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1. 发明授权

US4323517A Methoxy and methylsulfinylthiolesters 失效
标题翻译：甲氧基和甲基亚硫酰硫醇酯
公开(公告)号：US4323517A
公开(公告)日：1982-04-06
申请号：US182353
申请日：1980-08-29
申请人： Wolfgang Opitz , Eugen Etscherberg , Hans-Dieter Dell , Haireddin Jacobi
发明人： Wolfgang Opitz , Eugen Etscherberg , Hans-Dieter Dell , Haireddin Jacobi
IPC分类号： C07C327/22 , C07C153/017
CPC分类号： C07C327/22
摘要： The present invention provides, inter alia, antiphlogistically effective agents, including pharmaceutical compositions containing said agents. Also included are methods for the use of said agents. The active compounds are those of the formula ##STR1## or an ester thereof, in which X denotes a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl or alkylsulphonyl group or a hydroxyl or mercapto group,Y denotes a grouping ##STR2## in which R denotes a hydrogen atom or an alkyl group, andZ denotes a hydroxyl group or an alkoxy or alkylthio group, at least one of the substituents X or Z in each case denoting a sulphur-containing radical.
摘要翻译：本发明尤其提供消炎有效药剂，包括含有所述药物的药物组合物。还包括使用所述试剂的方法。活性化合物是下式（I）或其酯，其中X表示氢原子，烷基，烷氧基，烷硫基，烷基亚磺酰基或烷基磺酰基或羟基或巯基 Y表示其中R表示氢原子或烷基，Z表示羟基或烷氧基或烷硫基的分组，每种情况下至少一个取代基X或Z表示含硫的激进。

2. 发明授权

US4246278A Medicaments having an antiphlogistic action 失效
标题翻译：具有消炎作用的药物
公开(公告)号：US4246278A
公开(公告)日：1981-01-20
申请号：US963651
申请日：1978-11-24
申请人： Wolfgang Opitz , Eugen Etschenberg , Hans-Dieter Dell , Haireddin Jacobi
发明人： Wolfgang Opitz , Eugen Etschenberg , Hans-Dieter Dell , Haireddin Jacobi
IPC分类号： A61K9/12 , A61K9/14 , A61K9/20 , A61K31/265 , C07C323/52 , C07C327/22 , C07C327/28
CPC分类号： A61K31/265 , C07C323/52 , C07C327/22 , C07C327/28
摘要： The present invention provides, inter alia, antiphlogistically effective agents, including pharmaceutical compositions containing said agents. Also included are methods for the use of said agents. The active compounds are those of the formula ##STR1## or an ester thereof, in which X denotes a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl or alkylsulphonyl group or a hydroxyl or mercapto group,Y denotes a grouping ##STR2## in which R denotes a hydrogen atom or an alkyl group, andZ denotes a hydroxyl group or an alkoxy or alkylthio group, at least one of the substituents X or Z in each case denoting a sulphur-containing radical.
摘要翻译：本发明尤其提供消炎有效药剂，包括含有所述药物的药物组合物。还包括使用所述试剂的方法。活性化合物是下式（I）或其酯，其中X表示氢原子，烷基，烷氧基，烷硫基，烷基亚磺酰基或烷基磺酰基或羟基或巯基 Y表示其中R表示氢原子或烷基，Z表示羟基或烷氧基或烷硫基的分组，每种情况下至少一个取代基X或Z表示含硫的激进。

3. 发明授权

US4332819A Antiphlogistic agent and its use 失效
标题翻译：消炎药及其用途
公开(公告)号：US4332819A
公开(公告)日：1982-06-01
申请号：US241146
申请日：1981-03-06
申请人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
发明人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
IPC分类号： A61K9/12 , A61K31/10 , A61K31/21 , A61K31/265 , A61P29/00 , C07C327/20
CPC分类号： A61K31/265 , C07C327/00
摘要： The invention relates to compositions containing S-benzyl 3-benzylthiopropionothioate for the treatment of inflammatory processes. Also included in the invention are methods for combating illnesses caused by inflammatory, processes, which methods involve use of medicaments containing said S-benzyl 3-benzylthiopropionothioate.
摘要翻译：本发明涉及含有S-苄基3-苄硫基丙硫杆酸酯用于治疗炎症过程的组合物。本发明还包括用于对抗由炎症，过程引起的疾病的方法，该方法涉及使用含有所述S-苄基-3-硫代丙酸硫酸酯的药物。

4. 发明授权

US4285935A Dehydropeptide compounds, their production and their medical use 失效
标题翻译：脱氢肽化合物，其生产和医疗用途
公开(公告)号：US4285935A
公开(公告)日：1981-08-25
申请号：US114468
申请日：1980-01-23
申请人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
发明人： Eugen Etschenberg , Haireddin Jacobi , Wolfgang Opitz
IPC分类号： C07K1/113 , A61K38/00 , A61P7/02 , A61P43/00 , C07K5/06 , C07K5/065 , A61K37/00 , C07C103/52
CPC分类号： C07K5/06078 , A61K38/00
摘要： This invention relates to dehydropeptides containing a tryptophan moiety useful as tumour-resolving and/or histolytic medicaments. Also included in the invention are methods for the preparation of said dehydropeptides, compositions containing said dehydropeptides and methods for the use of said dehydropeptides and dehydropeptide compositions.
摘要翻译：本发明涉及含有可用作肿瘤分解和/或组织溶解药物的色氨酸部分的脱氢肽。本发明还包括制备所述脱氢肽的方法，含有所述脱氢肽的组合物和使用所述脱氢肽和脱氢肽组合物的方法。

5. 发明授权

US4539402A Quinazolinone derivatives 失效
标题翻译：喹唑啉酮衍生物
公开(公告)号：US4539402A
公开(公告)日：1985-09-03
申请号：US492775
申请日：1983-05-09
申请人： Wolfgang Opitz , Haireddin Jacobi , Bernhard Pelster
发明人： Wolfgang Opitz , Haireddin Jacobi , Bernhard Pelster
IPC分类号： A61K31/505 , A61P25/04 , A61P25/20 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to quinazolinone derivatives and of formula (I) as defined herein and processes for the production of said derivatives. Also included in the invention are pharmaceutical compositions containing a compound of said formula (I) as active ingredient and the use of said compounds and compositions as anti-inflammatory agents.
摘要翻译：本发明涉及喹唑啉酮衍生物和本文所定义的式（I）和用于制备所述衍生物的方法。本发明还包括含有所述式（I）化合物作为活性成分的药物组合物和所述化合物和组合物作为抗炎剂的用途。

6. 发明授权

US4370342A S-Alkyl 3-alkylthiopropionothioate compounds, their production and their medicinal use 失效
标题翻译： S-烷基3-烷硫基丙硫醇化合物，其生产及其药用
公开(公告)号：US4370342A
公开(公告)日：1983-01-25
申请号：US241147
申请日：1981-03-06
申请人： Haireddin Jacobi , Wolfgang Opitz
发明人： Haireddin Jacobi , Wolfgang Opitz
IPC分类号： A61K31/255 , A61K31/21 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P29/00 , C07C67/00 , C07C325/00 , C07C327/20 , C07C327/22 , C07D213/32 , C07D307/38 , C07D307/64 , C07D333/18 , C07D333/34 , C07C153/00 , C07D333/24
CPC分类号： C07D307/38 , C07C327/00 , C07D213/32 , C07D333/18
摘要： The invention relates to S-alkyl 3-alkylthiopropionothioates of Formula (I) as defined herein. Also included in the invention are methods for the manufacture of said S-alkylthiopropionothioates, compositions containing them and the use of said compounds and compositions for the treatment of inflammatory processes.
摘要翻译：本发明涉及如本文所定义的式（I）的3-烷基-3-烷基硫代丙酸硫酸酯。本发明还包括制备所述S-烷基硫代丙硫杆酸酯的方法，含有它们的组合物以及所述化合物和组合物用于治疗炎症过程的用途。

7. 发明授权

US4349543A Histolytic agents and their use 失效
标题翻译：组织溶解剂及其用途
公开(公告)号：US4349543A
公开(公告)日：1982-09-14
申请号：US108315
申请日：1979-12-31
申请人： Haireddin Jacobi , Wolfgang Opitz , Eugen Etschenberg
发明人： Haireddin Jacobi , Wolfgang Opitz , Eugen Etschenberg
IPC分类号： A61K38/00 , A61P35/00 , C07K5/06 , C07K5/065 , A61K37/02 , A61K37/00
CPC分类号： C07K5/06078 , A61K38/00
摘要： The invention relates to pharmaceutical compositions containing as an active ingredient a dipeptide or an acid salt or a base addition salt thereof or a stereoisomer thereof, said dipeptide being those of the formulaR--Phe--Trp--R.sub.1in whichPhe denote the radical ##STR1## Trp denotes the radical ##STR2## R denotes a hydrogen atom or a C.sub.1 to C.sub.6 optionally substituted alkanoyl group andR.sub.1 denotes a hydroxyl, C.sub.1 to C.sub.4 alkoxy, amino, C.sub.1 to C.sub.4 alkylamino or di-C.sub.1 to C.sub.4 alkylamino group.
摘要翻译：本发明涉及含有作为活性成分二肽或其酸盐或其碱加成盐或其立体异构体的药物组合物，所述二肽是式R-Phe-Trp-R1的二肽，其中Phe表示基团 Trp表示基团R 1表示氢原子或C 1〜C 6任选取代的烷酰基，R 1表示羟基，C 1〜C 4烷氧基，氨基，C 1〜C 4烷基氨基或二-C 1〜C 4烷基氨基。

8. 发明授权

US4628062A 1,4-naphthoquinone derivatives having anti-inflammatory action 失效
标题翻译：具有抗炎作用的1,4-萘醌衍生物
公开(公告)号：US4628062A
公开(公告)日：1986-12-09
申请号：US682408
申请日：1984-12-17
申请人： Wolfgang Opitz , Bernhard Pelster , Romanis Fruchtmann , Udo Krupka , Walter Gauss , Hartmut Kiehne , Hermann Oediger
发明人： Wolfgang Opitz , Bernhard Pelster , Romanis Fruchtmann , Udo Krupka , Walter Gauss , Hartmut Kiehne , Hermann Oediger
IPC分类号： A61K31/12 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/18 , A61K31/19 , A61P29/00 , C07C45/00 , C07C50/24 , C07C50/32 , C07C50/38 , C07C67/00 , C07C213/00 , C07C225/30 , C07C233/32 , C07C301/00 , C07C311/00 , C07C313/00 , C07C323/38 , C07C50/14 , C07C97/22
CPC分类号： C07C50/24 , A61K31/12 , A61K31/135 , A61K31/16 , C07C50/32 , C07C50/38
摘要： New compounds of the formula ##STR1## in which R.sub.1 is an allylamino, acetylamino or propionylamino radical,R.sub.2 is hydrogen or a 2-methoxyethoxy or ethoxy radical,R.sub.3 is hydrogen or a sulphamoyl radical, andR.sub.4 is hydrogen,and of the formula ##STR2## in which R.sub.1 is a halogen atom or a free or substituted hydroxyl, sulphhydryl or amino group,R.sub.2 is a hydrogen atom, an alkyl radical, a halogen atom, or a free or substituted hydroxyl, sulphhydryl or amino group,R.sub.3 and R.sub.4 each independently is hydrogen, alkyl, hydroxyl, alkoxy, sulphonamido or halogen, with the proviso that R.sub.2, R.sub.3 and R.sub.4 are hydrogen when R.sub.1 is hydroxyl,exhibit anti-inflammatory activity.
摘要翻译：式中，R1是烯丙基氨基，乙酰氨基或丙酰基氨基，R2是氢或2-甲氧基乙氧基或乙氧基的新化合物，其中R 3是氢或氨磺酰基，R 4是氢， IMAGE>其中R1是卤素原子或游离或取代的羟基，巯基或氨基，R2是氢原子，烷基，卤素原子或游离或取代的羟基，巯基或氨基，R3和R4 每个独立地是氢，烷基，羟基，烷氧基，磺酰胺基或卤素，条件是当R 1是羟基时，R 2，R 3和R 4是氢，表现出抗炎活性。

9. 发明授权

US5780793A Safety switch having a carbon fiber conductor 失效
标题翻译：具有碳纤维导体的安全开关
公开(公告)号：US5780793A
公开(公告)日：1998-07-14
申请号：US535130
申请日：1995-10-10
申请人： Hans-Volker Buchholz , Wolfgang Opitz
发明人： Hans-Volker Buchholz , Wolfgang Opitz
IPC分类号： E05F15/44 , H01H1/02 , H01H3/14 , H01H3/16
CPC分类号： H01H3/142 , E05F15/44 , H01H1/02 , E05Y2900/132
摘要： A safety switch (1) has a support (2) of an elastomer and a through-going cavity (3). Within the cavity (3) are arranged electrical conductors (4) and (5) which in a rest condition are arranged at a distance (9) from one another. The electrical conductors (4, 5) are each formed as a strip of carbon fibers and have one broad side (6) and (7) vulcanized to the support (2) either directly or by way of a coupling layer (8). Substantially perpendicular pressure (12, 13) on the safety switch (1) leads to the deformation of the support (2) and eventually to the contact of the electrical conductors (4, 5) with each other. By this means, safety functions are controlled.
摘要翻译： PCT No.PCT / EP94 / 00255 Sec。 371 1995年10月10日第 102（e）1995年10月10日日期PCT 1994年1月29日PCT PCT。第WO94 / 25972号公报日期：1994年11月10日安全开关（1）具有弹性体（2）和贯通腔（3）。在空腔（3）内布置有电导体（4）和（5），其在静止状态下彼此间隔距离（9）设置。电导体（4,5）各自形成为碳纤维条，并且具有直接或通过耦合层（8）硫化到支撑体（2）的一个宽边（6）和（7）。安全开关（1）上的基本垂直的压力（12,13）导致支撑件（2）的变形，并最终导致电导体（4,5）彼此接触。通过这种方式，可以控制安全功能。

10. 发明授权

US4115531A Production of hydrochloric acid by removing hydrogen chloride from combustion gas 失效
标题翻译：通过从燃烧气体中除去氯化氢来生产盐酸
公开(公告)号：US4115531A
公开(公告)日：1978-09-19
申请号：US820043
申请日：1977-07-29
申请人： Wolfgang Opitz , Hans Hennen
发明人： Wolfgang Opitz , Hans Hennen
IPC分类号： B01D53/68 , C01B7/00 , C01B7/01 , F23G7/00 , C01B7/08
CPC分类号： B01D53/68 , C01B7/01
摘要： Hydrochloric acid having a substantially constant HCl content of 20 to 36% is produced continuously by removing hydrogen chloride from hot combustion gas. To this end, hot combustion gas containing 1 to 10% by volume of HCl and steam, this gas being obtained by the joint combustion of off-gases containing chlorinated hydrocarbons and liquid residues of chlorinated hydrocarbons, is introduced into a quenching zone, and quenched therein, down to a temperature lower than its dew point, by means of cooled hydrochloric acid containing hydrogen chloride in a concentration of 20 to 36%, which concentration corresponds to the concentration of the hydrochloric acid which is to be produced. The resulting gas-liquid mixture is separated in an absorption cooling zone into cooled hydrochloric acid and cooled combustion gas containing 0.1 to 1% by volume of HCl. The cooled hydrochloric acid is introduced into a reservoir zone capable of receiving a multiple of the quantity of hydrochloric acid produced per hour, and recycled from the said reservoir zone to the quenching zone. Additional 20 to 36% hydrochloric acid produced is taken out of the quenching cycle.
摘要翻译：通过从热燃烧气体中除去氯化氢而连续生产具有20至36％基本上恒定的HCl含量的盐酸。为此，将含有1至10体积％的HCl和蒸汽的热燃烧气体引入淬火区域，该气体通过含氯化烃和氯化烃的液体残余物的废气的联合燃烧获得，并且被淬火通过含有浓度为20〜36％的氯化氢的冷盐酸，降至低于露点的温度，该浓度对应于将要生产的盐酸的浓度。将所得气液混合物在吸收冷却区中分离成冷却的盐酸，并将含有0.1至1体积％HCl的冷却的燃烧气体分离。将冷却的盐酸引入能够接收每小时产生的多次盐酸的储存区，并从所述储存区再循环到淬火区。另外20-30％的盐酸被从淬火循环中取出。

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