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1. 发明授权

US08362052B2 Isoindolin-1-one derivative 有权
标题翻译：异吲哚啉-1-酮衍生物
公开(公告)号：US08362052B2
公开(公告)日：2013-01-29
申请号：US13203843
申请日：2010-03-09
申请人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
发明人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
IPC分类号： A01N43/80 , A61K31/425 , C07D275/02
CPC分类号： C07D401/12 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I): (wherein R, R2, R3 and R4 each independently represent a hydrogen or halogen atom; R5 and R6 each independently represent a hydrogen atom or lower alkyl or together represent oxo; X represents C(O) or the like; Y represents an oxygen atom or the like; Z represents a hydrogen atom or the like; R represents 5- or 6-membered heteroaryl having 1-3 hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms, contained within a ring, or the like) or to a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由式（I）表示的化合物：（其中R，R 2，R 3和R 4各自独立地表示氢或卤素原子; R 5和R 6各自独立地表示氢原子或低级烷基或一起代表氧代; X 表示C（O）等; Y表示氧原子等; Z表示氢原子等; R表示具有1-3个选自氮，硫和氧原子，包含在环内等）或其药学上可接受的盐。

2. 发明申请

US20110312976A1 NOVEL ISOINDOLIN-1-ONE DERIVATIVE 有权
公开(公告)号：US20110312976A1
公开(公告)日：2011-12-22
申请号：US13203843
申请日：2010-03-09
申请人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
发明人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
IPC分类号： A61K31/497 , A61K31/4439 , C07D417/12 , A61P3/06 , A61K31/428 , C07D275/06 , A61P3/10 , A61P3/04 , C07D401/12 , A61K31/506
CPC分类号： C07D401/12 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I): (wherein R, R2, R3 and R4 each independently represent a hydrogen or halogen atom; R5 and R6 each independently represent a hydrogen atom or lower alkyl or together represent oxo; X represents C(O) or the like; Y represents an oxygen atom or the like; Z represents a hydrogen atom or the like; R represents 5- or 6-membered heteroaryl having 1-3 hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms, contained within a ring, or the like) or to a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由式（I）表示的化合物：（其中R，R 2，R 3和R 4各自独立地表示氢或卤素原子; R 5和R 6各自独立地表示氢原子或低级烷基或一起代表氧代; X 表示C（O）等; Y表示氧原子等; Z表示氢原子等; R表示具有1-3个选自氮，硫和氧原子，包含在环内等）或其药学上可接受的盐。

3. 发明授权

US07687502B2 Substituted quinazoline or pyridopyrimidine derivative 失效
标题翻译：取代喹唑啉或吡啶并嘧啶衍生物
公开(公告)号：US07687502B2
公开(公告)日：2010-03-30
申请号：US10593540
申请日：2005-03-23
申请人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
发明人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
IPC分类号： A61K31/519 , A61K31/497 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/14 , C07D419/12 , A61P3/04 , A61P3/10 , C07D471/04 , C07D513/04
CPC分类号： A61K31/513 , A61K31/517 , A61K31/519 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxygen atom, etc.; R1 is an optionally substituted five to six-membered heteroaryl group, etc.; R2 is hydrogen atom or fluorine atom; and ring A is a monocyclic or bicyclic heteroaryl group which may have a substituent represented by the formula (II)] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有葡糖激酶活化作用的化合物，其可用于预防或治疗由式（I）表示的糖尿病等：X为氮原子等; Y是氧原子等; R1是任选取代的五至六元杂芳基等; R2是氢原子或氟原子; 环A是可以具有式（II）表示的取代基的单环或双环杂芳基]或其药学上可接受的盐。

4. 发明申请

US20120015938A1 1,4-BENZODIAZEPIN-2-ON DERIVATIVES 审中-公开
标题翻译： 1,4-BENZODIAZEPIN-2-ON衍生物
公开(公告)号：US20120015938A1
公开(公告)日：2012-01-19
申请号：US13144090
申请日：2010-02-12
申请人： Masanori Asai , Tasuku Haketa , Seiichi Inamura , Hideki Kurihara , Teruyuki Nishimura , Tadashi Shimamura
发明人： Masanori Asai , Tasuku Haketa , Seiichi Inamura , Hideki Kurihara , Teruyuki Nishimura , Tadashi Shimamura
IPC分类号： A61K31/5513 , A61P3/10 , A61P3/06 , C07D243/14 , A61P3/04
CPC分类号： C07D243/24 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a compound represented by a formula (I): wherein R1 represents a halogen atom or the like; R2 represents a hydrogen atom or the like; R3 and R4 each independently represents lower alkyl; R5 represents phenyl or the like; R6 represents a halogen atom or the like; m is an integer of from 0 to 2; p is an integer of from 1 to 4; and q is an integer of from 1 to 5 as an inhibitor of DGAT1 and its use for the treatment of hyperlipidemia etc.
摘要翻译：本发明涉及由式（I）表示的化合物：其中R1表示卤素原子等; R2表示氢原子等; R 3和R 4各自独立地表示低级烷基; R5表示苯基等; R6表示卤素原子等; m为0〜2的整数; p是1至4的整数; q为1〜5的整数，作为DGAT1的抑制剂及其用于治疗高脂血症等。

5. 发明申请

US20080032996A1 Substituted Quinazoline or Pyridopyrimidine Derivative 失效
标题翻译：取代喹唑啉或吡啶并嘧啶衍生物
公开(公告)号：US20080032996A1
公开(公告)日：2008-02-07
申请号：US10593540
申请日：2005-03-23
申请人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
发明人： Morihiro Mitsuya , Makoto Bamba , Yasuhiro Sasaki , Teruyuki Nishimura , Jun-ichi Eiki , Keisuke Arakawa
IPC分类号： A61K31/519 , A61K31/517 , A61K38/28 , A61P3/04 , A61P3/10 , C07D403/12 , C07D413/12 , C07D417/14 , C07D471/04 , C07D513/04
CPC分类号： A61K31/513 , A61K31/517 , A61K31/519 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxygen atom, etc.; R1 is an optionally substituted five to six-membered heteroaryl group, etc.; R2 is hydrogen atom or fluorine atom; and ring A is a monocyclic or bicyclic heteroaryl group which may have a substituent represented by the formula (II)] or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有葡糖激酶活化作用的化合物，其可用于预防或治疗由式（I）表示的糖尿病等：X为氮原子等; Y是氧原子等; R 1是任选取代的五至六元杂芳基等; R 2是氢原子或氟原子; 环A是可以具有式（II）表示的取代基的单环或双环杂芳基]或其药学上可接受的盐。

6. 发明申请

US20080070928A1 Novel 2-Heteroaryl-Substituted Benzimidazole Derivative 有权
标题翻译：新型2-杂芳基取代的苯并咪唑衍生物
公开(公告)号：US20080070928A1
公开(公告)日：2008-03-20
申请号：US10582564
申请日：2004-12-28
申请人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura , Jun-Ichi Eiki
发明人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura , Jun-Ichi Eiki
IPC分类号： A61K31/497 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61K31/427 , A61P3/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/02 , C07D413/02 , C07D403/02 , A61P3/10 , A61K31/506 , A61K31/433 , A61K31/4439 , A61K31/444
CPC分类号： C07D401/14 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided.A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R1 represents an aryl, etc.; R2 represents a hydroxy, etc.; R3 represents a —C1-6 alkyl, etc.; R4 represents a —C1-6 alkyl, etc.; X5 represents —O—, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].
摘要翻译：提供葡糖激酶活化剂; 提供了糖尿病的补救措施和/或预防，糖尿病的补救和/或预防，如视网膜病变，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的补救措施和/或预防肥胖症。一种葡糖激酶活化剂，其特征在于含有通式（I-0）的2-杂芳基取代的苯并咪唑衍生物或其药学上可接受的盐：[式中X表示碳原子或氮原子; X 1，X 2，X 3和X 4各自独立地表示碳原子或氮原子; 环A表示式（II）的5-或6-元含氮芳族杂环：（式中，X表示碳原子或氮原子）; R 1表示芳基等; R 2表示羟基等; R 3表示-C 1-6烷基等; R 4表示-C 1-6烷基等; X 5表示-O-等; a表示1,2或3的整数; q表示0〜2的整数， m表示0〜2的整数]。

7. 发明申请

US20110065739A1 NOVEL ISOXAZOLE DRIVATIVE 审中-公开
标题翻译：新的异丙唑驱动剂
公开(公告)号：US20110065739A1
公开(公告)日：2011-03-17
申请号：US12992387
申请日：2009-05-28
申请人： Makoto Ishikawa , Tasuku Haketa , Chisato Nakama , Teruyuki Nishimura , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa
发明人： Makoto Ishikawa , Tasuku Haketa , Chisato Nakama , Teruyuki Nishimura , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa
IPC分类号： A61K31/506 , C07D261/12 , A61K31/42 , A61P3/10 , A61P3/04 , A61P3/06 , C07D413/04 , A61K31/4439
CPC分类号： C07D261/12 , C07D413/04 , C07D413/12
摘要： Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an agonistic activity on GPR120 and is therefore useful for the treatment of diabetes, obesity or hyperlipemia. [In formula (I), the A represents a phenyl group which may be substituted by a lower alkoxy group or the like; the 13 represents a bivalent group produced by removing two hydrogen atoms from a benzene ring which may be substituted by a halogen atom or the like; X represents a lower alkylene group having 2 to 4 carbon atoms in its main chain or the like, wherein a carbon atom constituting the main chain may be substituted by an oxygen atom or the like; and Y represents a hydrogen atom or the like.]
摘要翻译：公开了由式（I）表示的化合物或其药学上可接受的盐，其对GPR120具有激动作用，因此可用于治疗糖尿病，肥胖症或高脂血症。 [式（I）中，A表示可被低级烷氧基等取代的苯基， 13表示通过从可被卤素原子等取代的苯环除去2个氢原子而生成的二价基团; X表示其主链等中具有2〜4个碳原子的低级亚烷基，其中构成主链的碳原子可以被氧原子等取代; Y表示氢原子等。]

8. 发明授权

US07728025B2 2-heteroaryl-substituted benzimidazole derivative 有权
标题翻译： 2-杂芳基取代的苯并咪唑衍生物
公开(公告)号：US07728025B2
公开(公告)日：2010-06-01
申请号：US10582564
申请日：2004-12-28
申请人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura
发明人： Katsumasa Nonoshita , Makoto Ishikawa , Hiroshi Nakashima , Daisuke Tsukahara , Yoshio Ogino , Fumiko Sakai , Yoshikazu Nagae , Keisuke Arakawa , Teruyuki Nishimura
IPC分类号： A01N43/50
CPC分类号： C07D401/14 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided.A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R1 represents an aryl, etc.; R2 represents a hydroxy, etc.; R3 represents a —C1-6 alkyl, etc.; R4 represents a —C1-6 alkyl, etc.; X5 represents —O—, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].
摘要翻译：提供葡糖激酶活化剂; 提供了糖尿病的补救措施和/或预防，糖尿病的补救和/或预防，如视网膜病变，肾病，神经症，缺血性心脏病，动脉硬化，以及进一步的补救措施和/或预防肥胖症。一种葡糖激酶活化剂，其特征在于含有通式（I-0）的2-杂芳基取代的苯并咪唑衍生物或其药学上可接受的盐：[式中X表示碳原子或氮原子; X1，X2，X3和X4各自独立地表示碳原子或氮原子; 环A表示式（II）的5-或6-元含氮芳族杂环：（式中，X表示碳原子或氮原子）; R1表示芳基等。 R2代表羟基等; R3代表-C 1-6烷基等; R4代表-C 1-6烷基等; X5表示-O-等。 a表示1,2或3的整数; q表示0〜2的整数， m表示0〜2的整数]。

9. 发明申请

US20090018056A1 Heteroarylcarbamoylbenzene derivatives 有权
标题翻译：杂芳基氨基甲酰基苯衍生物
公开(公告)号：US20090018056A1
公开(公告)日：2009-01-15
申请号：US12231856
申请日：2008-09-05
申请人： Tomoharu Iino , Noriaki Hashimoto , Hiroshi Nakashima , Keiji Takahashi , Teruyuki Nishimura , Jun-ichi Eiki
发明人： Tomoharu Iino , Noriaki Hashimoto , Hiroshi Nakashima , Keiji Takahashi , Teruyuki Nishimura , Jun-ichi Eiki
IPC分类号： A61K38/28 , C07D277/28 , C07D241/10 , C07D239/28 , C07D261/14 , A61K31/426 , A61K31/495 , A61K31/433 , A61K31/4439 , A61P3/10 , A61K31/501 , A61K31/4365 , A61K31/42 , A61K31/4965 , C07D285/08 , C07D471/04 , C07D401/10 , C07D403/10
CPC分类号： C07D213/75 , C07D231/40 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/04 , C07D261/14 , C07D271/07 , C07D275/03 , C07D277/18 , C07D277/46 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/10 , C07D285/135 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): [wherein X1 represents oxygen, etc., X2 represents oxygen, etc., R1 represents a group on Ring A such as alkylsulfonyl, etc., R2 represents C3-7 cyclic alkyl optionally substituted with a halogen, etc., R3 represents a substituent on Ring B such as lower alkyl, etc., formula (II): [Chemical Formula 1] represents 6- to 10-membered aryl, etc., and formula (III): [Formula 1] represents monocyclic or bicyclic heteroaryl optionally having on Ring B a substituent represented by R3 above, wherein the carbon atom of Ring B which is bonded to the nitrogen atom of the amide group of formula (I) forms a C═N bond with the nitrogen atom of the ring], as well as their pharmaceutically acceptable salts.
摘要翻译：具有葡糖激酶活化作用的化合物，可用作由下式（I）表示的糖尿病治疗：[其中X1表示氧等，X2表示氧等，R1表示环A上的基团，例如烷基磺酰基等等，R 2表示任选被卤素取代的C 3-7环烷基等，R 3表示环B上的取代基，例如低级烷基等，式（II）：[化学式1]表示6-至10 （III）表示：[式1]表示在环B上任选具有由上述R 3表示的取代基的单环或双环杂芳基，其中键合到氮原子上的环B的碳原子式（I）的酰胺基与环的氮原子形成CN键，以及它们的药学上可接受的盐。

10. 发明授权

US08848293B2 Optical filter, optical filter module, and photometric analyzer 有权
标题翻译：光滤波器，光滤波器模块和光度分析仪
公开(公告)号：US08848293B2
公开(公告)日：2014-09-30
申请号：US13467360
申请日：2012-05-09
申请人： Teruyuki Nishimura , Nozomu Hirokubo
发明人： Teruyuki Nishimura , Nozomu Hirokubo
IPC分类号： G02B27/00 , G02B26/00
CPC分类号： G02B26/001
摘要： An optical filter includes a first substrate, a second substrate opposed to the first substrate, a first optical film provided on a surface of the first substrate facing the second substrate, a second optical film provided on the second substrate and opposed to the first optical film via a gap, a first electrode provided on the surface of the first substrate facing the second substrate, and a second electrode provided on the second substrate and opposed to the first electrode, wherein a first charged body film with charge is formed on top of the first optical film, a second charged body film with charge is formed on top of the second optical film, and the first charged body film and the second charged body film are charged with the same polarity and opposed.
摘要翻译：光滤波器包括第一基板，与第一基板相对的第二基板，设置在面向第二基板的第一基板的表面上的第一光学膜，设置在第二基板上并与第一光学膜相对的第二光学膜通过间隙，设置在面向第二基板的第一基板的表面上的第一电极和设置在第二基板上并与第一电极相对的第二电极，其中在第一基板的顶部形成有带电的第一带电体膜第一光学膜，在第二光学膜的顶部上形成带电的第二带电体膜，并且第一带电体膜和第二带电体膜以相同的极性充电并且相反。

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