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1. 发明授权

US06689614B1 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06689614B1
公开(公告)日：2004-02-10
申请号：US10369032
申请日：2003-02-18
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： G01N3350
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。

2. 发明授权

US06706483B1 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06706483B1
公开(公告)日：2004-03-16
申请号：US10368750
申请日：2003-02-18
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： C12Q168
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line. MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系。 MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。

3. 发明授权

US07666981B1 Inhibitors of prostasin 失效
标题翻译：前列腺素抑制剂
公开(公告)号：US07666981B1
公开(公告)日：2010-02-23
申请号：US10434349
申请日：2003-05-08
申请人： Karl X. Chai , Li-Mei Chen
发明人： Karl X. Chai , Li-Mei Chen
IPC分类号： C07K14/00
CPC分类号： C12N9/6424
摘要： A class of proteins useful as inhibitors of prostasin and method for identifying them are provided. These proteins have the structure wherein the amino acids P1-P4 from the scissile bond are respectively leu-ile-ala-arg and the amino acids at positions P5-P15 are serpin sequences.
摘要翻译：提供了一类可用作前列腺素抑制剂的蛋白质及其鉴定方法。这些蛋白质具有这样的结构，其中来自于剪切键的氨基酸P1-P4分别是亮氨酸，而位置P5-P15的氨基酸是丝氨酸序列。

4. 发明授权

US06864093B1 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06864093B1
公开(公告)日：2005-03-08
申请号：US10235255
申请日：2002-09-05
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/48 , A61K49/00 , C07H21/02 , C07H21/04
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line. The prostasin gene promoter region was found to be hypermethylated at specific sites in invasive cancer cells.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。发现前列腺素基因启动子区域在侵袭性癌细胞的特定部位被高甲基化。

5. 发明授权

US06569684B2 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06569684B2
公开(公告)日：2003-05-27
申请号：US09755811
申请日：2001-01-05
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： G01N3348
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。

6. 发明授权

US06426371B1 Sol materials 有权
标题翻译：溶胶材料
公开(公告)号：US06426371B1
公开(公告)日：2002-07-30
申请号：US09346075
申请日：1999-07-01
申请人： Lih-Ping Li , Li-Mei Chen , Chao-Jen Wang , Hsin-Hsen Lu
发明人： Lih-Ping Li , Li-Mei Chen , Chao-Jen Wang , Hsin-Hsen Lu
IPC分类号： C01B3314
CPC分类号： C01B33/16 , C01B33/145 , H01L23/145 , H01L23/49894 , H01L23/5329 , H01L2924/0002 , H01L2924/00
摘要： The invention provides a fast-cured sol material, which is produced by hydrolysis and condensation of the following starting materials: 2-60 parts by weight of a silicon alkoxide; 20-98 parts by weight of an alcohol; 0.5-50 parts by weight of an aqueous media; 0.0001-10 parts by weight of a base; 0.001-30 parts by weight of at least one additive; and optionally 0.0001-10 parts by weight of an acid. A coating of the sol material according to the invention can be directly cured (without aging) to obtain a microporous dielectric film without shrinkage or cracks.
摘要翻译：本发明提供一种快速固化的溶胶材料，其通过以下原料的水解和缩合制备：2-60重量份的硅烷醇盐; 20-98重量份醇; 0.5-50重量份的水性介质; 0.0001-10重量份的碱; 0.001-30重量份的至少一种添加剂; 和任选的0.0001-10重量份的酸。根据本发明的溶胶材料的涂层可以直接固化（不老化），以获得没有收缩或裂纹的微孔介电膜。

7. 发明授权

US08481917B2 System and method for calibrating an ambient light sensor 失效
标题翻译：用于校准环境光传感器的系统和方法
公开(公告)号：US08481917B2
公开(公告)日：2013-07-09
申请号：US12612012
申请日：2009-11-04
申请人： Li-Mei Chen , Ming-Fu Chen , Yi-Hsun Lin
发明人： Li-Mei Chen , Ming-Fu Chen , Yi-Hsun Lin
IPC分类号： G01D18/00 , G01J5/00 , G06F5/02
CPC分类号： G01J1/42 , G01J1/4204 , G01J1/44 , G09G2320/062
摘要： A system and a method for calibrating an ambient light sensor (ALS) are disclosed. The ALS, an adjustable resistor and a switch are located on a first surface of a printed circuit board (PCB), and the adjustable resistor and the switch are connected in series between an adjustable probe of the ALS and the ground. A resistor is connected between two pads located on a second surface of the PCB via two probes touching the pads. A controller connected to the PCB reads a light sensitivity of the ALS and calculates a calculated resistance value of the adjustable resistor by a formula “detected light sensitivity/resistance value of the resistor=objective light sensitivity/resistance value of the adjustable resistor”, wherein the objective light sensitivity and the resistance value of the resistor are given.
摘要翻译：公开了一种用于校准环境光传感器（ALS）的系统和方法。 ALS，可调电阻器和开关位于印刷电路板（PCB）的第一表面上，可调电阻器和开关串联连接在ALS的可调探针和地之间。电阻器通过两个接触焊盘的探头连接在位于PCB的第二表面上的两个焊盘之间。连接到PCB的控制器读取ALS的光灵敏度，并通过公式“电阻的检测光敏度/电阻值=可调电阻器的目标光灵敏度/电阻值”来计算可调电阻器的计算电阻值，其中给出了目标光敏度和电阻值的电阻值。

8. 发明授权

US07053019B2 Dielectric material compositions with high dielectric constant and low dielectric loss 失效
标题翻译：具有高介电常数和低介电损耗的介电材料组成
公开(公告)号：US07053019B2
公开(公告)日：2006-05-30
申请号：US10606859
申请日：2003-06-27
申请人： Li-Mei Chen , Chao-Jen Wang , Chien-Hsien Yu , Jen-Po Lin
发明人： Li-Mei Chen , Chao-Jen Wang , Chien-Hsien Yu , Jen-Po Lin
IPC分类号： C04B35/468
CPC分类号： H01L21/02197 , C04B35/4682 , C04B35/49 , C04B2235/3213 , C04B2235/3215 , C04B2235/3227 , C04B2235/3251 , C23C14/088 , H01C7/008 , H01C17/06533 , H01G4/1245 , H01G4/1254 , H01L21/02266 , H01L21/02282 , H01L21/31691
摘要： A new dielectric material composition with high dielectric constant and low dielectric loss, which includes a quaternary metallic oxide having a pervoskite structure and represented by a general formula, Ba1-xM1xTi1-yM2yOm. It is suitable for Gbit memory devices, embedded capacitance devices in multilayered structures, and modulable capacitors for high frequency devices.
摘要翻译：一种具有高介电常数和低介电损耗的新型介电材料组合物，其包括具有渗透性结构并由通式Ba 1-x M 1 O 2表示的季金属氧化物 > 1 适用于Gbit存储器件，多层结构中的嵌入式电容器件和高频器件的可调电容器。

9. 发明授权

US06897174B2 Dielectric material compositions 失效
标题翻译：电介质材料组成
公开(公告)号：US06897174B2
公开(公告)日：2005-05-24
申请号：US10606966
申请日：2003-06-27
申请人： Li-Mei Chen , Chao-Jen Wang , Chuan-Ya Hung
发明人： Li-Mei Chen , Chao-Jen Wang , Chuan-Ya Hung
IPC分类号： C04B35/01 , C04B35/45 , C04B35/46 , C04B35/462 , C04B35/48 , C04B35/495 , C04B35/50 , C04B35/505 , C23C14/08 , C23C14/14 , H01L21/316
CPC分类号： H01L21/02194 , C04B35/016 , C04B35/42 , C04B35/4504 , C04B35/453 , C04B35/462 , C04B35/48 , C04B35/495 , C04B35/50 , C04B2235/3206 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3229 , C04B2235/3232 , C04B2235/3239 , C04B2235/3241 , C04B2235/3244 , C04B2235/3256 , C04B2235/3262 , C04B2235/3267 , C04B2235/3281 , C04B2235/3284 , C04B2235/767 , C23C14/08 , H01L21/02266 , H01L21/02282 , H01L21/31691
摘要： A dielectric material composition including a metal oxide represented by a general formula, Y1−xM1xMn1−yM2yOm. M1 is Y, Ho, Er, Yb, Tm, or Lu. M2 is Ti, Zr, V, Mo, Mg, Cu, or Zn. X is a number of 0 to 1. Y is a number of 0 to 1. The metal oxide is of high dielectric constant and has the properties of ferroelectricity, piezoelectricity, and pyroelectricity.
摘要翻译：一种介电材料组合物，其包含由通式Y 1-x M 1，O 2，M 1，Y 2， M / O 2 / O 2。 Y 1，Y 1，H 2，Y 1，T m或Lu。 M 2是Ti，Zr，V，Mo，Mg，Cu或Zn。 X为0〜1的数.Y为0〜1的数。金属氧化物的介电常数高，具有铁电性，压电性，热电性等特性。

10. 发明授权

US6037260A Polishing composition 失效
标题翻译：抛光组成
公开(公告)号：US6037260A
公开(公告)日：2000-03-14
申请号：US76116
申请日：1998-05-12
申请人： Ming-Shyong Tsai , Li-Mei Chen , Yue-Chin Yeh , Chiu-Chih Hsieh , Ying-Tsung Chen
发明人： Ming-Shyong Tsai , Li-Mei Chen , Yue-Chin Yeh , Chiu-Chih Hsieh , Ying-Tsung Chen
IPC分类号： C09G1/02 , C09K3/14 , H01L21/304 , C07K13/00
CPC分类号： C09G1/02 , C09K3/1463 , Y10T29/47
摘要： The present invention provides a polishing composition which comprises 100 weight part of water; 0.5 to 20 weight part of boehmite, a hydroxide of aluminum, pseudoboehmite or mixtures thereof; 1 to 50 weight part of aluminum oxide (Al.sub.2 O.sub.3); and 1 to 20 weight part of an acidic solution. The polishing composition of the present invention is a thixotropic fluid and displays satisfactory suspension properties. Therefore, it is very suitable for use as a polishing slurry.
摘要翻译：本发明提供一种抛光组合物，其包含100重量份的水; 勃姆石0.5〜20重量份，铝氢氧化物，假勃姆石或其混合物; 1〜50重量份的氧化铝（Al2O3）; 和1〜20重量份的酸性溶液。本发明的研磨用组合物是触变性液体，显示出令人满意的悬浮性。因此，非常适合用作研磨浆料。

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