修饰的微观和纳米结构及其制造方法
公开(公告)号：US07887723B2
公开(公告)日：2011-02-15
申请号：US11623817
申请日：2007-01-17
申请人： Kenji Murao , Kosuke Kuwabara , Masahiko Ogino
发明人： Kenji Murao , Kosuke Kuwabara , Masahiko Ogino
IPC分类号： B29C65/00
CPC分类号： B81C1/0046 , B29C43/021 , B29C2043/025 , B81B2201/0214 , B81B2203/0361 , B81C2201/0153 , B82Y10/00 , B82Y15/00 , B82Y40/00 , G03F7/0002
摘要： It is an object of the present invention to provide a method which can easily and selectively modify specific sites on indentations or protrusions of indentation/protrusion structures fabricated by nano-imprinting. Pressing a mold having indentation/protrusion structures onto a polymer substrate comprising at least two layers of different chemical composition exposes the second layer, which has been covered by the outermost layer, in pillars formed as a result of the pressing. Site-specific chemical modification of the pillars can be achieved by formulating a desired chemical composition for the second layer beforehand, or by chemical modification of the exposed second layer cross-sections in the pillars.
摘要翻译：本发明的一个目的是提供一种方法，其可以容易且选择性地改变通过纳米压印制造的压痕/突起结构的凹陷或凸起上的特定部位。将具有凹陷/突起结构的模具压到包含至少两层不同化学组成的聚合物基材上，将由最外层覆盖的第二层暴露在由压制形成的柱中。可以通过预先为第二层配制所需的化学组合物，或者通过化学修饰柱中暴露的第二层横截面来实现柱的特定位点的化学修饰。

3. 发明授权

US08132505B2 Imprint apparatus and imprint method 失效
标题翻译：印刷装置和印记法
公开(公告)号：US08132505B2
公开(公告)日：2012-03-13
申请号：US11774216
申请日：2007-07-06
申请人： Kosuke Kuwabara , Takashi Ando , Masahiko Ogino , Hiroshi Yoshida , Yasuhiko Tada
发明人： Kosuke Kuwabara , Takashi Ando , Masahiko Ogino , Hiroshi Yoshida , Yasuhiko Tada
IPC分类号： B31F1/07
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G11B5/855 , H01L21/76817
摘要： The present invention provides an imprint apparatus transferring a surface structure of a stamper to material to be patterned by allowing the stamper come in contact with the material to be patterned. The imprint apparatus includes a holding means that holds the material to be patterned and the stamper with a distance therebetween, a pressure reduction means that reduces pressure of a chamber in which the material to be patterned and the stamper are placed, and an alignment means that aligns the stamper with the material to be patterned.
摘要翻译：本发明提供一种压印装置，通过允许压模与待图案化的材料接触，将压模的表面结构转移到待图案化的材料。压印装置包括保持装置，其保持要被图案化的材料和压模之间的距离;减压装置，其减小其中待图案化材料和压模放置的室的压力;以及对准装置，将压模与待图案化的材料对准。

4. 发明授权

US07341441B2 Nanoprint equipment and method of making fine structure 失效
标题翻译：纳米设备制作精细结构的方法
公开(公告)号：US07341441B2
公开(公告)日：2008-03-11
申请号：US10804101
申请日：2004-03-19
申请人： Masahiko Ogino , Akihiro Miyauchi , Shigehisa Motowaki , Kosuke Kuwabara
发明人： Masahiko Ogino , Akihiro Miyauchi , Shigehisa Motowaki , Kosuke Kuwabara
IPC分类号： B29C59/04
CPC分类号： B29C59/002 , B29C59/022 , B29C59/026 , B29C2035/0827 , B29C2059/023 , B29K2033/12 , Y10S977/887
摘要： Provided is a nanoprint apparatus in which a substrate and a mold formed on its surface with fine concavities and convexities are heated and pressed with each other through the intermediary of a buffer member interposed therebetwen, including a mechanism for successively replacing the buffer member with new one at each time which the mold and the substate are heated and pressed, thereby it is possible to form a fine structure on the substrate.
摘要翻译：本发明提供一种纳米打印装置，其中在其表面上形成有细小凹凸的基板和模具通过介于其间的缓冲构件相互加热和相互压制，包括用于将新的缓冲构件连续更换的机构在模具和基底被加热和压制的每一次，从而可以在基底上形成精细的结构。

5. 发明授权

US07655457B2 Cell culture vessel and cultured cell 失效
标题翻译：细胞培养容器和培养细胞
公开(公告)号：US07655457B2
公开(公告)日：2010-02-02
申请号：US10989910
申请日：2004-11-17
申请人： Kosuke Kuwabara , Akihiro Miyauchi , Masahiko Ogino , Takashi Ando
发明人： Kosuke Kuwabara , Akihiro Miyauchi , Masahiko Ogino , Takashi Ando
IPC分类号： C12M1/14 , C12M3/04 , C12M3/00 , C12M1/00
CPC分类号： C12M23/20 , C12M21/08 , C12M23/10
摘要： It is an object of this invention to provide a cell culture vessel which has a simple and convenient structure, can prevent the injury on the cells at the time of peeling, and accelerates the transportation of nutrients and discharge of waste materials. In order to solve the problem mentioned above, the cell culture vessel of this invention has protrusions having a corresponding diameter not smaller than 10 nm and not greater than 10 μm and a height not smaller than 10 nm and not greater than 1 mm on the surface of the cell culture vessel. The protrusions make the culture fluid permeate into the under part of the cells, accelerate the supply of nutrients and discharge of waste materials, and makes the contact between the cells and the vessel as a point-contact and thereby prevents the cells from the injury which the cells undergo at the time of peeling.
摘要翻译：本发明的目的是提供一种结构简单方便的细胞培养容器，可以防止剥离时对细胞的损伤，加速营养物质的运输和废料排出。为了解决上述问题，本发明的细胞培养容器具有相对应的直径不小于10nm且不大于10um的突起，并且在表面上具有不小于10nm且不大于1mm的高度的细胞培养容器。突起使得培养液渗透到细胞的下部，加速营养物质的供给和排出废物，并使细胞与血管之间的接触作为点接触，从而防止细胞受损，细胞在剥离时经历。

6. 发明申请

US20050095699A1 Functioning substrate with a group of columnar micro pillars and its manufacturing method 审中-公开
标题翻译：具有一组柱状微柱的功能基板及其制造方法
公开(公告)号：US20050095699A1
公开(公告)日：2005-05-05
申请号：US10985972
申请日：2004-11-12
申请人： Akihiro Miyauchi , Kosuke Kuwabara , Masahiko Ogino , Hiroshi Yoshida , Takashi Ando
发明人： Akihiro Miyauchi , Kosuke Kuwabara , Masahiko Ogino , Hiroshi Yoshida , Takashi Ando
IPC分类号： A45B25/18 , B01L3/00 , B81B1/00 , G01N27/42 , G02B1/11 , G02B5/18 , G02B5/28 , G02B6/12 , G02B6/122 , G02B6/43 , C12M1/14 , C12M3/04
CPC分类号： G02B1/111 , A45B25/18 , B01L3/502746 , B01L3/502761 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0877 , B01L2300/166 , B01L2400/086 , B81B1/00 , B81B2203/0361 , B81B2207/056 , B82Y20/00 , C12M25/00 , C12M25/06 , G01N27/423 , G02B1/005 , G02B1/118 , G02B5/289 , G02B6/12004 , G02B6/1225 , G02B6/42 , G02B6/43 , G02B2006/12147 , G02B2006/12166
摘要： A functioning substrate with a group of columnar micro pillars characterized in that a first matrix of organic polymer and a group of columnar micro pillars of organic polymer extending from this matrix are provided. This group of columnar micro pillars has an equivalent diameter of 10 nm through 500 μm and a height of 50 nm through 5000 μm; and the ratio (H/D) of the equivalent diameter (D) to the height (H) of the group of columnar micro pillars is 4 or more.
摘要翻译：具有一组柱状微柱的功能性基底，其特征在于提供了从该基体延伸的有机聚合物的第一基质和一组有机聚合物的柱状微柱。这组柱状微柱的当量直径为10nm至500μm，高度为50nm至5000μm; 并且当量直径（D）与一组柱状微柱的高度（H）的比（H / D）为4以上。

7. 发明授权

US08632714B2 Mold structures, and method of transfer of fine structures 失效
标题翻译：模具结构，精细结构转移方法
公开(公告)号：US08632714B2
公开(公告)日：2014-01-21
申请号：US13526708
申请日：2012-06-19
申请人： Masahiko Ogino , Akihiro Miyauchi , Sigehisa Motowaki , Kosuke Kuwabara
发明人： Masahiko Ogino , Akihiro Miyauchi , Sigehisa Motowaki , Kosuke Kuwabara
IPC分类号： B28B11/08 , B27N3/18 , A01J21/00
CPC分类号： B81C1/0046
摘要： A mold and a pattern transfer method using the same for a nanoprinting technology. The mold can be released from a substrate accurately and easily. The mold, which is used for forming a fine pattern on a substrate using a press machine, comprises a release mechanism.
摘要翻译：用于纳米印刷技术的模具和图案转印方法。模具可以准确而容易地从基材上脱模。使用压制机在基板上形成精细图案的模具包括释放机构。

8. 发明授权

US07520742B2 Nanoprint equipment and method of making fine structure 失效
标题翻译：纳米设备制作精细结构的方法
公开(公告)号：US07520742B2
公开(公告)日：2009-04-21
申请号：US10801579
申请日：2004-03-17
申请人： Shigehisa Motowaki , Akihiro Miyauchi , Masahiko Ogino , Kosuke Kuwabara
发明人： Shigehisa Motowaki , Akihiro Miyauchi , Masahiko Ogino , Kosuke Kuwabara
IPC分类号： B29C33/00 , B29C59/02
CPC分类号： B82Y10/00 , B29C33/58 , B29C37/0067 , B29C37/0075 , B29C59/022 , B29C59/025 , B29C2059/023 , B82Y40/00 , G03F7/0002 , G11B5/74 , G11B5/743 , G11B5/82 , G11B5/84 , H05K3/12 , Y10S977/887
摘要： A pillar with a high aspect ratio is transferred by a nanoprinting method. In order to form a fine structure on a substrate, a nanoprinting apparatus heats and presses the substrate and a mold with a fine concave-convex pattern formed thereon, the mold having a mechanism for transferring and applying a mold-releasing agent. A method for transferring a fine structure using the aforementioned nanoprinting apparatus.
摘要翻译：通过纳米印刷法转移具有高纵横比的支柱。为了在基板上形成精细结构，纳米印刷装置加热并压制基板和形成有细凹凸图案的模具，该模具具有用于转印和施加脱模剂的机构。使用上述纳米印刷装置转印精细结构的方法。

9. 发明申请

US20080229948A1 IMPRINT DEVICE AND METHOD OF MANUFACTURING IMPRINTED STRUCTURE 审中-公开
标题翻译：印刷装置及制造印花结构的方法
公开(公告)号：US20080229948A1
公开(公告)日：2008-09-25
申请号：US12019839
申请日：2008-01-25
申请人： Ryuta Washiya , Takashi Ando , Masahiko Ogino , Hideaki Kataho , Akihiro Miyauchi , Kosuke Kuwabara
发明人： Ryuta Washiya , Takashi Ando , Masahiko Ogino , Hideaki Kataho , Akihiro Miyauchi , Kosuke Kuwabara
IPC分类号： B41F1/40
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： An imprint device transfers a micropattern created on a stamper onto a material to be transferred, by bringing the stamper and the material to be transferred into contact with each other. The imprint device has a flow passage for discharging a fluid to a rear surface of the stamper or the material to be transferred, to thereby bend the stamper or the material to be transferred.
摘要翻译：压印装置通过使压模和被转印材料彼此接触来将形成在压模上的微图案转印到待转印的材料上。压印装置具有用于将流体排放到压模的后表面或待转印的材料的流动通道，从而弯曲压模或要转印的材料。

10. 发明申请

US20050214935A1 Cell culture vessel and cultured cell 失效
标题翻译：细胞培养容器和培养细胞
公开(公告)号：US20050214935A1
公开(公告)日：2005-09-29
申请号：US10989910
申请日：2004-11-17
申请人： Kosuke Kuwabara , Akihiro Miyauchi , Masahiko Ogino , Takashi Ando
发明人： Kosuke Kuwabara , Akihiro Miyauchi , Masahiko Ogino , Takashi Ando
IPC分类号： C12M1/14 , C12M3/00 , C12M3/04
CPC分类号： C12M23/20 , C12M21/08 , C12M23/10
摘要： It is an object of this invention to provide a cell culture vessel which has a simple and convenient structure, can prevent the injury on the cells at the time of peeling, and accelerates the transportation of nutrients and discharge of waste materials. In order to solve the problem mentioned above, the cell culture vessel of this invention has protrusions having a corresponding diameter not smaller than 10 nm and not greater than 10 μm and a height not smaller than 10 nm and not greater than 1 mm on the surface of the cell culture vessel. The protrusions make the culture fluid permeate into the under part of the cells, accelerate the supply of nutrients and discharge of waste materials, and makes the contact between the cells and the vessel as a point-contact and thereby prevents the cells from the injury which the cells undergo at the time of peeling.
摘要翻译：本发明的目的是提供一种结构简单方便的细胞培养容器，可以防止剥离时对细胞的损伤，加速营养物质的运输和废料排出。为了解决上述问题，本发明的细胞培养容器具有相对应的直径不小于10nm且不大于10um的突起，并且在表面上具有不小于10nm且不大于1mm的高度的细胞培养容器。突起使得培养液渗透到细胞的下部，加速营养物质的供给和排出废物，并使细胞与血管之间的接触作为点接触，从而防止细胞受损，细胞在剥离时经历。

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