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1. 发明授权

US08034785B2 Adsorbent adsorbing antibody against β1 adrenoreceptor 有权
标题翻译：吸附剂吸附抗1抗生素的受体
公开(公告)号：US08034785B2
公开(公告)日：2011-10-11
申请号：US11718184
申请日：2005-10-26
申请人： Kazumasa Ohara , Eiji Ogino , Sakiko Hanita , Takehiro Nishimoto
发明人： Kazumasa Ohara , Eiji Ogino , Sakiko Hanita , Takehiro Nishimoto
IPC分类号： A61K38/10 , A61K38/16 , C07K17/14
CPC分类号： C07K7/08 , C07K7/06
摘要： The present invention provides a peptide which selectively adsorbs an anti-β1 adrenoreceptor antibody being one of the contributing factors in dilated cardiomyopathy. The peptide of the invention can be immobilized on a carrier in a short period of time with rarely inducing side reactions, and adsorbent for adsorbing an anti-β1 adrenoreceptor antibody can be produced with good efficiency by using the peptide. In addition, the present invention provides an adsorbent comprising such peptide immobilized on a carrier, an adsorber wherein such adsorbent is used, and a method for adsorbing an anti-β1 adrenoreceptor antibody. The adsorbent and adsorber according to the invention can efficiently deprive an anti-β1 adrenoreceptor antibody-containing liquid, in particular body fluid, of the antibody.
摘要翻译：本发明提供了选择性吸附反扩散型心肌病的一种作用因子的抗β1肾上腺素受体抗体的肽。本发明的肽可以在短时间内固定在载体上，很少引起副反应，并且可以通过使用肽以高效率产生用于吸附抗 - 1载体的肾上腺素受体抗体的吸附剂。此外，本发明提供了一种包含固定在载体上的肽的吸附剂，其中使用这种吸附剂的吸附剂，以及用于吸附抗-1抗坏血酸受体抗体的方法。根据本发明的吸附剂和吸附剂可以有效地剥夺抗体的1抗肾上腺素受体抗体的液体，特别是体液。

2. 发明申请

US20090187008A1 ADSORBENT ADSORBING ANTIBODY AGAINST BETA 1 ADRENORECEPTOR 有权
标题翻译：吸附抗体对抗1型ADRENORECEPTOR的吸附抗体
公开(公告)号：US20090187008A1
公开(公告)日：2009-07-23
申请号：US11718184
申请日：2005-10-26
申请人： Kazumasa Ohara , Eiji Ogino , Sakiko Hanita , Takehiro Nishimoto
发明人： Kazumasa Ohara , Eiji Ogino , Sakiko Hanita , Takehiro Nishimoto
IPC分类号： C07K17/02 , C07K7/08
CPC分类号： C07K7/08 , C07K7/06
摘要： The present invention provides a peptide which selectively adsorbs an anti-β1 adrenoreceptor antibody being one of the contributing factors in dilated cardiomyopathy. The peptide of the invention can be immobilized on a carrier in a short period of time with rarely inducing side reactions, and adsorbent for adsorbing an anti-β1 adrenoreceptor antibody can be produced with good efficiency by using the peptide. In addition, the present invention provides an adsorbent comprising such peptide immobilized on a carrier, an adsorber wherein such adsorbent is used, and a method for adsorbing an anti-β1 adrenoreceptor antibody. The adsorbent and adsorber according to the invention can efficiently deprive an anti-β1 adrenoreceptor antibody-containing liquid, in particular body fluid, of the antibody.
摘要翻译：本发明提供了选择性吸附抗β1肾上腺素受体抗体的肽，其是扩张型心肌病的其中一个因素。本发明的肽可以在短时间内固定在载体上，很少引起副反应，并且可以通过使用肽以高效率产生用于吸附抗β1肾上腺素受体抗体的吸附剂。此外，本发明提供了一种包含固定在载体上的肽的吸附剂，其中使用这种吸附剂的吸附剂和用于吸附抗β1肾上腺素受体抗体的方法。根据本发明的吸附剂和吸附剂可以有效地剥夺抗体的抗β1肾上腺素受体抗体的液体，特别是体液。

3. 发明申请

US20050038228A1 Novel peptide, novel adsorbent, adsorption unit and adsorption method 有权
标题翻译：新型肽，新型吸附剂，吸附装置及吸附方法
公开(公告)号：US20050038228A1
公开(公告)日：2005-02-17
申请号：US10489202
申请日：2002-09-18
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
IPC分类号： C12N15/09 , C07K7/06 , C07K14/00 , C07K17/06 , C07K17/08 , C07K17/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C07H21/04 , C07K14/47
CPC分类号： C07K7/06 , C07K17/06 , C07K17/08
摘要： The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要翻译：本发明提供一种吸附剂，吸附单元和吸附方法，其可以有效地选择性地吸附存在于体液（例如血液，血浆等）中的免疫球蛋白和/或免疫复合物，而无需预处理体流体。通过将具有免疫球蛋白和/或免疫复合物的结合活性的化合物固定在水不溶性载体上，可以获得具有极好的吸附能力的吸附剂。

4. 发明授权

US07309488B2 Adsorbents for dilated cardiomyopathy 有权
标题翻译：扩张型心肌病的吸附剂
公开(公告)号：US07309488B2
公开(公告)日：2007-12-18
申请号：US10221042
申请日：2001-04-09
申请人： Eiji Ogino , Shigeo Furuyoshi , Fumiyasu Hirai , Takehiro Nishimoto
发明人： Eiji Ogino , Shigeo Furuyoshi , Fumiyasu Hirai , Takehiro Nishimoto
IPC分类号： A61K39/00 , C07K1/22
CPC分类号： C07K14/705 , A61K38/00 , A61M1/3679
摘要： An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against β1-adrenoceptor and/or an antibody against M2 muscarinic receptor exhibits a remarkably large adsorptive capacity.
摘要翻译：包含水不溶性载体和固定在所述载体上的具有对抗β1肾上腺素能受体的抗体和/或针对M2毒蕈碱受体的抗体的结合亲和力的吸附剂显示出非常大的吸附能力。

5. 发明申请

US20070059800A1 Novel peptide, novel adsorbent, adsorption unit and adsorption method 审中-公开
标题翻译：新型肽，新型吸附剂，吸附装置及吸附方法
公开(公告)号：US20070059800A1
公开(公告)日：2007-03-15
申请号：US11599281
申请日：2006-11-15
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
IPC分类号： C07K14/195 , C07H21/04 , C12P21/06 , C12N1/21 , C12N15/74
CPC分类号： C07K7/06 , C07K17/06 , C07K17/08
摘要： The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要翻译：本发明提供一种吸附剂，吸附单元和吸附方法，其可以有效地选择性地吸附存在于体液（例如血液，血浆等）中的免疫球蛋白和/或免疫复合物，而无需预处理体流体。通过将具有免疫球蛋白和/或免疫复合物的结合活性的化合物固定在水不溶性载体上，可以获得具有极好的吸附能力的吸附剂。

6. 发明授权

US07153945B2 Peptide, novel adsorbent, adsorption unit and adsorption method 有权
标题翻译：肽，新型吸附剂，吸附装置及吸附方法
公开(公告)号：US07153945B2
公开(公告)日：2006-12-26
申请号：US10489202
申请日：2002-09-18
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura , Shigeo Furuyoshi
IPC分类号： A61K39/00
CPC分类号： C07K7/06 , C07K17/06 , C07K17/08
摘要： The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.
摘要翻译：本发明提供一种吸附剂，吸附单元和吸附方法，其可以有效地选择性地吸附存在于体液（例如血液，血浆等）中的免疫球蛋白和/或免疫复合物，而无需预处理体流体。通过将具有免疫球蛋白和/或免疫复合物的结合活性的化合物固定在水不溶性载体上，可以获得具有极好的吸附能力的吸附剂。

7. 发明授权

US06252054B1 Immobilization of SH group-containing compounds in the presence of a sulfite-containing antioxidant 有权
标题翻译：含硫基化合物在含亚硫酸盐的抗氧化剂存在下的固定化
公开(公告)号：US06252054B1
公开(公告)日：2001-06-26
申请号：US09444305
申请日：1999-11-22
申请人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura
发明人： Eiji Ogino , Takehiro Nishimoto , Michio Nomura
IPC分类号： C07K1702
CPC分类号： C07K17/02 , G01N33/54393 , Y10S530/811 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/815
摘要： Immobilization of SH group-containing compounds on a solvent-insoluble support is carried out in the presence of an antioxidant to prevent oxidation of SH groups to S—S bonds. This improves immobilization efficiency and suppresses deterioration of inherent characteristics of the SH group-containing compound. Antioxidants include sodium pyrosulfite (sodium disulfite), sodium sulfite, sodium hydrogensulfite, sodium hydrosulfite and L-ascorbic acid. SH group-containing compounds include cysteine, peptides or proteins containing cysteine and thiol compounds such as ethanethiol, aminoethanethiol, benzylthiol and thiophenol. Preferably, the SH group-containing compound has a molecular weight not more than 3×104. The support may be activated by a functional group such as glycidyl, imidocarbonato, tosyl, tresyl, carboxyl, amino, azido or hydroxyl. The support can be inorganic such as glass beads or organic such as a synthetic polymer or a polysaccharide.
摘要翻译：在溶剂不溶性载体上固定含SH基团的化合物在抗氧化剂存在下进行，以防止SH基团氧化成S-S键。这提高了固定效率并抑制含SH基化合物的固有特性的劣化。抗氧化剂包括焦亚硫酸钠（亚硫酸氢钠），亚硫酸钠，亚硫酸氢钠，连二亚硫酸钠和L-抗坏血酸。含SH基团的化合物包括半胱氨酸，含有半胱氨酸和巯基化合物的肽或蛋白质，例如乙硫醇，氨基乙硫醇，苄硫醇和苯硫酚。优选地，含SH基团的化合物的分子量不大于3×10 4。载体可以被诸如缩水甘油基，亚氨基碳酸根，甲苯磺酰基，甲酚基，羧基，氨基，叠氮基或羟基之类的官能团活化。载体可以是无机的，例如玻璃珠或有机如合成聚合物或多糖。

8. 发明申请

US20060089587A1 Low density lipoprotein/fibrinogen adsorbent and adsorption apparatus capable of whole blood treatment 审中-公开
标题翻译：低密度脂蛋白/纤维蛋白原吸附剂和能够全血治疗的吸附装置
公开(公告)号：US20060089587A1
公开(公告)日：2006-04-27
申请号：US10516586
申请日：2004-04-23
申请人： Masaru Nakatani , Akira Robayashi , Takehiro Nishimoto , Shigeo Furuyoshi
发明人： Masaru Nakatani , Akira Robayashi , Takehiro Nishimoto , Shigeo Furuyoshi
IPC分类号： A61M37/00
CPC分类号： A61M1/3633 , A61M2202/0449 , A61M2202/046 , A61M2202/0057
摘要： The present invention provides an adsorbent, an adsorption method, and an adsorber for efficiently adsorbing low-density lipoproteins and fibrinogen directly from a body fluid, particularly whole blood, to decrease the concentrations of these components in the body fluid with minimizing losses of useful substances such as HDL and albumin. The adsorbent includes a tryptophan derivative and a polyanionic compound which are immobilized on a water-insoluble porous carrier, wherein the amount of the immobilized polyanionic compound is 0.10 μmol to 1.5 μmol per milliliter of wet volume of the adsorbent, and the molar ratio of the amount of the immobilized tryptophan derivative to the amount of the immobilized polyanionic compound is 1 to 70. The adsorbent is capable of whole blood treatment for safely and efficiently adsorbing low-density lipoproteins and fibrinogen.
摘要翻译：本发明提供一种吸附剂，吸附方法和吸附剂，用于从体液，特别是全血直接有效吸附低密度脂蛋白和纤维蛋白原，以最小化有用物质的损失来降低体液中这些成分的浓度如HDL和白蛋白。吸附剂包括固定在水不溶性多孔载体上的色氨酸衍生物和聚阴离子化合物，其中固定化聚阴离子化合物的量为每毫升湿体积的吸附剂为0.10μmol至1.5μmol，并且所述吸附剂的摩尔比固定化色氨酸衍生物的量相对于固定化聚阴离子化合物的量为1〜70。吸附剂能够进行全血处理，以安全有效地吸附低密度脂蛋白和纤维蛋白原。

9. 发明申请

US20070270523A1 Method of Modifying Blood Contact Material and Blood Contact Material Inhibited from Activating Granulocyte 审中-公开
标题翻译：修改血液接触材料和血液接触材料抑制活化粒细胞的方法
公开(公告)号：US20070270523A1
公开(公告)日：2007-11-22
申请号：US11718386
申请日：2005-11-01
申请人： Koshin Ushizaki , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
发明人： Koshin Ushizaki , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
IPC分类号： A61F2/84 , A61K8/72
CPC分类号： A61L31/10 , A61L27/34 , A61L27/50 , A61L33/08 , C08L5/02
摘要： An object of the present invention is to provide a method of modifying a blood contact material capable of reducing granulocyte activating action of the blood contact material in medical equipment used for parts which get contact with the blood. The present invention provides a method of modifying blood contact material characterized by granulocyte activating action when in contact with blood,the modifying blood contact material is considerably reduced compared with an original blood contact material by immobilizing a tryptophan derivative and a polyanionic compound to the blood contact material. Examples of the tryptophan derivative include tryptophan. Further, examples of the polyanionic compound include dextran sulfate.
摘要翻译：本发明的目的是提供一种能够减少血液接触材料的血液接触材料的方法，所述血液接触材料能够减少用于与血液接触的部位的医疗设备中的血液接触材料的粒细胞激活作用。本发明提供了一种改变血液接触材料的方法，其特征在于与血液接触时的粒细胞活化作用，与原始血液接触材料相比，通过将色氨酸衍生物和聚阴离子化合物固定在血液接触中而使修饰的血液接触材料显着降低材料。色氨酸衍生物的实例包括色氨酸。此外，聚阴离子化合物的实例包括硫酸葡聚糖。

10. 发明授权

US08272518B2 Direct hemoperfusion adsorber packed with adsorbent having water insoluble microparticle removed therefrom, and method of obtaining direct hemoperfusion adsorbent having water insoluble microparticle removed therefrom 有权
标题翻译：用从其中除去水不溶性微粒的吸附剂填充的直接血液灌注吸附器，以及从其中除去具有水不溶性微粒的直接血液灌注吸附剂的方法
公开(公告)号：US08272518B2
公开(公告)日：2012-09-25
申请号：US11572542
申请日：2005-07-20
申请人： Koji Fujita , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
发明人： Koji Fujita , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
IPC分类号： B01D24/10 , B01D24/12 , B01D39/00
CPC分类号： A61M1/3679 , A61M1/3627 , B01J20/24 , B01J20/28004 , B01J20/3212 , Y10T428/2982
摘要： The present invention has its object to provide a direct hemoperfusion adsorber packed with an adsorbent made by using a water-insoluble carrier having a relatively readily available particle size distribution, with water-insoluble microparticles having been removed therefrom, without needing any special granulation apparatus or coating apparatus, and method of obtaining a direct hemoperfusion adsorbent having water-insoluble microparticles removed therefrom.Now, a direct hemoperfusion adsorber has been obtained that is packed with an adsorbent having a number average particle diameter of not smaller than 300 μm but not larger than 600 μm, with the coefficient of variance in particle diameter distribution being not lower than 10% but not higher than 20%, and having water-insoluble microparticles removed therefrom to a safe level, without the loss of the adsorbent, by using a water-insoluble microparticle-removing-mesh such that the ratio of the mesh opening size for removing water-insoluble microparticles to the mesh opening size of the adsorber is not lower than 1.3 but not higher than 1.5.
摘要翻译：本发明的目的是提供一种直接血液灌注吸附器，其中填充有通过使用具有相对容易获得的粒度分布的水不溶性载体制备的吸附剂，其中不溶性微粒被除去，不需要任何特殊的造粒装置或涂布装置以及从其中除去具有水不溶性微粒的直接血液灌注吸附剂的方法。现在，已经获得了直接血液灌注吸附器，其中填充有数均粒径不小于300μm但不大于600μm的吸附剂，其粒径分布的变异系数不低于10％，但是不高于20％，并且通过使用不溶于水的微粒去除网，使除去水溶性微粒的网孔尺寸的比例，将水不溶性微粒除去，达到安全水平，而不损失吸附剂，不溶性微粒与吸附剂的网孔尺寸不小于1.3，但不高于1.5。

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