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1. 发明授权

US08945944B2 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules 有权
标题翻译：用于定量测定分析物的装置和方法，确定分子的有效尺寸的方法，将分子附着于基底的方法以及用于检测分子的装置
公开(公告)号：US08945944B2
公开(公告)日：2015-02-03
申请号：US12923588
申请日：2010-09-29
申请人： Kenji Arinaga , Ulrich Rant
发明人： Kenji Arinaga , Ulrich Rant
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , B01J2219/00605 , C12Q2527/137 , C12Q2527/143 , C12Q2565/518 , G01N33/543
摘要： A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated when the analyte detecting unit has detected the analyte is divided into a plurality of parts in the direction of the flow in the flow channel at the quantitative measurement unit for processing. Also provided are technologies including one for controlling the density of molecules attached to the surface of a solid. In these technologies, when molecules are attached to a substrate, the density of attached molecules is controlled, by having an electrolyte also present in a solution containing the molecules to adjust the screening effect by the electrolyte, and by taking into consideration the effective size of a molecule.
摘要翻译：提供了一种用于定量测定分析物的装置，以显着提高定量测定的性能。该装置配备有流路，用于捕获和检测分析物的分析物检测单元和用于定量测定分析物的定量测量单元，其中当分析物检测单元检测到分析物时产生的信号被分成多个在定量测量单元处的流动通道中的流动方向上的部件进行处理。还提供了包括用于控制附着在固体表面上的分子的密度的技术。在这些技术中，当分子连接到基底上时，通过在含有分子的溶液中也存在电解质来调节附着分子的密度，以调节电解质的筛选效果，并考虑到有效尺寸一个分子

2. 发明申请

US20090088333A1 TARGET MOLECULE EVALUATION METHOD AND APPARATUS 审中-公开
标题翻译：目标分子评估方法和装置
公开(公告)号：US20090088333A1
公开(公告)日：2009-04-02
申请号：US12236810
申请日：2008-09-24
申请人： Michihiko Aki , Kenji Arinaga
发明人： Michihiko Aki , Kenji Arinaga
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： G01N33/5438 , G01N21/66 , G01N21/68 , G01N21/69 , G01N2021/6439
摘要： AC potential is applied between a substrate electrode provided on a substrate and a counter electrode, a sample is brought into contact with a probe molecule bound to the substrate electrode, and a fluorescent signal obtained from a fluorescent marker provided on the probe molecule is observed to evaluate a target molecule in the sample that has bound to the probe molecule, wherein the target molecule is evaluated by measuring a signal intensity and/or a signal amplitude.
摘要翻译：在设置在基板上的基板电极和对置电极之间施加AC电位，使样品与与基板电极结合的探针分子接触，并且观察到从设置在探针分子上的荧光标记获得的荧光信号评估已经结合到探针分子的样品中的靶分子，其中通过测量信号强度和/或信号幅度来评估靶分子。

3. 发明申请

US20080003666A1 Method and apparatus for producing a molecular film with an adjusted density 有权
标题翻译：用于生产具有调节密度的分子膜的方法和设备
公开(公告)号：US20080003666A1
公开(公告)日：2008-01-03
申请号：US11700264
申请日：2007-01-31
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
IPC分类号： C12M1/00
CPC分类号： G01N33/54353
摘要： An object of the present invention is to provide a technique that can adjust a molecular density of the film of functional molecules (e.g. DNA molecules), which is utilized for biochips such as DNA chip, to a desired degree efficiently and easily. The method for producing a molecular film with an adjusted density according to the present invention includes forming a molecular film and adjusting a molecular density. In the forming a molecular film, a molecular film composed of molecules is formed on a conductive substrate, wherein the molecule includes a region capable of binding to the conductive substrate at least in a portion thereof. In the density adjusting, a molecular density of the molecular film is adjusted by desorbing a part of the molecules which make up the molecular film from the conductive substrate.
摘要翻译：本发明的一个目的是提供一种可以有效且容易地调整用于生物芯片如DNA芯片的功能分子（例如DNA分子）的膜的分子密度达到期望的程度的技术。根据本发明的具有调节密度的分子膜的制备方法包括形成分子膜并调节分子密度。在形成分子膜时，在导电性基板上形成由分子构成的分子膜，其中，所述分子具有能够至少部分地与导电性基板结合的区域。在密度调节中，分子膜的分子密度通过从导电性基材上解吸构成分子膜的一部分分子来调节。

4. 发明授权

US08568966B2 Method and apparatus for producing a molecular film with an adjusted density 有权
标题翻译：用于生产具有调节密度的分子膜的方法和设备
公开(公告)号：US08568966B2
公开(公告)日：2013-10-29
申请号：US11700264
申请日：2007-01-31
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Jelena Knezevic
IPC分类号： C12Q1/00
CPC分类号： G01N33/54353
摘要： An object of the present invention is to provide a technique that can adjust a molecular density of the film of functional molecules (e.g. DNA molecules), which is utilized for biochips such as DNA chip, to a desired degree efficiently and easily. The method for producing a molecular film with an adjusted density according to the present invention includes forming a molecular film and adjusting a molecular density. In the forming a molecular film, a molecular film composed of molecules is formed on a conductive substrate, wherein the molecule includes a region capable of binding to the conductive substrate at least in a portion thereof. In the density adjusting, a molecular density of the molecular film is adjusted by desorbing a part of the molecules which make up the molecular film from the conductive substrate.
摘要翻译：本发明的一个目的是提供一种可以有效且容易地调整用于生物芯片如DNA芯片的功能分子（例如DNA分子）的膜的分子密度达到期望的程度的技术。根据本发明的具有调节密度的分子膜的制备方法包括形成分子膜并调节分子密度。在形成分子膜时，在导电性基板上形成由分子构成的分子膜，其中，所述分子具有能够至少部分地与导电性基板结合的区域。在密度调节中，分子膜的分子密度通过从导电性基材上解吸构成分子膜的一部分分子来调节。

5. 发明授权

US08445262B2 Method for evaluating analyte 有权
标题翻译：评估分析物的方法
公开(公告)号：US08445262B2
公开(公告)日：2013-05-21
申请号：US12239987
申请日：2008-09-29
申请人： Kenji Arinaga , Ulrich Rant , Simon Scherer , Erika Pringsheim
发明人： Kenji Arinaga , Ulrich Rant , Simon Scherer , Erika Pringsheim
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6428 , G01N33/5438 , G01N2021/6432 , Y10T436/143333
摘要： In an analyte evaluation method for evaluating an analyte, AC voltage is applied between a substrate electrode on a substrate and a counter electrode, and signals obtained from a marker provided on an analyte bound to the substrate electrode are observed, wherein the frequency of the AC voltage is changed and the behavior of the average value of the marker signals is observed. A novel, highly-selective, low-noise method of evaluating a object of evaluation is thus achieved.
摘要翻译：在用于评价分析物的分析物评价方法中，在基板上的基板电极和对置电极之间施加AC电压，并且观察到从与基板电极结合的分析物上提供的标记获得的信号，其中AC的频率电压被改变，并且观察到标记信号的平均值的行为。从而实现了评价评价对象的新颖，高选择性，低噪声的方法。

6. 发明授权

US08309365B2 Method for evaluating target molecules 有权
标题翻译：靶分子评估方法
公开(公告)号：US08309365B2
公开(公告)日：2012-11-13
申请号：US12626729
申请日：2009-11-27
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
IPC分类号： G01N21/76 , G12Q1/00
CPC分类号： B82Y15/00 , G01N21/6428 , G01N27/3275 , G01N33/5438 , G01N2021/6432
摘要： A method for evaluating a target molecule bound to a probe molecule provided with a marker includes: applying AC voltage between a working electrode provided on a substrate and a counter electrode; and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine at least one of a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, a binding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween.
摘要翻译：用于评价与设置有标记的探针分子结合的靶分子的方法包括：在设置在基板上的工作电极和对电极之间施加交流电压; 并且当交流电压的频率发生变化时，使用从标记获得的信号在与工作电极结合的探针分子上，或者信号的平均值，以确定目标的斯托克斯半径或分子量中的至少一个分子，探针分子和靶分子之间的结合速率，它们之间的结合速率常数，它们之间的解离速率和它们之间的解离速率常数。

7. 发明授权

US07311889B2 Carbon nanotubes, process for their production, and catalyst for production of carbon nanotubes 有权
标题翻译：碳纳米管，其制备方法和用于生产碳纳米管的催化剂
公开(公告)号：US07311889B2
公开(公告)日：2007-12-25
申请号：US10464847
申请日：2003-06-19
申请人： Yuji Awano , Yoshitaka Yamaguchi , Kenji Arinaga , Shozo Fujita
发明人： Yuji Awano , Yoshitaka Yamaguchi , Kenji Arinaga , Shozo Fujita
IPC分类号： D01F9/12
CPC分类号： D01F9/12 , B82Y30/00 , D01F9/127 , D01F9/1272 , D01F9/133 , Y10S977/843
摘要： The invention provides a process for production of carbon nanotubes whereby a laminate prepared by alternating lamination of a metal catalyst and a material other than the metal catalyst is cut to expose the laminated structure, and carbon nanotubes are grown on the metal catalyst at the cut surface of the laminate. The process results in high-quality carbon nanotubes, with minimized bundle growth, which are each individually and independently arranged in a highly precise manner at prescribed locations.The invention also provides a carbon nanotube production process comprising a step of preparing a substrate which is inclined in one or two dimensions from a specific highly symmetrical crystal orientation and vapor depositing a metal catalyst along the atomic steps appearing on the surface of the substrate, and a step of growing the carbon nanotubes by chemical vapor deposition (CVD) using the metal catalyst as nuclei. It is thus possible to control the growth locations, diameters, orientation and chirality of carbon nanotubes.
摘要翻译：本发明提供一种碳纳米管的制造方法，其中通过交替层压金属催化剂和除了金属催化剂之外的材料制成的层压体被切割以暴露层压结构，并且碳纳米管在切割表面上在金属催化剂上生长的层压板。该方法产生高质量的碳纳米管，其最小化束生长，它们在规定的位置上以高度精确的方式各自独立地排列。本发明还提供一种碳纳米管制造方法，其包括以下步骤：制备从特定的高度对称的晶体取向倾斜一维或二维的衬底，并沿着出现在衬底表面上的原子台阶气相沉积金属催化剂，以及通过使用金属催化剂作为核的化学气相沉积（CVD）来生长碳纳米管的步骤。因此可以控制碳纳米管的生长位置，直径，取向和手性。

8. 发明申请

US20070048760A1 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules 审中-公开
标题翻译：用于定量测定分析物的装置和方法，确定分子的有效尺寸的方法，将分子附着于基底的方法以及用于检测分子的装置
公开(公告)号：US20070048760A1
公开(公告)日：2007-03-01
申请号：US11430045
申请日：2006-05-09
申请人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
发明人： Kenji Arinaga , Ulrich Rant , Tsuyoshi Fujihara , Shozo Fujita
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N33/5438 , B01J2219/00605 , C12Q2527/137 , C12Q2527/143 , C12Q2565/518 , G01N33/543
摘要： A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated when the analyte detecting unit has detected the analyte is divided into a plurality of parts in the direction of the flow in the flow channel at the quantitative measurement unit for processing. Also provided are technologies including one for controlling the density of molecules attached to the surface of a solid. In these technologies, when molecules are attached to a substrate, the density of attached molecules is controlled, by having an electrolyte also present in a solution containing the molecules to adjust the screening effect by the electrolyte, and by taking into consideration the effective size of a molecule.
摘要翻译：提供了一种用于定量测定分析物的装置，以显着提高定量测定的性能。该装置配备有流路，用于捕获和检测分析物的分析物检测单元和用于定量测定分析物的定量测量单元，其中当分析物检测单元检测到分析物时产生的信号被分成多个在定量测量单元处的流动通道中的流动方向上的部件进行处理。还提供了包括用于控制附着在固体表面上的分子的密度的技术。在这些技术中，当分子连接到基底上时，通过在含有分子的溶液中也存在电解质来调节附着分子的密度，以调节电解质的筛选效果，并考虑到有效尺寸一个分子

9. 发明申请

US20050164371A1 Cavity electrode structure, and sensor and protein detection device using the same 审中-公开
标题翻译：腔电极结构，以及使用传感器和蛋白质的检测装置
公开(公告)号：US20050164371A1
公开(公告)日：2005-07-28
申请号：US11074865
申请日：2005-03-09
申请人： Kenji Arinaga
发明人： Kenji Arinaga
IPC分类号： C12M1/34 , G01N27/02 , G01N33/543
CPC分类号： G01N33/5438 , G01N27/3278
摘要： A cavity electrode structure, which is provided with a pair of opposing electrodes having a precisely formed narrow gap, and a sensor and a protein detection device, in which the cavity electrode structure is used, are provided. The cavity electrode structure comprises a first electrode, an insulating layer located on this first electrode and having a through hole that partially exposes the first electrode, and a second electrode opposed to the exposed surface of the first electrode by protruding towards the inside of the through hole of the insulating layer and provided with an opening that leads to the through hole of the insulating layer, the structure having a cavity that is formed by the exposed surface of the first electrode, the inner walls of the through hole of the insulating layer, and the surface of the second electrode that opposes the first electrode. The sensor comprises an electrically conductive bridging member of which one end is fixed to the exposed surface of the first electrode of the aforementioned cavity electrode structure, while the other end is fixed to the opposing surface of the second electrode, and which has a site that specifically binds to a target protein to be detected. The protein detection device uses a bridging member provided with a site that specifically binds to a target protein to be detected.
摘要翻译：设置有具有精确形成的窄间隙的一对相对电极的空腔电极结构以及使用空腔电极结构的传感器和蛋白质检测装置。空腔电极结构包括第一电极，位于该第一电极上的绝缘层，并且具有部分地暴露第一电极的通孔，以及与第一电极的暴露表面相对的第二电极，所述绝缘层的通孔设置有通向所述绝缘层的通孔的开口，所述结构具有由所述第一电极的暴露表面，所述绝缘层的通孔的内壁形成的空腔，以及与第一电极相对的第二电极的表面。传感器包括导电桥接构件，其一端固定到上述空腔电极结构的第一电极的暴露表面，而另一端固定到第二电极的相对表面，并且具有特异性结合待检测的靶蛋白。蛋白质检测装置使用具有与待检测的靶蛋白特异性结合的位点的桥接成员。

10. 发明申请

US20100133121A1 METHOD FOR EVALUATING TARGET MOLECULES 有权
标题翻译：评估目标分子的方法
公开(公告)号：US20100133121A1
公开(公告)日：2010-06-03
申请号：US12626729
申请日：2009-11-27
申请人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
发明人： Kenji Arinaga , Ulrich Rant , Erika Pringsheim , Wolfgang Kaiser , Jelena Knezevic
IPC分类号： G01N27/26
CPC分类号： B82Y15/00 , G01N21/6428 , G01N27/3275 , G01N33/5438 , G01N2021/6432
摘要： A method for evaluating a target molecule bound to a probe molecule provided with a marker includes: applying AC voltage between a working electrode provided on a substrate and a counter electrode; and using a signal obtained from the marker on the probe molecule bound to the working electrode when a frequency of the AC voltage is varied, or an average value of the signal, to determine at least one of a Stokes radius or molecular weight of the target molecule, a binding rate between the probe molecule and the target molecule, a binding rate constant therebetween, a dissociation rate therebetween, and a dissociation rate constant therebetween.
摘要翻译：用于评价与设置有标记的探针分子结合的靶分子的方法包括：在设置在基板上的工作电极和对电极之间施加交流电压; 并且当交流电压的频率发生变化时，使用从标记获得的信号在与工作电极结合的探针分子上，或者信号的平均值，以确定目标的斯托克斯半径或分子量中的至少一个分子，探针分子和靶分子之间的结合速率，它们之间的结合速率常数，它们之间的解离速率和它们之间的解离速率常数。

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