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1. 发明申请

US20120015938A1 1,4-BENZODIAZEPIN-2-ON DERIVATIVES 审中-公开
标题翻译： 1,4-BENZODIAZEPIN-2-ON衍生物
公开(公告)号：US20120015938A1
公开(公告)日：2012-01-19
申请号：US13144090
申请日：2010-02-12
申请人： Masanori Asai , Tasuku Haketa , Seiichi Inamura , Hideki Kurihara , Teruyuki Nishimura , Tadashi Shimamura
发明人： Masanori Asai , Tasuku Haketa , Seiichi Inamura , Hideki Kurihara , Teruyuki Nishimura , Tadashi Shimamura
IPC分类号： A61K31/5513 , A61P3/10 , A61P3/06 , C07D243/14 , A61P3/04
CPC分类号： C07D243/24 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a compound represented by a formula (I): wherein R1 represents a halogen atom or the like; R2 represents a hydrogen atom or the like; R3 and R4 each independently represents lower alkyl; R5 represents phenyl or the like; R6 represents a halogen atom or the like; m is an integer of from 0 to 2; p is an integer of from 1 to 4; and q is an integer of from 1 to 5 as an inhibitor of DGAT1 and its use for the treatment of hyperlipidemia etc.
摘要翻译：本发明涉及由式（I）表示的化合物：其中R1表示卤素原子等; R2表示氢原子等; R 3和R 4各自独立地表示低级烷基; R5表示苯基等; R6表示卤素原子等; m为0〜2的整数; p是1至4的整数; q为1〜5的整数，作为DGAT1的抑制剂及其用于治疗高脂血症等。

2. 发明申请

US20110319396A1 BENZODIAZEPIN-2-ON DERIVATIVES 审中-公开
标题翻译：苯并咪唑-2-酮衍生物
公开(公告)号：US20110319396A1
公开(公告)日：2011-12-29
申请号：US13142005
申请日：2010-01-19
申请人： Masanori Asai , Tasuku Haketa , Seiichi Inamura , Makoto Ishikawa , Hideki Jona , Hiroshi Kawamoto , Hideki Kurihara , Jun Shibata , Tadashi Shimamura , Takuya Suga , Hitomi Watanabe
发明人： Masanori Asai , Tasuku Haketa , Seiichi Inamura , Makoto Ishikawa , Hideki Jona , Hiroshi Kawamoto , Hideki Kurihara , Jun Shibata , Tadashi Shimamura , Takuya Suga , Hitomi Watanabe
IPC分类号： A61K31/5513 , C07D401/12 , C07D417/12 , A61P3/04 , C07D409/12 , A61P3/06 , A61P3/10 , C07D243/14 , C07D403/12
CPC分类号： C07D243/12 , A61K31/551 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a compound represented by the formula (I): wherein R1 represents a hydrogen atom or the like; R2 represents lower alkyl or the like; R3 and R4 represent lower alkyl or the like; R5 represents phenyl or the like; R6 represents a hydrogen atom or the like; m is an integer of from 0 to 2; p is an integer of from 1 to 4; and q is an integer of from 1 to 5, or a pharmaceutical acceptable salt thereof, and a DGAT 1 inhibitor comprising the compound.
摘要翻译：本发明涉及由式（I）表示的化合物：其中R1表示氢原子等; R2代表低级烷基等; R3和R4表示低级烷基等; R5表示苯基等; R6表示氢原子等; m为0〜2的整数; p是1至4的整数; 和q为1〜5的整数，或其药学上可接受的盐和包含该化合物的DGAT 1抑制剂。

3. 发明申请

US20110065739A1 NOVEL ISOXAZOLE DRIVATIVE 审中-公开
标题翻译：新的异丙唑驱动剂
公开(公告)号：US20110065739A1
公开(公告)日：2011-03-17
申请号：US12992387
申请日：2009-05-28
申请人： Makoto Ishikawa , Tasuku Haketa , Chisato Nakama , Teruyuki Nishimura , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa
发明人： Makoto Ishikawa , Tasuku Haketa , Chisato Nakama , Teruyuki Nishimura , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa
IPC分类号： A61K31/506 , C07D261/12 , A61K31/42 , A61P3/10 , A61P3/04 , A61P3/06 , C07D413/04 , A61K31/4439
CPC分类号： C07D261/12 , C07D413/04 , C07D413/12
摘要： Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an agonistic activity on GPR120 and is therefore useful for the treatment of diabetes, obesity or hyperlipemia. [In formula (I), the A represents a phenyl group which may be substituted by a lower alkoxy group or the like; the 13 represents a bivalent group produced by removing two hydrogen atoms from a benzene ring which may be substituted by a halogen atom or the like; X represents a lower alkylene group having 2 to 4 carbon atoms in its main chain or the like, wherein a carbon atom constituting the main chain may be substituted by an oxygen atom or the like; and Y represents a hydrogen atom or the like.]
摘要翻译：公开了由式（I）表示的化合物或其药学上可接受的盐，其对GPR120具有激动作用，因此可用于治疗糖尿病，肥胖症或高脂血症。 [式（I）中，A表示可被低级烷氧基等取代的苯基， 13表示通过从可被卤素原子等取代的苯环除去2个氢原子而生成的二价基团; X表示其主链等中具有2〜4个碳原子的低级亚烷基，其中构成主链的碳原子可以被氧原子等取代; Y表示氢原子等。]

4. 发明授权

US08362052B2 Isoindolin-1-one derivative 有权
标题翻译：异吲哚啉-1-酮衍生物
公开(公告)号：US08362052B2
公开(公告)日：2013-01-29
申请号：US13203843
申请日：2010-03-09
申请人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
发明人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
IPC分类号： A01N43/80 , A61K31/425 , C07D275/02
CPC分类号： C07D401/12 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I): (wherein R, R2, R3 and R4 each independently represent a hydrogen or halogen atom; R5 and R6 each independently represent a hydrogen atom or lower alkyl or together represent oxo; X represents C(O) or the like; Y represents an oxygen atom or the like; Z represents a hydrogen atom or the like; R represents 5- or 6-membered heteroaryl having 1-3 hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms, contained within a ring, or the like) or to a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由式（I）表示的化合物：（其中R，R 2，R 3和R 4各自独立地表示氢或卤素原子; R 5和R 6各自独立地表示氢原子或低级烷基或一起代表氧代; X 表示C（O）等; Y表示氧原子等; Z表示氢原子等; R表示具有1-3个选自氮，硫和氧原子，包含在环内等）或其药学上可接受的盐。

5. 发明申请

US20110312976A1 NOVEL ISOINDOLIN-1-ONE DERIVATIVE 有权
公开(公告)号：US20110312976A1
公开(公告)日：2011-12-22
申请号：US13203843
申请日：2010-03-09
申请人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
发明人： Keisuke Arakawa , Teruyuki Nishimura , Yuichi Sugimoto , Hiroyuki Takahashi , Tadashi Shimamura
IPC分类号： A61K31/497 , A61K31/4439 , C07D417/12 , A61P3/06 , A61K31/428 , C07D275/06 , A61P3/10 , A61P3/04 , C07D401/12 , A61K31/506
CPC分类号： C07D401/12 , C07D417/12
摘要： The present invention relates to a compound represented by formula (I): (wherein R, R2, R3 and R4 each independently represent a hydrogen or halogen atom; R5 and R6 each independently represent a hydrogen atom or lower alkyl or together represent oxo; X represents C(O) or the like; Y represents an oxygen atom or the like; Z represents a hydrogen atom or the like; R represents 5- or 6-membered heteroaryl having 1-3 hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms, contained within a ring, or the like) or to a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及由式（I）表示的化合物：（其中R，R 2，R 3和R 4各自独立地表示氢或卤素原子; R 5和R 6各自独立地表示氢原子或低级烷基或一起代表氧代; X 表示C（O）等; Y表示氧原子等; Z表示氢原子等; R表示具有1-3个选自氮，硫和氧原子，包含在环内等）或其药学上可接受的盐。

6. 发明授权

US07709475B2 Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton 失效
标题翻译：具有氨基噻唑骨架的Cdk4和Cdk6选择性抑制剂
公开(公告)号：US07709475B2
公开(公告)日：2010-05-04
申请号：US11596735
申请日：2005-05-19
申请人： Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
发明人： Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
IPC分类号： C07D417/12 , A61K31/506 , C07D417/14 , C07D491/08
CPC分类号： C07D417/14 , C07D417/12 , C07D491/08
摘要： The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N; however, at least one of Y1, Y2, Y3, Y4 and Y5 is N; Z1 and Z2, which may be identical or different, are each CH or N; n is an integer from 1 to 3; R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like; and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及由式[I]表示的化合物：其中X是O，S，NH或CH 2; Y1，Y2，Y3，Y4和Y5可以相同或不同，分别为CH或N; 然而，Y 1，Y 2，Y 3，Y 4和Y 5中的至少一个为N; 可以相同或不同的Z 1和Z 2各自为CH或N; n为1〜3的整数， R1是C3-C8环烷基，C6-C10芳基，脂族杂环或芳族杂环，或双环脂族饱和烃基; R2和R3可以相同或不同，分别为氢原子，低级烷基，低级烯基，C3-C8环烷基，C6-C10芳基，芳族杂环等; R4为氢原子，低级烷基，C3-C6环烷基等，或其药学上可接受的盐或酯，以及对Cdk4和/或Cdk6的选择性抑制剂或含有该化合物或其药学上可接受的盐或酯。

7. 发明申请

US20080081811A1 Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton 失效
标题翻译：对具有氨基噻唑骨架的Cdk4和Cdk6的选择性抑制剂
公开(公告)号：US20080081811A1
公开(公告)日：2008-04-03
申请号：US11596735
申请日：2005-05-19
申请人： Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
发明人： Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
IPC分类号： A61K31/496 , A61K31/497 , A61K31/505 , A61K31/5377 , A61P35/00 , C07D239/32 , C07D403/14 , C07D413/14
CPC分类号： C07D417/14 , C07D417/12 , C07D491/08
摘要： The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N; however, at least one of Y1, Y2, Y3, Y4 and Y5 is N; Z1 and Z2, which may be identical or different, are each CH or N; n is an integer from 1 to 3; R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like; and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及由式[I]表示的化合物：其中X是O，S，NH或CH 2; Y 1，Y 2，Y 3，Y 4和Y 5，其可以相同或不同，各自为CH或N; 然而，Y 1，Y 2，Y 3，Y 4和Y 3中的至少一个， 5 是N; Z 1和Z 2可以相同或不同，各自为CH或N; n为1〜3的整数， R 1是C 3 -C 8环烷基，C 6 -C 10环烷基，C 6 -C 15环烷基，芳基，脂族杂环或芳族杂环，或双环脂族饱和烃基; R 2和R 3可以相同或不同，分别为氢原子，低级烷基，低级烯基，C 3， C 1 -C 8环烷基，C 6 -C 10芳基，芳族杂环等; 和R 4是氢原子，低级烷基，C 3 -C 6环烷基等，或药学上可接受的盐或酯，以及对Cdk4和/或Cdk6的选择性抑制剂或含有该化合物或其药学上可接受的盐或酯的抗癌剂。

8. 发明申请

US20090270436A1 SPIROCHROMANON DERIVATIVES 有权
标题翻译：螺吡喃衍生物
公开(公告)号：US20090270436A1
公开(公告)日：2009-10-29
申请号：US12518466
申请日：2008-01-08
申请人： Tomoharu Iino , Hideki Jona , Hideki Kurihara , Masayuki Nakamura , Kenji Niiyama , Jun Shibata , Tadashi Shimamura , Hitomi Watanabe , Takeru Yamakawa , Lihu Yang
发明人： Tomoharu Iino , Hideki Jona , Hideki Kurihara , Masayuki Nakamura , Kenji Niiyama , Jun Shibata , Tadashi Shimamura , Hitomi Watanabe , Takeru Yamakawa , Lihu Yang
IPC分类号： A61K31/438 , C07D401/14 , A61P3/00 , A61P35/00 , A61P31/00
CPC分类号： C07D491/107 , C07D491/20 , C07D519/00
摘要： The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine, indole, 1H-indazole, 1H-furo[2,3-c]pyrazole, 1H-thieno[2,3-c]pyrazole, benzimidazole, 1,2-benzisoxazole, imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine and 1H-pyrazolo[3,4-b]pyridine, having Ar2, and optionally having one or two or more substituents selected from R3: R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; or a C1-C6 alkyl group optionally having a substituent; or an aryl or heterocyclic group optionally having a substituent; or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a machine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
摘要翻译：本发明涉及通式（I）的化合物：其中Ar 1表示由选自苯，吡唑，异恶唑，吡啶，吲哚，1H-吲唑，1H-呋喃并[ 3-c]吡唑，1H-噻吩并[2,3-c]吡唑，苯并咪唑，1,2-苯并异恶唑，咪唑并[1,2-a]吡啶，咪唑并[1,5-a]吡啶和1H-吡唑并[ 具有Ar 2且任选具有一个或两个以上选自R 3：R 1和R 2的取代基的3,4-b]吡啶各自独立地表示氢原子，卤素原子，氰基，C 2 -C 6烯基， C1-C6烷氧基，C2-C7烷酰基，C2-C7烷氧基羰基，芳烷氧基羰基，氨基甲酰基C1-C6烷氧基，羧基-C2-C6链烯基或-Q1-N （Ra）-Q2-Rb; 或任选具有取代基的C1-C6烷基; 或任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或机组; V表示氧原子或硫原子。本发明的化合物可用作各种ACC相关疾病的治疗剂。

9. 发明授权

US08138197B2 Spirochromanon derivatives 有权
标题翻译：螺二色素衍生物
公开(公告)号：US08138197B2
公开(公告)日：2012-03-20
申请号：US12518466
申请日：2008-01-08
申请人： Tomoharu Iino , Hideki Jona , Hideki Kurihara , Masayuki Nakamura , Kenji Niiyama , Jun Shibata , Tadashi Shimamura , Hitomi Watanabe , Takeru Yamakawa , Lihu Yang
发明人： Tomoharu Iino , Hideki Jona , Hideki Kurihara , Masayuki Nakamura , Kenji Niiyama , Jun Shibata , Tadashi Shimamura , Hitomi Watanabe , Takeru Yamakawa , Lihu Yang
IPC分类号： A61K31/438 , C07D221/20
CPC分类号： C07D491/107 , C07D491/20 , C07D519/00
摘要： The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine, indole, 1H-indazole, 1H-furo[2,3-c]pyrazole, 1H-thieno[2,3-c]pyrazole, benzimidazole, 1,2-benzisoxazole, imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine and 1H-pyrazolo[3,4-a]pyridine, having Ar2, and optionally having one or two or more substituents selected from R3; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; or a C1-C6 alkyl group optionally having a substituent; or an aryl or heterocyclic group optionally having a substituent; or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
摘要翻译：本发明涉及通式（I）的化合物：其中Ar 1表示由选自苯，吡唑，异恶唑，吡啶，吲哚，1H-吲唑，1H-呋喃并[ 3-c]吡唑，1H-噻吩并[2,3-c]吡唑，苯并咪唑，1,2-苯并异恶唑，咪唑并[1,2-a]吡啶，咪唑并[1,5-a]吡啶和1H-吡唑并[ 3,4-a]吡啶，其具有Ar 2，并且任选具有一个或两个或更多个选自R 3的取代基; R 1和R 2各自独立地表示氢原子，卤素原子，氰基，C 2 -C 6烯基，C 1 -C 6烷氧基，C 2 -C 7烷酰基，C 2 -C 7烷氧基羰基，芳烷氧基羰基，氨基甲酰基-C 1 -C 6烷氧基，羧基-C 2 -C 6烯基或-Q 1 -N（R a）-Q 2 -R b的基团; 或任选具有取代基的C1-C6烷基; 或任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或次甲基; V表示氧原子或硫原子。本发明的化合物可用作各种ACC相关疾病的治疗剂。

10. 发明授权

US08093389B2 Substituted spirochromanone derivatives 有权
标题翻译：取代的螺二氢茚酮衍生物
公开(公告)号：US08093389B2
公开(公告)日：2012-01-10
申请号：US12007000
申请日：2008-01-08
申请人： Tomoharu Iino , Hideki Jona , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa , Lihu Yang
发明人： Tomoharu Iino , Hideki Jona , Jun Shibata , Tadashi Shimamura , Takeru Yamakawa , Lihu Yang
IPC分类号： C07D413/06 , C07D405/04 , A61K31/438
CPC分类号： C07D519/00 , C07D491/10
摘要： The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of indole, 1H-indazole, 2H-indazole, 1H-thieno[2,3-c]pyrazole, 1H-pyrazolo[3,4-b]pyridine, benzo[b]furan, benzimidazole, benzoxazole, 1,2-benzisoxazole and imidazo[1,2-a]pyridine; R1 and R2 each represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; an optionally-substituted C1-C6 alkyl, aryl or heterocyclic group; or a C1-C6 alkyl or C2-C6 alkenyl group having the aryl or heterocyclic group; R3 and R4 each represent a hydrogen atom, a halogen atom, a nitro group, a cyclo-C3-C6 alkyl group, a carbamoyl group optionally substituted with a C1-C6 alkyl or cyclo-C3-C6 alkyl group, or a group of —N(Re)Rf; an optionally-substituted C2-C7 alkanoyl, C1-C6 alkoxy, C2-C7 alkoxycarbonyl, cyclo-C3-C6 alkyloxycarbonyl, C1-C6 alkylsulfonyl, C1-C6 alkylthio, cyclo-C3-C6 alkyloxy, cyclo-C3-C6 alkyl-C1-C6 alkoxy, cyclo-C3-C6 alkylsulfonyl, cyclo-C3-C6 alkylthio or cyclo-C3-C6 alkyl-C1-C6 alkylthio group; or an optionally-substituted C1-C6 alkyl group; T and U each represent a nitrogen atom or a methine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
摘要翻译：本发明涉及通式（I）的化合物：其中Ar1表示由选自吲哚，1H-吲唑，2H-吲唑，1H-噻吩并[2,3-c]所示的芳环形成的基团，吡唑，1H-吡唑并[3,4-b]吡啶，苯并[b]呋喃，苯并咪唑，苯并恶唑，1,2-苯并异恶唑和咪唑并[1,2-a] R 1和R 2各自表示氢原子，卤素原子，氰基，C 2 -C 6烯基，C 1 -C 6烷氧基，卤代-C 1 -C 6烷氧基，环-C 3 -C 6烷氧基， C2-C7烷酰基，卤代-C2-C7烷酰基，C2-C7烷氧基羰基，卤代-C2-C7烷氧基羰基，环-C3-C6烷氧基羰基，芳烷氧基羰基，氨基甲酰基-C1-C6 烷氧基，羧基-C2-C6烯基或-Q1-N（Ra）-Q2-Rb的基团; 任选取代的C 1 -C 6烷基，芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; R 3和R 4各自表示氢原子，卤素原子，硝基，环-C 3 -C 6烷基，任选被C 1 -C 6烷基或环-C 3 -C 6烷基取代的氨基甲酰基，或者 -N（R f）R f; 任选取代的C 2 -C 7烷酰基，C 1 -C 6烷氧基，C 2 -C 7烷氧基羰基，环C 3 -C 6烷氧基羰基，C 1 -C 6烷基磺酰基，C 1 -C 6烷硫基，环C 3 -C 6烷氧基，环C 3 -C 6烷基 - C 1 -C 6烷氧基，环-C 3 -C 6烷基磺酰基，环-C 3 -C 6烷硫基或环-C 3 -C 6烷基-C 1 -C 6烷硫基; 或任选取代的C 1 -C 6烷基; T和U各自表示氮原子或次甲基; V表示氧原子或硫原子。本发明的化合物可用作各种ACC相关疾病的治疗剂。

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