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1. 发明授权

US4894362A Eel growth hormone 失效
标题翻译：鳗鱼生长激素
公开(公告)号：US4894362A
公开(公告)日：1990-01-16
申请号：US883051
申请日：1986-07-08
申请人： Kazuo Yamaguchi , Akiko Saito , Susumu Sekine , Moriyuki Sato , Seiga Itoh , Kunikatsu Shirahata , Tetsuya Hirano , Hiroshi Kawauchi
发明人： Kazuo Yamaguchi , Akiko Saito , Susumu Sekine , Moriyuki Sato , Seiga Itoh , Kunikatsu Shirahata , Tetsuya Hirano , Hiroshi Kawauchi
IPC分类号： C07K14/61 , C12N15/73
CPC分类号： C07K14/61 , C12N15/73
摘要： According to the present invention, a fish growth hormone was isolated from an organ culture broth of the pituitary gland of eels, and further a recombinant DNA incorporated with a DNA coding for the eel growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained. They can be used for mass production of an eel growth hormone.
摘要翻译：根据本发明，从鳗垂体的器官培养液中分离出鱼生长激素，得到与编码鳗鱼生长激素多肽的DNA和含有重组DNA的微生物结合的重组DNA。它们可用于大量生产鳗鱼生长激素。

2. 发明授权

US4645755A Fish growth hormone 失效
标题翻译：鱼生长激素
公开(公告)号：US4645755A
公开(公告)日：1987-02-24
申请号：US719888
申请日：1985-04-04
申请人： Hiroshi Kawauchi , Kazuo Yamaguchi , Kunikatsu Shirahata
发明人： Hiroshi Kawauchi , Kazuo Yamaguchi , Kunikatsu Shirahata
IPC分类号： A23K1/165 , A23K1/18 , A61K35/60 , A61K38/00 , A61K38/27 , C07K14/00 , C07K14/46 , C07K14/575 , A61K37/36 , C07K7/10
CPC分类号： C07K14/461 , A61K38/00 , Y10S930/12
摘要： A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:(i) amino acid composition: as indicated in Table 1;(ii) the sequences of 33 amino acids at the N-terminal and 23 amino acids at the C-terminal are as follows:N-terminal: H.sub.2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile-Ala-Val-Ser-Arg-Val-Gln-His-Leu-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu-C-terminal: -Met-His-Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-Glu-Ala-Asn-Cys-Thr-Leu-OH;(iii) molecular weight: about 22,000;(iv) isoelectric point: 5.6-5.7; and(v) soluble in an alkaline aqueous solution and hardly soluble or insoluble in neutral and acidic aqueous solutions.
摘要翻译：由从属于沙门氏菌的鱼的垂体获得的纯化提取物提供的鱼生长激素; 激素是具有以下物理化学性质的多肽：（i）氨基酸组成：如表1所示; （ii）N-末端的33个氨基酸和C末端的23个氨基酸的序列如下：N-末端：H 2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile -Ala-Val-Ser-Arg-Val-Gln-His-Le u-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu- C-末端：-Met-His-Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-G lu-Ala-Asn-Cys-Thr- Leu-OH; （iii）分子量：约22,000; （iv）等电点：5.6-5.7; 和（v）溶于碱性水溶液中，几乎不溶于或不溶于中性和酸性水溶液。

3. 发明授权

US4733000A Optially active 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid and derivatives thereof 失效
标题翻译：优选的1-氨基-2-（4-羟基苯基）乙基膦酸及其衍生物
公开(公告)号：US4733000A
公开(公告)日：1988-03-22
申请号：US842744
申请日：1986-03-17
申请人： Kunikatsu Shirahata , Masaji Kasai
发明人： Kunikatsu Shirahata , Masaji Kasai
IPC分类号： A61K38/00 , A61P9/12 , C07F9/38 , C07F9/40 , C07K5/00 , C07K5/06
CPC分类号： C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07K5/06191 , A61K38/00 , Y02P20/55
摘要： Disclosure is optically active 1-amino-2-(hydroxyphenyl) ethylphosphonic acid and derivatives thereof which are useful as intermediates for the preparation of phosphorus-containing oligopeptides exhibiting hypotensive activity.
摘要翻译：公开的是光学活性的1-氨基-2-（羟基苯基）乙基膦酸及其衍生物，其可用作制备显示低血压活性的含磷寡肽的中间体。

4. 发明授权

US4683220A Novel physiologically active substances K-26, a process for preparation thereof and a pharmaceutical composition containing the same 失效
标题翻译：新型生理活性物质K-26，其制备方法和含有它的药物组合物
公开(公告)号：US4683220A
公开(公告)日：1987-07-28
申请号：US912685
申请日：1986-09-26
申请人： Masayuki Yamato , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Takashi Deguchi , Katsuichi Shuto , Akira Karasawa , Ryo Okachi , Kiyoshi Nakayama
发明人： Masayuki Yamato , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Takashi Deguchi , Katsuichi Shuto , Akira Karasawa , Ryo Okachi , Kiyoshi Nakayama
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P9/12 , C07F9/38 , C07F9/40 , C07K5/06 , C07K14/005 , C07K14/195 , C07K14/41 , C12P21/02 , C12R1/01 , A61K37/64
CPC分类号： C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07K5/06191 , A61K38/00
摘要： Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.
摘要翻译：公开了一种新的生理活性物质K-26，其制备方法和含有该生物活性物质的药物组合物。物质的组成，K-26，作为一种降压剂是有用的。

5. 发明授权

US4522812A Novel physiologically active substance K-4, a process for preparation thereof and a pharmaceutical composition containing the same 失效
标题翻译：新型生理活性物质K-4，其制备方法和含有它的药物组合物
公开(公告)号：US4522812A
公开(公告)日：1985-06-11
申请号：US407082
申请日：1982-08-11
申请人： Toshiro Koguchi , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Ryo Okachi , Kiyoshi Nakayama
发明人： Toshiro Koguchi , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Ryo Okachi , Kiyoshi Nakayama
IPC分类号： C12N1/20 , A61K35/74 , A61K38/00 , A61P9/12 , C07F9/38 , C07F9/40 , C07G99/00 , C12P1/06 , C12R1/03 , C07C103/52 , A61K37/02
CPC分类号： C07F9/4056 , C07F9/3808 , C07F9/3882 , C07F9/4006 , A61K38/00
摘要： Disclosed is a novel physiologically active substance K-4 which has a hypotensive activity, a process production thereof and a pharmaceutical composition containing the same.
摘要翻译：公开了一种具有低血压活性的新型生理活性物质K-4，其制备方法和含有它们的药物组合物。

6. 发明授权

US4264504A Mitomycin derivatives 失效
标题翻译：丝裂霉素衍生物
公开(公告)号：US4264504A
公开(公告)日：1981-04-28
申请号：US58670
申请日：1979-07-18
申请人： Chikahiro Urakawa , Masaji Kasai , Haruko Tsuchiya , Kunikatsu Shirahata , Kinichi Nakano , Itaru Takahashi , Kazuyuki Mineura
发明人： Chikahiro Urakawa , Masaji Kasai , Haruko Tsuchiya , Kunikatsu Shirahata , Kinichi Nakano , Itaru Takahashi , Kazuyuki Mineura
IPC分类号： A01N43/90 , A61K31/40 , A61K31/70 , A61P31/04 , C07D487/14 , C12P17/10 , C12P17/18 , C12R1/465 , A61K31/33
CPC分类号： C07D487/14 , A01N43/90 , C12P17/182 , C12R1/465
摘要： New mitomycin derivatives having antibacterial activity are produced by semi-synthetic processes and also by a fermentative method. ##STR1##
摘要翻译：具有抗菌活性的新的丝裂霉素衍生物通过半合成方法以及发酵法生产。

7. 发明授权

US4748251A 7-n-aminomethylenemitomycin derivative 失效
标题翻译： 7-氨基亚甲基霉素衍生物
公开(公告)号：US4748251A
公开(公告)日：1988-05-31
申请号：US824227
申请日：1986-01-30
申请人： Kunikatsu Shirahata , Motomichi Kono , Masaji Kasai , Makoto Morimoto , Tadashi Ashizawa
发明人： Kunikatsu Shirahata , Motomichi Kono , Masaji Kasai , Makoto Morimoto , Tadashi Ashizawa
IPC分类号： A61K31/40 , A61P35/00 , C07D487/14
CPC分类号： C07D487/14
摘要： Mitomycin derivatives represented by the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different, and represent a hydrogen atom or a lower alkyl group; R.sub.3 and R.sub.4 mean that when R.sub.3 is a hydrogen atom, R.sub.4 represents --CH.sub.2 OCONH.sub.2 or ##STR2## (wherein R.sub.1 and R.sub.2 have the same significances as defined above), or R.sub.3 and R.sub.4 are combined to form .dbd.CH.sub.2 ; Y and Z may be the same or different, and represent a hydrogen atom or a methyl group; represents .alpha.- or .beta.-bond, provided that Y represents a hydrogen atom when R.sub.4 takes .beta.-configuration, have an excellent anti-tumor activity.
摘要翻译：由式（I）表示的丝裂霉素衍生物：其中R 1和R 2可以相同或不同，表示氢原子或低级烷基; R 3和R 4表示当R 3是氢原子时，R 4表示-CH 2 OCONH 2或者其中R 1和R 2具有与上述相同的含义，或者R 3和R 4组合形成= CH 2; Y和Z可以相同或不同，表示氢原子或甲基; 表示α或β键，条件是当R 4为β-构型时，Y表示氢原子，具有优异的抗肿瘤活性。

8. 发明授权

US4511560A Antibiotic substances DC-45, and their use as medicaments 失效
标题翻译：抗生素DC-45及其作为药物的用途
公开(公告)号：US4511560A
公开(公告)日：1985-04-16
申请号：US412693
申请日：1982-08-30
申请人： Fusao Tomita , Tatsuya Tamaoki , Kunikatsu Shirahata , Takao Iida , Makoto Morimoto , Kazuhisa Fujimoto
发明人： Fusao Tomita , Tatsuya Tamaoki , Kunikatsu Shirahata , Takao Iida , Makoto Morimoto , Kazuhisa Fujimoto
IPC分类号： C07H17/04 , A61K35/74 , A61P31/04 , A61P35/00 , C07G11/00 , C12P1/06 , C12R1/465 , A61K31/71 , C07H15/26 , C12P19/56
CPC分类号： C12R1/465 , C12P1/06
摘要： New substances designated as DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 and represented by the following general formula: ##STR1## wherein (i) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR2## and R.sub.3 represents ##STR3## (designated DC-45-A); (ii) R.sub.1 represents --OH, R.sub.2 represents --CH.sub.2 OH and R.sub.3 represents ##STR4## (designated DC-45-B.sub.1); or (iii) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR5## and R.sub.3 represents ##STR6## (designated DC-45-B.sub.2). DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 possess antibiotic and anti-tumor activity and may be obtained by culturing a microorganism of the genus Streptomyces. Preferred strain is Streptomyces bottropensis (FERM-P No. 5219; NRRL 12051).
摘要翻译：指定为DC-45-A，DC-45-B1和DC-45-B2的新物质，由以下通式表示：其中（i）R 1和R 2与它们之间的碳原子代表基团（指定为DC-45-A）; （ii）R 1表示-OH，R 2表示-CH 2 OH，R 3表示（指定为DC-45-B1）。或（iii）R 1和R 2与它们之间的碳原子代表基团，并且R 3代表“IMAGE”（指定为DC-45-B2）。 DC-45-A，DC-45-B1和DC-45-B2具有抗生素和抗肿瘤活性，可以通过培养链霉菌属的微生物获得。优选的菌株是巴斯德链霉菌（FERM-P No.5219; NRRL 12051）。

9. 发明授权

US4296040A Antibiotic nanaomycin E and a process for producing the same 失效
标题翻译：抗生素纳米霉素E及其制备方法
公开(公告)号：US4296040A
公开(公告)日：1981-10-20
申请号：US97001
申请日：1970-11-23
申请人： Satoshi Omura , Haruo Tanaka , Itaru Takahashi , Shinzo Ishii , Kazuyuki Mineura , Kunikatsu Shirahata , Masaji Kasai
发明人： Satoshi Omura , Haruo Tanaka , Itaru Takahashi , Shinzo Ishii , Kazuyuki Mineura , Kunikatsu Shirahata , Masaji Kasai
IPC分类号： A61K31/35 , A61P31/04 , C07D493/08 , C12P17/18 , C12R1/465 , C07D311/78
CPC分类号： C07D493/08 , C12P17/181 , Y10S435/886
摘要： The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting maerial for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.
摘要翻译：本发明教导了由下式表示的新型抗生素纳那霉素E：Nanaomycin E对革兰氏阳性菌，毛癣菌和支原体具有活性，可用作人和动物的抗菌剂和治疗剂。纳豆霉素E也是制备纳诺霉素A的有用起始物，后者纳那霉素在各种纳诺霉素型化合物中活性最高。纳豆霉素E是通过发酵属于链霉菌属的微生物产生的，并且能够产生纳诺霉素E，特别是罗氏变形链霉菌（FERM-P 2209; ATCC 31135），并从发酵液中回收。

10. 发明授权

US4209612A Fortimicin factors KF and KG and process for production thereof 失效
标题翻译： Fortimicin因子KF和KG及其生产方法
公开(公告)号：US4209612A
公开(公告)日：1980-06-24
申请号：US957845
申请日：1978-11-06
申请人： Keiichi Takahashi , Takao Iida , Kunikatsu Shirahata , Masahiro Sugimoto , Shinzo Ishii , Ryo Okachi , Takashi Nara
发明人： Keiichi Takahashi , Takao Iida , Kunikatsu Shirahata , Masahiro Sugimoto , Shinzo Ishii , Ryo Okachi , Takashi Nara
IPC分类号： A61K31/35 , A61K31/351 , A61P31/04 , C07D309/28 , C07H15/224 , C12P19/48 , C07H15/22
CPC分类号： C07H15/224 , C12P19/48
摘要： New antibiotic compounds, Fortimicin factors KF and KG are produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic compounds are accumulated in the culture liquor and are isolated therefrom.
摘要翻译：新型抗生素化合物，Fortimicin因子KF和KG通过发酵属于小单孢菌属的微生物产生。抗生素化合物在培养液中积聚并从中分离。

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