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1. 发明授权

US08247763B2 Ion trap time-of-flight mass spectrometer 有权
标题翻译：离子阱飞行时间质谱仪
公开(公告)号：US08247763B2
公开(公告)日：2012-08-21
申请号：US12519066
申请日：2007-12-12
申请人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
发明人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
IPC分类号： H01J49/40 , H01J49/42 , G01N27/62
CPC分类号： H01J49/424
摘要： The main voltage generator (5) applies a rectangular-wave radio-frequency voltage to the ring electrode (21) in order to capture ions inside the ion trap (2). In the case where the TOFMS (3) is operated in the reflectron mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 1.5π, and a voltage for expelling ions is applied to the end cap electrodes (22, 23) to expel the ions from the exit aperture (25) and introduce them into the TOFMS (3). In this case, since the velocity spread of the ions inside the ion trap (2) is small and so is the spatial spread thereof, a high mass resolution and accuracy can be achieved while assuring a high detection sensitivity. In the case where the TOFMS (3) is operated in the linear mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 0.5π, and then the ions are expelled. In this case, a high mass resolution and mass accuracy can be achieved since the variation of the ions' acceleration, which cannot be converged in the linear mode, can be suppressed.
摘要翻译：主电压发生器（5）向环形电极（21）施加矩形波射频电压，以便捕获离子阱（2）内部的离子。在TOFMS（3）以反射模式工作的情况下，当其相位为1.5＆pgr时，射频电压变为恒定电压值，并且将用于排出离子的电压施加到端盖电极（22,23）以从出口孔（25）排出离子并将它们引入到TOFMS（3）中。在这种情况下，由于离子阱（2）内的离子的速度扩散小，因此其空间扩展也可以实现高质量分辨率和精度，同时确保高检测灵敏度。在TOFMS（3）以线性模式操作的情况下，当其相位为0.5＆pgr时，射频电压变为恒定电压值，然后离子被排出。在这种情况下，可以实现高质量分辨率和质量精度，因为可以抑制不能收敛在线性模式中的离子加速度的变化。

2. 发明申请

US20090278042A1 ION TRAP TIME-OF-FLIGHT MASS SPECTROMETER 有权
标题翻译：离子捕捉飞行时间质谱仪
公开(公告)号：US20090278042A1
公开(公告)日：2009-11-12
申请号：US12519066
申请日：2007-12-12
申请人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
发明人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
IPC分类号： H01J49/00
CPC分类号： H01J49/424
摘要： The main voltage generator (5) applies a rectangular-wave radio-frequency voltage to the ring electrode (21) in order to capture ions inside the ion trap (2). In the case where the TOFMS (3) is operated in the reflectron mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 1.5π, and a voltage for expelling ions is applied to the end cap electrodes (22, 23) to expel the ions from the exit aperture (25) and introduce them into the TOFMS (3). In this case, since the velocity spread of the ions inside the ion trap (2) is small and so is the spatial spread thereof, a high mass resolution and accuracy can be achieved while assuring a high detection sensitivity. In the case where the TOFMS (3) is operated in the linear mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 0.5π, and then the ions are expelled. In this case, a high mass resolution and mass accuracy can be achieved since the variation of the ions' acceleration, which cannot be converged in the linear mode, can be suppressed.
摘要翻译：主电压发生器（5）向环形电极（21）施加矩形波射频电压，以便捕获离子阱（2）内部的离子。在TOFMS（3）以反射器模式工作的情况下，当其相位为1.5pi时，射频电压变为恒定电压值，并且将用于排出离子的电压施加到端盖电极（从出口孔（25）排出离子并将其引入到TOFMS（3）中。在这种情况下，由于离子阱（2）内的离子的速度扩散小，因此其空间扩展也可以实现高质量分辨率和精度，同时确保高检测灵敏度。在TOFMS（3）以线性模式操作的情况下，当其相位为0.5pi时，射频电压变为恒定电压值，然后离子被排出。在这种情况下，可以实现高质量分辨率和质量精度，因为可以抑制不能收敛在线性模式中的离子加速度的变化。

3. 发明申请

US20110248161A1 Multi-Turn Time-of-Flight Mass Spectrometer 审中-公开
标题翻译：多转飞行时间质谱仪
公开(公告)号：US20110248161A1
公开(公告)日：2011-10-13
申请号：US13122382
申请日：2008-10-02
申请人： Kengo Takeshita , Hideaki Izumi
发明人： Kengo Takeshita , Hideaki Izumi
IPC分类号： H01J49/46
CPC分类号： H01J49/004 , H01J49/408 , H01J49/424
摘要： The present invention aims at automatically obtaining a mass spectrum over a wide mass range with a high mass resolution, without the need of the complicated determination of the number of turns or other troublesome computations due to the overtaking of ions on a loop orbit. First, a mass analysis of a target sample is performed under conditions which ensure that the overtaking of ions does not occur, to obtain a mass spectrum with a low mass resolution (S1 and S2). One or more peaks appearing on the mass spectrum are extracted based on predetermined conditions, the mass ranges corresponding to the extracted peaks are determined, and the analysis conditions which ensure that the overtaking of ions does not occur are determined for each of the mass ranges (S3 and S4). Then, in accordance with the analysis conditions, ions within a restricted mass range are selected and ejected from the ion trap to be made to fly along the loop orbit, and mass spectra with a high mass resolution are obtained (S5 and S6). The mass spectrum with a low mass spectrum and the mass spectra with a high mass resolution are eventually combined to create a mass spectrum over a wide mass range (S8).
摘要翻译：本发明旨在以高质量分辨率自动获得在宽质量范围内的质谱，而不需要复杂的匝数确定或由于在环路轨道上超越离子而引起的其他麻烦的计算。首先，在确保不发生离子超驰的条件下进行目标样品的质量分析，以获得质量分辨率低的质谱（S1和S2）。基于预定条件提取出现在质谱上的一个或多个峰，确定与提取的峰相对应的质量范围，并且确定每个质量范围确保离子超驰的分析条件（ S3和S4）。然后，根据分析条件，选择限制质量范围内的离子并从离子阱排出，使其沿着环轨道飞行，并获得质量分辨率高的质谱（S5和S6）。具有低质谱的质谱和具有高质量分辨率的质谱最终被组合以在宽质量范围内产生质谱（S8）。

4. 发明申请

US20120175514A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20120175514A1
公开(公告)日：2012-07-12
申请号：US13380440
申请日：2009-06-22
申请人： Hideaki Izumi
发明人： Hideaki Izumi
IPC分类号： H01J49/26
CPC分类号： H01J49/025 , H01J43/30
摘要： In an ion detector, power supplies (21 through 23) generating independently controllable voltages are provided to respectively apply voltages to first to fifth dynodes (11 through 15), a final dynode (16), and an anode (17) in a secondary electron multiplier (10). Furthermore, the signal from the anode (17) is extracted, and the signal from the fifth dynode (15), which has a low electron multiplication rate, is extracted. These two signals are concurrently converted into digital values, taken in by a data processing unit (34), and stored in a data storage unit (35). When a mass spectrum is created in the data processing unit (34), the two detected data for the same time are read out and the presence or absence of signal saturation or waveform deformation is determined from the values of one of the detection data. If there is a high probability of signal saturation, the detection data based on the signals in the intermediate stages are selected, and the level of the selected data is corrected. The application of independent voltages to the secondary electron multiplier (10) makes the signal saturation less likely to occur. Even if saturation temporarily occurs, an unsaturated signal can be reflected in the mass spectrum.
摘要翻译：在离子检测器中，提供产生独立可控电压的电源（21至23），以分别施加电压到第二至第五倍增电极（11至15），最终倍增电极（16）和阳极（17）乘数（10）。此外，提取来自阳极（17）的信号，并且提取具有低电子倍率的来自第五倍增极（15）的信号。这两个信号同时被转换为由数据处理单元（34）接收的数字值，并存储在数据存储单元（35）中。当在数据处理单元（34）中产生质谱时，读出两个相同时间的检测数据，并根据检测数据之一的值确定是否存在信号饱和或波形变形。如果信号饱和的概率很高，则选择基于中间级的信号的检测数据，校正所选择的数据的电平。对二次电子倍增器（10）施加独立电压使得不太可能发生信号饱和。即使暂时发生饱和，也可以在质谱中反映不饱和信号。

5. 发明申请

US20090230301A1 MASS SPECTROMETRY APPARATUS AND METHOD 审中-公开
标题翻译：质谱仪器和方法
公开(公告)号：US20090230301A1
公开(公告)日：2009-09-17
申请号：US12355462
申请日：2009-01-16
申请人： Osamu furuhashi , Takahiro Harada , Hideaki Izumi , Kiyoshi Ogawa
发明人： Osamu furuhashi , Takahiro Harada , Hideaki Izumi , Kiyoshi Ogawa
IPC分类号： B01D59/44 , H01J49/10
CPC分类号： H01J49/4265
摘要： Disclosed is a mass spectrometry apparatus and method capable of providing enhanced analysis sensitivity in a mass spectrometric analysis for a small amount of ions. A quadrupole rod-type ion guide is employed to temporarily accumulate ions to be introduced into an ion trap, and ions are introduced into the ion guide in an amount less than a saturated ion amount in the ion guide, and accumulated in an exit end of the ion guide. As compared with an octopole rod-type ion guide, the quadrupole rod-type ion guide has a higher ion-converging capability, and therefore can confine and hold a small amount of ions around an ion optical axis, although it is inferior in ion-accumulating capability. This makes it possible to efficiently introduce the ions into the ion trap through two openings of an electric field-correcting electrode and an entrance endcap electrode, so as to perform a high-sensitive analysis.
摘要翻译：公开了能够在少量离子的质谱分析中提供增强的分析灵敏度的质谱装置和方法。采用四极杆型离子导向器暂时积聚离子以引入离子阱，并将离子以小于离子导向器中的饱和离子量的量引入离子导向器中，并且累积在离子导向。与八极杆型离子导向器相比，四极杆型离子导向器具有较高的离子收敛能力，因此可以限制和保持离子光轴周围的少量离子，尽管其离子 - 积累能力。这使得可以通过电场校正电极和入口端帽电极的两个开口有效地将离子引入离子阱中，从而进行高灵敏度分析。

6. 发明授权

US09613787B2 Time-of-flight mass spectrometer for conducting high resolution mass analysis 有权
公开(公告)号：US09613787B2
公开(公告)日：2017-04-04
申请号：US13119155
申请日：2008-09-16
申请人： Osamu Furuhashi , Shinichi Yamaguchi , Hideaki Izumi
发明人： Osamu Furuhashi , Shinichi Yamaguchi , Hideaki Izumi
IPC分类号： H01J49/00 , H01J49/04 , H01J49/40
CPC分类号： H01J49/0481 , H01J49/0031 , H01J49/408
摘要： A first mass analysis is executed in a condition that gas is not introduced into a loop-flight chamber (4), and a time-of-flight spectrum obtained in a data processor (12) is stored in a storage unit (13). Next, a second mass analysis is executed on the same sample as the one used in the first mass analysis in a condition that a valve (8) is opened and helium gas (He) is introduced into the loop-flight chamber (4), and the time-of-flight spectrum is obtained in the data processor (12). If different kinds of ions having the same m/z value exit, these ions form a single peak in the first time-of-flight spectrum, while these ions appear as separate peaks in the second time-of-flight spectrum even though they have the same m/z value. This is because, in the second mass analysis, the ions collide with the gas and have different times of flight depending on their difference in size. A spectrum comparator (14) judges a change in the position or shape of the peak by comparing the two spectra, and outputs information relating to the difference in the size of the ions (the molecular structure, charge state, or molecular class of the ions), and the like. Accordingly, a wider variety of information than ever before can be provided.

7. 发明授权

US08519327B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08519327B2
公开(公告)日：2013-08-27
申请号：US13380440
申请日：2009-06-22
申请人： Hideaki Izumi
发明人： Hideaki Izumi
IPC分类号： H01J49/26
CPC分类号： H01J49/025 , H01J43/30
摘要： In an ion detector, power supplies (21 through 23) generating independently controllable voltages are provided to respectively apply voltages to first to fifth dynodes (11 through 15), a final dynode (16), and an anode (17) in a secondary electron multiplier (10). Furthermore, the signal from the anode (17) is extracted, and the signal from the fifth dynode (15), which has a low electron multiplication rate, is extracted. These two signals are concurrently converted into digital values, taken in by a data processing unit (34), and stored in a data storage unit (35). When a mass spectrum is created in the data processing unit (34), the two detected data for the same time are read out and the presence or absence of signal saturation or waveform deformation is determined from the values of one of the detection data. If there is a high probability of signal saturation, the detection data based on the signals in the intermediate stages are selected, and the level of the selected data is corrected. The application of independent voltages to the secondary electron multiplier (10) makes the signal saturation less likely to occur. Even if saturation temporarily occurs, an unsaturated signal can be reflected in the mass spectrum.
摘要翻译：在离子检测器中，提供产生独立可控电压的电源（21至23），以分别施加电压到第二至第五倍增电极（11至15），最终倍增电极（16）和阳极（17）乘数（10）。此外，提取来自阳极（17）的信号，并且提取具有低电子倍率的来自第五倍增极（15）的信号。这两个信号同时被转换为由数据处理单元（34）接收的数字值，并存储在数据存储单元（35）中。当在数据处理单元（34）中产生质谱时，读出两个相同时间的检测数据，并根据检测数据之一的值确定是否存在信号饱和或波形变形。如果信号饱和的概率很高，则选择基于中间级的信号的检测数据，校正所选数据的电平。对二次电子倍增器（10）施加独立电压使得不太可能发生信号饱和。即使暂时发生饱和，也可以在质谱中反映不饱和信号。

8. 发明申请

US20110192972A1 Time-Of-Flight Mass Spectrometer 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US20110192972A1
公开(公告)日：2011-08-11
申请号：US13119155
申请日：2008-09-16
申请人： Osamu Furuhashi , Shinichi Yamaguchi , Hideaki Izumi
发明人： Osamu Furuhashi , Shinichi Yamaguchi , Hideaki Izumi
IPC分类号： H01J49/40
CPC分类号： H01J49/0481 , H01J49/0031 , H01J49/408
摘要： A first mass analysis is executed in a condition that gas is not introduced into a loop-flight chamber (4), and a time-of-flight spectrum obtained in a data processor (12) is stored in a storage unit (13). Next, a second mass analysis is executed on the same sample as the one used in the first mass analysis in a condition that a valve (8) is opened and helium gas (He) is introduced into the loop-flight chamber (4), and the time-of-flight spectrum is obtained in the data processor (12). If different kinds of ions having the same m/z value exit, these ions form a single peak in the first time-of-flight spectrum, while these ions appear as separate peaks in the second time-of-flight spectrum even though they have the same m/z value. This is because, in the second mass analysis, the ions collide with the gas and have different times of flight depending on their difference in size. A spectrum comparator (14) judges a change in the position or shape of the peak by comparing the two spectra, and outputs information relating to the difference in the size of the ions (the molecular structure, charge state, or molecular class of the ions), and the like. Accordingly, a wider variety of information than ever before can be provided.
摘要翻译：在没有将气体引入回路飞行室（4）的情况下执行第一质量分析，并且将在数据处理器（12）中获得的飞行时间频谱存储在存储单元（13）中。接下来，在打开阀（8）并且将氦气（He）引入回路飞行室（4）的状态下，在与第一质量分析中使用的样品相同的样品上进行第二质量分析，并且在数据处理器（12）中获得飞行时间频谱。如果具有相同m / z值的不同种类的离子退出，则这些离子在第一飞行时间谱中形成单个峰，而这些离子在第二时间飞行频谱中表现为单独的峰，即使它们具有相同的m / z值。这是因为在第二次质量分析中，离子与气体碰撞并且具有不同的飞行次数，这取决于它们的尺寸差异。光谱比较器（14）通过比较两个光谱来判断峰的位置或形状的变化，并且输出与离子的大小差异（离子的分子结构，电荷状态或分子类别）有关的信息）等。因此，可以提供比以往更广泛的信息。

9. 发明授权

US07066386B2 Loading apparatus for card type recording mediums 失效
标题翻译：卡式记录介质的装载装置
公开(公告)号：US07066386B2
公开(公告)日：2006-06-27
申请号：US11039942
申请日：2005-01-24
申请人： Hideaki Izumi
发明人： Hideaki Izumi
IPC分类号： G06K13/00
CPC分类号： G06K19/07732 , G06K7/0021
摘要： A loading apparatus for card type recording mediums comprises a first loading section for receiving a first IC card and a second loading section for receiving a second IC card, the first loading section and the second loading section being arranged in parallel with each other at the side of the top surface of the apparatus, along with a third loading section for receiving a third IC card arranged at the side of the bottom surface of the apparatus. The apparatus main body is connected to a host apparatus such as a personal computer by way of a cable. The first and second loading sections are provided with respective bulged sections showing plan views similar to those of the IC cards to be received therein so that the user can identify the loading sections simply by touching them.
摘要翻译：用于卡式记录介质的装载装置包括用于接收第一IC卡的第一装载部分和用于接收第二IC卡的第二装载部分，第一装载部分和第二装载部分在侧面彼此平行地布置的第三加载部分，用于接收布置在装置的底表面侧的第三IC卡。设备主体通过电缆连接到诸如个人计算机的主机设备。第一和第二加载部分设置有各自的凸出部分，其显示与要在其中接收的IC卡类似的平面图，使得用户可以通过触摸来识别加载部分。

10. 外观设计

USD503172S1 Reader/writer for storage medium 失效
标题翻译：用于存储介质的读写器
公开(公告)号：USD503172S1
公开(公告)日：2005-03-22
申请号：US29202784
申请日：2004-04-06
申请人： Hideaki Izumi
设计人： Hideaki Izumi

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