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1. 发明授权

US07122111B2 Sample discriminating method 有权
标题翻译：样本识别方法
公开(公告)号：US07122111B2
公开(公告)日：2006-10-17
申请号：US10878536
申请日：2004-06-29
申请人： Hiroyuki Tokunaga , Shoji Miyazaki , Hideyuki Baba , Yoichi Inoue , Kazuo Iketaki , Katsumi Hamamoto
发明人： Hiroyuki Tokunaga , Shoji Miyazaki , Hideyuki Baba , Yoichi Inoue , Kazuo Iketaki , Katsumi Hamamoto
IPC分类号： G01N27/327 , G01N33/48 , G01N31/00
CPC分类号： G01N27/3274 , Y10T436/11
摘要： A glucose sensor system comprising the steps of using as a sample discriminating parameter a ratio (I/ΔI) of a measured current value I to the time-differential value of the current value ΔI, defining a discrimination function that discriminates whether a sample is blood or control fluid and uses the discriminating parameter as an independent variable, quantitating as a discriminating index a numeric value obtained by substituting a discriminating parameter value into this discrimination function, and automatically discriminating, based on this index, whether the sample is blood or a control fluid, whereby a kind of the sample can be automatically quantitated by measuring electric current when a sensor system is used for quantitating the concentration of an analysis object in the sample.
摘要翻译：一种葡萄糖传感器系统，包括以下步骤：将测量电流值I与当前值ΔI的时间微分值的比值（I / DeltaI）用作样本鉴别参数，所述差分值定义了鉴别样品是否为血液的鉴别功能或控制流体，并将鉴别参数用作独立变量，作为鉴别指标，将通过将鉴别参数值代入该鉴别函数而获得的数值，并根据该指标自动鉴别样品是血液还是控制流体，从而当使用传感器系统来定量样品中的分析对象的浓度时，可以通过测量电流来自动量化样品的种类。

2. 发明授权

US06824670B2 Sample discriminating method 有权
标题翻译：样本识别方法
公开(公告)号：US06824670B2
公开(公告)日：2004-11-30
申请号：US09890097
申请日：2001-10-29
申请人： Hiroyuki Tokunaga , Shoji Miyazaki , Hideyuki Baba , Yoichi Inoue , Kazuo Iketaki , Katsumi Hamamoto
发明人： Hiroyuki Tokunaga , Shoji Miyazaki , Hideyuki Baba , Yoichi Inoue , Kazuo Iketaki , Katsumi Hamamoto
IPC分类号： G01N2726
CPC分类号： G01N27/3274 , Y10T436/11
摘要： A glucose sensor system comprising the steps of using as a sample discriminating parameter a ratio (I/&Dgr;I) of a measured current value I to the time-differential value of the current value &Dgr;I, defining a discrimination function that discriminates whether a sample is blood or control fluid and uses the discriminating parameter as an independent variable, quantitating as a discriminating index a numeric value obtained by substituting a discriminating parameter value into this discrimination function, and automatically discriminating, based on this index, whether the sample is blood or a control fluid, whereby a kind of the sample can be automatically quantitated by measuring electric current when a sensor system is used for quantitating the concentration of an analysis object in the sample.
摘要翻译：一种葡萄糖传感器系统，包括以下步骤：将测量电流值I与当前值ΔI的时间微分值的比值（I / DeltaI）用作样本鉴别参数，所述差分值定义了鉴别样品是否为血液的鉴别功能或控制流体，并将鉴别参数用作独立变量，作为鉴别指标，将通过将鉴别参数值代入该鉴别函数而获得的数值，并根据该指标自动鉴别样品是血液还是控制流体，从而当使用传感器系统来定量样品中的分析对象的浓度时，可以通过测量电流来自动量化样品的种类。

3. 发明授权

US06730046B1 Body fluid sampling apparatus 失效
标题翻译：体液取样仪
公开(公告)号：US06730046B1
公开(公告)日：2004-05-04
申请号：US10089296
申请日：2002-03-27
申请人： Katsumi Hamamoto , Atsushi Murakami , Hiroshi Hyodo
发明人： Katsumi Hamamoto , Atsushi Murakami , Hiroshi Hyodo
IPC分类号： A61B515
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150412 , A61B5/15113 , A61B5/15117
摘要： A body fluid sampling apparatus (A), comprising a piston (11) provided in a tubular main case (10), a first plunger rod (12) extending into the piston (11) integrally with each other; a first spring (13) elastically energzing the piston (11) toward the upper end side, a second plunger rod (15) installed in the first plunger rod (12) through a second spring (14), a lancet mounted body (16) provided on the second plunger rod (15) and having a lancet (B) mounted therein, a third spring (17) elastically energizing the lancet mounted body (16) toward the upper end side, latch mechanisms (20, 30) suppressing the second plunger rod (15) and first plunger rod (12) when the first plunger rod (12) is moved to the lower end side by he push-down of the piston (11), and a release mechanism (40) for releasing the locked state of the first plunger rod (12) and the second plunger rod (15).
摘要翻译：一种体液取样装置（A），包括设置在管状主壳体（10）中的活塞（11），彼此一体地延伸到所述活塞（11）中的第一柱塞杆（12）第一弹簧（13）朝向上端侧弹性地激励活塞（11），通过第二弹簧（14）安装在第一柱塞杆（12）中的第二柱塞杆（15），刺血针安装体（16）设置在所述第二柱塞杆（15）上并且具有安装在其中的刺血针（B）的第三弹簧（17）朝向所述上端侧弹性激励所述刺血针安装体（16），所述闩锁机构（20,30）当第一活塞杆（12）通过活塞（11）的下推移动到下端侧时，柱塞杆（15）和第一柱塞杆（12）以及用于释放锁定的释放机构第一柱塞杆（12）和第二柱塞杆（15）的状态。

4. 发明授权

US5272060A Method for determination of glucose concentration in whole blood 失效
标题翻译：全血葡萄糖浓度测定方法
公开(公告)号：US5272060A
公开(公告)日：1993-12-21
申请号：US821452
申请日：1992-01-16
申请人： Katsumi Hamamoto , Kazunori Hirose
发明人： Katsumi Hamamoto , Kazunori Hirose
IPC分类号： C12Q1/00 , C12Q1/54 , C12Q1/26 , C12Q1/02 , G01N33/00 , G01N33/48
CPC分类号： C12Q1/54 , C12Q1/006 , Y10T436/144444
摘要： There is provided a method for the determination of a glucose concentration in a whole blood utilizing a biosensor. A correction of the measured glucose concentration for dilution error introduced by the solid component of blood cells is calculated based on the change in glucose concentration measured before and after significant glucose has diffused from blood cells into the buffer used to dilute the sample. Thus, the need to centrifuge blood samples to obtain a cell-free serum sample for glucose determination is eliminated.
摘要翻译：提供了利用生物传感器测定全血中葡萄糖浓度的方法。基于在显着葡萄糖从血液细胞扩散到用于稀释样品的缓冲液中之前和之后测量的葡萄糖浓度的变化来计算由血细胞的固体组分引入的用于稀释误差的测量葡萄糖浓度的校正。因此，消除了离心血液样品以获得用于葡萄糖测定的无细胞血清样品的需要。

5. 发明授权

US07470400B2 Sensor cartridge, sensor feeder, and measuring instrument 有权
标题翻译：传感器墨盒，传感器进纸器和测量仪器
公开(公告)号：US07470400B2
公开(公告)日：2008-12-30
申请号：US10204508
申请日：2001-02-22
申请人： Takatoshi Uchigaki , Takao Fukuoka , Yasuhide Kusaka , Katsumi Hamamoto
发明人： Takatoshi Uchigaki , Takao Fukuoka , Yasuhide Kusaka , Katsumi Hamamoto
IPC分类号： G01N33/00
CPC分类号： G01N33/48757 , B01L9/52 , B01L2300/0825
摘要： A sensor cartridge (1) for use on a sensor feeder includes a cartridge body (10) and a mold (12). The cartridge body (10) has an upper surface (10a), a front (10c) extending continously from the upper surface, and a plurality of sensor-holding slots (11). Each of the sensor-holding slots (11) includes a first opening formed in the upper surface (10a) and a second opening formed in the front (10c) and communicating with the first opening. The mold (12) closes the first opening and second openings in case sensors are charged in the sensor-holding slots (11).
摘要翻译：用于传感器馈送器的传感器盒（1）包括盒体（10）和模具（12）。盒体（10）具有上表面（10a），从上表面连续延伸的前（10c）和多个传感器保持槽（11）。每个传感器保持槽（11）包括形成在上表面（10a）中的第一开口和形成在前面（10c）中并与第一开口连通的第二开口。在传感器保持槽（11）中，传感器被充电的情况下，模具（12）封闭第一开口和第二开口。

6. 发明授权

US06849052B2 Body fluid measuring apparatus with lancet and lancet holder used for the measuring apparatus 有权
标题翻译：用于测量装置的具有刺血针和刺血针架的体液测量装置
公开(公告)号：US06849052B2
公开(公告)日：2005-02-01
申请号：US10149636
申请日：2000-12-13
申请人： Takatoshi Uchigaki , Katsumi Hamamoto , Yasuhide Kusaka
发明人： Takatoshi Uchigaki , Katsumi Hamamoto , Yasuhide Kusaka
IPC分类号： A61B5/00 , A61B5/15 , G01N33/487
CPC分类号： G01N33/4875 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150099 , A61B5/150358 , A61B5/150435 , A61B5/150809 , A61B5/150946 , A61B5/15105 , A61B5/15194 , A61B5/157
摘要： A body fluid measuring apparatus, comprising a main body (20) and a lancet holder (30) installed on the main body (20), the lancet holder (30) further comprising a lancet (31) capable of being moved for piercing to allow body fluid to be bled from skin (S) and a biosensor (36) introducing the bled body fluid for a specified measurement, wherein the biosensor (36) is moved in a specified direction by a sensor moving mechanism (40, 42).
摘要翻译：一种体液测量装置，包括安装在主体（20）上的主体（20）和刺血针保持架（30），所述柳叶刀套（30）还包括能够移动以刺穿的刺血针（31）从皮肤（S）排出的体液和引导体液的生物传感器（36）进行规定的测量，其中，生物传感器（36）通过传感器移动机构（40,42）在规定的方向移动。

7. 发明授权

US06576117B1 Method and apparatus for electrochemical measurement using statistical technique 失效
标题翻译：使用统计学方法进行电化学测量的方法和装置
公开(公告)号：US06576117B1
公开(公告)日：2003-06-10
申请号：US09700765
申请日：2001-01-29
申请人： Kazuo Iketaki , Yoichi Inoue , Katsumi Hamamoto
发明人： Kazuo Iketaki , Yoichi Inoue , Katsumi Hamamoto
IPC分类号： G01N27327
CPC分类号： G01N27/3274
摘要： A predetermined voltage is applied to a biosensor twice to promote an electrochemical reaction, and the following parameters (P1 and P2) are calculated from the values of detected current. A statistical technique is used with these parameters to compensate for errors so that the concentration of an object can be determined. P1: the ratio (If/Ib) of the maximum current (If) or a current occurring the maximum in the first excitation to a current (Ib) read at any point in the second excitation. P2: a current (Ib) read at any point in the second excitation.
摘要翻译：将预定电压施加到生物传感器两次以促进电化学反应，并根据检测电流的值计算以下参数（P1和P2）。使用这些参数的统计技术来补偿误差，从而可以确定物体的浓度。 P1：最大电流（If）的比率（If / Ib）或在第一激励中在第二激励中的任何点读取的电流（Ib）中发生的最大值的电流。 P2：在第二激励中的任何点读取电流（Ib）。

8. 发明授权

US5720862A Sensor and production method of and measurement method using the same 失效
标题翻译：传感器及其制作方法及测量方法采用相同的方法
公开(公告)号：US5720862A
公开(公告)日：1998-02-24
申请号：US628485
申请日：1996-04-05
申请人： Katsumi Hamamoto , Hisashi Okuda
发明人： Katsumi Hamamoto , Hisashi Okuda
IPC分类号： G01N27/327 , C12M1/34 , C12Q1/00 , C12Q1/26 , G01N27/416 , G01N27/26
CPC分类号： C12Q1/002 , C12Q1/005 , Y10S435/817
摘要： There is provided a sensor for the measurement of a content of a material in liquid which material is oxidized with an oxidase enzyme in which sensor a reagent layer is formed on an electrode system composed of a measuring electrode and a counter electrode both of which are formed on an insulating substrate, the reagent layer is composed of a hydrophilic polymer layer comprising a hydrophilic polymer and a reactive layer comprising the oxidase enzyme and an electron carrier, and the reagent layer further comprises a phosphate.
摘要翻译：提供了一种传感器，用于测量液体中的材料的含量，该材料被氧化酶氧化，其中传感器在其上形成有测量电极和对电极的电极系统上形成试剂层在绝缘基板上，试剂层由包含亲水性聚合物的亲水性聚合物层和包含氧化酶和电子载体的反应层构成，试剂层还包含磷酸盐。

9. 发明申请

US20090074617A1 SENSOR CARTRIDGE, SENSOR FEEDER, AND MEASURING INSTRUMENT 有权
标题翻译：传感器盒，传感器进给器和测量仪器
公开(公告)号：US20090074617A1
公开(公告)日：2009-03-19
申请号：US12274912
申请日：2008-11-20
申请人： Takatoshi UCHIGAKI , Takao Fukuoka , Yasuhide Kusaka , Katsumi Hamamoto
发明人： Takatoshi UCHIGAKI , Takao Fukuoka , Yasuhide Kusaka , Katsumi Hamamoto
IPC分类号： B01J19/00
CPC分类号： G01N33/48757 , B01L9/52 , B01L2300/0825
摘要： A sensor cartridge (1) for use on a sensor feeder includes a cartridge body (10) and a mold (12). The cartridge body (10) has an upper surface (10a), a front (10c) extending continuously from the upper surface, and a plurality of sensor-holding slots (11). Each of the sensor-holding slots (11) includes a first opening formed in the upper surface (10a) and a second opening formed in the front (10c) and communicating with the first opening. The mold (12) closes the first opening and second openings in case sensors are charged in the sensor-holding slots (11).
摘要翻译：用于传感器馈送器的传感器盒（1）包括盒体（10）和模具（12）。盒体（10）具有上表面（10a），从上表面连续延伸的前（10c）和多个传感器保持槽（11）。每个传感器保持槽（11）包括形成在上表面（10a）中的第一开口和形成在前面（10c）中并与第一开口连通的第二开口。在传感器保持槽（11）中，传感器被充电的情况下，模具（12）封闭第一开口和第二开口。

10. 发明授权

US07250056B2 Lancet-integrated mounter and method of making the same 有权
标题翻译：柳叶刀综合贴片机及其制作方法
公开(公告)号：US07250056B2
公开(公告)日：2007-07-31
申请号：US10479528
申请日：2002-06-10
申请人： Katsumi Hamamoto
发明人： Katsumi Hamamoto
IPC分类号： A61B17/32 , A61B5/151
CPC分类号： A61B5/1486 , A61B5/150022 , A61B5/150099 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15142 , A61B5/1519 , A61B5/15194 , A61B5/157 , A61B2562/0295
摘要： A mounter (3) integrally provided with a lancing element (47B) and analyzer includes a lancing member (47) provided with the lancing element (47B), a first member (4) including an accommodation portion (40) for holding the lancing member (47), and a second member (5) formed separately from the first member (4) for holding the analyzer (6). The accommodation portion (40) includes an accommodation space (43) communicable with the outside through a first opening (43a) and a second opening (43b). The lancing member (47) is held and hermetically sealed in the accommodation space (43) by closing the first opening (43a) and the second opening (43b) with a first seal member (44a) and a second seal member (44b).
摘要翻译：整体设置有穿刺元件（47B）和分析器的安装器（3）包括设置有穿刺元件（47B）的穿刺构件（47），包括容纳部分（40）的第一构件（4）以及与用于保持分析器（6）的第一构件（4）分开形成的第二构件（5）。容纳部分（40）包括通过第一开口（41a）和第二开口（43b）与外部连通的容纳空间（43）。通过用第一密封构件（44a）和第二密封构件（44a）封闭第一开口（43a）和第二开口（43b），将穿刺构件（47）保持并气密地密封在容纳空间（43） 44 b）。

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