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1. 发明授权

US5720862A Sensor and production method of and measurement method using the same 失效
标题翻译：传感器及其制作方法及测量方法采用相同的方法
公开(公告)号：US5720862A
公开(公告)日：1998-02-24
申请号：US628485
申请日：1996-04-05
申请人： Katsumi Hamamoto , Hisashi Okuda
发明人： Katsumi Hamamoto , Hisashi Okuda
IPC分类号： G01N27/327 , C12M1/34 , C12Q1/00 , C12Q1/26 , G01N27/416 , G01N27/26
CPC分类号： C12Q1/002 , C12Q1/005 , Y10S435/817
摘要： There is provided a sensor for the measurement of a content of a material in liquid which material is oxidized with an oxidase enzyme in which sensor a reagent layer is formed on an electrode system composed of a measuring electrode and a counter electrode both of which are formed on an insulating substrate, the reagent layer is composed of a hydrophilic polymer layer comprising a hydrophilic polymer and a reactive layer comprising the oxidase enzyme and an electron carrier, and the reagent layer further comprises a phosphate.
摘要翻译：提供了一种传感器，用于测量液体中的材料的含量，该材料被氧化酶氧化，其中传感器在其上形成有测量电极和对电极的电极系统上形成试剂层在绝缘基板上，试剂层由包含亲水性聚合物的亲水性聚合物层和包含氧化酶和电子载体的反应层构成，试剂层还包含磷酸盐。

2. 发明授权

US5397451A Current-detecting type dry-operative ion-selective electrode 失效
标题翻译：电流检测型干式离子选择电极
公开(公告)号：US5397451A
公开(公告)日：1995-03-14
申请号：US187067
申请日：1994-01-27
申请人： Mitsugi Senda , Katsumi Hamamoto , Hisashi Okuda
发明人： Mitsugi Senda , Katsumi Hamamoto , Hisashi Okuda
IPC分类号： G01N27/28 , G01N27/327 , G01N27/333 , G01N27/403 , G01N27/406 , G01N27/407 , G01N27/411 , G01N27/26
CPC分类号： G01N27/4071 , G01N27/4035 , G01N27/4115 , Y10S435/817
摘要： A current-detecting type dry-operative ion-selective electrode having a working electrode and a counter electrode which are mounted on an insulating substrate, a first electrolyte layer containing a hydrophilic polymer and an ion-sensitive layer containing a hydrophobic polymer which are formed on the working electrode, and a second electrolyte layer containing a hydrophilic polymer which is laminated over the whole electrode system.
摘要翻译：一种电流检测型干式离子选择性电极，其具有安装在绝缘基板上的工作电极和对电极，含有亲水性聚合物的第一电解质层和含有疏水性聚合物的离子敏感层，其形成于工作电极以及层叠在整个电极系统上的含有亲水性聚合物的第二电解质层。

3. 发明授权

US5757002A Method of and apparatus for measuring lactic acid in organism 失效
标题翻译：生物体内乳酸测定方法及仪器
公开(公告)号：US5757002A
公开(公告)日：1998-05-26
申请号：US704987
申请日：1996-08-29
申请人： Yutaka Yamasaki , Hisashi Okuda , Koji Matsuoka , Kexin Xu
发明人： Yutaka Yamasaki , Hisashi Okuda , Koji Matsuoka , Kexin Xu
IPC分类号： A61B5/00 , G01N21/35 , G01N21/47
CPC分类号： G01N21/359 , A61B5/1455 , G01N21/4795 , G01N2201/1293
摘要： A light source pa light of a plurality of wavelengths of a near infrared region, and a spectroscopic part selects a wavelength subjected to absorption by lactic acid as a measuring wavelength from measuring light of a plurality of wavelengths emitted from the light source part. A probe comes into contact with an organism measuring portion and irradiates the organism measuring portion with the measuring light of the wavelength selected by the spectroscopic part, while a photoreceiving part detects transmitted/scattered light of the measuring light incident upon the organism measuring portion. A light signal detected by the photoreceiving part is converted to absorbance in a signal processing part, so that the concentration of lactic acid is calculated by a host computer serving as an arithmetic-control part and displayed on a display part. No reagent is required, while difference between lactic acid concentrations varied with measuring portions can also be noninvasively measured.
摘要翻译：近红外区域的多个波长的光源pa光，并且分光部从测量从光源部发射的多个波长的光中选择被乳酸吸收的波长作为测量波长。探测器与有机体测量部分接触，并且利用由分光部分选择的波长的测量光照射生物体测量部分，而光接收部分检测入射到生物体测量部分上的测量光的透射/散射光。由光接收部分检测到的光信号在信号处理部分被转换为吸光度，从而通过用作运算控制部分的主计算机计算出乳酸浓度，并显示在显示部分上。不需要试剂，乳酸浓度随测量部分变化的差异也可以非侵入性地测量。

4. 发明授权

US5496453A Biosensor and method of quantitative analysis using the same 失效
公开(公告)号：US5496453A
公开(公告)日：1996-03-05
申请号：US321604
申请日：1994-10-12
申请人： Harumi Uenoyama , Hisashi Okuda
发明人： Harumi Uenoyama , Hisashi Okuda
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/416 , G01N27/26
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor which electrochemically detects a material which relates to a reaction of a specific compound in a liquid sample with a biologically active substance or its related substance, in which the biologically active material or an optionally used mediator is placed at a part which is remote from a position of an electrode which acts as electrochemical detector means, and optionally the biological active material or the mediator is covered with a polymer layer.

5. 发明授权

US07491310B2 Concentration measuring method and concentration measuring apparatus 有权
标题翻译：浓度测量方法和浓度测量仪
公开(公告)号：US07491310B2
公开(公告)日：2009-02-17
申请号：US10492432
申请日：2002-10-09
申请人： Hisashi Okuda , Yoshimi Oura , Kotaro Kado
发明人： Hisashi Okuda , Yoshimi Oura , Kotaro Kado
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： The present invention relates to a technique for measuring the concentration of a particular component in a sample liquid using a test tool (2). The test tool (2) includes a first through a third detection elements (31a-33a) arranged in the mentioned order in the moving direction of the sample liquid for measuring an electro-physical quantity. The present invention provides a concentration measuring method which includes a first detection step for detecting whether or not liquid conduction is established between the first and the second detection elements (31a, 32a), a second detection step for detecting whether or not liquid conduction is established between the second and the third detection elements (31a, 33a), a measurement step for measuring an electro-physical quantity by using the first through the third detection elements (31a-33a), and a concentration computation step for computing the concentration of the particular component based on the electro-physical quantity. The present invention also provides a concentration measuring apparatus (1) for realizing the concentration measuring method.
摘要翻译：本发明涉及使用测试工具（2）测量样品液体中特定组分的浓度的技术。测试工具（2）包括在用于测量电物量的样品液体的移动方向上按照上述顺序排列的第一至第三检测元件（31a-33a）。本发明提供了一种浓度测定方法，其特征在于，包括检测第一和第二检测元件（31a，32a）之间是否形成液体导通的第一检测步骤，检测是否形成液体导通的第二检测步骤在第二和第三检测元件（31a，33a）之间，使用第一至第三检测元件（31a-33a）测量电物量的测量步骤和用于计算第一至第三检测元件基于电物理量的特定部件。本发明还提供一种用于实现浓度测定方法的浓度测定装置（1）。

6. 发明授权

US5332479A Biosensor and method of quantitative analysis using the same 失效
标题翻译：生物传感器和定量分析方法采用相同的方法
公开(公告)号：US5332479A
公开(公告)日：1994-07-26
申请号：US883367
申请日：1992-05-15
申请人： Harumi Uenoyama , Hisashi Okuda
发明人： Harumi Uenoyama , Hisashi Okuda
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/416 , G01N27/26
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor which electrochemically detects a material which relates to a reaction of a specific compound in a liquid sample with a biologically active substance or its related substance, in which the biologically active material or an optionally used mediator is placed at a part which is remote from a position of an electrode which acts as electrochemical detector means, and optionally the biological active material or the mediator is covered with a polymer layer.
摘要翻译：电化学检测与液体样品中的特定化合物与生物活性物质或其相关物质的反应相关的材料的生物传感器，其中生物活性物质或任选使用的介体放置在远离充当电化学检测器装置的电极的位置，以及任选的生物活性材料或介体的聚合物层被覆盖。

7. 发明授权

US06325975B1 Suction generating device and sample analysis apparatus using the same 失效
标题翻译：抽吸发生装置和使用其的样品分析装置
公开(公告)号：US06325975B1
公开(公告)日：2001-12-04
申请号：US09137169
申请日：1998-08-20
申请人： Michio Naka , Kouji Hirayama , Yoshihiko Higuchi , Masafumi Koike , Hisashi Okuda
发明人： Michio Naka , Kouji Hirayama , Yoshihiko Higuchi , Masafumi Koike , Hisashi Okuda
IPC分类号： G01N2100
摘要： A suction generating device for a sample analysis device is provided. The device comprises four parts, namely, a cover plate 61, a middle plate 62, a bottom plate 63 and an operation plate 64. A protruding portion 642 for compressing the suction generating chamber is formed in an approximately center portion on the lower side of the operation plate 64, a protruding portion 641 for operation is formed in an approximately center portion on the upper side of the operation plate 64. A cavity 631 for inserting the sample analysis device therein is formed in an approximately center portion in the bottom plate 63, and a hole 632 for light irradiation is punched in a determined portion in the cavity 631. A concave portion 623 for fitting the operation plate 64 therein is formed in the middle plate 62, and a window section 621 is formed in the center of the concave portion 623 to let the lower protruding portion 642 on the operation plate 64 protrude therethrough. A window section 611 is formed in the cover plate 61 to let the upper protruding portion 641 on the operation plate 64 protrude therethrough.
摘要翻译：提供了一种用于样本分析装置的抽吸产生装置。该装置包括四个部分，即盖板61，中板62，底板63和操作板64.用于压缩抽吸发生室的突出部分642形成在下侧的大致中心部分操作板64，用于操作的突出部分641形成在操作板64的上侧的大致中心部分。用于将样品分析装置插入其中的空腔631形成在底板63中的大致中心部分并且在空腔631的确定部分中冲压用于光照射的孔632.在中间板62中形成有用于将操作板64装配在其中的凹部623，并且窗口部621形成在凹部623使操作板64上的下突出部642突出。在盖板61上形成窗口部611，使操作板64上的上突出部641突出。

8. 发明授权

US6001307A Device for analyzing a sample 失效
标题翻译：用于分析样品的设备
公开(公告)号：US6001307A
公开(公告)日：1999-12-14
申请号：US847745
申请日：1997-04-22
申请人： Michio Naka , Kouji Hirayama , Yoshihiko Higuchi , Masufumi Koike , Hisashi Okuda
发明人： Michio Naka , Kouji Hirayama , Yoshihiko Higuchi , Masufumi Koike , Hisashi Okuda
IPC分类号： B01L3/00 , G01N33/48
CPC分类号： B01L3/50273 , B01L3/502 , B01L3/502723 , B01L3/502746 , G01N27/3272 , B01L2200/0684 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0825 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , Y10T436/114165 , Y10T436/114998
摘要： This invention provides a device for analyzing a sample which is capable of performing rapid and precise analysis of a small amount of sample, and whose gradient in a measuring apparatus is not limited. This device comprises approximately a rectangular plate shaped body comprising a base member made of resin and a transparent covering. A first depressed cylindrical concave portion is formed in the upper surface of the base member, and a groove is formed in communication with the first depressed cylindrical concave portion, the groove extending to the end of the protrusion portion 5c, and a second depressed cylindrical concave portion which is smaller than the first depressed cylindrical concave portion is formed in a certain position in the groove, the end of the groove opening to the outside at the end of the protrusion portion 5c. Then, the transparent covering is placed over the upper surface of the base member and then integrated together. As a result, the first depressed cylindrical concave portion, the groove, the second depressed cylindrical concave portion, and the opening at the end of the groove are formed into a suction pressure generating chamber, a drawing channel, an analytical section, and an opening for drawing a sample, respectively.
摘要翻译：本发明提供了一种用于分析能够对少量样品进行快速和精确分析的样品的装置，并且其测量装置中的梯度不受限制。该装置包括大致矩形的板状主体，该主体包括由树脂制成的基部构件和透明覆盖物。第一凹陷的圆柱形凹部形成在基部构件的上表面中，并且形成有与第一凹陷的圆柱形凹部连通的凹槽，延伸到突出部5c的端部的凹槽和第二凹陷的圆柱形凹部小于第一凹陷圆柱形凹部的部分形成在凹槽中的一定位置，凹槽的端部在突出部5c的端部向外侧开口。然后，将透明覆盖物放置在基底构件的上表面上，然后将其集成在一起。结果，第一凹陷的圆柱形凹部，凹槽，第二凹陷圆柱形凹部和凹槽的端部处的开口形成为吸入压力产生室，拉伸通道，分析部分和开口分别绘制样品。

9. 发明授权

US5382346A Biosensor and method of quantitative analysis using the same 失效
标题翻译：生物传感器和定量分析方法采用相同的方法
公开(公告)号：US5382346A
公开(公告)日：1995-01-17
申请号：US138263
申请日：1993-10-20
申请人： Harumi Uenoyama , Hisashi Okuda
发明人： Harumi Uenoyama , Hisashi Okuda
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/416 , G01N27/26
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A biosensor which electrochemically detects a material which relates to a reaction of a specific compound in a liquid sample with a biologically active substance or its related substance, in which the biologically active material or an optionally used mediator is placed at a part which is remote from a position of an electrode which acts as electrochemical detector means, and optionally the biological active material or the mediator is covered with a polymer layer.
摘要翻译：电化学检测与液体样品中的特定化合物与生物活性物质或其相关物质的反应相关的材料的生物传感器，其中生物活性物质或任选使用的介体放置在远离充当电化学检测器装置的电极的位置，以及任选的生物活性材料或介体的聚合物层被覆盖。

10. 发明申请

US20060018790A1 Device and method for analyizing a sample 审中-公开
标题翻译：用于分析样品的装置和方法
公开(公告)号：US20060018790A1
公开(公告)日：2006-01-26
申请号：US11234455
申请日：2005-09-23
申请人： Michio Naka , Kouji Hirayama , Yoshihiko Higuchi , Masufumi Koike , Hisashi Okuda
发明人： Michio Naka , Kouji Hirayama , Yoshihiko Higuchi , Masufumi Koike , Hisashi Okuda
IPC分类号： G01N21/00
CPC分类号： G01N1/14 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2300/0645 , B01L2300/0816 , B01L2300/0825 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/084 , G01N21/03 , G01N21/05 , G01N21/11 , G01N21/78 , G01N33/52 , G01N33/521 , G01N2021/0321 , G01N2021/0325 , G01N2021/0346
摘要： This invention provides a device for analyzing a sample which is capable of performing rapid and precise analysis of a small amount of sample, and whose gradient in a measuring apparatus is not limited. This device comprises approximately a rectangular plate shaped body comprising a base member made of resin and a transparent covering. A first depressed cylindrical concave portion is formed in the upper surface of the base member, and a groove is formed in communication with the first depressed cylindrical concave portion, the groove extending to the end of the protrusion portion 5c, and a second depressed cylindrical concave portion which is smaller than the first depressed cylindrical concave portion is formed in a certain position in the groove, the end of the groove opening to the outside at the end of the protrusion portion 5c. Then, the transparent covering is placed over the upper surface of the base member and then integrated together. As a result, the first depressed cylindrical concave portion, the groove, the second depressed cylindrical concave portion, and the opening at the end of the groove are formed into a suction pressure generating chamber, a drawing channel, an analytical section, and an opening for drawing a sample, respectively.
摘要翻译：本发明提供了一种用于分析能够对少量样品进行快速和精确分析的样品的装置，并且其测量装置中的梯度不受限制。该装置包括大致矩形的板状主体，该主体包括由树脂制成的基部构件和透明覆盖物。第一凹陷的圆柱形凹部形成在基部构件的上表面中，并且形成有与第一凹陷圆柱形凹部连通的凹槽，凹槽延伸到突出部分5c的端部，并且第二凹陷圆柱形小于第一凹陷圆柱形凹部的凹部形成在凹槽中的一定位置，凹槽的端部在突出部5c的端部向外侧开口。然后，将透明覆盖物放置在基底构件的上表面上，然后将其集成在一起。结果，第一凹陷的圆柱形凹部，凹槽，第二凹陷圆柱形凹部和凹槽的端部处的开口形成为吸入压力产生室，拉伸通道，分析部分和开口分别绘制样品。

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