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1. 发明授权

US07914503B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US07914503B2
公开(公告)日：2011-03-29
申请号：US11084738
申请日：2005-03-16
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

2. 发明授权

US08012121B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
公开(公告)号：US08012121B2
公开(公告)日：2011-09-06
申请号：US11768390
申请日：2007-06-26
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.

3. 发明授权

US07780628B1 Apparatus and methods for treating congestive heart disease 失效
标题翻译：用于治疗充血性心脏病的装置和方法
公开(公告)号：US07780628B1
公开(公告)日：2010-08-24
申请号：US09562493
申请日：2000-05-01
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
IPC分类号： A61M29/00
CPC分类号： A61M25/00 , A61B17/12013 , A61B2017/00243 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1096 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.
摘要翻译：提供了通过积极或被动地增强对肾动脉灌注的治疗充血性心脏的方法和装置。第一实施例包括特别配置的气囊导管和体外泵，其中泵以“一次通过”方式或交替容积位移模式操作。在另一个实施例中，导管包括一对隔离主动脉区域的气球和将流动引导到肾动脉的第三气囊。在另外的实施例中，具有收缩区域的支架或袖带分别展开在主动脉或其周围，以在支架或袖带的上游产生背压。还提供了增强肾脏灌注的方法。

4. 发明授权

US07335192B2 Apparatus and methods for treating congestive heart disease 有权
标题翻译：用于治疗充血性心脏病的装置和方法
公开(公告)号：US07335192B2
公开(公告)日：2008-02-26
申请号：US10438176
申请日：2003-05-13
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61B17/1219 , A61B17/12013 , A61B17/12036 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B2017/00243 , A61B2017/00898 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/1072 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/00 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M27/002 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.
摘要翻译：提供了通过积极或被动地增强对肾动脉灌注的治疗充血性心脏的方法和装置。第一实施例包括特别配置的气囊导管和体外泵，其中泵以“一次通过”方式或交替容积位移模式操作。在另一个实施例中，导管包括一对隔离主动脉区域的气球和将流动引导到肾动脉的第三气囊。在另外的实施例中，具有收缩区域的支架或袖带分别展开在主动脉或其周围，以在支架或袖带的上游产生背压。还提供了增强肾脏灌注的方法。

5. 发明授权

US07766892B2 Apparatus and methods for treating congestive heart disease 失效
公开(公告)号：US07766892B2
公开(公告)日：2010-08-03
申请号：US10153050
申请日：2002-05-21
申请人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
发明人： Gad Keren , Ascher Shmulewitz , Benjamin Spenser , Michael Arad , Randy J. Kesten , Sophia Pesotchinsky , Michael H. Rosenthal , Andrew W. Kramer , Sam G. Payne
IPC分类号： A61M31/00
CPC分类号： A61M25/00 , A61B17/12013 , A61B2017/00243 , A61B2017/061 , A61B2017/22054 , A61F2002/068 , A61M1/101 , A61M1/1018 , A61M1/1034 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1096 , A61M1/122 , A61M1/125 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M25/10 , A61M25/1011 , A61M2025/1052 , A61M2210/1082 , A61M2210/125
摘要： Methods and apparatus are provided for treating congestive heart by actively or passively enhancing perfusion to the renal arteries. A first embodiment comprises a specially configured balloon catheter and extracorporeal pump, wherein the pump operates in a “once-through” fashion or alternating volume displacement mode. In another embodiment the catheter includes a pair of balloons to isolate a region of the aorta, and a third balloon that directs flow into the renal arteries. In still further embodiments, a stent or cuff having a constricted region is deployed in or around the aorta, respectively, to create a backpressure upstream of the stent or cuff. Methods of enhancing renal perfusion also are provided.

6. 发明授权

US07329236B2 Intra-aortic renal drug delivery catheter 有权
标题翻译：主动脉内肾脏药物输送导管
公开(公告)号：US07329236B2
公开(公告)日：2008-02-12
申请号：US11221679
申请日：2005-09-07
申请人： Randy J. Kesten , Michael H. Rosenthal , Sam G. Payne , Andrew W. Kramer , Sophia Pesotchinsky
发明人： Randy J. Kesten , Michael H. Rosenthal , Sam G. Payne , Andrew W. Kramer , Sophia Pesotchinsky
IPC分类号： A61M29/00
CPC分类号： A61M25/1002 , A61M2025/0034 , A61M2025/0035 , A61M2025/0036 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/1004 , A61M2025/105 , A61M2025/1059 , A61M2025/1084
摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
摘要翻译：用于将治疗剂或诊断剂递送到主要血管的分支金黄色血管的导管包括细长轴，其具有至少一个内腔，其与所述轴的远侧部分中的药剂输送端口流体连通，所述可扩张管状构件所述轴的远端部分和所述管状部件上的径向可扩张部件。管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流管状构件的外部和管状构件的内部通道内的内部血流。

7. 发明授权

US07122019B1 Intra-aortic renal drug delivery catheter 失效
标题翻译：主动脉内肾脏药物输送导管
公开(公告)号：US07122019B1
公开(公告)日：2006-10-17
申请号：US09724691
申请日：2000-11-28
申请人： Randy J. Kesten , Michael H. Rosenthal , Sam G. Payne , Andrew K. Kramer , Sophia Pesotchinsky
发明人： Randy J. Kesten , Michael H. Rosenthal , Sam G. Payne , Andrew K. Kramer , Sophia Pesotchinsky
IPC分类号： A61M31/00 , A61M29/00 , A61M37/00 , A61N1/362
CPC分类号： A61M25/10 , A61M2025/0037
摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member. The radially expandable member is located down-stream of the shaft agent delivery port, and has an expanded configuration with an outer diameter larger than an outer diameter of the tubular member. The expanded radially expandable member is configured to decrease the blood flow in the outer blood flow stream down-stream of the branch vessel. The catheter provides for delivery of an agent to a branch vessel of a major vessel, and continuous perfusion of the major blood vessel. Another aspect of the invention is directed to methods of delivering a therapeutic or diagnostic agent to one or both kidney's of a patient.
摘要翻译：一种用于将治疗剂或诊断剂递送到主要血管的分支血管的导管，通常包括细长轴，所述细长轴具有与所述轴的远端部分中的药剂输送端口流体连通的至少一个内腔，在所述轴的远侧部分上，以及在所述管状构件上的径向可扩张构件。管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流管状构件的外部和管状构件的内部通道内的内部血流。径向可膨胀构件位于轴剂输送口的下游，并且具有外径大于管状构件的外径的膨胀构型。扩张的可径向扩张的构件被配置为减小分支容器下游的外部血液流中的血流。导管提供将药剂递送到主血管的分支血管，并连续灌注主血管。本发明的另一方面涉及将治疗剂或诊断剂递送到患者的一种或两种肾脏的方法。

8. 发明授权

US07481803B2 Intra-aortic renal drug delivery catheter 失效
标题翻译：主动脉内肾脏药物输送导管
公开(公告)号：US07481803B2
公开(公告)日：2009-01-27
申请号：US10422624
申请日：2003-04-23
申请人： Randy J. Kesten , Michael H. Rosenthal , Sam G. Payne , Andrew K. Kramer , Sophia Pesotchinsky
发明人： Randy J. Kesten , Michael H. Rosenthal , Sam G. Payne , Andrew K. Kramer , Sophia Pesotchinsky
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61K31/55 , A61M25/005 , A61M25/1002 , A61M25/1011 , A61M29/02 , A61M2025/0034 , A61M2025/0035 , A61M2025/0036 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/105 , A61M2025/1052 , A61M2025/1072 , A61M2025/1095 , A61M2025/1097
摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
摘要翻译：一种用于将治疗剂或诊断剂递送到主要血管的分支血管的导管，通常包括细长轴，所述细长轴具有与所述轴的远端部分中的药剂输送端口流体连通的至少一个内腔，在所述轴的远侧部分上，以及在所述管状构件上的径向可扩张构件。管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流管状构件的外部和管状构件的内部通道内的内部血流。

9. 发明授权

US06322548B1 Delivery catheter system for heart chamber 失效
标题翻译：心室输送导管系统
公开(公告)号：US06322548B1
公开(公告)日：2001-11-27
申请号：US09052971
申请日：1998-03-31
申请人： Sam G. Payne , Randy J. Kesten , Michael Aita , Stewart Kume , Stephen B. Pearce , Manuel A. Javier, Jr. , Michael H. Rosenthal
发明人： Sam G. Payne , Randy J. Kesten , Michael Aita , Stewart Kume , Stephen B. Pearce , Manuel A. Javier, Jr. , Michael H. Rosenthal
IPC分类号： A61M3100
CPC分类号： A61B18/24 , A61B17/0218 , A61B17/32002 , A61B17/3203 , A61B17/3478 , A61B18/12 , A61B90/39 , A61B2017/00243 , A61B2017/00247 , A61B2017/003 , A61B2017/22082 , A61B2017/2905 , A61B2017/2927 , A61B2017/320004 , A61B2017/3488 , A61B2018/00392 , A61B2090/036 , A61M25/0041 , A61M25/0084 , A61M25/0662 , A61M2025/0089 , A61M2210/125
摘要： A delivery catheter system for delivering a substance delivery member into a patient's left ventricle which includes a first delivery catheter with a shaped distal extremity configured to be aligned with or parallel to a longitudinal axis or long dimension of the patient's left ventricle and a second delivery catheter slidably and rotatably disposed within an inner lumen of the first delivery catheter which has a shaped distal shaft section and an inner lumen configured to slidably receive a substance delivery member such as an elongated cannula slidably disposed within a polymer sheath. The shaped distal section of the first delivery catheter is shaped or is shapeable within the patient's heart chamber. The second delivery catheter is advanced out of the inner lumen of the first delivery catheter until the distal end extends out of the port in the distal end of the first delivery catheter and provides a passageway for substance delivery member to engage the endocardial surface at a perpendicular or near perpendicular orientation.
摘要翻译：一种输送导管系统，用于将物质递送部件输送到患者的左心室中，该输送导管系统包括具有成形远端的第一输送导管，该第一输送导管被构造为与患者的左心室的纵向轴线或长度尺寸对准或平行，可滑动地和可旋转地设置在第一输送导管的内腔内，该第一输送导管具有成形的远端轴部分和内腔，其构造成可滑动地容纳诸如可滑动地设置在聚合物护套内的细长插管的物质输送构件。第一输送导管的形状的远端部分在患者的心室内成形或可成形。第二输送导管从第一输送导管的内腔推出，直到远端从第一输送导管的远端中的端口延伸出来，并且提供用于物质输送构件在垂直方向上接合心内膜表面的通道或近垂直取向。

10. 发明授权

US06285903B1 Intracorporeal device with radiopaque marker 失效
标题翻译：具有不透射线标记的体内器械
公开(公告)号：US06285903B1
公开(公告)日：2001-09-04
申请号：US09107843
申请日：1998-06-30
申请人： Michael H. Rosenthal , Manuel A. Javier, Jr. , Sam G. Payne , Stephen B. Pearce , Randy J. Kesten
发明人： Michael H. Rosenthal , Manuel A. Javier, Jr. , Sam G. Payne , Stephen B. Pearce , Randy J. Kesten
IPC分类号： A61B505
CPC分类号： A61M25/0108 , A61B6/12 , A61B90/39
摘要： An intracorporeal device generally having an elongate shaft with an asymmetric radiopaque marker disposed upon or within the distal end thereof. The radiopaque marker member enables the user to determine the orientation of the distal end of the device under fluoroscopic and similar imaging techniques. In certain embodiments the device is configured as a delivery catheter system having multiple delivery catheters, some or all of which may have radiopaque marker members disposed upon or within their distal ends. The delivery catheter system is configured in some embodiments to deliver an elongated diagnostic or therapeutic device to a desired location within a patient's heart.
摘要翻译：体内装置通常具有设置在其远端上或其远端内的具有不对称不透射线标记的细长轴。不透射线的标记构件使得用户能够在荧光镜和类似成像技术下确定装置的远端的取向。在某些实施例中，该装置被配置为具有多个输送导管的递送导管系统，其中一些或全部可具有设置在其远端上或其远端内的不透射线的标记构件。输送导管系统在一些实施例中被配置以将细长的诊断或治疗装置递送到患者心脏内的期望位置。

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