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    • 2. 发明授权
    • Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction
    • 用于控制基于微生物相互作用的方法的烷氧基内酯,烷氧基内酰胺和烷氧基硫醇内酰胺
    • US07825268B2
    • 2010-11-02
    • US11473795
    • 2006-06-22
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndré Hätzelt
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndré Hätzelt
    • A61K31/4015A61K31/341C07D207/26C07D307/33
    • C07D307/33A61L2/0082A61L2/16
    • Compounds of the Formula I, wherein A1 is O or NH; A2 is O or S; each of R1 and R2 is independently hydrogen, a methyl or C2-C8-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R3 is a C1-C18-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R1, R2 and R3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C1-C6-alkyl, trifluoromethyl, C1-C6-alkoxy, C6-C10-aryl, and C1-C6-alkyl-C6-C10-aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
    • 式I的化合物,其中A1是O或NH; A2为O或S; R 1和R 2各自独立地为氢,甲基或C 2 -C 8饱和或单或双不饱和,支链或直链烃基; 并且R 3是C 1 -C 18饱和或单或双不饱和,支链或直链烃基,其中R 1,R 2和R 3各自包含选自链和O中的O和S的杂原子和/或是单 或被选自卤素,羟基,C 1 -C 6 - 烷基,三氟甲基,C 1 -C 6 - 烷氧基,C 6 -C 10 - 芳基和C 1 -C 6 - 烷基-C 6 -C 10 - 芳基的取代基取代或多取代 可用于控制微生物之间的相互作用过程,例如在生物膜的开发和/或成熟中; 多细胞群体行为; 抗生素抗药性的协调发展; 协同合成抗生素; 色素的协同合成; 协同生产细胞外酶; 或协同生产的毒力因素。