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1. 发明授权

US5945450A Naphthalene derivative 失效
标题翻译：萘衍生物
公开(公告)号：US5945450A
公开(公告)日：1999-08-31
申请号：US737991
申请日：1996-11-22
申请人： Kazuya Takenouchi , Katsushi Takahashi , Masaichi Hasegawa , Takahiro Takeuchi , Keiji Komoriya
发明人： Kazuya Takenouchi , Katsushi Takahashi , Masaichi Hasegawa , Takahiro Takeuchi , Keiji Komoriya
IPC分类号： C07C233/11 , C07C233/22 , C07C233/55 , C07C233/65 , C07C233/75 , C07C233/81 , C07C235/38 , C07C235/42 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/20 , C07C237/44 , C07C255/60 , C07C311/46 , C07C323/29 , C07C323/60 , C07C323/62 , C07D257/04 , A61K31/24 , C07C229/00
CPC分类号： C07D257/04 , C07C233/11 , C07C233/22 , C07C233/55 , C07C233/65 , C07C233/75 , C07C233/81 , C07C235/38 , C07C235/42 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/20 , C07C237/44 , C07C255/60 , C07C311/46 , C07C323/29 , C07C323/60 , C07C323/62
摘要： Naphthalene derivatives represented by formula �I!: ##STR1## (wherein A is a hydrogen atom, a hydroxy group, a C.sub.7 -C.sub.11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C.sub.1 -C.sub.12 aliphatic or alicyclic, saturated or unsaturated hydrocarbon group where the allyl may be substituted with a C.sub.6 -C.sub.10 allyloxy group; Q represents O, S, CH.sub.2, O--CH.sub.2, S--CH.sub.2, CO, or CHOR.sup.1 ; L represents CO, CR.sup.2 R.sup.3 CO, CH.sub.2 CH.sub.2 CO, or CH.dbd.CHCO; D represents a hydrogen atom, NO.sub.2, NH.sub.2, CO.sub.2 R.sup.4, or a group having the following formula �II!: ##STR2## (wherein G represents. a hydrogen atom, OH, SO.sub.2 NH.sub.2, CO.sub.2 R.sup.6, CN, or a tetrazol-5-yl group); E represents a hydrogen atom, OH, SO.sub.2 NH.sub.2, CO.sub.2 R.sup.5, CN, or a tetrazol-5-yl group; M represents a hydrogen atom, a C.sub.1 -C.sub.4 lower alkyl group, a nitro group, or a halogen atom; and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are, independently each other, a hydrogen atom or a C.sub.1 -C.sub.4 lower alkyl group);pharmacologically acceptable salts thereof, or pharmacologically acceptable solvates thereof, which have, for example, an inhibitory effect on the production of IgE antibodies, and will be useful for prophylaxis and/or treatment of allergic diseases.
摘要翻译： PCT No.PCT / JP95 / 01035 Sec。 371日期：1996年11月22日 102（e）日期1996年11月22日PCT提交1995年5月30日PCT公布。第WO95 / 32943号公报日期：1995年12月7日由式[I]表示的萘衍生物：其中A为氢原子，羟基，C7-C11芳烷氧基或由氧基和C1-C12脂族或脂环族饱和或不饱和的烃基，其中烯丙基可以被C 6 -C 10烯丙氧基取代; Q代表O，S，CH2，O-CH2，S-CH2，CO或CHOR1; L代表CO，CR2R3CO，CH2CH2CO或 CH = CHCO; D表示氢原子，NO 2，NH 2，CO 2 R 4或具有下式[II]的基团：（其中G表示氢原子，OH，SO 2 NH 2，CO 2 R 6，CN或四唑-5-基） E表示氢原子，OH，SO 2 NH 2，CO 2 R 5，CN或四唑-5-基; M表示氢原子，C1-C4低级烷基，硝基或卤素原子; R1，R2，R3，R4，R5和R6彼此独立地为氢原子或C1-C4低级烷基）。其药理学上可接受的盐或其药学上可接受的溶剂化物，其具有例如对IgE抗体产生的抑制作用，并且可用于预防和/或治疗过敏性疾病。

2. 发明申请

US20100197394A1 Game machine, game information display method and game program 有权
标题翻译：游戏机，游戏信息显示方法和游戏程序
公开(公告)号：US20100197394A1
公开(公告)日：2010-08-05
申请号：US12657720
申请日：2010-01-26
申请人： Michiaki Imachi , Takahiro Takeuchi , Masahiro Nishiyama , Yoshihiko Aramaki , Kazuma Konishi
发明人： Michiaki Imachi , Takahiro Takeuchi , Masahiro Nishiyama , Yoshihiko Aramaki , Kazuma Konishi
IPC分类号： A63F13/00 , A63F9/24
CPC分类号： G07F17/3295 , G07F17/32 , G07F17/3276
摘要： A game machine comprises a game progress controller which accepts operational information entered from a touch panel and from other game machines and successively obtain tile objects representing tiles of individual players, a main image display controller which defines arrangement zones for the tile objects representing the tiles of the individual players within a main screen area, displays the tile objects in such a manner that types of the tile objects of a primary player are visually recognizable, and substitutes the tile objects obtained by drawing actions for specified ones of the tile objects, a supplementary information generator which generates supplementary information regarding the tile objects representing the tiles of the primary player that are displayed in a visually recognizable fashion, and a sub-image display controller which displays the supplementary information in a sub-screen area located adjacent to the main screen area. The supplementary information creates situational variations and exciting feelings in a game.
摘要翻译：游戏机包括游戏进程控制器，其接受从触摸面板和其他游戏机输入的操作信息，并且连续地获取代表各个玩家的瓦片的瓦片对象;主图像显示控制器，其定义用于代表瓦片的瓦片对象的布置区域主屏幕区域内的各个玩家以这样的方式显示瓦片对象，使得主玩家的瓦片对象的类型在视觉上可识别，并且替换通过绘制针对指定的瓦片对象的动作而获得的瓦片对象，补充信息生成器，其生成关于表示以可视识别的方式显示的主播放器的瓦片的瓦片对象的补充信息;以及子图像显示控制器，其将辅助信息显示在与主屏幕相邻的子屏幕区域中区。补充信息在游戏中创建情境变化和令人兴奋的感觉。

3. 发明授权

US08360876B2 Networked game machine, game information display and game program for mahjong game 有权
标题翻译：网络游戏机，游戏信息显示和麻将游戏程序
公开(公告)号：US08360876B2
公开(公告)日：2013-01-29
申请号：US12657720
申请日：2010-01-26
申请人： Michiaki Imachi , Takahiro Takeuchi , Masahiro Nishiyama , Yoshihiko Aramaki , Kazuma Konishi
发明人： Michiaki Imachi , Takahiro Takeuchi , Masahiro Nishiyama , Yoshihiko Aramaki , Kazuma Konishi
IPC分类号： A63F9/20
CPC分类号： G07F17/3295 , G07F17/32 , G07F17/3276
摘要： A game machine includes a game progress controller, a main image display controller, a supplementary information generator, and a sub-image display controller. The game progress controller accepts operational information entered from a touch panel and from other game machines and successively obtains tile objects representing tiles of individual players. The main image display controller defines arrangement zones for the tile objects representing the tiles of the individual players within a main screen area, displays the tile objects so that patterns of tile objects of a primary player are visually recognizable, and substitutes the tile objects obtained by drawing actions for specified ones of the tile objects. The supplementary information generator generates supplementary information regarding the tile objects that are displayed in a visually recognizable fashion. The sub-image display controller displays the supplementary information in a sub-screen area located adjacent to the main screen area.
摘要翻译：游戏机包括游戏进程控制器，主图像显示控制器，辅助信息发生器和子图像显示控制器。游戏进度控制器接受从触摸面板和其他游戏机输入的操作信息，并且依次获得代表各个玩家的瓦片的瓦片对象。主图像显示控制器定义表示主屏幕区域内的各个玩家的瓦片的瓦片对象的布置区域，显示瓦片对象，使得主要玩家的瓦片对象的图案被视觉识别，并且代替通过绘制指定的tile对象的动作。补充信息生成器生成关于以视觉上可识别的方式显示的瓦片对象的补充信息。子图像显示控制器将辅助信息显示在与主屏幕区域相邻的子屏幕区域中。

4. 发明授权

US07528140B2 Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors 失效
标题翻译：取代的吡咯并[3,2-d]嘧啶作为糖原合酶激酶（GSK）抑制剂
公开(公告)号：US07528140B2
公开(公告)日：2009-05-05
申请号：US10504583
申请日：2003-02-24
申请人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
发明人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
IPC分类号： C07D487/04 , C07D417/12 , C07D417/06 , C07D413/12 , C07D413/06 , C07D519/00 , A61K31/519 , A61K31/541 , A61K31/5355 , A61K31/497
CPC分类号： C07D487/04
摘要： The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.
摘要翻译：本发明提供由式（I）表示的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐。本发明的化合物显示出GSK-3抑制活性，因此预期其可用作GSK-3涉及的病症的治疗或预防剂，例如糖尿病，糖尿病并发症，阿尔茨海默病，神经变性疾病，躁狂抑郁症，创伤性脑病，脱发，炎性疾病，癌症和免疫缺陷。

5. 发明申请

US20050171094A1 Pyrrolopyrimidine derivatives 审中-公开
标题翻译：吡咯并嘧啶衍生物
公开(公告)号：US20050171094A1
公开(公告)日：2005-08-04
申请号：US10505228
申请日：2003-02-24
申请人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Yoji Yamamoto , Noboru Yoshioka
发明人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Yoji Yamamoto , Noboru Yoshioka
IPC分类号： A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P15/00 , A61P17/14 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D487/14 , A61K31/551 , A61K31/519
CPC分类号： C07D487/14
摘要： A pyrrolo[3,2-d]pyrimidine derivative represented by the formula (I) or a pharamaceutically acceptable salt of the derivative. The derivative or salt is useful as a GSK-3 inhibitor.
摘要翻译：由式（I）表示的吡咯并[3,2-d]嘧啶衍生物或衍生物的药学上可接受的盐。衍生物或盐可用作GSK-3抑制剂。

6. 发明授权

US07005978B2 Vehicle direction indication device with flash rate that does not appear to change when battery voltage varies 失效
标题翻译：车辆方向指示装置，当电池电压变化时闪光灯速率不会改变
公开(公告)号：US07005978B2
公开(公告)日：2006-02-28
申请号：US10701420
申请日：2003-11-06
申请人： Takahiro Takeuchi , Hirofumi Mokuya , Yoshichika Abe
发明人： Takahiro Takeuchi , Hirofumi Mokuya , Yoshichika Abe
IPC分类号： B60Q1/34
CPC分类号： B60Q1/38
摘要： A vehicle direction indication device is configured such that a voltage of a battery power supply is detected, and when a direction indication light switch is switched to ON, a pulse width modulated signal is output. This pulse width modulated signal is generated by pulse width modulating a flash signal for driving a direction indication light in a flashing manner with a duty ratio based upon the detected voltage of the battery power supply; the duty ratio at which the voltage of the battery power supply is high becomes smaller than that at which the voltage of the battery power supply is low. The direction indication light is then driven in the flashing manner based upon the output signal.
摘要翻译：车辆方向指示装置被配置为使得检测到电池电源的电压，并且当方向指示灯开关切换到ON时，输出脉宽调制信号。该脉冲宽度调制信号通过脉冲宽度调制闪光信号来产生，用于以基于电池电源的检测电压的占空比以闪烁的方式驱动方向指示灯; 电池电源的电压高的占空比变得比电池电源的电压低的占空比变小。然后基于输出信号以闪烁的方式驱动方向指示灯。

7. 发明申请

US20050277773A1 Pyrrolopyrimidine derivatives 失效
标题翻译：吡咯并嘧啶衍生物
公开(公告)号：US20050277773A1
公开(公告)日：2005-12-15
申请号：US10504583
申请日：2003-02-24
申请人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
发明人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
IPC分类号： A61P3/10 , A61P17/14 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D487/04 , A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.
摘要翻译：本发明提供由式（I）表示的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐。本发明的化合物显示出GSK-3抑制活性，因此预期其可用作GSK-3涉及的病症的治疗或预防剂，例如糖尿病，糖尿病并发症，阿尔茨海默病，神经变性疾病，躁狂抑郁症，创伤性脑病，脱发，炎性疾病，癌症和免疫缺陷。

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