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1. 发明授权

US4454289A Polysaccharides having anticarcinogenic activity and method for producing same 失效
标题翻译：具有抗癌活性的多糖及其制备方法
公开(公告)号：US4454289A
公开(公告)日：1984-06-12
申请号：US351364
申请日：1982-02-23
申请人： Kazuo Nakajima , Yoshiaki Hirata , Hiroyuki Uchida , Tomoko Shiomi , Tsutomu Taniguchi , Akira Obayashi , Osamu Tanabe , Takuma Sasaki
发明人： Kazuo Nakajima , Yoshiaki Hirata , Hiroyuki Uchida , Tomoko Shiomi , Tsutomu Taniguchi , Akira Obayashi , Osamu Tanabe , Takuma Sasaki
IPC分类号： C12P19/00 , A61K31/715 , C07H3/06 , C12P19/04 , C08B37/00
CPC分类号： A61K31/715 , C07H3/06 , C12P19/04
摘要： The invention relates to a high molecular weight .beta.-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR1## The .beta.-1,3-glucan exhibits anticarcinogenic activity. A process for producing said glucan is also claimed.
摘要翻译：本发明涉及由重复的吡喃葡萄糖单元组成的高分子量β-1,3-葡聚糖，每个单元由下式表示：β-1,3-葡聚糖表现出抗癌活性。还要求生产所述葡聚糖的方法。

2. 发明授权

US4409385A Polysaccharides having anticarcinogenic activity and method for producing same 失效
标题翻译：具有抗癌活性的多糖及其制备方法
公开(公告)号：US4409385A
公开(公告)日：1983-10-11
申请号：US231575
申请日：1981-02-03
申请人： Kazuo Nakajima , Yoshiaki Hirata , Hiroyuki Uchida , Yoshie Kimizuka , Tsutomu Taniguchi , Akira Obayashi , Osamu Tanabe
发明人： Kazuo Nakajima , Yoshiaki Hirata , Hiroyuki Uchida , Yoshie Kimizuka , Tsutomu Taniguchi , Akira Obayashi , Osamu Tanabe
IPC分类号： C08B37/00 , A61K31/715 , A61K36/062 , A61K36/07 , A61P35/00 , C07G11/00 , C12N1/14 , C12P1/02 , C12P19/04 , C12P19/26 , C12P21/00 , C12R1/645 , C07H1/08
CPC分类号： C12P21/005 , A61K31/715 , A61K36/062 , C12P1/02 , C12P19/26
摘要： A polysaccharide having anticarcinogenic activity, and a process for its production from a strain of the genus Isaria of the class Hyphomycetes.
摘要翻译：一种具有致癌活性的多糖，以及由致病菌属的Isaria属的菌株生产的方法。

3. 发明授权

US4452897A Method of preparing optically active .beta.-(S)-aminoglutaric acid monoalkyl esters 失效
标题翻译：光学活性β-（S） - 氨基戊二酸单烷基酯的制备方法
公开(公告)号：US4452897A
公开(公告)日：1984-06-05
申请号：US388475
申请日：1982-06-14
申请人： Hamao Umezawa , Masaji Ohno , Hirokazu Kotani , Toshinori Miyabe , Akira Obayashi , Osamu Tanabe
发明人： Hamao Umezawa , Masaji Ohno , Hirokazu Kotani , Toshinori Miyabe , Akira Obayashi , Osamu Tanabe
IPC分类号： C12P13/04 , C07B20/00 , C12R1/20
CPC分类号： C12P13/04 , Y10S435/85
摘要： The present invention provides a process for preparing a optically active .beta.-(S)-aminoglutaric acid monoalkyl ester of the formula: ##STR1## wherein R is a lower alkyl group having 1 to 4 carbon atoms, which comprises subjecting a .beta.-N-protected aminoglutaric acid dialkyl ester of the formula: ##STR2## wherein each R is as defined above and A is an easily removable protecting group, to an action of an enzyme produced by a microorganism belonging to the genera Flavobacterium, Achromobacter, Xanthomonas, Alcaligenes, Serratia, Gluconobacter, Chromobacterium and Acetobacter, to selectively hydrolyze only one of the two ester groups, and then removing the protecting group.
摘要翻译：本发明提供了制备下式的光学活性β-（S） - 氨基戊二酸单烷基酯的方法：其中R是具有1至4个碳原子的低级烷基，其包括使β N-保护的下式的化合物的氨基戊二酸二烷基酯：其中每个R如上定义并且A是容易除去的保护基团，涉及由属于黄杆菌属的微生物产生的酶的作用，无色杆菌，黄单胞菌属，产碱杆菌属，沙雷氏菌属，葡萄糖酸杆菌属，色杆菌属和醋杆菌属，仅选择性地水解两个酯基中的一个，然后除去保护基团。

4. 发明授权

US4009077A Process for the preparation of phenopicolinic acid 失效
标题翻译：制备异喹啉酸的方法
公开(公告)号：US4009077A
公开(公告)日：1977-02-22
申请号：US607039
申请日：1975-08-22
申请人： Osamu Tanabe , Akira Obayashi , Teruya Nakamura , Osamu Suzuka , Masao Murayama , Shingo Matsumura
发明人： Osamu Tanabe , Akira Obayashi , Teruya Nakamura , Osamu Suzuka , Masao Murayama , Shingo Matsumura
IPC分类号： C07D213/79 , C12P17/12 , C12D13/02
CPC分类号： C07D213/79 , C12P17/12 , Y10S435/911
摘要： Phenopicolinic acid is produced by culturing a strain of Paecilomyces. The compound, which may be alternatively named as 5-(4-hydroxybenzyl)-2-pyridinecarboxylic acid, is a hypotensive agent.
摘要翻译：通过培养拟青霉菌株产生异喹啉酸。可以将其称为5-（4-羟基苄基）-2-吡啶羧酸的化合物是降压剂。

5. 发明授权

US4049345A Apparatus for exposing a photosensitive beltlike material 失效
标题翻译：用于曝光感光带状材料的设备
公开(公告)号：US4049345A
公开(公告)日：1977-09-20
申请号：US672383
申请日：1976-03-31
申请人： Osamu Tanabe , Hisao Nishizawa , Kazuo Hata
发明人： Osamu Tanabe , Hisao Nishizawa , Kazuo Hata
IPC分类号： G03B27/46 , G03B27/58 , H05K3/00 , G03B27/52 , G03B27/32
CPC分类号： G03B27/587
摘要： Apparatus for exposing an image of a desired pattern, such as a lead frame pattern for producing lead frames of IC devices, with a predetermined pitch on a photosensitive beltlike material consisting of a film carrier and a photoresist-coated metallic foil laminated on the carrier.Apparatus typically comprises a first means for positively supporting and accurately positioning the beltlike material at an exposing position, a second means for intermittently conveying the material and a third means for photoelectrically detecting the amount of the movement of the beltlike material to control the first and the second means.
摘要翻译：用于在由薄膜载体和层压在载体上的光致抗蚀剂涂覆的金属箔组成的感光带状材料上以预定间距曝光所需图案的图像，例如用于制造IC器件引线框架的引线框架图案的图像。

6. 发明授权

US3980522A Production of a new antibiotic, calvatic acid 失效
标题翻译：生产新型抗生素，胼atic体酸
公开(公告)号：US3980522A
公开(公告)日：1976-09-14
申请号：US607641
申请日：1975-08-25
申请人： Hamao Umezawa , Tomio Takeuchi , Hironobu Iinuma , Osamu Tanabe
发明人： Hamao Umezawa , Tomio Takeuchi , Hironobu Iinuma , Osamu Tanabe
IPC分类号： C07G11/00 , C12D9/04
CPC分类号： C07G11/00 , Y10S435/803 , Y10S435/911
摘要： There is disclosed a new antibiotic called calvatic acid having the structure p-carboxyphenyl-azoxycarbonitrile and processes for its production by fermentation and processes for its recovery and purification. This substance is effective in inhibiting the growth of Gram-positive bacteria and carcinoma.
摘要翻译：公开了具有对羧基苯基 - 氮氧化羰基结构的新生抗生素，称为蓖麻酸，其通过发酵及其回收和纯化方法生产。该物质有效抑制革兰氏阳性菌和癌细胞的生长。

7. 发明授权

US08975293B2 Epigenetic co-repressors of the gamma-globin gene and methods of using same 有权
标题翻译： γ-珠蛋白基因的表观遗传学共抑制因子及其使用方法
公开(公告)号：US08975293B2
公开(公告)日：2015-03-10
申请号：US13480036
申请日：2012-05-24
申请人： James Douglas Engel , Osamu Tanabe , Lihong Shi
发明人： James Douglas Engel , Osamu Tanabe , Lihong Shi
IPC分类号： A61P7/00 , A61K31/708 , G01N33/68 , G01N33/80
CPC分类号： G01N33/6854 , A61K31/135 , A61K31/145 , A61K31/7068 , A61K31/708 , G01N33/80 , G01N2333/91017 , G01N2500/10
摘要： This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.
摘要翻译：本公开描述了筛选化合物的方法，该化合物破坏DNMT1与γ-珠蛋白启动子之间或LSD-1与γ-珠蛋白启动子之间的相互作用。本公开描述了筛选抑制γ-珠蛋白基因的化合物的方法。

8. 发明授权

US08916608B2 Epigenetic co-repressors of the gamma-globin gene and methods of using same 有权
公开(公告)号：US08916608B2
公开(公告)日：2014-12-23
申请号：US13480036
申请日：2012-05-24
申请人： James Douglas Engel , Osamu Tanabe , Lihong Shi
发明人： James Douglas Engel , Osamu Tanabe , Lihong Shi
IPC分类号： A61P7/00 , A61K31/708 , G01N33/68 , G01N33/80
摘要： This disclosure describes methods of screening for compounds that disrupt the interaction between DNMT1 and the gamma-globin promoter or between LSD-1 and the gamma-globin promoter. This disclosure describes methods of screening for compounds that de-repress the gamma-globin gene.

9. 发明授权

US08601293B2 Recording/reproduction apparatus, and power supply control method of video server and recording/reproduction apparatus 有权
标题翻译：记录/再现装置以及视频服务器和记录/再现装置的电源控制方法
公开(公告)号：US08601293B2
公开(公告)日：2013-12-03
申请号：US12841583
申请日：2010-07-22
申请人： Osamu Tanabe
发明人： Osamu Tanabe
IPC分类号： G06F1/00
CPC分类号： H04N21/4147 , H04N21/241 , H04N21/4432 , H04N21/4436
摘要： According to one embodiment, a recording/reproduction apparatus includes a power source controller. The power source controller includes a determination unit, a stand-by mode execution unit, and a pause mode execution unit. The determination unit determines whether or not an event associated with at least one of recording and reproduction of the information signal occurs at start-up time. The stand-by mode execution unit executes a stand-by mode in which the power level of each of the encoder, the decoder, the recording medium, and the plurality of signal processors is controlled to be lower than a predetermined level. The pause mode execution unit executes a pause mode in which the power to each of the encoder, the decoder, the recording medium, and the plurality of signal processors is turned off, and the power level of the process controller is controlled to be lower than the predetermined level.
摘要翻译：根据一个实施例，记录/再现装置包括电源控制器。电源控制器包括确定单元，待机模式执行单元和暂停模式执行单元。确定单元确定在启动时是否发生与信息信号的记录和再现中的至少一个相关联的事件。待机模式执行单元执行待机模式，其中编码器，解码器，记录介质和多个信号处理器中的每一个的功率电平被控制为低于预定电平。暂停模式执行单元执行暂停模式，其中关闭每个编码器，解码器，记录介质和多个信号处理器的电源，并且将处理控制器的功率电平控制为低于预定水平。

10. 发明授权

US4009155A P-carboxyphenyl-azoxycarbonitrile and its methyl ester 失效
标题翻译：对羧基苯基 - 唑氧基腈及其甲酯
公开(公告)号：US4009155A
公开(公告)日：1977-02-22
申请号：US503553
申请日：1974-09-05
申请人： Hamao Umezawa , Tomio Takeuchi , Hironobu Iinuma , Osamu Tanabe
发明人： Hamao Umezawa , Tomio Takeuchi , Hironobu Iinuma , Osamu Tanabe
IPC分类号： C07G11/00 , C07C105/00
CPC分类号： C07G11/00 , Y10S435/911
摘要： There is disclosed a new antibiotic called calvatic acid having the structure p-carboxyphenyl-azoxycarbonitrile and processes for its production by fermentation and processes for its recovery and purification. This substance is effective in inhibiting the growth of Gram-positive bacteria and carcinoma.
摘要翻译：公开了具有对羧基苯基 - 氮氧化羰基结构的新生抗生素，称为蓖麻酸，其通过发酵及其回收和纯化方法生产。该物质有效抑制革兰氏阳性菌和癌细胞的生长。

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