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1. 发明授权

US06034234A Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient 失效
标题翻译：含有与活性成分相同的双链寡核苷酸和抗癌剂
公开(公告)号：US06034234A
公开(公告)日：2000-03-07
申请号：US676241
申请日：1996-07-17
申请人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
发明人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13
摘要： This invention provides a double-stranded oligonucleotide or a derivative thereof which comprises 15 to 40 base pairs, wherein at least one side of the strands contains at least one nucleotide sequence represented by 5'-TTTSSCGS-3' (S is G or C). Also, since the compound of the present invention can inhibit expression of growth-related genes which are regulated by E2F, through its function to undergo sequence-specific competitive inhibition of the binding of E2F protein to the transcription region at a low concentration, a pharmaceutical composition containing the inventive compound as its active ingredient is useful as a drug having low side effects for use in the prevention and treatment of cancers.
摘要翻译： PCT No.PCT / JP95 / 02348 Sec。 371日期：1996年7月17日 102（e）日期1996年7月17日PCT提交1995年11月16日PCT公布。公开号WO96 / 16074 日期：1996年5月30日本发明提供了包含15〜40个碱基对的双链寡核苷酸或其衍生物，其中链的至少一侧含有至少一个由5'-TTTSSCGS-3'表示的核苷酸序列（S为 G或C）。此外，由于本发明的化合物可以抑制由E2F调节的生长相关基因的表达，通过其以低浓度进行E2F蛋白与转录区域的结合的序列特异性竞争性抑制的功能，药物含有本发明化合物作为其活性成分的组合物可用作用于预防和治疗癌症的副作用低的药物。

2. 发明授权

US5869246A Triplex Oligonucleotides targeted to p120 失效
标题翻译：靶向p120的三重寡核苷酸
公开(公告)号：US5869246A
公开(公告)日：1999-02-09
申请号：US666420
申请日：1996-06-12
申请人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Norio Masuko , Yuji Yamada
发明人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Norio Masuko , Yuji Yamada
IPC分类号： C07H21/04 , A61K31/70 , A61K38/00 , A61P35/00 , C07H21/02 , C12N15/113 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/113 , C07H21/02 , A61K38/00 , C12N2310/15
摘要： This invention provides a method for inhibiting transcription of a p120 gene, which comprises using an oligonucleotide capable of forming a triple-stranded chain in a homopurine/homopyrimidine region of the p120 gene, as well as an oligonucleotide capable of forming a triple-stranded chain, or a derivative thereof, which has the following nucleotide sequence GAAWGGAGGAGGAGAAA or a complementary sequence thereof, and a pharmaceutical composition which contains the oligonucleotide as its active ingredient and is useful as an agent for the prevention and treatment of cancers with less side effects.
摘要翻译： PCT No.PCT / JP95 / 02113 Sec。 371日期：1996年6月12日 102（e）日期1996年6月12日PCT提交1995年10月13日PCT公布。公开号WO96 / 11938 日期：1996年04月25日本发明提供了抑制p120基因转录的方法，该方法包括使用能够在p120基因的均嘌呤/同型嘧啶区域中形成三链链的寡核苷酸，以及能够形成具有以下核苷酸序列GAAWGGAGGAGGAGAAA或其互补序列的三链链或其衍生物，以及含有该寡核苷酸作为其活性成分并可用作预防和治疗癌症的药物的药物组合物，少副作用。

3. 发明授权

US4897503A 1,1,2-triaryl-1-alkene derivatives 失效
标题翻译： 1,1,2-三芳基-1-烯烃衍生物
公开(公告)号：US4897503A
公开(公告)日：1990-01-30
申请号：US159590
申请日：1988-01-27
申请人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
发明人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
IPC分类号： C07F9/12
CPC分类号： C07F9/12
摘要： This invention provides a 1,1,2-triaryl-1-butene derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, one of R.sub.3 and R.sub.4 is a lower alkyl group and the other is a group of the formula ##STR2## (in which R.sub.5 is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom or --OPO(OH).sub.2 group); or a pharmacologically acceptable salt thereof, its preparation and agents containing the derivative for treating mammary cancer and anovulatory infertility.

4. 发明申请

US20100240682A1 PHOPHYLACTIC OR THERAPEUTIC AGENT FOR INFLAMATORY DISEASE COMPRISING THYMIDINE PHOSPHORYLASE INHIBITOR AS ACTIVE INGREDIENT 审中-公开
标题翻译：作为活性成分包含酪氨酸磷酸酶抑制剂的炎性疾病的药物或治疗剂
公开(公告)号：US20100240682A1
公开(公告)日：2010-09-23
申请号：US12682670
申请日：2008-10-10
申请人： Kazuki Sakamoto , Yoshikazu Sugimoto
发明人： Kazuki Sakamoto , Yoshikazu Sugimoto
IPC分类号： A61K31/515 , C07D239/553 , A61P29/00 , A61P19/02 , A61P1/00
CPC分类号： C07D403/06 , A61K31/513
摘要： To provide an excellent agent for prevention or treatment of an inflammatory disease.The agent for prevention or treatment of an inflammatory disease contains a thymidine phosphorylase inhibitor as an active ingredient, wherein when the thymidine phosphorylase inhibitor is 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione or a salt thereof, the inflammatory disease is an inflammatory disease other than inflammatory bowel disease.
摘要翻译：提供预防或治疗炎症性疾病的优异剂。用于预防或治疗炎性疾病的药物含有胸苷磷酸化酶抑制剂作为活性成分，其中当胸苷磷酸化酶抑制剂为5-氯-6-（2-亚氨基吡咯烷-1-基）甲基-2,4（1H， 3H） - 嘧啶二酮或其盐，炎症性疾病是除炎性肠病以外的炎性疾病。

5. 发明申请

US20090208982A1 ASSAY METHOD FOR HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE PROTEIN 审中-公开
标题翻译：人类磷酸二酯酶蛋白质的测定方法
公开(公告)号：US20090208982A1
公开(公告)日：2009-08-20
申请号：US11817415
申请日：2006-02-28
申请人： Kazuki Sakamoto , Yoshikazu Sugimoto
发明人： Kazuki Sakamoto , Yoshikazu Sugimoto
IPC分类号： G01N33/573 , C07K16/40
CPC分类号： C07K16/40 , C12Q1/48 , G01N2333/91142
摘要： To establish an immunoassay method for human OPRT.The method for assaying human orotate phosphoribosyltransferase protein includes employing, in combination, an anti-human orotate phosphoribosyltransferase antibody which recognizes an epitope present in a region of 86th to 108th amino acid residues from the N-terminus of human orotate phosphoribosyltransferase, and an anti-human orotate phosphoribosyltransferase antibody which recognizes an epitope present in a region of 454th to 474th amino acid residues from the N-terminus of human orotate phosphoribosyltransferase.
摘要翻译：建立人OPRT免疫测定方法。用于测定人乳头状磷酸核糖基转移酶蛋白质的方法包括组合使用抗人乳头状磷酸核糖转移酶抗体，其识别存在于人乳清酸磷酸核糖基转移酶N末端的第86至第108位氨基酸残基的表位，人类乳清酸磷酸核糖基转移酶抗体，其识别存在于人类乳酸脱氢磷酸核糖基转移酶的N末端的第454位至第474位氨基酸残基的表位。

6. 发明申请

US20100249089A1 ABCG2 INHIBITOR 审中-公开
标题翻译： ABCG2抑制剂
公开(公告)号：US20100249089A1
公开(公告)日：2010-09-30
申请号：US12745899
申请日：2008-12-02
申请人： Ryuta Yamazaki , Hiroshi Hatano , Takashi Yaegashi , Yoshiaki Igarashi , Oh Yoshida , Yoshikazu Sugimoto
发明人： Ryuta Yamazaki , Hiroshi Hatano , Takashi Yaegashi , Yoshiaki Igarashi , Oh Yoshida , Yoshikazu Sugimoto
IPC分类号： A61K31/4545 , C07D409/14 , A61K31/4535 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00
CPC分类号： C07D409/04 , C07D409/14
摘要： The present invention relates to a breast cancer resistance protein (BCRP/ABCG2) inhibitor.The invention provides an acrylonitrile derivative represented by formula (1): (wherein A represents an optionally substituted 3- to 8-membered heterocyclic ring) or a salt thereof.
摘要翻译：本发明涉及乳腺癌抗性蛋白（BCRP / ABCG2）抑制剂。本发明提供由式（1）表示的丙烯腈衍生物：其中A表示任选取代的3-至8-元杂环）或其盐。

7. 发明授权

US4123356A Filter cleaning method and filter system 失效
标题翻译：过滤器清洗方法和过滤系统
公开(公告)号：US4123356A
公开(公告)日：1978-10-31
申请号：US752150
申请日：1976-12-20
申请人： Yoshikazu Sugimoto , Hideo Yusa , Yomei Kato , Kunio Kamiya , Makoto Kikuchi
发明人： Yoshikazu Sugimoto , Hideo Yusa , Yomei Kato , Kunio Kamiya , Makoto Kikuchi
IPC分类号： B01D29/46 , B01D29/15 , B01D41/04
CPC分类号： B01D29/15
摘要： A cleaning method of an etched disc filter and the system therefor, in which a plurality of discs having grooved surfaces are assembled or piled one on top of another. This filter is used for removing cruds and the like in a nuclear plant. For separating cruds and the like from small flow passages provided between each two of the discs thus assembled, reverse cleaning is applied, with the discs relieved from an assembled or piled condition for providing clearances among the discs.
摘要翻译：蚀刻盘式过滤器及其系统的清洁方法，其中具有开槽表面的多个盘组装或堆叠在另一个之上。该过滤器用于去除核电厂中的粗屑等。为了将这些组装的每个两个盘之间的小流动通道分离出来，可以进行反向清洗，从组装好的或堆积的状态上卸下，以便在盘之间提供间隙。

8. 发明申请

US20090253656A1 BCRP/ABCG2 INHIBITOR 有权
标题翻译： BCRP / ABCG2抑制剂
公开(公告)号：US20090253656A1
公开(公告)日：2009-10-08
申请号：US11909805
申请日：2006-03-29
申请人： Ryuta Yamazaki , Yukiko Nishiyama , Tomio Furuta , Takeshi Matsuzaki , Hiroshi Hatano , Oh Yoshida , Masato Nagaoka , Ritsuo Aiyama , Shusuke Hashimoto , Yoshikazu Sugimoto
发明人： Ryuta Yamazaki , Yukiko Nishiyama , Tomio Furuta , Takeshi Matsuzaki , Hiroshi Hatano , Oh Yoshida , Masato Nagaoka , Ritsuo Aiyama , Shusuke Hashimoto , Yoshikazu Sugimoto
IPC分类号： A61K31/277 , A61K31/675 , A61K31/5377 , A61K31/496 , A61K31/47 , A61K31/4709 , A61K31/4545 , A61K31/4535 , A61K31/44 , A61K31/426 , A61K31/428 , A61K31/42 , A61K31/4184 , A61K31/4164 , A61K31/403 , A61K31/40 , A61K31/381 , A61K31/343 , A61K31/341 , C07D413/04 , C07F9/576 , C07D215/16 , C07D409/04 , C07D405/04 , C07D213/84 , C07D417/04 , C07D277/62 , C07D277/30 , C07D261/14 , C07D235/16 , C07D233/90 , C07D209/18 , C07D207/337 , C07D333/42 , C07D333/20 , C07D307/82 , C07D307/66 , C07C255/32 , A61P35/00 , C07D333/36 , A61K31/4525
CPC分类号： C07C255/37 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/4164 , A61K31/4184 , A61K31/42 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4525 , A61K31/4535 , A61K31/47 , A61K31/5377 , A61K31/661 , C07C2603/26 , C07D207/337 , C07D209/18 , C07D213/57 , C07D215/14 , C07D215/18 , C07D233/64 , C07D233/84 , C07D235/16 , C07D261/08 , C07D277/30 , C07D277/64 , C07D307/54 , C07D307/56 , C07D307/66 , C07D307/72 , C07D307/79 , C07D307/81 , C07D333/28 , C07D333/36 , C07D333/44 , C07D333/60 , C07D401/04 , C07D401/06 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/06 , C07F9/65586
摘要： The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor.The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 represents a cyano group and the other represents a hydrogen atom;Ar1 represents a group selected from among the groups represented by formulas (2) to (4): and Ar2 represents an aromatic hydrocarbon group having a condensed ring which may be substituted by a halogen atom, or a group selected from among the groups represented by the following formulas (5) to (15): or a salt thereof.
摘要翻译：本发明涉及一种乳腺癌抗性蛋白（BCRP / ABCG2）抑制剂。 BCRP抑制剂含有式（1）表示的丙烯腈衍生物作为活性成分：其中R1和R2之一表示氰基，另一个表示氢原子; Ar 1表示由式（2）〜（4）表示的基团中的基团，Ar 2表示具有可被卤素原子取代的稠环的芳香族烃基或选自由下述式（5）〜（15）表示：或其盐。

9. 发明申请

US20080249036A1 Antagonist Against Tolerance to Anticancer Drugs 审中-公开
标题翻译：反对抗癌药物的抗药性
公开(公告)号：US20080249036A1
公开(公告)日：2008-10-09
申请号：US11661353
申请日：2005-08-31
申请人： Yoshikazu Sugimoto , Satomi Tsukahara , Yasuo Imai
发明人： Yoshikazu Sugimoto , Satomi Tsukahara , Yasuo Imai
IPC分类号： A61K31/704 , C07J1/00 , C12N5/00 , A61P35/00 , C12Q1/02 , A61K31/56
CPC分类号： A61K31/136 , A61K31/00 , A61K31/05 , A61K31/337 , A61K31/352 , A61K31/353 , A61K31/4745 , A61K31/475 , A61K31/553 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/57 , A61K45/06 , G01N33/57415 , G01N2333/4704 , G01N2500/10 , A61K2300/00
摘要： An ABC transporter protein expression inhibitor comprising, as the active ingredient(s), 0.001 to 100 nM of one or more members selected from among steroid hormones, compounds having a female hormone function, analogous compounds thereof and antagonistic inhibitors therefor; an anticancer composition containing this ABC transporter protein expression inhibitor and an anticancer drug; and cells useful in the development of an anticancer drug. The present invention provides a drug which inhibits the expression of an ABC transporter to thereby overcome resistance to anticancer drugs; cancer cells useful in screening such drugs; and an anticancer drug efficacious even against such a cancer as having acquired resistance to anticancer drugs.
摘要翻译：一种ABC转运蛋白表达抑制剂，其包含作为活性成分的0.001至100nM的一种或多种选自类固醇激素，具有雌激素功能的化合物，其类似物及其拮抗性抑制剂; 含有该ABC转运蛋白表达抑制剂和抗癌药物的抗癌组合物; 和可用于开发抗癌药物的细胞。本发明提供抑制ABC转运蛋白表达从而克服对抗癌药物的抗性的药物; 可用于筛选此类药物的癌细胞; 和抗癌药物即使对抗抗癌药物也具有抗药性。

10. 发明申请

US20070159933A1 Optical pickup 审中-公开
标题翻译：光学拾音
公开(公告)号：US20070159933A1
公开(公告)日：2007-07-12
申请号：US11650444
申请日：2007-01-08
申请人： Yoshikazu Sugimoto , Tetsuya Yoshida
发明人： Yoshikazu Sugimoto , Tetsuya Yoshida
IPC分类号： G11B7/085 , G11B21/08
CPC分类号： G11B7/0932 , G11B7/0933
摘要： An optical pickup that improves recording and reproducing performances on a disc without increasing the cost includes first and second magnets. The first magnet is placed on protrusions provided to a first wall portion of a base of an actuator portion. Both end portions of the bottom surface of the first magnet, the first wall portion on a surface facing a second wall portion, and a pedestal are adhered together by using an UV adhesive. Similarly, a second magnet is placed on protrusions provided to the second wall portion of the base. Both end portions of the bottom surface of the second magnet, the second wall portion on a surface facing the first wall portion, and a pedestal are adhered together by using an UV adhesive.
摘要翻译：在不增加成本的情况下改善盘上的记录和再现性能的光学拾取器包括第一和第二磁体。第一磁体被放置在提供到致动器部分的基部的第一壁部分的突起上。第一磁体的底面的两端部，面向第二壁部的面的第一壁部和基座通过使用UV粘合剂粘接在一起。类似地，第二磁体被放置在设置到基座的第二壁部分的突起上。第二磁体的底面的两端部，与第一壁部相对的面的第二壁部和基座通过使用UV粘合剂粘接在一起。

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