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1. 发明授权

US06528648B2 Detecting reagent for double-stranded nucleic acid and double-stranded nucleic acid detecting method 失效
标题翻译：双链核酸检测试剂和双链核酸检测方法
公开(公告)号：US06528648B2
公开(公告)日：2003-03-04
申请号：US10012211
申请日：2001-12-05
申请人： Kazuko Matsumoto , Takahiko Nojima , Hideo Tashiro , Yasumitsu Kondoh , Shigeori Takenaka
发明人： Kazuko Matsumoto , Takahiko Nojima , Hideo Tashiro , Yasumitsu Kondoh , Shigeori Takenaka
IPC分类号： C07D29100
CPC分类号： C09B57/10 , C09B57/08 , C12Q1/6816 , C12Q2563/173
摘要： The present invention provides a novel detecting reagent for double-stranded nucleic acid, and a method of using it to detect double-stranded nucleic acid formed by hybridization with a probe, with absolutely no labeling of the target nucleic acid. The detecting reagent for double-stranded nucleic acid of the invention is characterized by comprising, in the same molecule, a naphthalenediimide group which is intercalatable into double-stranded nucleic acid and a &bgr;-diketone group capable of forming a lanthanoid metal complex.
摘要翻译：本发明提供了一种用于双链核酸的新型检测试剂及其用于检测与探针杂交形成的双链核酸的方法，绝对没有靶核酸的标记。双重检测试剂其特征在于在相同分子中包含可插入双链核酸的萘二酰亚胺基团和能够形成镧系元素金属络合物的β-二酮基团。

2. 发明授权

US07541195B2 Substrate for biomolecule microarray, biomolecule microarray, device and method of promoting interaction, and method of detecting interaction 失效
标题翻译：用于生物分子微阵列的基质，生物分子微阵列，促进相互作用的装置和方法以及检测相互作用的方法
公开(公告)号：US07541195B2
公开(公告)日：2009-06-02
申请号：US10560584
申请日：2004-06-09
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
IPC分类号： G01N33/543
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C40B40/06 , C40B40/10 , G01N21/253 , G01N21/6428 , G01N33/5438 , G01N2021/6482
摘要： The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. The biomolecule microarray comprises the above substrate and a biomolecule and the biomolecule is immobilized on at least the flat surface for spotting on the substrate. The device of promoting interaction between biomolecules comprises a biomolecule microarray having one or more biomolecule-immobilized spots on a substrate, an electrode provided so as to face the surface having the biomolecule-immobilized spots of the microarray, and a power source for applying an electric field between the microarray and the electrode. The method of promoting interaction between biomolecules employing the above device. The method of detecting interaction between biomolecules. Provided are a substrate having biomolecule immobilization regions of prescribed shape on a biomolecule microarray, and means by which the interaction of biomolecules is rapidly conducted, the interaction of trace quantities of sample is promoted, and the interaction is detected and analyzed rapidly and with high sensitivity.
摘要翻译：用于生物分子微阵列的底物具有用于固定生物分子的一个或多个斑点。用于固定生物分子的点从基板的表面突出，并且具有用于在其顶部上点样的平坦表面，至少在突出的点部分周围的基板的表面，突出的点部分的侧表面和平坦表面用于点样由导电物质组成。或者，用于固定生物分子的斑点从基板的表面突出，并且具有用于在其顶部上斑点的平坦表面，突出的点部分彼此相邻，通过突出的斑点部分的侧表面，并且至少横向突出点部分的表面和用于点样的平坦表面由导电物质组成。生物分子微阵列包括上述底物和生物分子，生物分子至少固定在平坦表面上以便在基底上进行点样。促进生物分子之间的相互作用的装置包括在基底上具有一个或多个生物分子固定斑点的生物分子微阵列，设置成面对具有微阵列的生物分子固定点的表面的电极，以及用于施加电微阵列和电极之间的场。促进使用上述装置的生物分子之间相互作用的方法。检测生物分子之间相互作用的方法。提供了一种在生物分子微阵列上具有规定形状的生物分子固定区的底物，以及快速进行生物分子相互作用的手段，促进了微量样品的相互作用，并快速，高灵敏度地检测和分析了相互作用。

3. 发明申请

US20070275405A1 Member for producing a probe array and probe array producing method 审中-公开
标题翻译：用于生产探针阵列和探针阵列制造方法的成员
公开(公告)号：US20070275405A1
公开(公告)日：2007-11-29
申请号：US11826060
申请日：2007-07-12
申请人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
发明人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B60/14
摘要： In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are produced by cutting the members M1, M2 . . . Mn for producing a probe array, and a predetermined number of pieces F1, F2 . . . Fn are detached from a release sheet 13 and are attached via the adhesive layer 12 onto the supporting member 2a at predetermined locations.
摘要翻译：为了提供用于制造探针阵列的构件，其可以在建立探针装置之后立即产生所需的探针阵列，并且提供使用该构件产生探针阵列的探针阵列产生方法，片F 1 ，F＆lt; 2＆lt; 2＆gt ;. 。。通过切割构件M 1，M 2 2产生F n N n。。。用于产生探针阵列的M＆lt; N＆gt;和预定数量的F 1，F 2 2。。。 F＆lt; N＆gt;从剥离片13分离，并且经由粘合剂层12附着到预定位置的支撑构件2a上。

4. 发明申请

US20060035220A1 Substrate for biomolecule microarray, process for producing the same, biomolecule microarray and method of collecting data on biomolecule microarray 审中-公开
标题翻译：用于生物分子微阵列的底物，其制备方法，生物分子微阵列和收集生物分子微阵列数据的方法
公开(公告)号：US20060035220A1
公开(公告)日：2006-02-16
申请号：US10494517
申请日：2002-11-21
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Kaori Honda
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Kaori Honda
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A biomolecular microarray substrate having a spot for fixing a biomolecular probe on a surface thereof. The spot of light-reflecting layer is present between the biomolecular probe-fixing spot and the substrate surface. A method of manufacturing the biomolecular microarray substrate. A biomolecular microarray having a biomolecular probe-fixing spot in which a biomolecular probe is fixed by a biomolecular probe-fixing spot having the biomolecular microarray substrate. A data collection method for biomolecular arrays. Fluorescently labeled target biomolecules is interacted with a biomolecular microarray having, on a substrate surface, biomolecular probe-fixing spots that fix biomolecular probes on light-reflecting layer spots; excitation light is directed onto the biomolecular microarray obtained and reflected light and fluorescence are simultaneously measured from the biomolecular microarray; a biomolecular probe-fixing spot present on a light-reflecting layer spot is specified from differences in the intensity of the light reflecting off of the biomolecular microarray; and fluorescence data are obtained from within the scope of the specified spot. Alternatively, light is directed onto the biomolecular microarray obtained and reflected light is measured from the biomolecular microarray; a biomolecular probe-fixing spot having a light-reflecting layer spot is specified from differences in the intensity of the light reflecting off of the biomolecular microarray; excitation light is directed only onto the scope of the specified biomolecular probe-fixing spot and measuring the fluorescence; and fluorescence data are obtained from the scope of the specified spot.
摘要翻译：生物分子微阵列基板，其表面上具有用于固定生物分子探针的斑点。光反射层的光点存在于生物分子探针固定点和基片表面之间。制造生物分子微阵列基板的方法。具有生物分子探针固定点的生物分子微阵列，其中生物分子探针通过具有生物分子微阵列基底的生物分子探针固定点固定。生物分子阵列的数据采集方法。荧光标记的目标生物分子与生物分子微阵列相互作用，其在衬底表面上具有将生物分子探针固定在光反射层点上的生物分子探针固定点; 激发光被引导到获得的生物分子微阵列上，并从生物分子微阵列同时测量反射光和荧光; 存在于光反射层点上的生物分子探针固定点由生物分子微阵列反射光的强度的差异来确定; 并且在指定斑点的范围内获得荧光数据。或者，将光引导到获得的生物分子微阵列上，并从生物分子微阵列测量反射光; 具有光反射层点的生物分子探针固定点由生物分子微阵列的反射光强度的差异来确定; 激发光仅指向指定的生物分子探针固定点的范围并测量荧光; 并且从指定斑点的范围获得荧光数据。

5. 发明申请

US20070037155A1 Substrate for biomolecule microarray, biomolecule microarray, device and method of promoting interaction, and method of detecting interaction 失效
标题翻译：用于生物分子微阵列的基质，生物分子微阵列，促进相互作用的装置和方法以及检测相互作用的方法
公开(公告)号：US20070037155A1
公开(公告)日：2007-02-15
申请号：US10560584
申请日：2004-06-09
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Satoru Hatakeyama
IPC分类号： C12Q1/68 , G01N33/53 , C12M3/00
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C40B40/06 , C40B40/10 , G01N21/253 , G01N21/6428 , G01N33/5438 , G01N2021/6482
摘要： The substrate for biomolecule microarray has one or more spots for immobilizing a biomolecule. The spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, at least the surface of the substrate around the protruding spot part, the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. Alternatively, the spot for immobilizing a biomolecule protrudes from the surface of the substrate and has a flat surface for spotting on the top thereof, the protruding spot parts adjacent each other border through the lateral surface of the protruding spot part, and at least the lateral surface of the protruding spot part and the flat surface for spotting are comprised of an electrically conductive substance. The biomolecule microarray comprises the above substrate and a biomolecule and the biomolecule is immobilized on at least the flat surface for spotting on the substrate. The device of promoting interaction between biomolecules comprises a biomolecule microarray having one or more biomolecule-immobilized spots on a substrate, an electrode provided so as to face the surface having the biomolecule-immobilized spots of the microarray, and a power source for applying an electric field between the microarray and the electrode. The method of promoting interaction between biomolecules employing the above device. The method of detecting interaction between biomolecules. Provided are a substrate having biomolecule immobilization regions of prescribed shape on a biomolecule microarray, and means by which the interaction of biomolecules is rapidly conducted, the interaction of trace quantities of sample is promoted, and the interaction is detected and analyzed rapidly and with high sensitivity.
摘要翻译：用于生物分子微阵列的底物具有用于固定生物分子的一个或多个斑点。用于固定生物分子的点从基板的表面突出，并且具有用于在其顶部上点样的平坦表面，至少在突出的点部分周围的基板的表面，突出的点部分的侧表面和平坦表面用于点样由导电物质组成。或者，用于固定生物分子的斑点从基板的表面突出，并且具有用于在其顶部上斑点的平坦表面，突出的点部分彼此相邻，通过突出的斑点部分的侧表面，并且至少横向突出点部分的表面和用于点样的平坦表面由导电物质组成。生物分子微阵列包括上述底物和生物分子，生物分子至少固定在平坦表面上以便在基底上进行点样。促进生物分子之间的相互作用的装置包括在基底上具有一个或多个生物分子固定斑点的生物分子微阵列，设置成面对具有微阵列的生物分子固定点的表面的电极，以及用于施加电微阵列和电极之间的场。促进使用上述装置的生物分子之间相互作用的方法。检测生物分子之间相互作用的方法。提供了一种在生物分子微阵列上具有规定形状的生物分子固定区的底物，以及快速进行生物分子相互作用的手段，促进了微量样品的相互作用，并快速，高灵敏度地检测和分析了相互作用。

6. 发明授权

US06844185B2 Integrated biomolecule sensor, method and apparatus for fabricating the sensor, and method and apparatus for detecting biomolecules using the sensor 失效
标题翻译：集成生物分子传感器，用于制造传感器的方法和装置，以及使用传感器检测生物分子的方法和装置
公开(公告)号：US06844185B2
公开(公告)日：2005-01-18
申请号：US09962434
申请日：2001-09-25
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
IPC分类号： G01N33/53 , C12Q1/68 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/58 , G01N37/00 , C12M1/34
CPC分类号： G01N21/6452 , C12Q1/6816 , C12Q1/6837 , G01N21/6428 , G01N21/7703 , G01N33/54373 , G01N2021/6484 , G01N2021/772 , Y10S435/808 , Y10S435/81 , C12Q2565/601 , C12Q2565/518 , C12Q2563/107
摘要： An integrated biomolecule sensor comprising a plurality of optical fibers whose proximal ends are held together with the end-faces arranged substantially in the same plane and oriented substantially in the same direction and which have probe polymers with different base sequences bound to the core end-face at their distal ends. The method and apparatus for fabricating the integrated biomolecule sensor, and the method and apparatus for detecting biomolecules using the integrated biomolecule sensor are also disclosed. Researchers can make their own sensors best suited for individual requirements, and detect the presence of target biomolecules quickly, without need of expensive equipment.
摘要翻译：一种集成的生物分子传感器，包括多个光纤，其近端保持在一起，端面基本上布置在相同的平面上并且基本上沿相同的方向取向，并且具有不同的碱基序列的探针聚合物结合到芯的端面在他们的远端。还公开了用于制造集成生物分子传感器的方法和装置，以及使用该集成生物分子传感器检测生物分子的方法和装置。研究人员可以使自己的传感器最适合个人需求，并快速检测目标生物分子的存在，而无需昂贵的设备。

7. 发明申请

US20100256004A1 Device of Testing Interaction Between Biomolecules, Method of Testing Interaction Between Biomolecules,Method of Measuring Melting Temperature of Biomolecule,Method of Sequencing Nucleic Acid,Method of Causing Interaction Between Biomolecules,and Method of Causing Migration of Biomolecule 审中-公开
公开(公告)号：US20100256004A1
公开(公告)日：2010-10-07
申请号：US11791072
申请日：2005-11-04
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tikara Koike , Takayuki Shimamura
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tikara Koike , Takayuki Shimamura
IPC分类号： C40B30/04 , C40B40/00 , C40B40/04 , C40B40/08 , C40B40/06 , C40B40/10 , C40B40/12 , G01N27/26
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00495 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01L3/5027 , C12Q1/6837 , G01N33/5438 , C12Q2565/629 , C12Q2565/607
摘要： The device of testing interaction between biomolecules comprising a biomolecule microarray in which a biomolecule is immobilized on a substrate and a transparent electrode (opposite electrode) positioned so as to face the surface of the substrate of the microarray on which the bimolecule is immobilized. The device comprises a nonconductive spacer between the microarray and the opposite electrode, and a cavity is formed by the microarray, spacer and opposite electrode, and the microarray comprises a conductive material surface on at least a portion of the surface on which the biomolecule is immobilized, as well as comprises two through-holes communicating with the cavity, one of which is a hole for introducing a solution into the cavity, and the other of which is a hole for discharging a solution from the cavity. The method in which a solution comprising a target biomolecule is placed between a biomolecule microarray comprising one or more spots in which a biomolecule is immobilized on a substrate surface and an opposite electrode to cause interaction between the biomolecule immobilized on the substrate surface and the target biomolecule. The microarray comprises a conductive material surface on at least a portion of the surface on which the biomolecule is immobilized, and a voltage at a frequency ranging from 0.01 to 10 Hz is applied between the conductive material surface and the opposite electrode to promote the interaction. the method of causing migration of a biomolecule comprised in a solution placed between a substrate on at least a portion of which a conductive material surface is comprised and an opposite electrode. A voltage at a frequency ranging from 0.01 to 10 Hz is applied between the conductive material surface and the opposite electrode to cause the biomolecule to migrate toward either the substrate or the opposite electrode.

8. 发明申请

US20050251046A1 Probe array producing method 审中-公开
标题翻译：探头阵列制作方法
公开(公告)号：US20050251046A1
公开(公告)日：2005-11-10
申请号：US11091714
申请日：2005-03-29
申请人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
发明人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
IPC分类号： G01N33/53 , B01J19/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N37/00 , A61B8/12
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： In order to provide a method for producing easily a probe array with probes arranged in the hollow portion of a tubular member, the present invention provides a method for producing a probe array comprising a step of forming a flexible sheet member 11 having a probe-immobilizing surface 110 into a tubular member in such a way that the probe-immobilizing surface 110 constitutes the inner face of the tubular member.
摘要翻译：为了提供容易地制造具有布置在管状构件的中空部分中的探针的探针阵列的方法，本发明提供了一种用于制造探针阵列的方法，其包括形成具有探针固定的柔性片构件11的步骤表面110成为管状构件，使得探针固定表面110构成管状构件的内表面。

9. 发明申请

US20050250139A1 Member for producing a probe array and probe array producing method 审中-公开
标题翻译：用于生产探针阵列和探针阵列制造方法的成员
公开(公告)号：US20050250139A1
公开(公告)日：2005-11-10
申请号：US11091707
申请日：2005-03-29
申请人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
发明人： Yuko Yamamoto , Hideaki Okabe , Hideo Tashiro , Yasumitsu Kondoh
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C40B40/06 , C40B60/14 , G01N37/00 , C12Q1/68 , C12P19/34
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00475 , B01J2219/00511 , B01J2219/00538 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B60/14
摘要： In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are produced by cutting the members M1, M2 . . . Mn for producing a probe array, and a predetermined number of pieces F1, F2 . . . Fn are detached from a release sheet 13 and are attached via the adhesive layer 12 onto the supporting member 2a at predetermined locations.
摘要翻译：为了提供用于制造探针阵列的构件，其可以在建立探针装置之后立即产生所需的探针阵列，并且提供使用该构件产生探针阵列的探针阵列产生方法，片F 1 F / 2。。。通过切割构件M 1，M 2 2来产生F / N。。。用于产生探针阵列的M＆lt; N＆gt;和预定数量的F 1，F 2 2。。。 F＆lt; N＆gt;从剥离片13分离，并且经由粘合剂层12附着到预定位置的支撑构件2a上。

10. 发明授权

US06855541B2 Kit used for fabricating an integrated biomolecule sensor 失效
标题翻译：用于制造集成生物分子传感器的试剂盒
公开(公告)号：US06855541B2
公开(公告)日：2005-02-15
申请号：US10676241
申请日：2003-10-01
申请人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
发明人： Hideo Tashiro , Yasumitsu Kondoh , Tokuji Kitsunai , Tomoko Tashiro
IPC分类号： G01N33/53 , C12Q1/68 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/58 , G01N37/00 , C12M1/34
CPC分类号： G01N21/6452 , C12Q1/6816 , C12Q1/6837 , G01N21/6428 , G01N21/7703 , G01N33/54373 , G01N2021/6484 , G01N2021/772 , Y10S435/808 , Y10S435/81 , C12Q2565/601 , C12Q2565/518 , C12Q2563/107
摘要： This invention provides a kit used for fabricating an integrated biomolecule sensor. The kit includes an optical fiber bundle unit, which holds the proximal ends of the plurality of optical fibers together with the end-face arranged substantially in the same plane and oriented substantially in the same direction, a plate with wells for holding solutions containing probe polymers with different base sequences, and an auxiliary plate having holes, which corresponds to the wells of the plate respectively. According to this invention, researchers and other people can easily fabricate the integrated biomolecule under individual requirements without need of expensive equipment.
摘要翻译：本发明提供了用于制造集成生物分子传感器的试剂盒。该套件包括光纤束单元，该光纤束单元将多个光纤的近端保持在一起，并将端面基本上布置在相同的平面上并且基本上沿相同的方向定向，具有用于保持含有探针聚合物的溶液的孔的平板具有不同的碱基序列和具有孔的辅助板，其分别对应于板的孔。根据本发明，研究人员和其他人可以根据个人需求轻松制造整合的生物分子，而不需要昂贵的设备。

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