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1. 发明授权

US5776739A Process for producing disaccharides and novel disaccharides 失效
标题翻译：生产二糖和新型二糖的方法
公开(公告)号：US5776739A
公开(公告)日：1998-07-07
申请号：US596262
申请日：1996-07-05
申请人： Kazuo Aisaka , Yutaka Saitoh , Youichi Uosaki
发明人： Kazuo Aisaka , Yutaka Saitoh , Youichi Uosaki
IPC分类号： C07H3/04 , C12P19/12
CPC分类号： C07H3/04 , C12P19/12
摘要： A process for producing a disaccharide which comprises: conducting the condensation reaction of .beta.-glucose-1-phosphate with a monosaccharide in an aqueous medium in the presence of an enzyme source which is derived from a microorganism belonging to the genus Catellatospora, Kineosporia, Propionibacterium, or Enterococcus and which has sugar phosphorylase activity; and recovering the disaccharide formed in the aqueous medium, as well as a novel disaccharide obtained by the process. The disaccharide obtained by the present invention is useful as a stabilizer for medicine, food, cosmetic and enzyme.
摘要翻译： PCT No.PCT / JP94 / 02060 Sec。 371日期：1996年7月5日第 102（e）日期1996年7月5日PCT 1994年12月8日PCT公布。出版物WO95 / 34570 日期1995年12月21日一种制备二糖的方法，该方法包括：在衍生自属于该属的微生物的酶源的存在下，在水性介质中进行β-葡萄糖-1-磷酸与单糖的缩合反应卡氏菌属，活细胞菌属，丙酸杆菌属或肠球菌属，具有糖磷酸化酶活性; 并回收在水性介质中形成的二糖，以及通过该方法获得的新型二糖。通过本发明获得的二糖可用作药物，食品，化妆品和酶的稳定剂。

2. 发明授权

US5987133A Electronic authentication system 失效
标题翻译：电子认证系统
公开(公告)号：US5987133A
公开(公告)日：1999-11-16
申请号：US802754
申请日：1997-02-20
申请人： Kazuo Aisaka
发明人： Kazuo Aisaka
IPC分类号： G09C1/00 , H04L9/08 , H04L9/30 , H04L9/32 , H04L9/00
CPC分类号： H04L9/3249 , H04L9/302
摘要： As a public key, a character string which can be easily reasoned by a person, e.g., a character string obtained by adding a specific character string, e.g., "?", of which code is an odd number to the end of a name, is used. A signature given to a document to be sent is encrypted by using a secret key generated from the public key, and the encrypted signature is sent together with a plaintext document. On the reception side, the encrypted signature is decrypted by using a public key obtained by adding a character string, "?" in this case, whose code is an odd number to the end of the name of the sender. The decrypted signature is compared with a signature included in the plaintext document, so that authentication can be performed. Since the public key need not be stored in an electronic dictionary file or the like, illegal authentication is not easily established by falsifying the public key in the electronic dictionary file.
摘要翻译：作为公开密钥，可以容易地推理人的字符串，例如通过在名称的末尾添加代码为奇数的特定字符串（例如“？”）而获得的字符串，用来。通过使用从公开密钥生成的秘密密钥来加密要发送的文档的签名，并且将加密的签名与明文文档一起发送。在接收侧，通过使用通过添加字符串“○”获得的公开密钥对加密的签名进行解密，在这种情况下，其代码是发送者名称末尾的奇数。将解密的签名与包含在明文文档中的签名进行比较，从而可以执行认证。由于公钥不需要存储在电子词典文件等中，所以通过伪造电子词典文件中的公开密钥，不容易建立非法认证。

3. 发明授权

US08304249B2 Fructosyl peptide oxidase 有权
标题翻译：果糖基氧化酶
公开(公告)号：US08304249B2
公开(公告)日：2012-11-06
申请号：US13123049
申请日：2009-10-08
申请人： Kazuo Aisaka , Toshiko Aisaka, legal representative , Keiko Suzuki
发明人： Kazuo Aisaka , Keiko Suzuki
IPC分类号： G01N33/00 , C12N9/04
CPC分类号： C12Q1/28 , C07K14/805 , C12N9/0022 , C12N9/0032 , C12P21/005 , C12Q1/26 , C12Q1/37 , G01N33/6893 , G01N2333/9065 , G01N2400/00 , G01N2800/042
摘要： The invention is directed to a protein comprising the amino acid sequence represented by SEQ ID NO: 1; a protein comprising an amino acid sequence with one to ten amino acid deletions, substitutions, or additions in the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; a protein comprising an amino acid sequence having 99% or higher homology to the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; and a protein having fructosyl peptide oxidase activity, which is encoded by an expression plasmid harbored by the Escherichia coli XL1-Blue MRF′ strain deposited under Accession No. FERM BP-11026; as well as uses of such proteins.
摘要翻译：本发明涉及包含由SEQ ID NO：1表示的氨基酸序列的蛋白质; 包含在SEQ ID NO：1所示的氨基酸序列中具有1至10个氨基酸缺失，取代或添加并具有果糖基氧化酶活性的氨基酸序列的蛋白质; 包含与SEQ ID NO：1所示的氨基酸序列具有99％以上同源性且具有果糖基肽氧化酶活性的氨基酸序列的蛋白质; 和具有果糖基氧化酶活性的蛋白质，其由以保藏号FERM BP-11026保藏的大肠杆菌XL1-Blue MRF'菌株所携带的表达质粒编码; 以及这些蛋白质的用途。

4. 发明授权

US06485931B2 CHOLESTEROL DEHYDROGENASE, COPROSTAN-3-ONE DEHYDROGENASE AND 4-CHOLESTEN-3-ONE DEHYDROGENASE, COMPOSITIONS CONTAINING THE DEHYDROGENASES, AND METHOD FOR REDUCING AMOUNT OF CHOLESTEROL USING THE COMPOSITIONS 失效
标题翻译：胆固醇脱氢酶，COPROSTAN-3-ONE脱氢酶和4-烯丙基-3-酮脱氢酶，含有脱氢酶的组合物，以及使用组合物降低胆固醇含量的方法
公开(公告)号：US06485931B2
公开(公告)日：2002-11-26
申请号：US09750692
申请日：2001-01-02
申请人： Chiaki Saitoh , Hideyo Kumazawa , Kazuo Aisaka , Toru Mizukami , Katsuhiko Ando , Keiko Ochiai , Ryoichi Katsumata
发明人： Chiaki Saitoh , Hideyo Kumazawa , Kazuo Aisaka , Toru Mizukami , Katsuhiko Ando , Keiko Ochiai , Ryoichi Katsumata
IPC分类号： C12P104
CPC分类号： C12Y101/99001 , A23K20/189 , A23L5/25 , A23L13/48 , A23L15/25 , A23L17/65 , C12N9/0006 , C12P33/00
摘要： According to the present invention, a process for producing a practical cholesterol-reduced substance by converting cholesterol contained in foods and feeds to coprostanol having very low intestinal tract absorbability by utilizing enzymatic action is provided. Cholesterol in a cholesterol-containing substance such as meat, egg, milk, seafood and cooked processed foods containing the same, or feeds for animals, poultry and pisciculture, and the like, can be treated with three kinds of enzymes which are a cholesterol dehydrogenase having an optimum pH in a neutral pH range and 4-cholesten-3-one dehydrogenase and coprostan-3-one dehydrogenase each having an optimum pH in a weak acidic range, or microbial cells containing the enzymes, for converting the cholesterol to coprostanol to reduce the amount of the cholesterol.
摘要翻译：根据本发明，提供了通过利用酶作用将食品和饲料中所含的胆固醇转化为具有非常低肠吸收能力的丙泊酚的生产实用性降胆固醇物质的方法。含胆固醇的物质如肉，鸡蛋，牛奶，海产品，含有该食品的熟化加工食品，动物，禽类和养殖用饲料等都可以用三种酶在中性pH范围内具有最佳pH值的胆固醇脱氢酶 - 胆固醇-3-酮脱氢酶和拮抗佐-3-酮脱氢酶，其各自具有弱酸性范围内的最佳pH，或含有酶的微生物细胞，用于将胆固醇转化为coprostanol以降低胆固醇的量。

5. 发明授权

US5719155A Chroman derivative and pharmaceutical use thereof 失效
标题翻译：色原衍生物及其药物用途
公开(公告)号：US5719155A
公开(公告)日：1998-02-17
申请号：US495424
申请日：1995-07-10
申请人： Hidetsura Cho , Shinsuke Sayama , Susumu Katoh , Kazuo Aisaka , Itsuo Uchida
发明人： Hidetsura Cho , Shinsuke Sayama , Susumu Katoh , Kazuo Aisaka , Itsuo Uchida
IPC分类号： A61K31/35 , A61K31/435 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , C07D311/22 , C07D311/68 , C07D311/70 , C07D405/04 , C07D405/12 , C07D487/04 , C07D498/04 , C08F255/00 , C08F255/02 , C08F255/04 , C08F255/06 , C08F255/08 , C08F257/02 , C08F279/02 , C08L51/00 , C08L51/06 , C10M143/00 , C10M149/06 , C10M149/10 , C10M151/02 , C10M157/04 , C10M167/00 , C10N30/04 , C10N40/25
CPC分类号： C07D405/04 , C07D311/22 , C07D311/68 , C07D311/70 , C07D405/12 , C07D487/04 , C08F255/00 , C08F255/02 , C08F255/04 , C08F255/06 , C08F255/08 , C08F257/02 , C08F279/02 , C08L51/003 , C10M149/06 , C10M149/10 , C10M151/02 , C10M157/04 , C10M167/00 , C10M2205/00 , C10M2205/02 , C10M2205/022 , C10M2205/024 , C10M2205/026 , C10M2205/04 , C10M2205/06 , C10M2205/14 , C10M2207/027 , C10M2207/028 , C10M2207/121 , C10M2207/122 , C10M2207/123 , C10M2207/129 , C10M2207/144 , C10M2207/146 , C10M2207/22 , C10M2207/26 , C10M2207/262 , C10M2207/289 , C10M2209/084 , C10M2209/086 , C10M2215/04 , C10M2215/06 , C10M2215/064 , C10M2215/065 , C10M2215/066 , C10M2215/067 , C10M2215/068 , C10M2215/086 , C10M2215/102 , C10M2215/26 , C10M2215/28 , C10M2217/022 , C10M2217/024 , C10M2217/026 , C10M2217/028 , C10M2217/046 , C10M2217/06 , C10M2219/022 , C10M2219/024 , C10M2219/044 , C10M2219/046 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2221/02 , C10M2223/045 , C10M2223/12 , C10M2225/04 , C10N2210/02 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106
摘要： Chroman derivatives of the formula �I! ##STR1## wherein R.sup.1 is a cyano, a nitro, a trihalomethyl, a trihalomethoxy or a halogen atom; R.sup.2 is a lower alkoxyalkyl, an aryloxyalkyl or a dialkoxyalkyl; R.sup.3 is a lower alkoxyalkyl or an aryloxyalkyl; R.sup.4 is a hydroxy, a formyloxy or a lower alkanoyloxy; X is N--H, an N--optionally substituted lower alkyl, an oxygen atom, a sulfur atom or a single bond; and Y is an optionally substituted aromatic ring residue or an optionally substituted heterocyclic residue, pharmaceutically acceptable salts thereof and pharmaceutical use thereof. The compound of the present invention and pharmaceutically acceptable salts thereof have selective and excellent coronary vasodilating action and extremely weak hypotensive action. Accordingly, it is possible to selectively increase the coronary blood flow without causing a sudden hypotention causative of tachycardia which has a detrimental effect on the heart, and they are useful as a coronary vasodilator, in particular, an agent for the prophylaxis and treatment of cardiovascular disorders such as angina pectoris and heart failure.
摘要翻译： PCT No.PCT / JP94 / 01901 Sec。 371日期：1995年7月10日 102（e）日期1995年7月10日PCT 1994年11月10日PCT PCT。 WO95 / 13272 PCT出版物日期：1995年5月18日通式[I]的化合物衍生物其中R 1是氰基，硝基，三卤甲基，三卤甲氧基或卤素原子; R2是低级烷氧基烷基，芳氧基烷基或二烷氧基烷基; R3是低级烷氧基烷基或芳氧基烷基; R4是羟基，甲酰氧基或低级烷酰氧基; X是N-H，N-任选取代的低级烷基，氧原子，硫原子或单键; 并且Y是任选取代的芳环残基或任选取代的杂环残基，其药学上可接受的盐及其药学用途。本发明的化合物及其药学上可接受的盐具有选择性和优异的冠状动脉血管扩张作用和极弱的降血压作用。因此，可以选择性地增加冠状动脉血流而不引起对心脏具有不利影响的心动过速的突然降低原因，并且它们可用作冠状血管扩张剂，特别是用于预防和治疗心血管的药剂疾病如心绞痛和心力衰竭。

6. 发明授权

US4335213A Process for the preparation of galactose oxidase 失效
标题翻译：制备半乳糖氧化酶的方法
公开(公告)号：US4335213A
公开(公告)日：1982-06-15
申请号：US164523
申请日：1980-07-02
申请人： Osamu Terada , Kazuo Aisaka
发明人： Osamu Terada , Kazuo Aisaka
IPC分类号： C12N9/04 , C12R1/645
CPC分类号： C12N9/0006 , Y10S435/911
摘要： Galactose oxidase is produced by culturing a microorganism belonging to the genus Gibberella. The enzyme is useful in the determination of galactose.
摘要翻译：通过培养属于赤霉菌属的微生物来产生半乳糖氧化酶。该酶可用于测定半乳糖。

7. 发明授权

US6153419A Method for quantitative determination of 1,5-anhydroglucitol 失效
标题翻译： 1,5-脱水葡萄糖醇定量测定方法
公开(公告)号：US6153419A
公开(公告)日：2000-11-28
申请号：US930709
申请日：1997-10-16
申请人： Kazuo Aisaka , Sakae Tazoe , Katsuhiko Ando , Keiko Ochiai
发明人： Kazuo Aisaka , Sakae Tazoe , Katsuhiko Ando , Keiko Ochiai
IPC分类号： C12N9/24 , C12Q1/34 , C12Q1/48
CPC分类号： C12Q1/34 , C12N9/2402 , C12Q1/48 , C12Y302/01028 , G01N2333/355 , G01N2333/924 , Y10S435/872
摘要： The present invention relates to a method for quantitative determination of 1,5-anhydroglucitol in a sample, which comprises mixing the sample and an enzyme having activity that is inhibited by 1,5-anhydroglucitol in a concentration-dependent manner, and measuring the activity of the enzyme; and a reagent for quantitative determination of 1,5-anhydroglucitol which comprises an enzyme having activity that is inhibited by 1,5-anhydroglucitol in a concentration-dependent manner, a substrate for the enzyme, and a reagent for quantitative determination of a product formed by the enzyme activity. The present invention also relates to novel trehalase having a Ki value of 0.33 mM or less for 1,5-anhydroglucitol; and a process for producing novel trehalase having the above-mentioned physicochemical properties, which comprises culturing in a medium a microorganism belonging to the genus Nocardia and capable of producing the trehalase, and recovering the trehalase from the culture.
摘要翻译： PCT No.PCT / JP97 / 00440 Sec。 371日期：1997年10月16日 102（e）1997年10月16日PCT PCT 1997年2月19日PCT公布。公开号WO97 / 31103 日期：1997年8月28日本发明涉及一种样品中1,5-脱水葡萄糖醇的定量测定方法，该方法包括以浓度依赖性方式将样品与具有1,5-脱水葡萄糖醇抑制活性的酶，并测定酶的活性; 以及用于定量测定1,5-脱水葡萄糖醇的试剂，该试剂含有以浓度依赖性方式被1,5-脱水葡萄糖醇抑制的活性的酶，酶底物和定量产物形成试剂通过酶活性。本发明还涉及1,5-脱水葡萄糖醇的Ki值为0.33mM以下的新型海藻糖酶; 以及具有上述物理化学性质的新型海藻糖酶的制造方法，其包括在培养基中培养属于诺卡氏菌属的微生物并能够生产海藻糖酶，并从培养物中回收海藻糖酶的方法。

8. 发明授权

US4710470A Process for producing neuraminidase 失效
标题翻译：生产神经氨酸酶的方法
公开(公告)号：US4710470A
公开(公告)日：1987-12-01
申请号：US636552
申请日：1984-08-01
申请人： Takayuki Uwajima , Kazuo Aisaka
发明人： Takayuki Uwajima , Kazuo Aisaka
IPC分类号： C12N9/24 , C12Q1/34 , C12R1/29 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12R1/30
CPC分类号： C12Y302/01018 , C12N9/2402 , C12Q1/34 , Y10S435/867 , Y10S435/868
摘要： Neuraminidase is produced by culturing a neuraminidase producing microorganism belonging to the genus Micromonospora. The neuraminidase is useful for the quantitative determination of a sialic acid-containing substance in a sample.
摘要翻译：通过培养属于小单孢菌属的神经氨酸酶产生微生物产生神经氨酸酶。神经氨酸酶可用于定量测定样品中含唾液酸的物质。

9. 发明授权

US4657856A Glutathione peroxidase, process for production thereof, method and composition for the quantitative determination of lipid peroxide 失效
标题翻译：谷胱甘肽过氧化物酶，其制备方法，用于定量测定脂质过氧化物的方法和组合物
公开(公告)号：US4657856A
公开(公告)日：1987-04-14
申请号：US303137
申请日：1981-09-17
申请人： Osamu Terada , Kazuo Aisaka
发明人： Osamu Terada , Kazuo Aisaka
IPC分类号： C12N9/08 , C12Q1/28 , C12R1/785 , C12Q1/32
CPC分类号： C12N9/0065 , C12Q1/28 , Y10S435/931
摘要： Glutathione peroxidase is produced by fermentation of a microorganism of the genus Mucor. This peroxidase may be used for the determination of lipid peroxide.
摘要翻译：谷胱甘肽过氧化物酶是通过毛霉属微生物的发酵产生的。该过氧化物酶可用于测定脂质过氧化物。

10. 发明申请

US20120003678A1 NOVEL FRUCTOSYL PEPTIDE OXIDASE 有权
标题翻译：新型果胶氧化酶
公开(公告)号：US20120003678A1
公开(公告)日：2012-01-05
申请号：US13123049
申请日：2009-12-10
申请人： Kazuo Aisaka , Toshiko Aisaka , Keiko Suzuki
发明人： Kazuo Aisaka , Toshiko Aisaka , Keiko Suzuki
IPC分类号： C12N9/02 , C12N5/10 , C12N1/21 , C12N1/19 , C12N15/53 , C12Q1/37
CPC分类号： C12Q1/28 , C07K14/805 , C12N9/0022 , C12N9/0032 , C12P21/005 , C12Q1/26 , C12Q1/37 , G01N33/6893 , G01N2333/9065 , G01N2400/00 , G01N2800/042
摘要： A protein described in any one of [1] to [4] below is provided according to the present invention: [1] a protein comprising the amino acid sequence represented by SEQ ID NO: 1; [2] a protein comprising an amino acid sequence with one or more amino acid deletions, substitutions, or additions in the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; [3] a protein comprising an amino acid sequence having 80% or higher homology to the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; and [4] a protein having fructosyl peptide oxidase activity, which is produced by an expression plasmid harbored by the Escherichia coli XL1-Blue MRF' strain deposited under Accession No. FERM BP-11026.
摘要翻译：根据本发明提供了下述[1]〜[4]中任一项所述的蛋白质。[1]一种蛋白质，其包含SEQ ID NO：1所示的氨基酸序列; [2]一种蛋白质，其包含在SEQ ID NO：1所示的氨基酸序列中具有一个或多个氨基酸缺失，取代或添加的氨基酸序列，并且具有果糖基肽氧化酶活性; [3]一种蛋白质，其包含与SEQ ID NO：1所示的氨基酸序列具有80％以上同源性的氨基酸序列，并且具有果糖基氧化酶活性; 和[4]具有果糖基氧化酶活性的蛋白质，其由以保藏号FERM BP-11026保藏的大肠杆菌XL1-Blue MRF'菌株所携带的表达质粒产生。

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