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1. 发明授权

US5948345A Method for making medical balloon catheter 失效
标题翻译：制造医用气囊导管的方法
公开(公告)号：US5948345A
公开(公告)日：1999-09-07
申请号：US002676
申请日：1998-01-05
申请人： Kaushik A. Patel , Samir R. Patel , Stephen A. Zimmerman
发明人： Kaushik A. Patel , Samir R. Patel , Stephen A. Zimmerman
IPC分类号： A61M25/00 , B29C49/10 , B29C49/18 , B29C49/08
CPC分类号： A61M25/1029 , B29C49/18 , A61M25/1034 , B29C2049/0089 , B29C2049/465 , B29C49/10 , B29K2077/00 , B29K2105/258 , B29L2031/7542
摘要： A method for making a medical balloon catheter in a single molding operation employs a parison which is molded and biaxially oriented by the use of first and second pressurization stages. The starting material is in the form of a tubular parison with a reduced diameter portion which is made of a biaxial orientable polyamide or polyetheramide material. The resulting balloon can be attached to a catheter that includes a tapered or stepped distal end without further shaping or modification of the balloon ends.
摘要翻译：在单次成型操作中制造医疗气囊导管的方法使用通过使用第一和第二加压阶段来模制和双轴取向的型坯。起始材料是由双轴取向的聚酰胺或聚醚酰胺材料制成的具有直径减小部分的管状型坯的形式。所得到的球囊可以附接到包括锥形或阶梯状远端的导管，而不进一步整形或修改球囊端部。

2. 发明授权

US07104981B2 Apparatus and method for inserting an intra-aorta catheter through a delivery sheath 有权
标题翻译：用于通过输送鞘插入主动脉内导管的装置和方法
公开(公告)号：US07104981B2
公开(公告)日：2006-09-12
申请号：US11259187
申请日：2005-10-25
申请人： Jeffrey M. Elkins , Harry B. Goodson , Mark A. Maguire , Aurelio Valencia , Samir R. Patel
发明人： Jeffrey M. Elkins , Harry B. Goodson , Mark A. Maguire , Aurelio Valencia , Samir R. Patel
IPC分类号： A61M25/01
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.
摘要翻译：导引器系统将局部给予患者的肾系统治疗。近端联接器组件联接到导引器鞘，其将多个装置同时输送到与第一和第二肾动脉口相关联的腹主动脉内的位置。耦合器组件具有布置成允许多个耦合器件的平滑可滑动接合而没有实质干涉的分支腔的网络。第一分支腔通常将经皮腔内介入装置（例如血管造影或引导导管）引入导引器鞘并且基本上与护套的纵向轴线对准。一个或多个其它分支腔从纵向轴线偏离约30度或更小，并且将双侧肾递送组件的组分与另一装置结合引入导引鞘中。提供了新的插入装置来协调多个装置的耦合。

3. 发明授权

US07914503B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US07914503B2
公开(公告)日：2011-03-29
申请号：US11084738
申请日：2005-03-16
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

4. 发明授权

US07364566B2 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US07364566B2
公开(公告)日：2008-04-29
申请号：US11084434
申请日：2005-03-18
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M29/00 , A61M25/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

5. 发明授权

US07585836B2 Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy 失效
标题翻译：用于治疗充血性心力衰竭和BNP治疗的双侧局部肾移植
公开(公告)号：US07585836B2
公开(公告)日：2009-09-08
申请号：US11129101
申请日：2005-05-13
申请人： Harry Burt Goodson, IV , Samir R. Patel , Craig A. Ball , Jeffrey M. Elkins
发明人： Harry Burt Goodson, IV , Samir R. Patel , Craig A. Ball , Jeffrey M. Elkins
IPC分类号： A61K38/00 , A61M25/00
CPC分类号： A61M25/0041 , A61K38/2242 , A61M25/0054 , A61M25/04 , A61M2025/0681 , A61M2210/1085
摘要： The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and methods of use.
摘要翻译：本发明涉及用于将局部肾递送给患有充血性心力衰竭和其他病症风险的受试者的系统和方法。本发明包括用于肾药物递送的装置和使用方法。

6. 发明申请

US20080154236A1 METHOD AND APPARATUS FOR INTRA-AORTIC SUBSTANCE DELIVERY TO A BRANCH VESSEL 有权
标题翻译：用于运输物流输送到分支机构的方法和装置
公开(公告)号：US20080154236A1
公开(公告)日：2008-06-26
申请号：US12044230
申请日：2008-03-07
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M31/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

7. 发明授权

US08585678B2 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US08585678B2
公开(公告)日：2013-11-19
申请号：US12044230
申请日：2008-03-07
申请人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
发明人： Jeffrey M. Elkins , Aurelio Valencia , Samir R. Patel , Ricardo Aboytes , Harry B. Goodson , Craig A. Ball
IPC分类号： A61M31/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

8. 发明申请

US20090305990A1 BI-LATERAL LOCAL RENAL DELIVERY FOR TREATING CONGESTIVE HEART FAILURE AND FOR BNP THERAPY 审中-公开
标题翻译：用于治疗顽固性心脏衰竭和BNP治疗的双侧局部肾移植
公开(公告)号：US20090305990A1
公开(公告)日：2009-12-10
申请号：US12511328
申请日：2009-07-29
申请人： Harry Burt Goodson , Samir R. Patel , Craig A. Ball , Jeffrey M. Elkins
发明人： Harry Burt Goodson , Samir R. Patel , Craig A. Ball , Jeffrey M. Elkins
IPC分类号： A61K38/16 , A61K38/02 , A61P9/00 , A61M25/01
CPC分类号： A61M25/0041 , A61K38/2242 , A61M25/0054 , A61M25/04 , A61M2025/0681 , A61M2210/1085
摘要： The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and method of use.
摘要翻译：本发明涉及用于将局部肾递送给患有充血性心力衰竭和其他病症风险的受试者的系统和方法。本发明包括用于肾药物递送的装置和使用方法。

9. 发明授权

US06994700B2 Apparatus and method for inserting an intra-aorta catheter through a delivery sheath 有权
公开(公告)号：US06994700B2
公开(公告)日：2006-02-07
申请号：US11084295
申请日：2005-03-18
申请人： Jeffrey M. Elkins , Harry B. Goodson , Mark A. Maguire , Aurelio Valencia , Samir R. Patel
发明人： Jeffrey M. Elkins , Harry B. Goodson , Mark A. Maguire , Aurelio Valencia , Samir R. Patel
IPC分类号： A61M25/01
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.

10. 发明授权

US08012121B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
公开(公告)号：US08012121B2
公开(公告)日：2011-09-06
申请号：US11768390
申请日：2007-06-26
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.

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