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    • 3. 发明授权
    • Organonitrogen derivatives of 2-benzopyranone
    • 2-苯并吡喃酮的有机氮衍生物
    • US4241207A
    • 1980-12-23
    • US963652
    • 1978-11-24
    • Karl-Heinz BoltzePeter-Rudolf SeidelHaireddin JacobiHelmut Schwarz
    • Karl-Heinz BoltzePeter-Rudolf SeidelHaireddin JacobiHelmut Schwarz
    • A61K31/37A61P9/08A61P9/10C07D311/16C07D311/08C07D407/14
    • C07D311/16Y10S514/929
    • Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and eachR individually is selected from the group consisting of alkylamino and dialkylamino in which one carbon atom in the alkyl moiety may be replaced by an oxygen atom and one hydrogen atom may be replaced by a hydroxyl group which may in turn be esterified with a 3,4,5-trimethoxybenzoyl or 3,4,5-trimethoxycinnamoyl group; amino substituted once or twice by alkenyl, aralkyl, or cycloalkyl; ora 4- to 7-membered N-containing heterocyclic ring linked through a nitrogen atom and which contains up to 3 hetero atoms, which heterocyclic ring may be substituted by phenyl, alkyl or hydroxyalkyl, wherein the hydroxy group may be esterfied by a 3,4,5-trimethoxy benzoyl or 3,4,5-trimethoxy cinnamoyl group;or a salt of each compound with a physiologically acceptable acid; possess outstanding activity as coronary dilators. Processes for producing such compounds are also disclosed.
    • 新颖的2-苯并吡喃酮化合物,其中X是3,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 并且每个R各自选自烷基氨基和二烷基氨基,其中烷基部分中的一个碳原子可以被氧原子代替,一个氢原子可以被羟基代替,羟基可以依次用3 ,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 氨基被烯基,芳烷基或环烷基取代一次或两次; 或通过氮原子连接并含有至多3个杂原子的4至7元含氮杂环,该杂环可被苯基,烷基或羟烷基取代,其中羟基可被3 ,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 或每种化合物与生理上可接受的酸的盐; 作为冠状动脉扩张器具有突出的活性。 还公开了用于生产这些化合物的方法。
    • 6. 发明授权
    • 2-Benzopyranone derivatives, process for their production, their use as
medicaments, more especially as coronary dilators
    • 2-苯并吡喃酮衍生物,其制备方法,用作药物,更特别地作为冠状动脉扩张剂
    • US4144336A
    • 1979-03-13
    • US703340
    • 1976-07-08
    • Karl-Heinz BoltzePeter-Rudolf SeidelHaireddin JacobiHelmut Schwarz
    • Karl-Heinz BoltzePeter-Rudolf SeidelHaireddin JacobiHelmut Schwarz
    • A61K31/37A61P9/08A61P9/10C07D311/16C07D407/14
    • C07D311/16Y10S514/929
    • Novel 2-benzopyranone compounds of the formula ##STR1## wherein X is a 3,4,5-trimethoxybenzoyl group or a 3,4,5-trimethoxycinnamoyl group; and eachR individually is selected from the group consisting of alkylamino and dialkylamino in which one carbon atom in the alkyl moiety may be replaced by an oxygen atom and one hydrogen atom may be replaced by a hydroxyl group which may in turn be esterified with a 3,4,5-trimethoxybenzoyl or 3,4,5-trimethoxycinnamoyl group; amino substituted once or twice by alkenyl, aralkyl, or cycloalkyl; or a 4- to 7-membered N-containing heterocyclic ring linked through a nitrogen atom and which contains up to 3 hetero atoms, which heterocyclic ring may be substituted by phenyl, alkyl or hydroxyalkyl, wherein the hydroxy group may be esterified by a 3,4,5-trimethoxy benzoyl or 3,4,5-trimethoxy cinnamoyl group;Or a salt of each compound with a physiologically acceptable acid; possess outstanding activity as coronary dilators. Processes for producing such compounds are also disclosed.
    • 新颖的2-苯并吡喃酮化合物,其中X是3,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 并且每个R各自选自烷基氨基和二烷基氨基,其中烷基部分中的一个碳原子可以被氧原子代替,一个氢原子可以被羟基代替,羟基可以依次用3 ,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 氨基被烯基,芳烷基或环烷基取代一次或两次; 或通过氮原子连接并含有至多3个杂原子的4至7元含氮杂环,该杂环可以被苯基,烷基或羟烷基取代,其中羟基可以被3 ,4,5-三甲氧基苯甲酰基或3,4,5-三甲氧基肉桂酰基; 或每种化合物的盐与生理上可接受的酸; 作为冠状动脉造影器的不可忽视的活动。 还公开了用于生产这些化合物的方法。