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1. 发明授权

US06300331B1 Naphthalimidobenzamide derivatives 失效
标题翻译：萘酰亚胺酰胺衍生物
公开(公告)号：US06300331B1
公开(公告)日：2001-10-09
申请号：US09508044
申请日：2000-03-03
申请人： Kazuharu Noguchi , Motoji Wakida , Kenji Suzuki , Yuji Yamada , Tetsuji Asao
发明人： Kazuharu Noguchi , Motoji Wakida , Kenji Suzuki , Yuji Yamada , Tetsuji Asao
IPC分类号： A61K31473
CPC分类号： C07D221/14 , C07D401/14 , C07D471/04
摘要： The present invention relates to a naphthalimidobenzamide derivative represented by the following formula (1): (wherein, R1 represents a hydrogen atom, etc., Y represents a hydrogen atom or —CON(R4)—A2—X2, R2 and R4 are the same or different and each independently represents a hydrogen atom, etc., A1 and A2 are the same or different and each independently represents an alkylene group which may be interrupted at least once by —N(R3)— (R3 representing a hydrogen atom, etc.) and X1 and X2 are the same or different and each independently represents a (hetero)aryl group which may have a substituent, etc.) or salt thereof; and a pharmaceutical comprising it as an effective ingredient. The compound is useful as an antitumor agent and the like.
摘要翻译：本发明涉及由下式（1）表示的萘二甲酰亚胺酰胺衍生物:(其中，R1表示氢原子等，Y表示氢原子或-CON（R4）-A2-X2，R2和R4表示相同或不同，各自独立地表示氢原子等，A1和A2相同或不同，并且各自独立地表示可以被-N（R3） - （R3表示氢原子，等等），X 1和X 2相同或不同，并且各自独立地表示可以具有取代基的（杂）芳基等）或其盐; 和包含它作为有效成分的药物。该化合物可用作抗肿瘤剂等。

2. 发明授权

US6028079A Condensed-indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩水甘油衍生物及其药学上可接受的盐
公开(公告)号：US6028079A
公开(公告)日：2000-02-22
申请号：US909934
申请日：1997-08-12
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: wherein ring A represents an optionally substituted benzene ring or naphthalene ring, or a benzene ring having a lower alkylenedioxy group, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR.dbd.N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group, except when R represents an optionally substituted nitrogen-containing heterocyclic group; ring A and ring B are a benzene ring having no substituent group.
摘要翻译：由式（1）表示的缩合 - 茚满衍生物及其药学上可接受的盐：其中环A表示任选取代的苯环或萘环，或具有低亚烷基二氧基的苯环，环B表示任选取代的苯环或具有低亚烷基二氧基的苯环。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基，除了当R表示任意取代的含氮杂环基时; 环A和环B是没有取代基的苯环。

3. 发明授权

US5733918A Condensed-Indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩合 - 茚满衍生物及其药学上可接受的盐
公开(公告)号：US5733918A
公开(公告)日：1998-03-31
申请号：US578542
申请日：1996-01-19
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00 , A61K31/47 , C07D491/56
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## wherein ring A represents an optionally substituted benzene ring or naphthalene ring, or a benzene ring having a lower alkylenedioxy group, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR=N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group, except when R represents an optionally substituted nitrogen-containing heterocyclic group; ring A and ring B are a benzene ring having no substituent group.
摘要翻译： PCT No.PCT / JP95 / 00944 Sec。 371日期1996年1月19日 102（e）日期1996年1月19日PCT提交1995年5月18日PCT公布。出版物WO95 / 32187 日期：1995年11月30日由式（1）表示的缩合 - 缩水甘油衍生物及其药学上可接受的盐：其中环A表示任选取代的苯环或萘环，或具有低级亚烷基二氧基基团，环B表示任选取代的苯环或具有较低亚烷基二氧基的苯环。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基，除了当R表示任意取代的含氮杂环基时; 环A和环B是没有取代基的苯环。

4. 发明授权

US5710162A Condensed-indan derivatives and pharmaceutically acceptable salts thereof 失效
标题翻译：缩水甘油衍生物及其药学上可接受的盐
公开(公告)号：US5710162A
公开(公告)日：1998-01-20
申请号：US713224
申请日：1996-09-12
申请人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Motoji Wakida , Keisuke Ishida , Masato Washinosu , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/44 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/12 , C07D491/04 , C07D491/056 , C07D521/00 , C07D471/00 , A61K31/435
CPC分类号： C07D231/12 , C07D221/18 , C07D233/56 , C07D249/08 , C07D401/12 , C07D491/04
摘要： A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## wherein ring A represents an optionally substituted naphthalene ring, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents --N.dbd.CR-- or --CR.dbd.N--, R represents a --NR.sub.1 R.sub.2 group, an optionally substituted nitrogen-containing heterocyclic group or a --OR.sub.3 group, wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R.sub.3 represents a lower alkyl group optionally substituted by a substituted amino group.
摘要翻译：由式（1）表示的缩合 - 茚满衍生物及其药学上可接受的盐：其中环A表示任选取代的萘环，环B表示任选取代的苯环或具有低级亚烷基二氧基的苯环组。 Y表示-N = CR-或-CR = N-，R表示-NR1R2基，任选取代的含氮杂环基或-OR 3基，其中R1和R2相同或不同，各自为氢原子 ; 苯基; 任选取代的含氮杂环基; 或可以被选自任选取代的氨基，低级烷氧基，苯基，含氮杂环基，被低级烷基取代的氧化胺基中的至少一种取代的低级烷基基团或羟基; R3表示任选被取代的氨基取代的低级烷基。

5. 发明授权

US4897503A 1,1,2-triaryl-1-alkene derivatives 失效
标题翻译： 1,1,2-三芳基-1-烯烃衍生物
公开(公告)号：US4897503A
公开(公告)日：1990-01-30
申请号：US159590
申请日：1988-01-27
申请人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
发明人： Tetsuji Asao , Setsuo Takeda , Yoshikazu Sugimoto , Toshiyuki Toko , Yuji Yamada , Kazuo Ogawa , Norio Unemi
IPC分类号： C07F9/12
CPC分类号： C07F9/12
摘要： This invention provides a 1,1,2-triaryl-1-butene derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, one of R.sub.3 and R.sub.4 is a lower alkyl group and the other is a group of the formula ##STR2## (in which R.sub.5 is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom or --OPO(OH).sub.2 group); or a pharmacologically acceptable salt thereof, its preparation and agents containing the derivative for treating mammary cancer and anovulatory infertility.

6. 发明授权

US5763453A Condensed indan derivatives and salts thereof 失效
标题翻译：稠合茚满衍生物及其盐
公开(公告)号：US5763453A
公开(公告)日：1998-06-09
申请号：US809602
申请日：1997-04-03
申请人： Shinji Okazaki , Tetsuji Asao , Teruhiro Utsugi , Yuji Yamada
发明人： Shinji Okazaki , Tetsuji Asao , Teruhiro Utsugi , Yuji Yamada
IPC分类号： A61K31/47 , A61K31/473 , A61P35/00 , C07D221/18 , C07D401/04 , C07D491/056
CPC分类号： C07D401/04 , C07D221/18
摘要： A condensed indan derivative represented by the formula (1) ##STR1## wherein the ring A is an optionally substituted benzene ring or a benzene ring which has lower alkylenedioxy group(s), the ring B is an optionally substituted benzene ring or a benzene ring which has lower alkylene dioxy group(s), and R is a group --NR.sub.1 R.sub.2, an optionally substituted nitrogen-containing heterocyclic group, a group --OR.sub.3 or a group --SR.sub.4 (wherein R.sub.1 and R.sub.2 are the same or different and each represent a hydrogen atom, a phenyl group, an optionally substituted nitrogen-containing heterocyclic group, or a lower alkyl group which may be substituted by optionally substituted amino group(s), lower alkoxy group(s), phenyl group(s), nitrogen-containing heterocyclic group(s) or hydroxyl group(s), and R.sub.3 and R.sub.4 each represent a lower alkyl group which may be substituted by substituted amino group(s)), provided that at least one of the rings A and B is a substituted benzene ring and R is not --NHCH.sub.3, and salts thereof, and medical use of said derivative and salts.
摘要翻译： PCT No.PCT / JP96 / 02195 Sec。 371日期1997年4月3日 102（e）日期1997年4月3日PCT提交1996年8月2日PCT公布。公开号WO97 / 06145 日本公报1997年2月20日由式（1）表示的缩合茚满衍生物（1）其中环A为任选取代的苯环或具有低亚烷基二氧基的苯环，环B为任选取代的苯环或具有低级亚烷基二氧基的苯环，R为基团-NR1R2，任选取代的含氮杂环基，-OR3基或-SR4基（其中R1和R2为相同或不同，各自表示氢原子，苯基，任选取代的含氮杂环基或可被任选取代的氨基取代的低级烷基，低级烷氧基，苯基基团，含氮杂环基或羟基，R 3和R 4各自表示可以被取代的氨基取代的低级烷基），条件是至少一个环A和B是取代的苯环，R不是-NHCH 3及其盐，以及所述衍生物和盐的医疗用途。

7. 发明授权

US06034234A Double-stranded oligonucleotide and anticancer agent containing the same as active ingredient 失效
标题翻译：含有与活性成分相同的双链寡核苷酸和抗癌剂
公开(公告)号：US06034234A
公开(公告)日：2000-03-07
申请号：US676241
申请日：1996-07-17
申请人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
发明人： Ken-ichi Matsuo , Yoshikazu Sugimoto , Kenji Suzuki , Keisuke Ishida , Yuji Yamada
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13
摘要： This invention provides a double-stranded oligonucleotide or a derivative thereof which comprises 15 to 40 base pairs, wherein at least one side of the strands contains at least one nucleotide sequence represented by 5'-TTTSSCGS-3' (S is G or C). Also, since the compound of the present invention can inhibit expression of growth-related genes which are regulated by E2F, through its function to undergo sequence-specific competitive inhibition of the binding of E2F protein to the transcription region at a low concentration, a pharmaceutical composition containing the inventive compound as its active ingredient is useful as a drug having low side effects for use in the prevention and treatment of cancers.
摘要翻译： PCT No.PCT / JP95 / 02348 Sec。 371日期：1996年7月17日 102（e）日期1996年7月17日PCT提交1995年11月16日PCT公布。公开号WO96 / 16074 日期：1996年5月30日本发明提供了包含15〜40个碱基对的双链寡核苷酸或其衍生物，其中链的至少一侧含有至少一个由5'-TTTSSCGS-3'表示的核苷酸序列（S为 G或C）。此外，由于本发明的化合物可以抑制由E2F调节的生长相关基因的表达，通过其以低浓度进行E2F蛋白与转录区域的结合的序列特异性竞争性抑制的功能，药物含有本发明化合物作为其活性成分的组合物可用作用于预防和治疗癌症的副作用低的药物。

8. 发明授权

US10544425B2 Plant having increased resistance or susceptibility to 4-HPPD inhibitor 有权
公开(公告)号：US10544425B2
公开(公告)日：2020-01-28
申请号：US13976526
申请日：2011-12-26
申请人： Hiroshi Kato , Hideo Maeda , Yoshihiro Sunohara , Ikuo Ando , Masahiro Oshima , Motoshige Kawata , Hitoshi Yoshida , Sakiko Hirose , Makiko Kawagishi , Yojiro Taniguchi , Kazumasa Murata , Hiroaki Maeda , Yuji Yamada , Keisuke Sekino , Akihiko Yamazaki
发明人： Hiroshi Kato , Hideo Maeda , Yoshihiro Sunohara , Ikuo Ando , Masahiro Oshima , Motoshige Kawata , Hitoshi Yoshida , Sakiko Hirose , Makiko Kawagishi , Yojiro Taniguchi , Kazumasa Murata , Hiroaki Maeda , Yuji Yamada , Keisuke Sekino , Akihiko Yamazaki
IPC分类号： C12N15/82 , C12Q1/6895
摘要： By a QTL analysis and so forth using 4-HPPD inhibitor-susceptible rice and 4-HPPD inhibitor-resistant rice, a hypothetical gene (HIS1 gene) of an iron/ascorbate-dependent oxidoreductase gene located on a short arm of chromosome 2 of rice has been identified as a 4-HPPD inhibitor-resistance gene. Further, it has also been revealed that a homologous gene (HSL1 gene) of the HIS1 gene is located on chromosome 6 of rice. Furthermore, it has been found out that utilizations of these genes make it possible to efficiently produce a plant having increased resistance or susceptibility to a 4-HPPD inhibitor and to efficiently determine whether a plant has resistance or susceptibility to a 4-HPPD inhibitor.

9. 发明授权

US08814271B2 Vehicle seat 有权
标题翻译：车座
公开(公告)号：US08814271B2
公开(公告)日：2014-08-26
申请号：US13699545
申请日：2010-08-05
申请人： Manabu Ishimoto , Yuji Yamada , Keisuke Ishizaki
发明人： Manabu Ishimoto , Yuji Yamada , Keisuke Ishizaki
IPC分类号： A47C1/10 , A47C7/36 , A61G15/00 , B60R22/28
CPC分类号： B60N2/806 , B60N2/809 , B60N2/838 , B60N2/853 , B60N2/888
摘要： A headrest with a function of a dynamic damper that damps vibrations of a vehicle seat, and provide the headrest with an impact absorbing function with respect to a head portion of a seated vehicle occupant. A stay of a headrest is held at a seat back, and a cover, that covers at least a portion of the stay, is supported at the stay so as to be swingable in a seat front-rear direction around a seat transverse direction. Due to a torsion coil spring (an elastic member) elastically deforming when the cover swings, restoring force in a direction opposing a swinging direction of the cover is generated. Further, displacement other than in the swinging direction is suppressed by a suppressing portion that is provided between the stay and the cover.
摘要翻译：具有动力阻尼器的功能的头枕，其抑制车辆座椅的振动，并且使头枕相对于坐着的乘客的头部提供冲击吸收功能。头枕的停留被保持在座椅靠背处，并且覆盖至少一部分支架的盖子被支撑在支撑件处，以便能够围绕座椅横向方向在座椅前后方向上摆动。由于当盖摆动时扭转螺旋弹簧（弹性构件）弹性变形，产生与盖的摆动方向相反的方向的恢复力。此外，通过设置在支架和盖之间的抑制部分来抑制除了摆动方向之外的位移。

10. 发明申请

US20130127222A1 VEHICLE SEAT 有权
标题翻译：车辆座椅
公开(公告)号：US20130127222A1
公开(公告)日：2013-05-23
申请号：US13699545
申请日：2010-08-05
申请人： Manabu Ishimoto , Yuji Yamada , Keisuke Ishizaki
发明人： Manabu Ishimoto , Yuji Yamada , Keisuke Ishizaki
IPC分类号： B60N2/48
CPC分类号： B60N2/806 , B60N2/809 , B60N2/838 , B60N2/853 , B60N2/888
摘要： A headrest with a function of a dynamic damper that damps vibrations of a vehicle seat, and provide the headrest with an impact absorbing function with respect to a head portion of a seated vehicle occupant. A stay of a headrest is held at a seat back, and a cover, that covers at least a portion of the stay, is supported at the stay so as to be swingable in a seat front-rear direction around a seat transverse direction. Due to a torsion coil spring (an elastic member) elastically deforming when the cover swings, restoring force in a direction opposing a swinging direction of the cover is generated. Further, displacement other than in the swinging direction is suppressed by a suppressing portion that is provided between the stay and the cover.
摘要翻译：具有动力阻尼器的功能的头枕，其抑制车辆座椅的振动，并且使头枕相对于坐着的乘客的头部提供冲击吸收功能。头枕的停留被保持在座椅靠背处，并且覆盖至少一部分支架的盖子被支撑在支撑件处，以便能够围绕座椅横向方向在座椅前后方向上摆动。由于当盖摆动时扭转螺旋弹簧（弹性构件）弹性变形，产生与盖的摆动方向相反的方向的恢复力。此外，通过设置在支架和盖之间的抑制部分来抑制除了摆动方向之外的位移。

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