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1. 发明授权

US5252474A Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use 失效
标题翻译：克隆来自阿维链霉菌的阿维菌素生物合成的基因及其使用方法
公开(公告)号：US5252474A
公开(公告)日：1993-10-12
申请号：US490723
申请日：1990-03-14
申请人： Keith M. Gewain , Douglas J. MacNeil , Tanya MacNeil , Philip S. Paress , Carolyn L. Ruby , Stanley L. Streicher
发明人： Keith M. Gewain , Douglas J. MacNeil , Tanya MacNeil , Philip S. Paress , Carolyn L. Ruby , Stanley L. Streicher
IPC分类号： C12N9/10 , C12N9/88 , C12N15/10 , C12N15/52 , C12N15/76 , C12P17/18 , C12P19/62 , C12N15/00 , C12N15/11
CPC分类号： C12P17/181 , C12N15/10 , C12N15/52 , C12N15/76 , C12N9/1007 , C12N9/88 , C12P19/623
摘要： There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis, the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
摘要翻译：公开了含有从阿维链霉菌（Streptomyces avermitilis）分离的DNA的质粒，该微生物用于制备被鉴定为pAT1，pVE650 pVE855，pVE859，pVE1446，pVE923和pVE924的除虫菌素化合物，其含有阿维菌素生物合成的遗传信息。还公开了分离这种质粒和用于操纵质粒以改变阿维菌素化合物形成的方法。

2. 发明授权

US5312753A Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions 失效
标题翻译：阿维链霉菌菌株能在13和14A位置糖基化除虫菌素化合物
公开(公告)号：US5312753A
公开(公告)日：1994-05-17
申请号：US855311
申请日：1992-03-23
申请人： Douglas J. MacNeil , Tanya MacNeil
发明人： Douglas J. MacNeil , Tanya MacNeil
IPC分类号： C07H19/01 , C12P19/58 , C12P19/62 , C12N1/20 , C12N1/00
CPC分类号： C07H19/01 , C12P19/58 , C12P19/623 , C12R1/465
摘要： Avermectin compounds are glycosylated at the 4',13- Or 14a-positions by adding the avermectin compounds to the fermentation medium of a novel strain of Streptomyces avermitilis. The 13-hydroxy and 14a-hydroxy methyl groups of the avermectin compound are glycosylated with a glycosyl moiety, specifically an oleandrose group. The new strain offers the added advantage of not producing any C5-O-methylation products. The compounds are potent anthelmintic and antiparasite agents, and compositions for such uses are also disclosed.
摘要翻译：阿维菌素化合物通过将阿维菌素化合物加入到新型阿维链霉菌菌株的发酵培养基中，在4'，13-或14a位置被糖基化。阿维菌素化合物的13-羟基和14a-羟基甲基用糖基部分，特别是夹竹桃糖基团糖基化。新的菌株提供了不生产任何C5-O-甲基化产物的附加优点。这些化合物是有效的驱虫剂和抗寄生虫剂，并且还公开了用于此类用途的组合物。

3. 发明申请

US20090104210A1 Peptide compounds for treating obesity and insulin resistance 审中-公开
标题翻译：用于治疗肥胖和胰岛素抵抗的肽化合物
公开(公告)号：US20090104210A1
公开(公告)日：2009-04-23
申请号：US12287211
申请日：2008-10-07
申请人： Michael R. Tota , Shirly Pinto , Douglas J. MacNeil , Heather H. Zhou , Fubao Wang , Chen-Ni Chin
发明人： Michael R. Tota , Shirly Pinto , Douglas J. MacNeil , Heather H. Zhou , Fubao Wang , Chen-Ni Chin
IPC分类号： A61K39/44 , C07K14/47 , C07K14/76 , C07K19/00 , C07K14/79 , A61K38/17
CPC分类号： C07K16/22 , A61K38/40 , A61K47/543 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/515 , A61K2300/00
摘要： Compounds comprising an angiopoietin-like protein 6 (Angptl6) peptide for use in the treatment of metabolic syndrome, in particular, obesity and insulin resistance are described.
摘要翻译：描述了包含用于治疗代谢综合征，特别是肥胖症和胰岛素抵抗的血管生成素样蛋白6（Angptl6）肽的化合物。

4. 发明授权

US06638942B1 Spiro-indolines as Y5 receptor antagonists 失效
标题翻译：螺吲哚啉作为Y5受体拮抗剂
公开(公告)号：US06638942B1
公开(公告)日：2003-10-28
申请号：US10228250
申请日：2002-08-26
申请人： Ying-Duo Gao , Douglas J. MacNeil , Lihu Yang , Nancy R. Morin , Takehiro Fukami , Akio Kanatani , Takahiro Fukuroda , Yasuyuki Ishii , Masaki Ihara
发明人： Ying-Duo Gao , Douglas J. MacNeil , Lihu Yang , Nancy R. Morin , Takehiro Fukami , Akio Kanatani , Takahiro Fukuroda , Yasuyuki Ishii , Masaki Ihara
IPC分类号： C07D47110
CPC分类号： C07D221/20 , C07D471/10
摘要： Compounds of general structural formula I are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.
摘要翻译：通用结构式的化合物Iare选择性NPY Y5受体拮抗剂，可用于治疗肥胖及其相关并发症。

5. 发明授权

US07029865B2 DNA molecules encoding the melanocortin 4 receptor protein from rhesus monkey 失效
公开(公告)号：US07029865B2
公开(公告)日：2006-04-18
申请号：US10373355
申请日：2003-02-25
申请人： Douglas J. MacNeil , David H. Weinberg , Leonardus H. T. Van Der Ploeg
发明人： Douglas J. MacNeil , David H. Weinberg , Leonardus H. T. Van Der Ploeg
IPC分类号： G01N33/567 , C07K1/00 , C07H21/04 , C12N1/20 , C12P21/02
CPC分类号： C07K14/723
摘要： The present invention relates to rhesus monkey DNA molecules encoding the melanocortin-4 receptor protein, recombinant vectors comprising DNA molecules encoding rhesus MC-4R, recombinant host cells which contain a recombinant vectors encoding rhesus MC-4R, the rhesus MC-4R protein encoded by the DNA molecule, and methods of identifying selective agonists and antagonists of rhesus MC-4R.

6. 发明授权

US06313298B1 Spiro-indolines as Y5 receptor antagonists 失效
标题翻译：螺吲哚啉作为Y5受体拮抗剂
公开(公告)号：US06313298B1
公开(公告)日：2001-11-06
申请号：US09656698
申请日：2000-09-07
申请人： Ying-Duo Gao , Lihu Yang , Douglas J. MacNeil , Nancy R. Morin , Takehiro Fukami , Takahiro Fukuroda , Akio Kanatani , Yasuyuki Ishii , Masaki Ihara
发明人： Ying-Duo Gao , Lihu Yang , Douglas J. MacNeil , Nancy R. Morin , Takehiro Fukami , Takahiro Fukuroda , Akio Kanatani , Yasuyuki Ishii , Masaki Ihara
IPC分类号： C07D47120
CPC分类号： C07D221/20 , C07D471/10
摘要： Compounds of general structural formula I such as that shown in structural formula II are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.
摘要翻译：一般结构式I的化合物如结构式II所示的化合物是选择性NPY Y5受体拮抗剂，可用于治疗肥胖症及其相关并发症。

7. 发明授权

US06693184B1 DNA molecules encoding splice variants of the human melanocortin 1 receptor protein 失效
标题翻译：编码人黑素皮质素1受体蛋白的剪接变体的DNA分子
公开(公告)号：US06693184B1
公开(公告)日：2004-02-17
申请号：US09868552
申请日：2001-06-18
申请人： Andrew D. Howard , Douglas J. MacNeil , Leonardus H. T. Van Der Ploeg
发明人： Andrew D. Howard , Douglas J. MacNeil , Leonardus H. T. Van Der Ploeg
IPC分类号： C07K100
CPC分类号： C07K14/723
摘要： The present invention relates to DNA molecules encoding splice variants of the melanocortin-1 receptor (MC-R1) protein belonging to the rhodopsin sub-family of G-protein coupled receptors, recombinant vectors comprising DNA molecules encoding MC-R1B protein, recombinant host cells which contain a recombinant vector encoding MC-R1B, the human MC-R1B protein encoded by the DNA molecule, and methods of identifying selective agonists and antagonists of MC-R1B proteins disclosed throughout this specification.
摘要翻译：本发明涉及编码属于G蛋白偶联受体的视紫质亚族的黑皮质素-1受体（MC-R1）蛋白的剪接变体的DNA分子，包含编码MC-R1B蛋白的DNA分子的重组载体，重组宿主细胞其包含编码MC-R1B的重组载体，由DNA分子编码的人MC-R1B蛋白，以及鉴定本说明书中公开的MC-R1B蛋白的选择性激动剂和拮抗剂的方法。

8. 发明授权

US5194387A Process for the incorporation of DNA molecules into microorganisms with methyl-specific restriction systems 失效
标题翻译：用甲基特异性限制系统将DNA分子掺入微生物的方法
公开(公告)号：US5194387A
公开(公告)日：1993-03-16
申请号：US792998
申请日：1991-11-15
申请人： Douglas J. MacNeil
发明人： Douglas J. MacNeil
IPC分类号： C07K14/36 , C12N15/64 , C12N15/76
CPC分类号： C07K14/36 , C12N15/64 , C12N15/76
摘要： There is disclosed a process for the incorporation of DNA into a microorganism that, because of natural restrictions in the organism, normally would prevent or limit the incorporation of the DNA. The process involves the selection of an intermediate host organism that has no restrictions to the incorporation of DNA. The DNA is then transferred into the intermediate host which is readily accomplished because there are no restrictions. The DNA is then isolated from the intermediate host and transferred into the target organism. Using this process the natural restrictions of the host organism are circumvented and DNA is transferred from a source organism to a target organism that normally would not be possible. In this manner desirable characteristics from the source organism can be imparted into the target organism.
摘要翻译：公开了将DNA并入微生物的方法，由于生物体中的天然限制，通常会阻止或限制DNA的引入。该方法涉及对并入DNA没有限制的中间宿主生物的选择。然后将DNA转移到容易实现的中间宿主中，因为没有限制。然后将DNA从中间体宿主分离并转移到靶生物中。使用这个过程，规避宿主生物的自然限制，DNA从源生物转移到通常不可能的目标生物体。以这种方式，可以将来自源生物体的所需特征赋予目标生物体。

9. 发明授权

US06573070B1 DNA molecules encoding the melanocortin 4 receptor protein from rhesus monkey 失效
公开(公告)号：US06573070B1
公开(公告)日：2003-06-03
申请号：US09831206
申请日：2001-05-04
申请人： Douglas J. MacNeil , David H. Weinberg , Leonardus H. T. Van Der Ploeg
发明人： Douglas J. MacNeil , David H. Weinberg , Leonardus H. T. Van Der Ploeg
IPC分类号： C07K100
CPC分类号： C07K14/723
摘要： The present invention relates to rhesus monkey DNA molecules encoding the melanocortin-4 receptor protein, recombinant vectors comprising DNA molecules encoding rhesus MC-4R, recombinant host cells which contain a recombinant vectors encoding rhesus MC-4R, the rhesus MC-4R protein encoded by the DNA molecule, and methods of identifying selective agonists and antagonists of rhesus MC-4R.

10. 发明授权

US5939263A Neuropeptide Y receptor 失效
标题翻译：神经肽Y受体
公开(公告)号：US5939263A
公开(公告)日：1999-08-17
申请号：US894236
申请日：1997-07-25
申请人： Margaret A. Cascieri , Douglas J. MacNeil , Lin-Lin Shiao , David H. Weinberg , Carina P. Tan , David L. Linemeyer , Catherine D. Strader
发明人： Margaret A. Cascieri , Douglas J. MacNeil , Lin-Lin Shiao , David H. Weinberg , Carina P. Tan , David L. Linemeyer , Catherine D. Strader
IPC分类号： G01N33/53 , A61K38/00 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , G01N33/15 , G01N33/74 , C12Q1/68 , C12N15/85 , C12Q1/02
CPC分类号： C07K14/70571 , G01N33/74 , A61K38/00 , C12N2799/026
摘要： A novel mammalian neuropeptide Y receptor and method of making the receptor are provided. The invention includes DNA encoding the receptor, the receptor, assays employing the receptor, cells expressing the receptor, antibodies which bind specifically to the receptor, RNA encoded by the DNA sequence or its complementary sequence, and single-stranded DNA with a sequence complementary to the RNA which encodes the receptor. The receptor and assays employing the receptor are useful for identifying compounds which bind to the receptor, including specific modulators of the receptor. Such compounds are useful for treating a variety of disease conditions, including obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma and ganglioneuroblastoma, and Huntington's, Alzheimer's and Parkinson's diseases.
摘要翻译： PCT No.PCT / US96 / 01444 Sec。 371日期1997年7月25日 102（e）日期1997年7月25日PCT 1996年1月30日PCT PCT。第WO96 / 23809号公报日期：1996年8月8日提供了一种新型哺乳动物神经肽Y受体及其制备方法。本发明包括编码受体的DNA，受体，使用受体的测定，表达受体的细胞，与受体特异性结合的抗体，由DNA序列或其互补序列编码的RNA，以及与DNA序列互补的单链DNA 编码受体的RNA。使用受体的受体和测定法可用于鉴定结合受体的化合物，包括受体的特异性调节剂。这些化合物可用于治疗各种疾病状况，包括肥胖症，糖尿病，焦虑症，高血压，可卡因戒断，充血性心力衰竭，记忆增强，心脏和脑血管痉挛，嗜铬细胞瘤和神经节细胞瘤，亨廷顿舞蹈症，阿尔茨海默病和帕金森病。

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