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1. 发明授权

US08012121B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
公开(公告)号：US08012121B2
公开(公告)日：2011-09-06
申请号：US11768390
申请日：2007-06-26
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew K. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.

2. 发明授权

US07914503B2 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US07914503B2
公开(公告)日：2011-03-29
申请号：US11084738
申请日：2005-03-16
申请人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
发明人： Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel , Aurelio Valencia , Ricardo Aboytes , Craig A. Ball , Randy J. Kesten , Andrew W. Kramer , Sam G. Payne , Sophia Pesotchinsky , Michael H. Rosenthal
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

3. 发明申请

US20090306625A1 TREATMENT SYSTEMS AND METHODS FOR RENAL-RELATED DISEASES 审中-公开
标题翻译：治疗系统与方法相关的疾病
公开(公告)号：US20090306625A1
公开(公告)日：2009-12-10
申请号：US12404137
申请日：2009-03-13
申请人： Nikhil L. Pereira-Kamath , Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel
发明人： Nikhil L. Pereira-Kamath , Harry B. Goodson, IV , Jeffrey M. Elkins , Samir R. Patel
IPC分类号： A61M25/01
CPC分类号： A61K31/436 , A61B5/201 , A61B5/412 , A61K35/28 , A61K35/545 , A61K38/18 , A61K38/2013 , A61K38/212 , A61M25/0067 , A61M25/0071 , A61M2025/1045 , A61M2210/1082
摘要： Systems and methods are provided for locally delivering specific prophylactic, regenerative, or therapeutic agents within the body of a patient. Systems and methods can involve direct delivery of prophylactic, regenerative, or therapeutic agents into branch blood vessels or body lumens from a main vessel or lumen, respectively, and in particular into renal arteries extending from an aorta in a patient. Drug infusion techniques encompass specific treatment and prevention regimes for renal diseases including, but not limited to, Acute Kidney Injury, Renal Cell Carcinoma, Polycystic Kidney Disease, and Chronic Kidney Disease.
摘要翻译：提供的系统和方法用于在患者体内局部递送特定的预防，再生或治疗剂。系统和方法可以包括将预防性，再生的或治疗剂分别直接递送到分支血管或来自主血管或内腔的体腔，特别是从病人主动脉延伸的肾动脉。药物输注技术包括肾脏疾病的具体治疗和预防方案，包括但不限于急性肾损伤，肾细胞癌，多囊肾病和慢性肾脏疾病。

4. 发明授权

US07766961B2 Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens 失效
标题翻译：在分支体内进行双侧干预或诊断的系统和方法
公开(公告)号：US07766961B2
公开(公告)日：2010-08-03
申请号：US11295735
申请日：2005-12-05
申请人： Samir Patel , Harry B. Goodson, IV , Jeffrey M. Elkins , Craig A. Ball , Vandana S. Mathur
发明人： Samir Patel , Harry B. Goodson, IV , Jeffrey M. Elkins , Craig A. Ball , Vandana S. Mathur
IPC分类号： A61F2/06
CPC分类号： A61F2/954 , A61B2017/00331 , A61B2017/22068 , A61B2017/22071 , A61F2/013 , A61F2/958 , A61F2002/065 , A61F2002/821 , A61F2002/9517 , A61F2002/9528 , A61M25/1002
摘要： Bifurcated delivery assemblies provide bilateral access to first and second branch lumens extending from a main body space or lumen in a patient. One or more interventional devices are combined with the delivery assemblies for delivery s into one or both of the branch lumens. Bilateral renal stenting or embolic protection procedures are performed using the combination delivery/interventional device assemblies. Fluids may also be injected or aspirated from the assemblies. A bifurcated catheter has a first fluid port located on one bifurcation branch, a second fluid port located on a second branch of the bifurcation, and a third fluid port positioned so as to be located within a vena cava when the first and second ports are positioned bilaterally within first and second renal veins.
摘要翻译：分叉输送组件提供从患者的主体空间或内腔延伸的第一和第二分支腔的双向通路。将一个或多个介入装置与输送组件组合以用于输送到分支腔中的一个或两个。使用组合递送/介入装置组件进行双侧肾支架置入或栓塞保护程序。流体也可以从组件注入或吸出。分叉导管具有位于一个分叉分支上的第一流体端口，位于分叉的第二分支上的第二流体端口和位于第一和第二端口定位的位于腔静脉内的第三流体端口在第一和第二肾静脉内双侧。

5. 发明申请

US20090318857A1 SHEATH FOR USE IN PERIPHERAL INTERVENTIONS 有权
标题翻译：用于外围干预的治疗
公开(公告)号：US20090318857A1
公开(公告)日：2009-12-24
申请号：US12549486
申请日：2009-08-28
申请人： Harry B. Goodson, IV , Craig A. Ball , Jeffrey M. Elkins
发明人： Harry B. Goodson, IV , Craig A. Ball , Jeffrey M. Elkins
IPC分类号： A61M3/00 , A61M29/00
CPC分类号： A61M25/0662 , A61M25/0032 , A61M25/007
摘要： A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.
摘要翻译：双腔引导器护套提供对患者的至少一个肾动脉和至少一个外周血管的通路。导引鞘包括近端毂，其包括第一和第二端口，第一腔和第二腔。第一腔从第一端口延伸到第一远端孔并且具有足够的长度，使得当第一端口位于患者外部时，第一远端孔可定位在患者肾动脉起点处或其附近的腹主动脉中。所述第二腔从所述第二端口延伸到第二远端孔，具有比所述第一腔的长度更短的长度，并且构造成允许导管装置通过所述第二腔并进入或穿过对侧的髂动脉导引鞘的插入点进入患者。

6. 发明授权

US08518011B2 Sheath for use in peripheral interventions 有权
标题翻译：护套用于外围干预
公开(公告)号：US08518011B2
公开(公告)日：2013-08-27
申请号：US12549486
申请日：2009-08-28
申请人： Harry B. Goodson, IV , Craig A. Ball , Jeffrey M. Elkins
发明人： Harry B. Goodson, IV , Craig A. Ball , Jeffrey M. Elkins
IPC分类号： A61M31/00
CPC分类号： A61M25/0662 , A61M25/0032 , A61M25/007
摘要： A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.
摘要翻译：双腔引导器护套提供对患者的至少一个肾动脉和至少一个外周血管的通路。导引鞘包括近端毂，其包括第一和第二端口，第一腔和第二腔。第一腔从第一端口延伸到第一远端孔并且具有足够的长度，使得当第一端口位于患者外部时，第一远端孔可定位在患者肾动脉起点处或其附近的腹主动脉中。所述第二腔从所述第二端口延伸到第二远端孔，具有比所述第一腔的长度更短的长度，并且被配置为允许导管装置通过所述第二腔并进入或穿过对侧的髂动脉导引鞘的插入点进入患者。

7. 发明授权

US06945992B2 Single-piece crown stent 有权
标题翻译：单件冠支架
公开(公告)号：US06945992B2
公开(公告)日：2005-09-20
申请号：US10421054
申请日：2003-04-22
申请人： Harry B. Goodson, IV , Trevor Greenan
发明人： Harry B. Goodson, IV , Trevor Greenan
IPC分类号： A61F2/06 , A61F2/90
CPC分类号： A61F2/915 , A61F2/07 , A61F2/848 , A61F2/91 , A61F2002/075 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2220/0075 , A61F2230/0054
摘要： A stent for a stent-graft includes: a first ring; a second ring; and spring elements coupling the first ring to the second ring, wherein the first ring, the second ring and the spring elements are integral. During maneuvering of the stent-graft through the tortuous human anatomy, the first ring is bent or flexed relative to the second ring. However, the spring elements are distorted to accommodate this bending. Further, since the stent is integral, a graft material only has to be sewn to the second ring minimizing the delivery profile of the stent-graft.
摘要翻译：用于支架移植物的支架包括：第一环; 第二个戒指以及将所述第一环联接到所述第二环的弹簧元件，其中所述第一环，所述第二环和所述弹簧元件是一体的。在通过弯曲的人体解剖学来操纵支架移植物时，第一环相对于第二环弯曲或弯曲。然而，弹簧元件变形以适应这种弯曲。此外，由于支架是一体的，所以只需将接枝材料缝合到第二环上，使得支架移植物的输送轮廓最小化。

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