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1. 发明授权

US08232389B2 Method for crystallization of azetidinonecarboxylic acid 失效
标题翻译：氮杂环丁烷羧酸结晶方法
公开(公告)号：US08232389B2
公开(公告)日：2012-07-31
申请号：US12308413
申请日：2007-06-13
申请人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
发明人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
IPC分类号： C07F7/18
CPC分类号： C07F7/1804
摘要： The present invention relates to a method for crystallization of (2R)-2-{(3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidin-4-yl}propionic acid, and is characterized in that crystallization is carried out by mixing a solution containing the compound with a substituted aromatic hydrocarbon solvent and/or a halogenated hydrocarbon solvent. The method can provide a crystal of the compound with a high purity and a high yield while the content of 2S isomer is kept at a low level.
摘要翻译：本发明涉及（2R）-2 - {（3S，4S）-3 - [（1R）-1-（叔丁基二甲基甲硅烷氧基）乙基] -2-氧代氮杂环丁烷-4-基}丙酸其特征在于，通过将含有该化合物的溶液与取代的芳烃溶剂和/或卤代烃溶剂混合来进行结晶。该方法可以提供具有高纯度和高产率的化合物的晶体，而2S异构体的含量保持在低水平。

2. 发明授权

US08093378B2 Crystallization method for intermediates of carbapenem antibiotics 有权
标题翻译：碳青霉烯类抗生素中间体的结晶方法
公开(公告)号：US08093378B2
公开(公告)日：2012-01-10
申请号：US12226771
申请日：2007-04-18
申请人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
发明人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
IPC分类号： C07F9/568
CPC分类号： C07F9/65611 , C07D477/18
摘要： An improved crystallization method for an azetidinone compound represented by the formula 1: , which is extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present method provides crystals having higher quality and stability than conventional crystals and excellent filterability at the time of recovery; and an azetidinone compound having a low content of impurity, and which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound.
摘要翻译：用于由式1表示的氮杂环丁酮化合物的改进的结晶方法：其作为合成1'-溴代 - 甲基碳青霉烯化合物的常用中间体非常有用。本方法提供比常规晶体更高的质量和稳定性的晶体，并且在回收时具有优异的过滤性; 和具有低杂质含量的氮杂环丁酮化合物，其具有可控的晶体粒度分布和改进的可操作性和稳定性。结晶是通过将烃溶剂加入到其中作为合成1'-溴代 - 碳代青霉烯化合物的常用中间体的氮杂环丁酮化合物在种子存在下溶解200重量％的溶液或更少，基于氮杂环丁酮化合物的重量。

3. 发明申请

US20100298556A1 Method for crystallization of azetidinonecarboxylic acid 失效
标题翻译：氮杂环丁烷羧酸结晶方法
公开(公告)号：US20100298556A1
公开(公告)日：2010-11-25
申请号：US12308413
申请日：2007-06-13
申请人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
发明人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
IPC分类号： C07D205/04
CPC分类号： C07F7/1804
摘要： The present invention relates to a method for crystallization of (2R)-2-{(3S, 4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidin-4-yl}propionic acid, and is characterized in that crystallization is carried out by mixing a solution containing the compound with a substituted aromatic hydrocarbon solvent and/or a halogenated hydrocarbon solvent. The method can provide a crystal of the compound with a high purity and a high yield while the content of 2S isomer is kept at a low level.
摘要翻译：本发明涉及（2R）-2 - {（3S，4S）-3 - [（1R）-1-（叔丁基二甲基甲硅烷氧基）乙基] -2-氧代氮杂环丁烷-4-基}丙酸其特征在于，通过将含有该化合物的溶液与取代的芳烃溶剂和/或卤代烃溶剂混合来进行结晶。该方法可以提供具有高纯度和高产率的化合物的晶体，而2S异构体的含量保持在低水平。

4. 发明申请

US20090118496A1 Crystallization Method for Intermediates of Carbapenem Antibiotics 有权
标题翻译：碳青霉烯类抗生素中间体的结晶方法
公开(公告)号：US20090118496A1
公开(公告)日：2009-05-07
申请号：US12226771
申请日：2007-04-18
申请人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
发明人： Keita Nishino , Teruyoshi Koga , Masafumi Fukae , Yasuyoshi Ueda
IPC分类号： C07D487/04
CPC分类号： C07F9/65611 , C07D477/18
摘要： The present invention relates to an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds. The present invention provides a crystallization method to obtain a crystal which has a higher quality and a higher stability than a conventional crystal and is excellent in filterability at the time of recovering crystal; an azetidinone compound having a low content of impurity; and an azetidinone compound which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound. According to the method, the crystal having a high quality and a high stability and excellent filterability at the time of recovering the crystal can be obtained.
摘要翻译：本发明涉及作为合成1'-甲基碳青霉烯化合物的常用中间体非常有用的氮杂环丁酮化合物。本发明提供一种获得具有比常规晶体更高质量和更高稳定性的晶体的结晶方法，并且在回收晶体时的过滤性优异; 具有低杂质含量的氮杂环丁酮化合物; 和具有可控的晶体粒度分布和改进的可操作性和稳定性的氮杂环丁酮化合物。结晶是通过将烃溶剂加入到其中作为合成1,1-甲基碳青霉烯化合物的常用中间体非常有用的氮杂环丁酮化合物在200重量％的种子晶种存在下溶解的溶液进行的，或少于氮杂环丁酮化合物的重量。根据该方法，可以获得在回收晶体时具有高质量和高稳定性以及优异的过滤性的晶体。

5. 发明授权

US09388109B2 Reduced coenzyme Q10 crystal having excellent stability 有权
标题翻译：还原型辅酶Q10晶体具有优异的稳定性
公开(公告)号：US09388109B2
公开(公告)日：2016-07-12
申请号：US14129003
申请日：2012-06-21
申请人： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
发明人： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K31/12 , C07C49/577 , A23L2/52 , A23K1/16 , A23L1/30 , A61K8/34 , A61Q19/00 , C07C45/81 , C07C41/40 , C07C41/46 , C07C43/23
CPC分类号： C07C49/577 , A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K8/347 , A61K9/28 , A61K31/122 , A61Q19/00 , C07C41/40 , C07C41/46 , C07C43/23 , C07C45/81
摘要： With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.
摘要翻译：关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体和/或还原型辅酶Q10晶体通过粉末X射线（Cu-Kα）衍射，辅助Q10晶体在衍射角（2θ;±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°处显示出特征峰。晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。

6. 发明授权

US09315839B2 Processes for producing coenzyme Q10 有权
标题翻译：生产辅酶Q10的方法
公开(公告)号：US09315839B2
公开(公告)日：2016-04-19
申请号：US13020500
申请日：2011-02-03
申请人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12P7/66 , C12P7/22
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及一种还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有还原型辅酶Q10比例不小于70摩尔％的微生物细胞，任选地破坏细胞并回收所生成的还原型辅酶Q10。本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至此后氧化由此得到的还原型辅酶Q10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

7. 发明授权

US08067217B2 Method for preserving reduced coenzyme Q10 有权
标题翻译：保留还原型辅酶Q10的方法
公开(公告)号：US08067217B2
公开(公告)日：2011-11-29
申请号：US11315161
申请日：2005-12-23
申请人： Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12N9/98
CPC分类号： A61K9/4816
摘要： The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.
摘要翻译：本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药物，补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过超过60％。根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。

8. 发明申请

US20110263906A1 METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES 有权
标题翻译：生产具有优异处理性能的还原型COYZYME Q10水晶的方法
公开(公告)号：US20110263906A1
公开(公告)日：2011-10-27
申请号：US13176479
申请日：2011-07-05
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C41/40
CPC分类号： C07C41/40 , C07C43/23
摘要： The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.
摘要翻译：本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。因此，可以高产率获得高纯度还原型辅酶Q10。

9. 发明授权

US07897169B2 Ubiquinol-enriched fat-containing foods 有权
标题翻译：富含蛋白质的富含脂肪的食物
公开(公告)号：US07897169B2
公开(公告)日：2011-03-01
申请号：US10501669
申请日：2003-01-20
申请人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
发明人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
IPC分类号： A61K47/00
CPC分类号： A23G9/32 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/0056 , A23D7/015 , A23D9/007 , A23F3/163 , A23F5/243 , A23L7/111 , A23L7/122 , A23L7/13 , A23L7/165 , A23L9/12 , A23L9/22 , A23L19/03 , A23L19/14 , A23L23/00 , A23L27/60 , A23L33/10 , A23P20/11 , A23P30/40 , A23V2002/00 , C11B5/0092 , A23V2250/314
摘要： To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living. A ubiquinol-enriched oil/fat-containing food.
摘要翻译：提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。富含ubiquinol的含油/脂肪的食物。

10. 发明授权

US07524975B2 Peroxisome proliferator activated receptor ligand and process for producing the same 失效
标题翻译：过氧化物酶体增殖物激活受体配体及其制备方法
公开(公告)号：US07524975B2
公开(公告)日：2009-04-28
申请号：US10490641
申请日：2002-10-11
申请人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
发明人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
IPC分类号： C07D311/00
CPC分类号： C07D311/06 , A23K20/111 , A23K20/121 , A23K50/00 , A23K50/40 , A23L33/10 , A23L33/105 , A61K31/12 , A61K31/353 , A61K31/37 , A61K36/484 , A61K2300/00
摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.
摘要翻译：本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质，食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

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