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1. 发明授权

US4410536A 7,8,9,10-Tetrahydrothieno[3,2-e]pyrido[4,3-b]indole compounds and their anti-depressant use 失效
标题翻译： 7,8,9,10-四氢噻吩并[3,2-e]吡啶并[4,3-b]吲哚化合物及其抗抑郁剂用途
公开(公告)号：US4410536A
公开(公告)日：1983-10-18
申请号：US258174
申请日：1981-04-27
申请人： Karl-Heinz Boltze , Peter-Rudolf Seidel , Haireddin Jacobi , Helmut H. Schwarz , Gunter Schollnhammer , Hans-Dieter Dell
发明人： Karl-Heinz Boltze , Peter-Rudolf Seidel , Haireddin Jacobi , Helmut H. Schwarz , Gunter Schollnhammer , Hans-Dieter Dell
IPC分类号： A61K31/395 , A61K31/435 , A61P25/00 , A61P25/24 , A61P25/26 , C07C45/00 , C07D333/54 , C07D333/70 , C07D495/14 , C07D495/18 , C07D471/22 , A61K31/44 , A61K31/495 , A61K31/54
CPC分类号： C07D333/54 , C07C205/45 , C07C45/004 , C07D333/70 , C07D495/14
摘要： The present invention relates to certain new 7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole compound, to a process for their production and to their use as agents which have an influence on the central nervous system.The ring system according to the invention has not hitherto been described in the literature.
摘要翻译：本发明涉及某些新的7,8,9,10-四氢噻吩并[3,2-e]吡啶并[4,3-b]吲哚化合物，其制备方法及其用作具有影响的试剂在中枢神经系统上。迄今为止尚未描述根据本发明的环系统。

2. 发明授权

US4241207A Organonitrogen derivatives of 2-benzopyranone 失效
标题翻译： 2-苯并吡喃酮的有机氮衍生物
公开(公告)号：US4241207A
公开(公告)日：1980-12-23
申请号：US963652
申请日：1978-11-24
申请人： Karl-Heinz Boltze , Peter-Rudolf Seidel , Haireddin Jacobi , Helmut Schwarz
发明人： Karl-Heinz Boltze , Peter-Rudolf Seidel , Haireddin Jacobi , Helmut Schwarz
IPC分类号： A61K31/37 , A61P9/08 , A61P9/10 , C07D311/16 , C07D311/08 , C07D407/14
CPC分类号： C07D311/16 , Y10S514/929
摘要： Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and eachR individually is selected from the group consisting of alkylamino and dialkylamino in which one carbon atom in the alkyl moiety may be replaced by an oxygen atom and one hydrogen atom may be replaced by a hydroxyl group which may in turn be esterified with a 3,4,5-trimethoxybenzoyl or 3,4,5-trimethoxycinnamoyl group; amino substituted once or twice by alkenyl, aralkyl, or cycloalkyl; ora 4- to 7-membered N-containing heterocyclic ring linked through a nitrogen atom and which contains up to 3 hetero atoms, which heterocyclic ring may be substituted by phenyl, alkyl or hydroxyalkyl, wherein the hydroxy group may be esterfied by a 3,4,5-trimethoxy benzoyl or 3,4,5-trimethoxy cinnamoyl group;or a salt of each compound with a physiologically acceptable acid; possess outstanding activity as coronary dilators. Processes for producing such compounds are also disclosed.
摘要翻译：新颖的2-苯并吡喃酮化合物，其中X是3,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 并且每个R各自选自烷基氨基和二烷基氨基，其中烷基部分中的一个碳原子可以被氧原子代替，一个氢原子可以被羟基代替，羟基可以依次用3 ，4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 氨基被烯基，芳烷基或环烷基取代一次或两次; 或通过氮原子连接并含有至多3个杂原子的4至7元含氮杂环，该杂环可被苯基，烷基或羟烷基取代，其中羟基可被3 ，4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 或每种化合物与生理上可接受的酸的盐; 作为冠状动脉扩张器具有突出的活性。还公开了用于生产这些化合物的方法。

3. 发明授权

US4144336A 2-Benzopyranone derivatives, process for their production, their use as medicaments, more especially as coronary dilators 失效
标题翻译： 2-苯并吡喃酮衍生物，其制备方法，用作药物，更特别地作为冠状动脉扩张剂
公开(公告)号：US4144336A
公开(公告)日：1979-03-13
申请号：US703340
申请日：1976-07-08
申请人： Karl-Heinz Boltze , Peter-Rudolf Seidel , Haireddin Jacobi , Helmut Schwarz
发明人： Karl-Heinz Boltze , Peter-Rudolf Seidel , Haireddin Jacobi , Helmut Schwarz
IPC分类号： A61K31/37 , A61P9/08 , A61P9/10 , C07D311/16 , C07D407/14
CPC分类号： C07D311/16 , Y10S514/929
摘要： Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and eachR individually is selected from the group consisting of alkylamino and dialkylamino in which one carbon atom in the alkyl moiety may be replaced by an oxygen atom and one hydrogen atom may be replaced by a hydroxyl group which may in turn be esterified with a 3,4,5-trimethoxybenzoyl or 3,4,5-trimethoxycinnamoyl group; amino substituted once or twice by alkenyl, aralkyl, or cycloalkyl; or a 4- to 7-membered N-containing heterocyclic ring linked through a nitrogen atom and which contains up to 3 hetero atoms, which heterocyclic ring may be substituted by phenyl, alkyl or hydroxyalkyl, wherein the hydroxy group may be esterified by a 3,4,5-trimethoxy benzoyl or 3,4,5-trimethoxy cinnamoyl group;Or a salt of each compound with a physiologically acceptable acid; possess outstanding activity as coronary dilators. Processes for producing such compounds are also disclosed.
摘要翻译：新颖的2-苯并吡喃酮化合物，其中X是3,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 并且每个R各自选自烷基氨基和二烷基氨基，其中烷基部分中的一个碳原子可以被氧原子代替，一个氢原子可以被羟基代替，羟基可以依次用3 ，4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 氨基被烯基，芳烷基或环烷基取代一次或两次; 或通过氮原子连接并含有至多3个杂原子的4至7元含氮杂环，该杂环可以被苯基，烷基或羟烷基取代，其中羟基可以被3 ，4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 或每种化合物的盐与生理上可接受的酸; 作为冠状动脉造影器的不可忽视的活动。还公开了用于生产这些化合物的方法。

4. 发明授权

US4324787A 2-Oxo-1-pyrrolidineacetic acid compounds and their medicinal use 失效
标题翻译： 2-氧代-1-吡咯烷乙酸化合物及其药用
公开(公告)号：US4324787A
公开(公告)日：1982-04-13
申请号：US965374
申请日：1978-11-30
申请人： Karl-Heinz Boltze , Hans-Dieter Dell , Haireddin Jacobi
发明人： Karl-Heinz Boltze , Hans-Dieter Dell , Haireddin Jacobi
IPC分类号： A61K31/40 , A61K31/4015 , A61P25/28 , C07D207/26 , C07D207/27 , A61K31/495 , C07D207/12 , C07D403/14
CPC分类号： C07D207/27
摘要： The invention relates to 2-oxo-1-pyrrolidineacetic acid compounds, useful as psychopharmacological agents. Also included in the invention are pharmaceutical compositions containing said compounds and methods for the use of said compounds and compositions.
摘要翻译：本发明涉及可用作精神药理学药剂的2-氧代-1-吡咯烷酸乙酸化合物。本发明还包括含有所述化合物的药物组合物和使用所述化合物和组合物的方法。

5. 发明授权

US3966956A [1-(P-Chlorobenzoyl)-5-methoxy-2-methyl-3-indole]acetoxyacetic acid and salts in treating inflammation 失效
标题翻译： {8- 1-（对氯苯甲酰基）-5-甲氧基-2-甲基-3-吲哚{9乙酰氧基乙酸和治疗炎症的盐
公开(公告)号：US3966956A
公开(公告)日：1976-06-29
申请号：US566452
申请日：1975-04-09
申请人： Karl-Heinz Boltze , Otfried Brendler , Hans-Dieter Dell , Haireddin Jacobi
发明人： Karl-Heinz Boltze , Otfried Brendler , Hans-Dieter Dell , Haireddin Jacobi
IPC分类号： C07D209/28 , A61K31/40
CPC分类号： C07D209/28
摘要： [1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-3-INDOLE]-ACETOXYACETIC ACID OF THE FORMULA ##SPC1##Possesses outstanding antiphlogistic activity without the side effects of certain conventional antiphlogistic pharmaceuticals.
摘要翻译： [1-（对氯苯甲酰基）-5-甲氧基-2-甲基-3-吲哚基] - 乙酰氧基酸的公式表现超过某些常规抗药性药物的副作用超过抗菌活性。

6. 发明授权

US4246278A Medicaments having an antiphlogistic action 失效
标题翻译：具有消炎作用的药物
公开(公告)号：US4246278A
公开(公告)日：1981-01-20
申请号：US963651
申请日：1978-11-24
申请人： Wolfgang Opitz , Eugen Etschenberg , Hans-Dieter Dell , Haireddin Jacobi
发明人： Wolfgang Opitz , Eugen Etschenberg , Hans-Dieter Dell , Haireddin Jacobi
IPC分类号： A61K9/12 , A61K9/14 , A61K9/20 , A61K31/265 , C07C323/52 , C07C327/22 , C07C327/28
CPC分类号： A61K31/265 , C07C323/52 , C07C327/22 , C07C327/28
摘要： The present invention provides, inter alia, antiphlogistically effective agents, including pharmaceutical compositions containing said agents. Also included are methods for the use of said agents. The active compounds are those of the formula ##STR1## or an ester thereof, in which X denotes a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl or alkylsulphonyl group or a hydroxyl or mercapto group,Y denotes a grouping ##STR2## in which R denotes a hydrogen atom or an alkyl group, andZ denotes a hydroxyl group or an alkoxy or alkylthio group, at least one of the substituents X or Z in each case denoting a sulphur-containing radical.
摘要翻译：本发明尤其提供消炎有效药剂，包括含有所述药物的药物组合物。还包括使用所述试剂的方法。活性化合物是下式（I）或其酯，其中X表示氢原子，烷基，烷氧基，烷硫基，烷基亚磺酰基或烷基磺酰基或羟基或巯基 Y表示其中R表示氢原子或烷基，Z表示羟基或烷氧基或烷硫基的分组，每种情况下至少一个取代基X或Z表示含硫的激进。

7. 发明授权

US4323517A Methoxy and methylsulfinylthiolesters 失效
标题翻译：甲氧基和甲基亚硫酰硫醇酯
公开(公告)号：US4323517A
公开(公告)日：1982-04-06
申请号：US182353
申请日：1980-08-29
申请人： Wolfgang Opitz , Eugen Etscherberg , Hans-Dieter Dell , Haireddin Jacobi
发明人： Wolfgang Opitz , Eugen Etscherberg , Hans-Dieter Dell , Haireddin Jacobi
IPC分类号： C07C327/22 , C07C153/017
CPC分类号： C07C327/22
摘要： The present invention provides, inter alia, antiphlogistically effective agents, including pharmaceutical compositions containing said agents. Also included are methods for the use of said agents. The active compounds are those of the formula ##STR1## or an ester thereof, in which X denotes a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl or alkylsulphonyl group or a hydroxyl or mercapto group,Y denotes a grouping ##STR2## in which R denotes a hydrogen atom or an alkyl group, andZ denotes a hydroxyl group or an alkoxy or alkylthio group, at least one of the substituents X or Z in each case denoting a sulphur-containing radical.
摘要翻译：本发明尤其提供消炎有效药剂，包括含有所述药物的药物组合物。还包括使用所述试剂的方法。活性化合物是下式（I）或其酯，其中X表示氢原子，烷基，烷氧基，烷硫基，烷基亚磺酰基或烷基磺酰基或羟基或巯基 Y表示其中R表示氢原子或烷基，Z表示羟基或烷氧基或烷硫基的分组，每种情况下至少一个取代基X或Z表示含硫的激进。

8. 发明授权

US4069336A (2-Oxo-pyrrolidines)-acetic hydrazides 失效
标题翻译：（2-氧代吡咯烷） - 甲基水合物
公开(公告)号：US4069336A
公开(公告)日：1978-01-17
申请号：US661138
申请日：1976-02-25
申请人： Fritz-Walter Lange , Haireddin Jacobi , Jens Muller
发明人： Fritz-Walter Lange , Haireddin Jacobi , Jens Muller
IPC分类号： C07D207/26 , C07D207/27 , A61K31/40 , C07D403/12
CPC分类号： C07D207/27
摘要： The present invention pertains to novel (2-oxo-pyrrolidine-1)-acetic hydrazides, methods for preparation and subsequent treatment therewith, and pharmaceutical preparations containing the same.
摘要翻译：本发明涉及新型（2-氧代 - 吡咯烷-1） - 乙酰肼，其制备方法和随后的处理方法以及含有该方法的药物制剂。

9. 发明授权

US4332819A Antiphlogistic agent and its use 失效
标题翻译：消炎药及其用途
公开(公告)号：US4332819A
公开(公告)日：1982-06-01
申请号：US241146
申请日：1981-03-06
申请人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
发明人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
IPC分类号： A61K9/12 , A61K31/10 , A61K31/21 , A61K31/265 , A61P29/00 , C07C327/20
CPC分类号： A61K31/265 , C07C327/00
摘要： The invention relates to compositions containing S-benzyl 3-benzylthiopropionothioate for the treatment of inflammatory processes. Also included in the invention are methods for combating illnesses caused by inflammatory, processes, which methods involve use of medicaments containing said S-benzyl 3-benzylthiopropionothioate.
摘要翻译：本发明涉及含有S-苄基3-苄硫基丙硫杆酸酯用于治疗炎症过程的组合物。本发明还包括用于对抗由炎症，过程引起的疾病的方法，该方法涉及使用含有所述S-苄基-3-硫代丙酸硫酸酯的药物。

10. 发明授权

US4285935A Dehydropeptide compounds, their production and their medical use 失效
标题翻译：脱氢肽化合物，其生产和医疗用途
公开(公告)号：US4285935A
公开(公告)日：1981-08-25
申请号：US114468
申请日：1980-01-23
申请人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
发明人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
IPC分类号： C07K1/113 , A61K38/00 , A61P7/02 , A61P43/00 , C07K5/06 , C07K5/065 , A61K37/00 , C07C103/52
CPC分类号： C07K5/06078 , A61K38/00
摘要： This invention relates to dehydropeptides containing a tryptophan moiety useful as tumour-resolving and/or histolytic medicaments. Also included in the invention are methods for the preparation of said dehydropeptides, compositions containing said dehydropeptides and methods for the use of said dehydropeptides and dehydropeptide compositions.
摘要翻译：本发明涉及含有可用作肿瘤分解和/或组织溶解药物的色氨酸部分的脱氢肽。本发明还包括制备所述脱氢肽的方法，含有所述脱氢肽的组合物和使用所述脱氢肽和脱氢肽组合物的方法。

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