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1. 发明授权

US08247763B2 Ion trap time-of-flight mass spectrometer 有权
标题翻译：离子阱飞行时间质谱仪
公开(公告)号：US08247763B2
公开(公告)日：2012-08-21
申请号：US12519066
申请日：2007-12-12
申请人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
发明人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
IPC分类号： H01J49/40 , H01J49/42 , G01N27/62
CPC分类号： H01J49/424
摘要： The main voltage generator (5) applies a rectangular-wave radio-frequency voltage to the ring electrode (21) in order to capture ions inside the ion trap (2). In the case where the TOFMS (3) is operated in the reflectron mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 1.5π, and a voltage for expelling ions is applied to the end cap electrodes (22, 23) to expel the ions from the exit aperture (25) and introduce them into the TOFMS (3). In this case, since the velocity spread of the ions inside the ion trap (2) is small and so is the spatial spread thereof, a high mass resolution and accuracy can be achieved while assuring a high detection sensitivity. In the case where the TOFMS (3) is operated in the linear mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 0.5π, and then the ions are expelled. In this case, a high mass resolution and mass accuracy can be achieved since the variation of the ions' acceleration, which cannot be converged in the linear mode, can be suppressed.
摘要翻译：主电压发生器（5）向环形电极（21）施加矩形波射频电压，以便捕获离子阱（2）内部的离子。在TOFMS（3）以反射模式工作的情况下，当其相位为1.5＆pgr时，射频电压变为恒定电压值，并且将用于排出离子的电压施加到端盖电极（22,23）以从出口孔（25）排出离子并将它们引入到TOFMS（3）中。在这种情况下，由于离子阱（2）内的离子的速度扩散小，因此其空间扩展也可以实现高质量分辨率和精度，同时确保高检测灵敏度。在TOFMS（3）以线性模式操作的情况下，当其相位为0.5＆pgr时，射频电压变为恒定电压值，然后离子被排出。在这种情况下，可以实现高质量分辨率和质量精度，因为可以抑制不能收敛在线性模式中的离子加速度的变化。

2. 发明申请

US20090278042A1 ION TRAP TIME-OF-FLIGHT MASS SPECTROMETER 有权
标题翻译：离子捕捉飞行时间质谱仪
公开(公告)号：US20090278042A1
公开(公告)日：2009-11-12
申请号：US12519066
申请日：2007-12-12
申请人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
发明人： Hideaki Izumi , Kengo Takeshita , Kiyoshi Ogawa
IPC分类号： H01J49/00
CPC分类号： H01J49/424
摘要： The main voltage generator (5) applies a rectangular-wave radio-frequency voltage to the ring electrode (21) in order to capture ions inside the ion trap (2). In the case where the TOFMS (3) is operated in the reflectron mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 1.5π, and a voltage for expelling ions is applied to the end cap electrodes (22, 23) to expel the ions from the exit aperture (25) and introduce them into the TOFMS (3). In this case, since the velocity spread of the ions inside the ion trap (2) is small and so is the spatial spread thereof, a high mass resolution and accuracy can be achieved while assuring a high detection sensitivity. In the case where the TOFMS (3) is operated in the linear mode, the radio-frequency voltage is changed into a constant voltage value when the phase thereof is 0.5π, and then the ions are expelled. In this case, a high mass resolution and mass accuracy can be achieved since the variation of the ions' acceleration, which cannot be converged in the linear mode, can be suppressed.
摘要翻译：主电压发生器（5）向环形电极（21）施加矩形波射频电压，以便捕获离子阱（2）内部的离子。在TOFMS（3）以反射器模式工作的情况下，当其相位为1.5pi时，射频电压变为恒定电压值，并且将用于排出离子的电压施加到端盖电极（从出口孔（25）排出离子并将其引入到TOFMS（3）中。在这种情况下，由于离子阱（2）内的离子的速度扩散小，因此其空间扩展也可以实现高质量分辨率和精度，同时确保高检测灵敏度。在TOFMS（3）以线性模式操作的情况下，当其相位为0.5pi时，射频电压变为恒定电压值，然后离子被排出。在这种情况下，可以实现高质量分辨率和质量精度，因为可以抑制不能收敛在线性模式中的离子加速度的变化。

3. 发明授权

US07683316B2 Ion trap mass spectrometer 有权
标题翻译：离子阱质谱仪
公开(公告)号：US07683316B2
公开(公告)日：2010-03-23
申请号：US12117311
申请日：2008-05-08
申请人： Kengo Takeshita , Kiyoshi Ogawa
发明人： Kengo Takeshita , Kiyoshi Ogawa
IPC分类号： H01J49/42
CPC分类号： H01J49/42
摘要： The number of times of repetition of mass spectrometry analysis for integrating mass profiles is reduced to facilitate reduction in measurement time-period and increase a signal intensity. In a state when ions are trapped by a high-frequency electric field formed within an ion trap, a rectangular-wave high-frequency voltage to be applied from a main voltage generation section to a ring electrode is temporarily stopped, and next ions are introduced from an ion entrance port into the ion trap in a state when only a static electric field exists within the ion trap. The high-frequency voltage application is re-started while at least a part of previously-trapped ions remain within the ion trap, to trap the newly-introduced ions in addition to the previous ions so as to increase an amount of ions to be accumulated, and the accumulated ions are subjected to the mass spectrometry analysis.
摘要翻译：减少用于积分质量分布的质谱分析重复次数，以便减少测量时间段并增加信号强度。在离子被离子阱内形成的高频电场捕获的状态下，暂时停止从主电压产生部向环状电极施加的矩形波高频电压，并将下一个离子引入在离子阱内仅存在静电场的状态下从离子入口进入离子阱。高频电压施加被重新启动，而至少一部分先前捕获的离子保留在离子阱内，以除去先前的离子以捕获新引入的离子，以增加要积聚的离子的量，并对积分的离子进行质谱分析。

4. 发明授权

US07582866B2 Ion trap mass spectrometry 有权
标题翻译：离子阱质谱法
公开(公告)号：US07582866B2
公开(公告)日：2009-09-01
申请号：US11866794
申请日：2007-10-03
申请人： Osamu Furuhashi , Kengo Takeshita , Kiyoshi Ogawa
发明人： Osamu Furuhashi , Kengo Takeshita , Kiyoshi Ogawa
IPC分类号： H01J49/42 , H01J49/26
CPC分类号： H01J49/424 , H01J49/0059 , H01J49/427
摘要： Disclosed is an ion trap mass spectrometer for MSn analysis, which comprises a frequency-driven ion trap section operable to trap sample ions and isolate a precursor ion from the sample ions, while setting an ion-trapping RF voltage waveform at a first frequency providing a first low-mass cutoff (LMCO) value, and, then after setting the ion-trapping RF voltage waveform at a second frequency greater than the first frequency to provide a second LMCO value less than the first LMCO value, without changing an amplitude of the ion-trapping RF voltage waveform, to irradiate the precursor ion in a trapped state with light so as to photodissociate the precursor ion into fragment ions; and an analyzer section operable to subject the fragment ions ejected from the ion trap section, to mass spectrometry so as to obtain information about a molecular structure of the precursor ion. The ion trap mass spectrometer of the present invention can maximize a mass range coverable in one cycle of MSn analysis.
摘要翻译：公开了一种用于MSn分析的离子阱质谱仪，其包括频率驱动的离子阱部分，其可操作以捕获样品离子并将前体离子与样品离子隔离，同时将第一频率处的离子捕获RF电压波形设置为提供第一低质量截止值（LMCO）值，然后在大于第一频率的第二频率设置离子捕获RF电压波形之后，提供小于第一LMCO值的第二LMCO值，而不改变离子捕获RF电压波形，用光照射处于捕获状态的前体离子，以将前体离子光致离解成碎片离子; 以及分析器部，其可操作以使从离子阱部分喷射的碎片离子进行质谱分析，以获得关于前体离子的分子结构的信息。本发明的离子阱质谱仪可以在MSn分析的一个循环中使质量范围最大化。

5. 发明申请

US20080277580A1 ION TRAP MASS SPECTROMETER 有权
标题翻译：离子阱质谱仪
公开(公告)号：US20080277580A1
公开(公告)日：2008-11-13
申请号：US12117311
申请日：2008-05-08
申请人： Kengo TAKESHITA , Kiyoshi Ogawa
发明人： Kengo TAKESHITA , Kiyoshi Ogawa
IPC分类号： H01J49/42
CPC分类号： H01J49/42
摘要： The number of times of repetition of mass spectrometry analysis for integrating mass profiles is reduced to facilitate reduction in measurement time-period and increase a signal intensity. In a state when ions are trapped by a high-frequency electric field formed within an ion trap, a rectangular-wave high-frequency voltage to be applied from a main voltage generation section to a ring electrode is temporarily stopped, and next ions are introduced from an ion entrance port into the ion trap in a state when only a static electric field exists within the ion trap. The high-frequency voltage application is re-started while at least a part of previously-trapped ions remain within the ion trap, to trap the newly-introduced ions in addition to the previous ions so as to increase an amount of ions to be accumulated, and the accumulated ions are subjected to the mass spectrometry analysis.
摘要翻译：减少用于积分质量分布的质谱分析重复次数，以便减少测量时间段并增加信号强度。在离子被离子阱内形成的高频电场捕获的状态下，暂时停止从主电压产生部向环状电极施加的矩形波高频电压，并将下一个离子引入在离子阱内仅存在静电场的状态下从离子入口进入离子阱。高频电压施加被重新启动，而至少一部分先前捕获的离子保留在离子阱内，以除去先前的离子以捕获新引入的离子，以增加要积聚的离子的量，并对积分的离子进行质谱分析。

6. 发明申请

US20090230301A1 MASS SPECTROMETRY APPARATUS AND METHOD 审中-公开
标题翻译：质谱仪器和方法
公开(公告)号：US20090230301A1
公开(公告)日：2009-09-17
申请号：US12355462
申请日：2009-01-16
申请人： Osamu furuhashi , Takahiro Harada , Hideaki Izumi , Kiyoshi Ogawa
发明人： Osamu furuhashi , Takahiro Harada , Hideaki Izumi , Kiyoshi Ogawa
IPC分类号： B01D59/44 , H01J49/10
CPC分类号： H01J49/4265
摘要： Disclosed is a mass spectrometry apparatus and method capable of providing enhanced analysis sensitivity in a mass spectrometric analysis for a small amount of ions. A quadrupole rod-type ion guide is employed to temporarily accumulate ions to be introduced into an ion trap, and ions are introduced into the ion guide in an amount less than a saturated ion amount in the ion guide, and accumulated in an exit end of the ion guide. As compared with an octopole rod-type ion guide, the quadrupole rod-type ion guide has a higher ion-converging capability, and therefore can confine and hold a small amount of ions around an ion optical axis, although it is inferior in ion-accumulating capability. This makes it possible to efficiently introduce the ions into the ion trap through two openings of an electric field-correcting electrode and an entrance endcap electrode, so as to perform a high-sensitive analysis.
摘要翻译：公开了能够在少量离子的质谱分析中提供增强的分析灵敏度的质谱装置和方法。采用四极杆型离子导向器暂时积聚离子以引入离子阱，并将离子以小于离子导向器中的饱和离子量的量引入离子导向器中，并且累积在离子导向。与八极杆型离子导向器相比，四极杆型离子导向器具有较高的离子收敛能力，因此可以限制和保持离子光轴周围的少量离子，尽管其离子 - 积累能力。这使得可以通过电场校正电极和入口端帽电极的两个开口有效地将离子引入离子阱中，从而进行高灵敏度分析。

7. 发明授权

US10012572B2 Mass-analysis data processing method and system 有权
公开(公告)号：US10012572B2
公开(公告)日：2018-07-03
申请号：US13458850
申请日：2012-04-27
申请人： Masaaki Matsuura , Masaru Ushijima , Masatoshi Wakui , Mitsutoshi Setou , Shigeki Kajihara , Kiyoshi Ogawa
发明人： Masaaki Matsuura , Masaru Ushijima , Masatoshi Wakui , Mitsutoshi Setou , Shigeki Kajihara , Kiyoshi Ogawa
IPC分类号： G01N1/28 , G06F15/00 , H01J49/00
CPC分类号： G01N1/28 , G06F15/00 , H01J49/0004 , H01J49/0027
摘要： Provided is a technique for using an optical microscope image of an area on a sample to collect area-specific information characterizing each kind of biological tissue from imaging mass analysis data. On an optical image of a two-dimensional target area on a sample, a difference is examined in the kind of tissue or other features and areas are specified, each regarded as the same kind of tissue. When data processing is initiated, peak information is extracted, for each specified area, from mass spectrum data of all the measurement points. A peak method is applied to each area to extract peak information. Then, when a command to compare a set of areas is given, the peak information of those areas is collected. By comparing the peak information of different areas by a machine learning algorithm or similar judging technique, area-specific peak information is obtained, and this information is stored in memory.

8. 发明授权

US08650721B2 Buckle device for seat belt and manufacturing method thereof 有权
标题翻译：安全带带扣装置及其制造方法
公开(公告)号：US08650721B2
公开(公告)日：2014-02-18
申请号：US12676800
申请日：2008-09-11
申请人： Kiyoshi Ogawa , Goushu Kataoka , Katsuyasu Ono , Yuji Sakata , Hitoshi Futaki , Masanao Yamazaki
发明人： Kiyoshi Ogawa , Goushu Kataoka , Katsuyasu Ono , Yuji Sakata , Hitoshi Futaki , Masanao Yamazaki
IPC分类号： A44B11/00 , B60R22/22
CPC分类号： B60R22/12 , B60R22/22 , B60R2022/1806 , Y10T24/4047 , Y10T24/4086 , Y10T24/45241 , Y10T24/45623 , Y10T24/4736 , Y10T24/4745 , Y10T29/49826
摘要： A buckle device 10 for a seat belt includes: an anchor plate 11 that can be attached to a vehicle body side; a buckle 20 to which a tongue of the seat belt can be detachably attached; and a woven fabric 30 that is passed through hole portions 14, 26 formed respectively in the anchor plate 11 and the buckle 20, the woven fabric 30 being folded back so as to overlap at least triply and being sewn together in the overlapping part. A tip end portion 31a of the woven fabric 30 tucked into the inner side contacts the opposing buckle 20.
摘要翻译：用于座椅安全带的带扣装置10包括：可附接到车体侧的锚板11; 安全带的舌头可拆卸地安装在其上的带扣20; 以及穿过分别形成在锚固板11和带扣20中的孔部分14,26的织物30，将织物30折叠成至少三重重叠并在重叠部分缝合在一起。卷入内侧的织物30的前端部31a与相对的扣环20接触。

9. 发明授权

US08286903B2 Seat belt retractor 有权
标题翻译：安全带卷收器
公开(公告)号：US08286903B2
公开(公告)日：2012-10-16
申请号：US12945478
申请日：2010-11-12
申请人： Kiyoshi Ogawa , Masuo Matsuki
发明人： Kiyoshi Ogawa , Masuo Matsuki
IPC分类号： B65H75/48
CPC分类号： B60R22/4676 , B60R2022/287 , B60R2022/289
摘要： A retractor includes a slide nut that is caused to slide toward a tread head while rotating by a mesh between a first male screw groove and a female screw groove when the tread head is locked and a spindle rotates in a direction for unreeling a webbing, and a slider that is caused to slide toward the slide nut by a mesh between the female screw groove and a second male screw groove. A torsional rigidity of a second shaft part of a torsion bar is larger than that of a first shaft part, and a play is eliminated before a gap such that the slide nut and the slider are integrated.
摘要翻译：牵开器包括滑动螺母，当滑动螺母被锁定并且主轴沿用于松开织带的方向旋转时，滑动螺母在通过第一外螺纹槽和内螺纹槽之间的网转动的同时朝向胎面头滑动，以及滑动件通过内螺纹槽和第二外螺纹槽之间的网状物向滑动螺母滑动。扭杆的第二轴部的扭转刚性大于第一轴部的扭转刚性，并且在滑动螺母和滑块一体化的间隙之前消除了间隙。

10. 发明申请

US20120132799A1 Mass Spectrometer 审中-公开
标题翻译：质谱仪
公开(公告)号：US20120132799A1
公开(公告)日：2012-05-31
申请号：US13260061
申请日：2009-03-31
申请人： Kazuteru Takahashi , Kiyoshi Ogawa , Mitsutoshi Setou
发明人： Kazuteru Takahashi , Kiyoshi Ogawa , Mitsutoshi Setou
IPC分类号： H01J49/26
CPC分类号： H01J49/0004 , G01N2001/045
摘要： A samples stage (2) on which a sample (4) is placed can reciprocally move along a guide (5) by a driving mechanism. An image taken by an imaging unit (7) when the sample stage (2) is at an observation position (A) is processed by an image processor (34) and is displayed on a window of a display unit (38). When an analysis operator specifies a measurement area by an operation unit (37), a controller (3) moves, through a stage driver (33), the stage (2) to a sample operation position (B) and a matrix is applied to the specified measurement area by an ejector (9). After that, the stage (2) is moved to an analysis position (C) and a laser light is delivered onto the measurement area on the sample (4) to which the matrix was applied, and the ionization by the MALDI method is performed. This eliminates the need to take out the sample from the apparatus to apply the matrix after the measurement point or measurement area is determined based on a microscopic observation of the sample. Accordingly, the efficiency of the measurement can be increased, and since no positional error of the sample occurs, it is possible to perform an imaging mass analysis for a measurement area of interest with high positional accuracy.
摘要翻译：其上放置有样品（4）的样品台（2）可以通过驱动机构沿引导件（5）往复运动。当样本台（2）处于观察位置（A）时由成像单元（7）拍摄的图像由图像处理器（34）处理并显示在显示单元（38）的窗口上。当分析操作者通过操作单元（37）指定测量区域时，控制器（3）通过平台驱动器（33）将平台（2）移动到采样操作位置（B），并将矩阵应用于由喷射器（9）指定的测量区域。之后，将阶段（2）移动到分析位置（C），并将激光输送到施加了矩阵的样品（4）的测量区域上，并通过MALDI方法进行电离。这消除了在基于样品的显微镜观察确定测量点或测量区域之后，从设备中取出样品以施加基质的需要。因此，可以提高测量效率，并且由于不发生样本的位置误差，因此可以以高位置精度对感兴趣的测量区域进行成像质量分析。

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