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1. 发明申请

US20080069829A1 Antigenic protein originating in Malassezia 失效
标题翻译：起源于马拉色霉菌的抗原蛋白
公开(公告)号：US20080069829A1
公开(公告)日：2008-03-20
申请号：US11116371
申请日：2005-04-28
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K39/00 , C07H21/04 , C07K14/39 , C07K16/14
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译：从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。

2. 发明授权

US06911208B2 Antigenic protein originating in malassezia 失效
标题翻译：源于马拉色菌的抗原蛋白
公开(公告)号：US06911208B2
公开(公告)日：2005-06-28
申请号：US10109670
申请日：2002-04-01
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K38/00 , C07K14/37 , C07K16/14 , C12N15/31 , C12P21/08 , A61K39/35 , A61K39/36 , C12N21/04 , C12N21/06
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergies; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergies, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译：一种基本上纯的，分离的抗原蛋白，其来源于马拉色氏菌属的真菌，其特征在于所述抗原蛋白具有与过敏患者IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。此外，可以提供用于马拉色氏菌过敏症的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。

3. 发明授权

US06432407B1 Antigenic protein originating in malassezia 失效
标题翻译：源于马拉色菌的抗原蛋白
公开(公告)号：US06432407B1
公开(公告)日：2002-08-13
申请号：US09091097
申请日：1998-06-12
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K3900
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译：从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。

4. 发明授权

US07491405B2 Antigenic protein originating in Malassezia 失效
标题翻译：起源于马拉色霉菌的抗原蛋白
公开(公告)号：US07491405B2
公开(公告)日：2009-02-17
申请号：US11116371
申请日：2005-04-28
申请人： Kazutoh Takesako , Takashi Okada , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okada , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K39/35 , A61K38/00 , C12P21/04
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译：从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。

5. 发明授权

US06478451B2 Vehicular lamp unit and method for manufacturing same 有权
标题翻译：车灯单元及其制造方法
公开(公告)号：US06478451B2
公开(公告)日：2002-11-12
申请号：US09794243
申请日：2001-02-28
申请人： Kazuo Akiyama , Fujihiko Sugiyama
发明人： Kazuo Akiyama , Fujihiko Sugiyama
IPC分类号： F21V3100
CPC分类号： B29C65/1654 , B23K26/28 , B29C65/1635 , B29C65/1687 , B29C65/169 , B29C66/114 , B29C66/12261 , B29C66/12449 , B29C66/12463 , B29C66/12464 , B29C66/12469 , B29C66/131 , B29C66/342 , B29C66/542 , B29C66/652 , B29C66/71 , B29C66/712 , B29C66/73361 , B29C66/73365 , B29C66/73921 , B29C66/8322 , B29C66/836 , B29C66/863 , B29K2033/12 , B29K2055/02 , B29K2069/00 , B29K2101/12 , B29K2995/0025 , B29K2995/0027 , B29K2995/0072 , B29L2031/30 , B29L2031/3055 , B29L2031/747 , F21S43/51 , F21S45/37 , F21V17/101 , B29K2025/08
摘要： A vehicular lamp in which bonding failure between a front lens and a lamp body is prevented while enhancing the bonding strength and improving the quality of the outer appearance around the bonded surface therebetween. An edge surface of a seal leg of the front lens and a receiving surface of a lamp body are bonded together by laser beam welding so as to improve the quality of the outer appearance of the portion around the bonded surfaces. The bonded surface is inclined at a predetermined angle with respect to a plane perpendicular to the bonding direction. Even if the edge surface of the seal leg or the receiving surface has a wave-like irregularity such that gaps are created in areas therebetween, the pressure in the bonding direction acting on the members to be bonded causes slippage between them, resulting in sealing the gaps. The beam spot diameter of a laser beam irradiated onto the receiving surface is increased in an amount corresponding to the angle of inclination of the bonded surface, thus increasing the bonding width and enhancing the bonding strength.
摘要翻译：防止前透镜和灯体之间的接合故障同时提高接合强度并提高其间的接合表面的外观质量的车灯。前透镜的密封腿的边缘表面和灯体的接收表面通过激光束焊接结合在一起，以提高接合表面周围部分的外观质量。接合表面相对于垂直于接合方向的平面以预定角度倾斜。即使密封腿或接收面的边缘表面具有波状不规则性，使得在其间的区域中产生间隙，作用在待接合构件上的接合方向上的压力也会导致它们之间的滑动，从而密封差距照射到接收面上的激光束的光点直径以与接合面的倾斜角对应的量增加，从而增加接合宽度并提高接合强度。

6. 发明授权

US5560706A Seal structure and process for a vehicular lamp 失效
标题翻译：车灯的密封结构和工艺
公开(公告)号：US5560706A
公开(公告)日：1996-10-01
申请号：US368911
申请日：1995-01-05
申请人： Kazuhiro Yamazaki , Kazuo Akiyama , Michihiko Suzuki
发明人： Kazuhiro Yamazaki , Kazuo Akiyama , Michihiko Suzuki
IPC分类号： F21S8/10 , F21V17/00 , F21V31/00 , B29C44/12 , B29C44/06
CPC分类号： F21V17/101 , B29C65/56 , B29C65/562 , B29C65/58 , B29C66/12449 , B29C66/12463 , B29C66/12469 , B29C66/301 , B29C66/322 , B29C66/54 , B29C66/55 , F21S48/1208 , B29C65/565 , B29C66/727 , B29L2031/747
摘要： A seal structure between a leg part 15 of a front lens and a seal groove 12, wherein a seal member 20 is applied into the seal groove 12 formed on a periphery of a front opening portion of a lamp body 10, the leg part 15 of the front lens engaging with the seal groove 12 is secured to the seal groove 12 by a mechanical fastening means (clip 30) to prevent a removal, and the seal member 20 in the seal groove 12 is compressed by the lens leg part 15, characterized in that the seal member 20 is formed of a solid foamed material which foams from an initial fluid state and hardens while keeping elasticity, and which can be stripped off.
摘要翻译：前透镜的腿部15和密封槽12之间的密封结构，其中密封构件20被施加到形成在灯体10的前开口部的周边的密封槽12中，腿部15 与密封槽12接合的前透镜通过机械紧固装置（夹30）固定到密封槽12以防止移除，并且密封槽12中的密封构件20被透镜腿部15压缩，其特征在于因为密封件20由固体泡沫材料形成，其从初始流体状态发泡并且在保持弹性的同时硬化，并且可被剥离。

7. 发明申请

US20090084276A1 Apparatus for reducing volume of a beverage container and apparatus for separating beverage containers 审中-公开
标题翻译：用于减小饮料容器体积的装置和用于分离饮料容器的装置
公开(公告)号：US20090084276A1
公开(公告)日：2009-04-02
申请号：US12232358
申请日：2008-09-16
申请人： Kazuo Akiyama
发明人： Kazuo Akiyama
IPC分类号： B30B9/00 , B30B5/02
CPC分类号： B30B9/325
摘要： An apparatus for separating beverage containers according to the present invention has a vibrating screen arranged with a slope, over which an apparatus for reducing the volume of a beverage container is installed. The volume reduction apparatus has a pair of tires which have a fixed center distance therebetween and are in pressure contact with each other. A plurality of engaging members are circumferentially arranged on the outer periphery of one of the tires. Empty cans and PET bottles are fed to and crushed in the pressure contact area in the volume reduction apparatus. The separation apparatus screens out the crushed empty cans during vibration transfer, based on a difference in thickness between the crushed empty cans and the crushed PET bottles. Empty cans passed unscreened and the PET bottles are separated by a weir member, utilizing a difference in the height direction. The crushed cans are simply let through, and the crushed PET bottles are guided to either side of the vibrating screen by the weir member and discharged from outlets.
摘要翻译：根据本发明的用于分离饮料容器的设备具有布置成具有斜面的振动筛，在该摆动筛上安装用于减小饮料容器体积的装置。体积减小装置具有一对在其间具有固定的中心距离并且彼此压力接触的轮胎。多个接合构件沿周向布置在一个轮胎的外周上。空罐和PET瓶在体积减小装置的压力接触区域中进料并压碎。基于破碎的空罐与破碎的PET瓶之间的厚度差异，分离装置在振动传递期间筛出破碎的空罐。空罐通过未筛选，PET瓶由堰构件分开，利用高度方向的差异。破碎的罐只是简单地通过，并且压碎的PET瓶被堰构件引导到振动筛的任一侧并从出口排出。

8. 发明授权

US06241936B1 Method of forming a gasket for automotive lamps 失效
标题翻译：形成汽车灯垫片的方法
公开(公告)号：US06241936B1
公开(公告)日：2001-06-05
申请号：US09236335
申请日：1999-01-25
申请人： Takahiko Shimada , Kazuo Akiyama , Kazuhiro Yamazaki
发明人： Takahiko Shimada , Kazuo Akiyama , Kazuhiro Yamazaki
IPC分类号： B29C3910
CPC分类号： B60Q1/0466 , F21S41/29 , F21S45/50 , F21V31/005
摘要： An automotive lamp which includes a lamp body, a gasket disposed between the lamp body and an automobile body panel for sealing a back side of the lamp, a seal leg projecting from the lamp body for attaching thereto the gasket, wherein the foamed gasket is molded integrally with a tip end part of the seal leg.
摘要翻译：一种汽车灯，包括灯体，设置在灯体和用于密封灯的背面的汽车车身面板之间的垫圈，从灯体突出的用于附接到衬垫的密封腿，其中，所述发泡垫圈被模制与密封腿的末端部一体地形成。

9. 发明授权

US5993036A Automotive lamps 失效
标题翻译：汽车灯
公开(公告)号：US5993036A
公开(公告)日：1999-11-30
申请号：US703781
申请日：1996-08-27
申请人： Takahiko Shimada , Kazuo Akiyama , Kazuhiro Yamazaki
发明人： Takahiko Shimada , Kazuo Akiyama , Kazuhiro Yamazaki
IPC分类号： F21V31/00 , B29C39/10 , B29C44/12 , B29C67/24 , B29K105/04 , B29L31/26 , B29L31/30 , B60Q1/00 , B60Q1/04 , F21S8/10 , F21V17/00 , F21W101/10 , F21W101/14 , F21V31/02
CPC分类号： B60Q1/0466 , F21S48/1208 , F21S48/33 , F21V31/005
摘要： An automotive lamp which includes a lamp body, a gasket disposed between the lamp body and an automobile body panel for sealing a back side of the lamp, a seal leg projecting from the lamp body for attaching thereto the gasket, wherein the foamed gasket is molded integrally with a tip end part of the seal leg.
摘要翻译：一种汽车灯，包括灯体，设置在灯体和用于密封灯的背面的汽车车身面板之间的垫圈，从灯体突出的用于附接到衬垫的密封腿，其中，所述发泡垫圈被模制与密封腿的末端部一体地形成。

10. 发明授权

US06592239B1 Vehicular lamp and method for producing same 失效
标题翻译：车灯及其制造方法
公开(公告)号：US06592239B1
公开(公告)日：2003-07-15
申请号：US09548361
申请日：2000-04-12
申请人： Kazuo Akiyama , Fujihiko Sugiyama
发明人： Kazuo Akiyama , Fujihiko Sugiyama
IPC分类号： F21V2900
CPC分类号： B29C66/542 , B29C65/06 , B29C65/08 , B29C65/1635 , B29C65/1638 , B29C65/1654 , B29C65/1677 , B29C65/1687 , B29C65/169 , B29C65/20 , B29C65/7814 , B29C66/114 , B29C66/12461 , B29C66/12463 , B29C66/131 , B29C66/24244 , B29C66/301 , B29C66/322 , B29C66/652 , B29C66/71 , B29C66/712 , B29C66/73341 , B29C66/73921 , B29C66/836 , B29C66/863 , B29K2033/12 , B29K2069/00 , B29K2101/12 , B29K2995/0027 , B29L2011/0016 , B29L2031/30 , B29L2031/747 , F21S41/29 , F21S43/51 , F21V17/101 , B29K2055/02 , B29K2025/08
摘要： A vehicular lamp with improved appearance quality (i.e., having no burrs or the like) around the joint interface between a front lens and a lamp body, and sufficient joint strength even in regions where the joint interface shape changes three dimensionally. A sealing leg, formed on the front lens, has a tip face which abuts and is joined by laser welding to a receiving face formed on the lamp body. To carry out the welding operation, a laser beam is irradiated from the front side of the front lens to the receiving face through the sealing leg. Therefore, even if the laser beam enters diagonally, it can be reflected internally by both side faces of the sealing leg so that the beam reliably reaches the tip face. As a result, the energy of the laser beam is not reduced, making it possible to efficiently heat the lamp body.
摘要翻译：在前透镜和灯体之间的接合界面周围具有改善的外观质量（即，不具有毛刺等）的车灯，并且即使在接合界面形状三维地改变的区域中也具有足够的接合强度。形成在前透镜上的密封腿具有通过激光焊接抵接并连接到形成在灯体上的接收面的尖端面。为了进行焊接操作，通过密封腿将激光束从前透镜的前侧照射到接收面。因此，即使激光束对角线入射，也可以在密封腿的两侧面内部反射，从而可靠地到达顶端面。结果，激光束的能量不会降低，能够有效地对灯体进行加热。

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