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1. 发明申请

US20070181503A1 Affinity particle and affinity separation method 审中-公开
标题翻译：亲和粒子和亲和力分离法
公开(公告)号：US20070181503A1
公开(公告)日：2007-08-09
申请号：US11580000
申请日：2005-05-18
申请人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
发明人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
IPC分类号： B01D15/08
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/28004 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3259 , B01J20/3274 , B01J20/3285 , B01J2220/58 , C07F9/091 , G01N33/54393
摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder. The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
摘要翻译：本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，并且还具有与某种共价键合或吸附在表面上的某些目标物质具有特异亲和力的配体无机粉末。本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。

2. 发明申请

US20100137133A1 Affinity Particle And Affinity Separation Method 失效
标题翻译：亲和粒子和亲和力分离法
公开(公告)号：US20100137133A1
公开(公告)日：2010-06-03
申请号：US12495936
申请日：2009-07-01
申请人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
发明人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
IPC分类号： B01J20/22
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/28004 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3259 , B01J20/3274 , B01J20/3285 , B01J2220/58 , C07F9/091 , G01N33/54393
摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder.The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
摘要翻译：本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，并且还具有与某种共价键合或吸附在表面上的某些目标物质具有特异亲和力的配体无机粉末。本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。

3. 发明授权

US08551332B2 Affinity particle and affinity separation method 失效
标题翻译：亲和粒子和亲和力分离法
公开(公告)号：US08551332B2
公开(公告)日：2013-10-08
申请号：US12495936
申请日：2009-07-01
申请人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
发明人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
IPC分类号： B01D15/08
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/28004 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3259 , B01J20/3274 , B01J20/3285 , B01J2220/58 , C07F9/091 , G01N33/54393
摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder.The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
摘要翻译：本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，还可以通过将具有特定亲和力的配体与共价键合或吸附在无机粉末。本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。

4. 发明申请

US20090321357A1 Affinity Particle And Affinity Separation Method 审中-公开
标题翻译：亲和粒子和亲和力分离法
公开(公告)号：US20090321357A1
公开(公告)日：2009-12-31
申请号：US12490216
申请日：2009-06-23
申请人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
发明人： Katsuyuki Maeno , Kazuyuki Miyazawa , Akira Ishikubo , Kazuhiko Ishihara
IPC分类号： B01D15/36 , C07F9/02 , C07F9/09 , C07K17/14 , C12N9/96 , B32B5/16
CPC分类号： B01J20/286 , B01D15/3804 , B01J20/28004 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3259 , B01J20/3274 , B01J20/3285 , B01J2220/58 , C07F9/091 , G01N33/54393
摘要： The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain target substance covalently bonded or adsorbed onto the surface of inorganic powder.The object of the present invention is to provide an affinity separation method that uses affinity particles utilizing inexpensive inorganic particles and is capable of separating the target substance easily and with high accuracy.
摘要翻译：本发明是亲水性粒子，其特征在于将由下式（1）表示的磷酸胆碱基团共价键合到无机粉末的表面上，还可以通过将具有特定亲和力的配体与共价键合或吸附在无机粉末。本发明的目的是提供使用廉价的无机粒子的亲和粒子的亲和力分离方法，能够容易且高精度地分离目标物质。

5. 发明授权

US08496919B2 Cosmetic composition and hair wash 有权
标题翻译：化妆品组合和洗发
公开(公告)号：US08496919B2
公开(公告)日：2013-07-30
申请号：US13208681
申请日：2011-08-12
申请人： Akira Ishikubo , Shoya Yoda
发明人： Akira Ishikubo , Shoya Yoda
IPC分类号： A61K8/81 , A61K8/49 , A61K8/02 , A61Q5/12
CPC分类号： A61K8/4933 , A61K8/817 , A61K2800/5426 , A61Q5/006 , A61Q5/02
摘要： To provide a cosmetic composition and a hair wash which are excellent in metal pyrithione salt persistence after washing with a washing liquid containing a surfactant, etc.A cosmetic composition and a hair wash, which comprise a copolymer and a metal pyrithione salt, wherein the copolymer contains constituting units corresponding to a cationic vinyl monomer of a specific structure and constituting units corresponding to a nonionic vinyl monomer of a specific structure.
摘要翻译：提供在含有表面活性剂的洗涤液洗涤后金属吡啶硫酮盐持久性优异的化妆品组合物和洗发剂。包含共聚物和金属吡啶硫酮盐的化妆品组合物和洗发剂，其中共聚物含有对应于特定结构的阳离子乙烯基单体的构成单元，并且构成对应于特定结构的非离子型乙烯基单体的单元。

6. 发明授权

US08673326B2 Oil-in-water emulsion composition and method for producing the same 有权
标题翻译：水包油乳液组合物及其制备方法
公开(公告)号：US08673326B2
公开(公告)日：2014-03-18
申请号：US12597502
申请日：2008-04-25
申请人： Akira Ishikubo , Yuji Matsushita , Yosuke Ikebe , Taizo Fujiyama , Tomonori Toyoda , Kazuho Koiwa
发明人： Akira Ishikubo , Yuji Matsushita , Yosuke Ikebe , Taizo Fujiyama , Tomonori Toyoda , Kazuho Koiwa
IPC分类号： A61K8/02 , A61K8/18 , A61K8/41 , A61K8/27 , A61Q1/02 , A61Q5/06 , A61Q19/00
CPC分类号： A61K8/416 , A61K8/062 , A61K8/27 , A61K2800/75 , A61Q1/02 , A61Q5/06 , A61Q19/00
摘要： The present invention provides an oil-in-water emulsion composition having excellent emulsion stability, low sticky feeling, and low skin irritation. The oil-in-water emulsion composition according to the present invention comprising (a) 1 to 20 mass % of a powder component, (b) 0.001 to 0.5 mass % of a cationic surfactant having two alkyl chains with 12 or more and 22 or less carbon atoms, (c) an oil phase component, and (d) a water phase component, having a structure wherein (a) powder particles are adsorbed on the oil droplets dispersed in the water phase.
摘要翻译：本发明提供了具有优异的乳液稳定性，低粘度感和低皮肤刺激性的水包油乳液组合物。本发明的水包油型乳液组合物，其含有（a）1〜20质量％的粉末成分，（b）0.001〜0.5质量％的具有12个以上且22以上的2个烷基链的阳离子性表面活性剂，较少的碳原子，（c）油相组分和（d）水相组分，具有以下结构：（a）粉末颗粒被吸附在分散在水相中的油滴上。

7. 发明申请

US20100247458A1 Emulsified External Skin Preparations 审中-公开
标题翻译：乳化外用皮肤制剂
公开(公告)号：US20100247458A1
公开(公告)日：2010-09-30
申请号：US11996752
申请日：2006-07-26
申请人： Hiroyuki Kakoki , Takashi Ohmori , Akio Nasu , Akira Ishikubo
发明人： Hiroyuki Kakoki , Takashi Ohmori , Akio Nasu , Akira Ishikubo
IPC分类号： A61K8/34 , A61Q17/04
CPC分类号： C07C43/135 , A61K8/062 , A61K8/39 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/02
摘要： The emulsified external skin preparation of the present invention is characterized by comprising a polyglycerol derivative represented by formula (1): wherein, m+2 represents the average polymerization degree of polyglycerol and 1≦m≦4; R1 is a hydrocarbon group having 1 to 4 carbon atoms or a hydrogen atom; AO is an oxyalkylene group having 3 to 4 carbon atoms; and n is the average addition mole number of the oxyalkylene group and 1≦m n≦200. In a water-in-oil type external skin preparation, and especially in that containing a polar oil or a silicone oil, emulsion stability is improved. In an oil-in-water type external skin preparation, feeling in use and emulsion stability are improved. Especially, in an oil-in-water type external skin preparation containing hydrophobized powder, powder dispersion stability is improved as well as feeling in use and emulsion stability.
摘要翻译：本发明的乳化外用皮肤制剂的特征在于，含有式（1）表示的聚甘油衍生物：其中，m +2表示聚甘油的平均聚合度，1＆nlE; m＆lt; 1l; 4; R1为碳原子数为1〜4的烃基或氢原子; AO是具有3〜4个碳原子的氧化烯基; 并且n是氧化烯基的平均加成摩尔数和1＆nlE; m n＆nlE; 200。在油包水型外用皮肤制剂中，特别是含有极性油或硅油的乳化稳定性提高。在水包油型外用皮肤制剂中，使用感和乳液稳定性得到改善。特别地，在含有疏水化粉末的水包油型外用皮肤制剂中，粉末分散稳定性以及使用感和乳液稳定性均得到改善。

8. 发明申请

US20100190864A1 Alkylene Oxide Derivative And Skin External Preparation Containing The Same 有权
标题翻译：含氧化烯衍生物和皮肤外用制剂
公开(公告)号：US20100190864A1
公开(公告)日：2010-07-29
申请号：US12670181
申请日：2008-07-25
申请人： Takashi Ohmori , Akira Ishikubo , Yuki Sugiyama , Yuko Matsui , Tomoyuki Kawasoe , Yoji Tezuka , Hiroyasu Mizuno , Kei-ichi Maruyama
发明人： Takashi Ohmori , Akira Ishikubo , Yuki Sugiyama , Yuko Matsui , Tomoyuki Kawasoe , Yoji Tezuka , Hiroyasu Mizuno , Kei-ichi Maruyama
IPC分类号： A61K8/86 , C07C43/15 , A61Q5/12 , A61Q1/00 , A61Q1/14 , A61Q19/10 , A61Q5/02
CPC分类号： A61Q1/02 , A61K8/86 , A61Q19/00 , C08G65/2609 , C08G65/2615 , C08G65/337 , C08L71/02
摘要： The present invention is to provide a new compound having a rough skin improving effect, excellent in safety, excellent in texture in use, especially free of sticky feeling, excellent in refreshing feeling, and capable to improve the base agent stability as a component. An alkylene oxide derivative is characterized by being represented by the below-described general formula (I): (formula I) Z-{O-[(AO)a-(EO)b]-R}2 (I) (In the formula, Z is the residue obtained by removing hydroxyl groups from the dimer diol, EO is an oxyethylene group, AO is an oxyalkylene group having 3 to 4 carbon atoms, and the addition form is block-type. The symbols a and b are the average addition mole numbers of the above-described oxyalkylene group and the oxyethylene group, respectively, and they are 1≦2 a≦150 and 1≦2 b≦150. The percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 10 to 99 mass %. Rs may be either identical to or different from each other, and they are hydrocarbon groups having 1 to 4 carbon atoms.)
摘要翻译：本发明提供一种具有粗糙皮肤改善效果，安全性优异，使用质地优异，特别是无粘性，清爽感好，能提高作为成分的基剂稳定性的新化合物。氧化烯衍生物的特征在于由下述通式（I）表示：（式I）Z- {O - [（AO）a-（EO）b] -R} 2（I）式中，Z为从二聚二醇中除去羟基得到的残基，EO为氧化乙烯基，AO为碳原子数3〜4的氧化烯基，添加形式为嵌段型，符号a和b为分别为上述氧化烯基和氧化乙烯基的平均加成摩尔数，它们分别为1和n 1; 2 a＆nlE; 150和1＆nlE; 2 b＆nlE; 150。氧化乙烯基相对于氧化烯基的总和的百分比具有3〜4个碳原子，氧化乙烯基为10〜99质量％，Rs可以相同也可以不同，为碳原子数1〜4的烃基）

9. 发明授权

US07973085B2 Gel composition 有权
标题翻译：凝胶组成
公开(公告)号：US07973085B2
公开(公告)日：2011-07-05
申请号：US12304173
申请日：2007-06-06
申请人： Akira Ishikubo , Takashi Ohmori , Yuki Suzuki
发明人： Akira Ishikubo , Takashi Ohmori , Yuki Suzuki
IPC分类号： A01N25/00 , A61K47/00
CPC分类号： A61K8/06 , A61K8/064 , A61K8/31 , A61K8/585 , A61K8/86 , A61K8/922 , A61K2800/262 , A61K2800/31 , A61Q1/02 , A61Q1/14 , A61Q5/12 , A61Q19/10
摘要： A gel composition having the formula R1O-[(AO)k(EO)m(AO)n]-R2 comprises (a) 0.1 to 60 mass % of a block-type alkylene oxide derivative, (b) an oil, and (c) 0.1 to 10 mass % of water. AO represents a C3-C4 oxyalkylene group; EO represents an oxyethylene group; k and n represent average addition mole numbers of the oxyalkylene group and m represents average addition mole number of the oxyethylene group, 1≦m≦70 and 1≦k+n≦70. The oxyethylene group is 20 to 80 mass % with respect to the sum of the oxyalkylene group (AO) and the oxyethylene group. R1 and R2 may be identical to or different from one another and are each a C1-C4 hydrocarbon group or a hydrogen atom. The composition has a continuous phase comprising the oil; and the viscosity of the composition at 25° C. is 500 mPa·s or more.
摘要翻译：具有式R1O - [（AO）k（EO）m（AO）n] -R2的凝胶组合物包含（a）0.1至60质量％的嵌段型烯化氧衍生物，（b）油和（ c）0.1〜10质量％的水。 AO表示C3-C4氧化烯基; EO表示氧乙烯基; k和n表示氧化烯基的平均加成摩尔数，m表示氧化乙烯基的平均加成摩尔数，1＆nlE; m＆lt; 111; 70和1＆nlE; k + n＆nlE; 70。氧化乙烯基相对于氧化烯基（AO）和氧化乙烯基的总和为20〜80质量％。 R 1和R 2可以彼此相同或不同，并且各自为C 1 -C 4烃基或氢原子。组合物具有包含油的连续相; 并且组合物在25℃下的粘度为500mPa·s以上。

10. 发明申请

US20110070173A1 Oil-in-Water Type Emulsion Cosmetic Composition 审中-公开
标题翻译：油包水型乳液化妆品组合物
公开(公告)号：US20110070173A1
公开(公告)日：2011-03-24
申请号：US10540041
申请日：2003-12-26
申请人： Susumu Yoshida , Tadashi Nakamura , Keiko Nakamura-Sole Heir , Akira Ishikubo , Akio Nasu
发明人： Susumu Yoshida , Tadashi Nakamura , Keiko Nakamura-Sole Heir , Akira Ishikubo , Akio Nasu
IPC分类号： A61K8/30 , A61K47/00 , A61K47/12 , A61K47/26
CPC分类号： A61Q19/00 , A61K8/06 , A61K8/062 , A61K8/73 , A61Q1/02 , A61Q17/04
摘要： This object of the invention is to provide an oil-in water emulsion cosmetic composition having fine sense of use and excellent dispersion stability, and does not occur twisting upon drying.In advance, a hydrophobicized powder is dispersed in an oil phase and processed with wet type disperser such as beads mill, dispersing solution is obtained. And then said dispersing solution and a water phase are processed with homomixer, an oil-in water emulsion composition having excellent sense of use and dispersibility of powder after applying to skin can be obtained. The dispersing stability of powder is extremely good by using a particular dispersant and a particular oil component. The dispersion stability of powder is further improved, and the precipitation and creaming of the emulsion particle can be solved by blending thickener having salt tolerance.Sticky feeling is solved by using succinoglycan as a thickener, and twisting is solved by plasticizing said succinoglycan.
摘要翻译：本发明的目的是提供一种具有优良的使用感和优异的分散稳定性的油包水乳液化妆品组合物，并且在干燥时不会发生扭曲。预先将疏水化粉末分散在油相中，用湿式分散机如珠磨机进行处理，得到分散液。然后用均质混合机处理所述分散溶液和水相，可以获得在施用于皮肤之后具有优异的使用感和粉末分散性的水包油乳液组合物。通过使用特定的分散剂和特定的油组分，粉末的分散稳定性非常好。粉末的分散稳定性进一步提高，乳化颗粒的沉淀和乳化可以通过混合具有耐盐性的增稠剂来解决。通过使用琥珀酰聚糖作为增稠剂来解决粘稠的感觉，并且通过使所述琥珀酰聚糖增塑来解决扭曲。

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