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1. 发明申请

US20050171094A1 Pyrrolopyrimidine derivatives 审中-公开
标题翻译：吡咯并嘧啶衍生物
公开(公告)号：US20050171094A1
公开(公告)日：2005-08-04
申请号：US10505228
申请日：2003-02-24
申请人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Yoji Yamamoto , Noboru Yoshioka
发明人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Yoji Yamamoto , Noboru Yoshioka
IPC分类号： A61P3/00 , A61P3/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P15/00 , A61P17/14 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D487/14 , A61K31/551 , A61K31/519
CPC分类号： C07D487/14
摘要： A pyrrolo[3,2-d]pyrimidine derivative represented by the formula (I) or a pharamaceutically acceptable salt of the derivative. The derivative or salt is useful as a GSK-3 inhibitor.
摘要翻译：由式（I）表示的吡咯并[3,2-d]嘧啶衍生物或衍生物的药学上可接受的盐。衍生物或盐可用作GSK-3抑制剂。

2. 发明申请

US20050277773A1 Pyrrolopyrimidine derivatives 失效
标题翻译：吡咯并嘧啶衍生物
公开(公告)号：US20050277773A1
公开(公告)日：2005-12-15
申请号：US10504583
申请日：2003-02-24
申请人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
发明人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
IPC分类号： A61P3/10 , A61P17/14 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D487/04 , A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.
摘要翻译：本发明提供由式（I）表示的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐。本发明的化合物显示出GSK-3抑制活性，因此预期其可用作GSK-3涉及的病症的治疗或预防剂，例如糖尿病，糖尿病并发症，阿尔茨海默病，神经变性疾病，躁狂抑郁症，创伤性脑病，脱发，炎性疾病，癌症和免疫缺陷。

3. 发明授权

US07528140B2 Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors 失效
标题翻译：取代的吡咯并[3,2-d]嘧啶作为糖原合酶激酶（GSK）抑制剂
公开(公告)号：US07528140B2
公开(公告)日：2009-05-05
申请号：US10504583
申请日：2003-02-24
申请人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
发明人： Kenichiro Kataoka , Tomomi Kosugi , Toshihiro Ishii , Takahiro Takeuchi , Takaharu Tsutsumi , Akira Nakano , Gen Unoki , Masanori Yamamoto , Yuri Sakai
IPC分类号： C07D487/04 , C07D417/12 , C07D417/06 , C07D413/12 , C07D413/06 , C07D519/00 , A61K31/519 , A61K31/541 , A61K31/5355 , A61K31/497
CPC分类号： C07D487/04
摘要： The invention provides pyrrolo[3,2-d]pyrimidine derivatives represented by formula (I), and their medically acceptable salts. The compounds of the invention exhibit GSK-3 inhibiting activity and are therefore expected to be useful as therapeutic or prophylactic agents for conditions in which GSK-3 is implicated, such as diabetes, diabetes complications, Alzheimer's disease, neurodegenerative diseases, manic depression, traumatic encephalopathy, alopecia, inflammatory diseases, cancer and immune deficiency.
摘要翻译：本发明提供由式（I）表示的吡咯并[3,2-d]嘧啶衍生物及其医学上可接受的盐。本发明的化合物显示出GSK-3抑制活性，因此预期其可用作GSK-3涉及的病症的治疗或预防剂，例如糖尿病，糖尿病并发症，阿尔茨海默病，神经变性疾病，躁狂抑郁症，创伤性脑病，脱发，炎性疾病，癌症和免疫缺陷。

4. 发明申请

US20050153992A1 Pyrrolopyrimidine thion derivatives 审中-公开
标题翻译：吡咯并嘧啶硫代衍生物
公开(公告)号：US20050153992A1
公开(公告)日：2005-07-14
申请号：US10928600
申请日：2004-08-26
申请人： Takaharu Tsutsumi , Satoshi Sugiura , Masahiro Koga , Yoshiyuki Matsumoto , Toshihiro Ishii , Akira Nakano , Gen Unoki , Yuri Sakai , Reiko Takarada , Hiroko Ogawa
发明人： Takaharu Tsutsumi , Satoshi Sugiura , Masahiro Koga , Yoshiyuki Matsumoto , Toshihiro Ishii , Akira Nakano , Gen Unoki , Yuri Sakai , Reiko Takarada , Hiroko Ogawa
IPC分类号： A61K31/519 , A61P3/10 , A61P17/14 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D487/02 , C07D487/04
CPC分类号： A61K31/519 , C07D487/04
摘要： A compound having GSK-3 inhibiting function. A1 and A3 are a single bond, an aliphatic hydrocarbon group; A2 and A4 are a single bond, CO, COO, CONR, O, OCO, NR, NRCO, NRCOO, etc.; G1 is a single bond, an aliphatic hydrocarbon, aromatic hydrocarbon, heterocyclic; G2 is a hydrogen atom, an aliphatic hydrocarbon, an alicyclic hydrocarbon, an aromatic hydrocarbon, heterocyclic; A5 is a single bond, NR; R2 is H, halogen, an aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; A6 is a single bond, NR, CO, NRCO, NRCONR, CONR, COO, O, etc.; R3 is H, halogen, nitro, saturated aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; and when A6 is CR═CR or C≡C; R3 may be a trimethylsilyl, formyl, acyl, carboxyl, alkoxylcarbonyl, carbamoyl, alkylcarbamoyl or cyano group; and R is H or an aliphatic hydrocarbon group.
摘要翻译：具有GSK-3抑制功能的化合物。 A 1和A 3是单键，脂族烃基; A <2>和A 4是单键，CO，COO，CONR，O，OCO，NR，NRCO，NRCOO等; G 1是单键，脂族烃，芳族烃，杂环基; G 2是氢原子，脂族烃，脂环烃，芳族烃，杂环基; A <5>是单键NR; R 2是H，卤素，脂族烃，脂环烃，芳烃，杂环; NR 6 CO 2，NRCO，NRCONR，CONR，COO，O等单键。 R 3是H，卤素，硝基，饱和脂族烃，脂环烃，芳族烃，杂环; 当A <6> CR-CR或C≡C时; R 3可以是三甲基甲硅烷基，甲酰基，酰基，羧基，烷氧基羰基，氨基甲酰基，烷基氨基甲酰基或氰基; R为H或脂族烃基。

5. 发明授权

US07557113B2 Substituted pyrrolo[3,2-d]pyrimidine derivatives 失效
标题翻译：取代的吡咯并[3,2-d]嘧啶衍生物
公开(公告)号：US07557113B2
公开(公告)日：2009-07-07
申请号：US10928969
申请日：2004-08-26
申请人： Takaharu Tsutsumi , Satoshi Sugiura , Masahiro Koga , Yoshiyuki Matsumoto , Toshihiro Ishii , Akira Nakano , Gen Unoki , Yuri Sakai , Reiko Takarada , Hiroko Ogawa
发明人： Takaharu Tsutsumi , Satoshi Sugiura , Masahiro Koga , Yoshiyuki Matsumoto , Toshihiro Ishii , Akira Nakano , Gen Unoki , Yuri Sakai , Reiko Takarada , Hiroko Ogawa
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04 , A61P25/18
CPC分类号： C07D487/04
摘要： A compound having GSK-3 inhibitory activity. A1 and A3 are a single bond, an aliphatic hydrocarbon group; A2 and A4 are a single bond, CO, COO, CONR, O, OCO, NR, NRCO, NRCOO, etc.; G1 is a single bond, an aliphatic hydrocarbon, aromatic hydrocarbon, heterocyclic; G2 is H, an aliphatic hydrocarbon, an alicyclic hydrocarbon, an aromatic hydrocarbon, heterocyclic; A5 is a single bond, NR; R2 is H, halogen, an aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; A6 is a single bond, NR, CO, NRCO, NRCONR, CONR, COO, O, etc.; R3 is H, halogen, nitro, saturated aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; and R3 may be a trimethylsilyl, formyl, acyl, carboxyl, alkoxylcarbonyl, carbamoyl, alkylcarbamoyl, or cyano group when A6 is CR═CR or C≡C, wherein R is H or an lower aliphatic hydrocarbon group.
摘要翻译：具有GSK-3抑制活性的化合物。 A1和A3是单键，脂族烃基; A2和A4是单键，CO，COO，CONR，O，OCO，NR，NRCO，NRCOO等; G1是单键，脂族烃，芳烃，杂环; G 2是H，脂族烃，脂环烃，芳烃，杂环; A5是单键，NR; R2是H，卤素，脂族烃，脂环族烃，芳烃，杂环; A6是单键，NR，CO，NRCO，NRCONR，CONR，COO，O等; R3是H，卤素，硝基，饱和脂肪烃，脂环族烃，芳烃，杂环; 当A6是CR-CR或C≡C时，R3可以是三甲基甲硅烷基，甲酰基，酰基，羧基，烷氧基羰基，氨基甲酰基，烷基氨基甲酰基或氰基，其中R是H或低级脂族烃基。

6. 发明申请

US20060160831A1 Pyrrolopyrimidinone derivatives 失效
标题翻译：吡咯并嘧啶酮衍生物
公开(公告)号：US20060160831A1
公开(公告)日：2006-07-20
申请号：US10928969
申请日：2004-08-26
申请人： Takaharu Tsutsumi , Satoshi Sugiura , Masahiro Koga , Yoshiyuki Matsumoto , Toshihiro Ishii , Akira Nakano , Gen Unoki , Yuri Sakai , Reiko Takarada , Hiroko Ogawa
发明人： Takaharu Tsutsumi , Satoshi Sugiura , Masahiro Koga , Yoshiyuki Matsumoto , Toshihiro Ishii , Akira Nakano , Gen Unoki , Yuri Sakai , Reiko Takarada , Hiroko Ogawa
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： A compound having GSK-3 inhibitory activity. A1 and A3 are a single bond, an aliphatic hydrocarbon group; A2 and A4 are a single bond, CO, COO, CONR, O, OCO, NR, NRCO, NRCOO, etc.; G1 is a single bond, an aliphatic hydrocarbon, aromatic hydrocarbon, heterocyclic; G2 is H, an aliphatic hydrocarbon, an alicyclic hydrocarbon, an aromatic hydrocarbon, heterocyclic; A5 is a single bond, NR; R2 is H, halogen, an aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; A6 is a single bond, NR, CO, NRCO, NRCONR, CONR, COO, O, etc.; R3 is H, halogen, nitro, saturated aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; and R3 may be a trimethylsilyl, formyl, acyl, carboxyl, alkoxylcarbonyl, carbamoyl, alkylcarbamoyl, or cyano group when A6 is CR═CR or C≡C, wherein R is H or an lower aliphatic hydrocarbon group.
摘要翻译：具有GSK-3抑制活性的化合物。 A 1和A 3是单键，脂族烃基; A <2>和A 4是单键，CO，COO，CONR，O，OCO，NR，NRCO，NRCOO等; G 1是单键，脂族烃，芳族烃，杂环基; G 2是H，脂族烃，脂环烃，芳族烃，杂环基; A <5>是单键NR; R 2是H，卤素，脂族烃，脂环烃，芳烃，杂环; NR 6 CO 2，NRCO，NRCONR，CONR，COO，O等单键。 R 3是H，卤素，硝基，饱和脂族烃，脂环烃，芳族烃，杂环; 当A 6是CR-CR或C≡C时，R 3可以是三甲基甲硅烷基，甲酰基，酰基，羧基，烷氧基羰基，氨基甲酰基，烷基氨基甲酰基或氰基，其中 R是H或低级脂族烃基。

7. 发明授权

US10764495B2 Image processing apparatus, image processing method, storage medium, system, and electronic apparatus 有权
公开(公告)号：US10764495B2
公开(公告)日：2020-09-01
申请号：US16217536
申请日：2018-12-12
申请人： Hiroyasu Uehara , Masakazu Terauchi , Masashi Miyata , Hiroshi Kano , Akira Nakano , Takeyoshi Nishimura
发明人： Hiroyasu Uehara , Masakazu Terauchi , Masashi Miyata , Hiroshi Kano , Akira Nakano , Takeyoshi Nishimura
IPC分类号： H04N5/262 , H04N5/232 , H04N5/347 , H04N5/349
摘要： An image processing apparatus includes processing circuitry. The processing circuitry is configured to detect a positional shift amount of each of a plurality of images; select a composite target image from the plurality of images based on the detected positional shift amount; and obtain a composite image based on the positional shift amount and the selected composite target image.

8. 发明授权

US09019387B2 Imaging device and method of obtaining image 有权
标题翻译：成像装置及获取图像的方法
公开(公告)号：US09019387B2
公开(公告)日：2015-04-28
申请号：US13413946
申请日：2012-03-07
申请人： Akira Nakano
发明人： Akira Nakano
IPC分类号： H04N5/232 , G06T5/50
CPC分类号： H04N5/23277 , G06T5/50 , G06T2207/10024 , G06T2207/20008 , G06T2207/20221 , G06T2207/30201 , H04N5/23219 , H04N5/23254
摘要： An imaging device including an image sensor, includes an image obtaining control unit that obtains plural continuous images of an object taken by the image sensor; a size determining unit that determines an image size of reduced images based on photographing information of at least one of the images, and generates reduced images from the images obtained by the image obtaining control unit based on the determined image size; a motion vector detection unit that detects a motion vector of the reduced images; and an image synthesis unit that synthesizes the images obtained by the image obtaining control unit based on the motion vector detected by the motion vector detection unit to obtain a synthesized image.
摘要翻译：一种包括图像传感器的成像装置，包括图像获取控制单元，其获得由图像传感器拍摄的对象的多个连续图像; 尺寸确定单元，其基于至少一个图像的拍摄信息确定缩小图像的图像尺寸，并且基于所确定的图像大小从由图像获取控制单元获得的图像生成缩小图像; 运动矢量检测单元，其检测所述缩小图像的运动矢量; 以及图像合成单元，其基于由运动矢量检测单元检测到的运动矢量来合成由图像获取控制单元获得的图像，以获得合成图像。

9. 发明授权

US07805901B2 Construction material and building 有权
标题翻译：建筑材料和建筑物
公开(公告)号：US07805901B2
公开(公告)日：2010-10-05
申请号：US11666489
申请日：2005-10-24
申请人： Muneto Yamada , Kazutaka Uekado , Akira Nakano
发明人： Muneto Yamada , Kazutaka Uekado , Akira Nakano
IPC分类号： E04B1/74
CPC分类号： E04B1/78 , E04B1/76 , E04B1/803 , E04B2001/742 , Y02A30/242 , Y02B80/12
摘要： The present invention provides a building to be constructed without any troublesome work.The building is a building comprising a construction material 12, which has a plane heat insulation material 14 in which a madreporic core material is enclosed in a vacuum and a plate structural face material 12a, and whose heat insulation material 14 and structural face material 12a are combined in a way that a plane surface of the heat insulation material 14 faces to one side of a plane surface of the structural face material 12a, and further comprising a wooden base 9b assembled on the construction material 12 and an external wall finishing material 3 fixed on the wooden base 9b.
摘要翻译：本发明提供一种建筑物，而不需要任何麻烦的工作。该建筑是一种建筑物，其包括建筑材料12，该建筑材料12具有平面绝热材料14，绝热材料14和结构面材料12a在真空中封闭有空心芯材和板结构面材料12a 以隔热材料14的平面表面朝向结构面材12a的平面的一侧的方式组合，并且还包括组装在建筑材料12上的木制底座9b和固定的外墙装饰材料3 在木制基座9b上。

10. 发明授权

US07316125B2 Insulated box body, refrigerator having the box body, and method of recycling materials for insulated box body 有权
标题翻译：绝缘箱体，带箱体的冰箱，以及隔热箱体回收材料的方法
公开(公告)号：US07316125B2
公开(公告)日：2008-01-08
申请号：US10479208
申请日：2002-05-31
申请人： Kazutaka Uekado , Masato Sasaki , Akira Nakano , Yoshiki Ohashi
发明人： Kazutaka Uekado , Masato Sasaki , Akira Nakano , Yoshiki Ohashi
IPC分类号： F25D11/02
CPC分类号： F25D23/062 , F25D2201/126 , F25D2201/14 , F25D2400/04
摘要： An insulation box unit and a refrigerator of the present invention employs i) rigid urethane foam with a 8.0 MPa-or-greater bending modulus, and a 60 kg/m3-or-lower density, and ii) a vacuum insulation material. The proper bending modulus provides the insulation box unit with a substantial strength, even in the case that the coverage of the vacuum insulation material with respect to the surface of the outer box exceeds 40%. The proper density prevents the insulation box unit from poor insulation efficiency due to undesired solid thermal conductivity. Despite of an extended use of the vacuum insulation material, the insulation box unit offers an excellent insulation efficiency and therefore accelerates energy saving. According to the recycling method of the present invention, rigid urethane foam formed of tolylene di-isocyanate composition, which was separated from refrigerator wastes, is recycled as a material of rigid urethane foam.
摘要翻译：本发明的绝缘箱单元和冰箱采用i）具有8.0MPa或更大弯曲模量和60kg / m 3以上低密度的硬质聚氨酯泡沫，ii ）真空绝缘材料。即使在真空绝热材料相对于外箱表面的覆盖范围超过40％的情况下，适当的弯曲模量也提供了具有相当强度的绝缘箱单元。适当的密度防止绝缘箱单元由于不期望的固体导热性而具有差的绝缘效率。尽管绝缘材料的使用得到了广泛的应用，绝缘箱单元提供了绝佳的绝缘效率，从而加速了节能。根据本发明的再循环方法，将与冰箱废物分离的甲苯二异氰酸酯组合物形成的硬质聚氨酯泡沫作为刚性聚氨酯泡沫材料进行再循环。

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