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1. 发明授权

US07190579B2 Data processing system with air purifying device 失效
标题翻译：带空气净化装置的数据处理系统
公开(公告)号：US07190579B2
公开(公告)日：2007-03-13
申请号：US10880768
申请日：2004-06-29
申请人： James Lee Chao
发明人： James Lee Chao
IPC分类号： H05K7/20
CPC分类号： G06F1/20
摘要： An air purifying data processing system includes a chassis, a planar, a microprocessor and an air purifier. The air purifier produces purified air that is exhausted exterior to the chassis to improve the air quality in the vicinity of the chassis. The air purifier produces an air flow that is preferably in proximity to the microprocessor to facilitate dissipation of heat generated by the microprocessor. The air purifier may be oriented to direct the air flow through an opening in a first face of the chassis. The air purifier may include a high voltage unit to create an electrical discharge within the air purifier. The high voltage unit preferably produces a voltage greater of 8000 V or at an output point of the high voltage unit. The air purifier includes a grounded and electrically conductive grid in the vicinity of the high voltage unit output point.
摘要翻译：空气净化数据处理系统包括底盘，平面，微处理器和空气净化器。空气净化器产生在底盘外部排出的净化空气，以改善底盘附近的空气质量。空气净化器产生优选靠近微处理器的空气流，以便于散发由微处理器产生的热量。空气净化器可以被定向成引导空气流通过底盘的第一面中的开口。空气净化器可以包括高压单元以在空气净化器内产生放电。高压单元优选地产生大于8000V的电压或高压单元的输出点。空气净化器包括在高压单元输出点附近的接地和导电栅格。

2. 发明授权

US06864093B1 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06864093B1
公开(公告)日：2005-03-08
申请号：US10235255
申请日：2002-09-05
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/48 , A61K49/00 , C07H21/02 , C07H21/04
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line. The prostasin gene promoter region was found to be hypermethylated at specific sites in invasive cancer cells.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。发现前列腺素基因启动子区域在侵袭性癌细胞的特定部位被高甲基化。

3. 发明授权

US06569684B2 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06569684B2
公开(公告)日：2003-05-27
申请号：US09755811
申请日：2001-01-05
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： G01N3348
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。

4. 发明授权

US5948616A Methods and compositions of correlating tissue kallikrein gene promoter polymorphisms with essential hypertension 失效
标题翻译：将组织激肽释放酶基因启动子多态性与原发性高血压相关联的方法和组成
公开(公告)号：US5948616A
公开(公告)日：1999-09-07
申请号：US856141
申请日：1997-05-14
申请人： Lee Chao , Julie Chao
发明人： Lee Chao , Julie Chao
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A method is provided for identifying a human subject as having an increased or decreased risk of developing essential hypertension, comprising determining the presence in the subject of an allele in the promoter region of the subject's tissue kallikrein gene correlated with an increased or decreased risk of developing essential hypertension, the presence of the allele identifying the subject as having an increased or decreased risk of developing essential hypertension.
摘要翻译：提供了一种用于鉴定人类受试者具有增加或降低发生原发性高血压风险的方法，包括确定受试者的组织激肽释放酶基因的启动子区中等位基因的存在与增加或减少的发展风险相关原发性高血压，确定受试者的等位基因的存在具有增加或降低发生原发性高血压的风险。

5. 发明授权

US06716518B2 Method and system for absorbent sponge membrane for spill protection in electronic devices 失效
标题翻译：吸收性海绵膜的方法和系统，用于电子设备中的溢出保护
公开(公告)号：US06716518B2
公开(公告)日：2004-04-06
申请号：US09907499
申请日：2001-07-17
申请人： James Lee Chao , Charles C. Sloop, III
发明人： James Lee Chao , Charles C. Sloop, III
IPC分类号： B32B514
CPC分类号： B32B5/24 , B32B5/18 , B32B2266/025 , B32B2266/0278 , B32B2266/0285 , B32B2266/06 , B32B2307/7265 , G06F3/0202 , H01H2223/002 , H01H2223/004 , Y10T428/24273 , Y10T428/24281 , Y10T428/24289 , Y10T428/24298 , Y10T428/24306 , Y10T428/24314 , Y10T428/24322 , Y10T428/24331 , Y10T428/24339 , Y10T428/24347 , Y10T428/24355 , Y10T428/249958 , Y10T428/249986 , Y10T442/3325 , Y10T442/335 , Y10T442/3358
摘要： A method and system of reversibly absorbing liquid penetrations into electronic devices having a body and circuitry is described. The method and system comprises providing an absorbent sponge membrane structure in sheet-like form. The structure contains a hydrogel-forming core integrated into a blown polymer foam. The method and system includes placing the absorbent structure within the electronic device such that the hydrogel-forming core and blown polymer foam at least partly covers the electronic circuitry to be protected. A method and system in accordance with the present invention has the further advantage that due to the inclusion of the crystals into the open cells of the sponge, that structure is much easier to manufacture into various templates by punching or stamping holes where the keys and other mechanical obstructions such as bosses and supports must be accommodated.
摘要翻译：描述了将液体穿透可逆地吸收到具有主体和电路的电子设备中的方法和系统。该方法和系统包括以片状形式提供吸收性海绵膜结构。该结构包含一体化成泡沫聚合物泡沫的水凝胶形成芯。该方法和系统包括将吸收结构放置在电子装置内，使得水凝胶形成芯和吹塑聚合物泡沫体至少部分地覆盖待保护的电子电路。根据本发明的方法和系统具有的另外的优点是，由于将晶体包含在海绵的开孔中，该结构通过冲压或冲压孔等而容易地制成各种模板必须容纳诸如凸起和支撑件的机械障碍物。

6. 发明授权

US06706483B1 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06706483B1
公开(公告)日：2004-03-16
申请号：US10368750
申请日：2003-02-18
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： C12Q168
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line. MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系。 MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。

7. 发明授权

US5123857A Electrical connector embedded with metal latches 失效
标题翻译：电连接器嵌入金属锁扣
公开(公告)号：US5123857A
公开(公告)日：1992-06-23
申请号：US792686
申请日：1991-11-15
申请人： Kuei L. Lee Chao
发明人： Kuei L. Lee Chao
IPC分类号： H01R12/70 , H01R13/62
CPC分类号： H01R12/7005
摘要： An electrical connector includes at least a pair of metal latches embedded in two opposite end portions of the connector, each latch having a pair of snapping leg members engageably locked in a recess portion recessed in each end portion of the connector and two latches insertably fixed on two opposite end portion of the connector for clamping a daughter printed circuit board on the connector so that the daughter board will be electrically connected with a mother printed circuit board secured under the connector.
摘要翻译：电连接器包括嵌入在连接器的两个相对端部中的至少一对金属闩锁，每个闩锁具有一对咬合脚部件，其卡合在锁定在连接器的每个端部中凹陷的凹部中，并且两个闩锁可插入地固定在连接器的两个相对端部，用于将连接器上的子印刷电路板夹紧，使得子板将与固定在连接器下方的母版印刷电路板电连接。

8. 发明授权

US06747140B2 Tissue kallikrein gene promoter polymorphisms 失效
标题翻译：组织激肽释放酶基因启动子多态性
公开(公告)号：US06747140B2
公开(公告)日：2004-06-08
申请号：US10059877
申请日：2002-01-29
申请人： Lee Chao , Julie Chao , Qing Song
发明人： Lee Chao , Julie Chao , Qing Song
IPC分类号： C07H2102
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides a method of identifying a human subject as having an increased likelihood of regulating blood pressure with dietary sodium intake, comprising determining the presence in the subject of a tissue kallikrein promoter allele genotype correlated with an increased likelihood of regulating blood pressure with dietary sodium intake, whereby the presence of the genotype identifies the subject as having an increased likelihood of regulating blood pressure by dietary sodium intake. Also provided is a method of identifying a tissue kallikrein promoter allele genotype correlated with an increased likelihood of regulating blood pressure with dietary sodium intake, comprising a) determining the tissue kallikrein promoter allele genotype of a subject; and b) correlating the presence of the genotype of step (a) with the ability of the subject to regulate blood pressure by dietary sodium intake, thereby identifying a genotype correlated with an increased likelihood of regulating blood pressure by dietary sodium intake.
摘要翻译：本发明提供了一种将人受试者鉴定为具有增加的饮食钠摄入调节血压的可能性的方法，其包括确定受试者中存在与饮食调节血压的增加的可能性相关的组织激肽释放酶启动子等位基因基因型钠摄入量，从而基因型的存在将受试者识别为具有通过饮食钠摄入调节血压的可能性增加。还提供了鉴定与膳食钠摄入调节血压的可能性增加相关的组织激肽释放酶启动子等位基因型的方法，其包括a）确定受试者的组织激肽释放酶启动子等位基因型; 和b）将步骤（a）的基因型的存在与受试者通过饮食钠摄入调节血压的能力相关联，从而鉴定与膳食钠摄入调节血压的可能性增加相关的基因型。

9. 发明授权

US07161098B2 Method and system for sticky key prevention for keyboard or keypad devices 失效
公开(公告)号：US07161098B2
公开(公告)日：2007-01-09
申请号：US09824496
申请日：2001-04-02
申请人： James Lee Chao , Leonard Douglas Hobgood
发明人： James Lee Chao , Leonard Douglas Hobgood
IPC分类号： H01H9/00
CPC分类号： H01H13/70 , H01H2209/016 , H01H2223/002
摘要： A method and system of minimizing sticky keys in an electronic device having a body, circuitry, and a plurality of keypads is disclosed. The method and system comprise providing a protectant coating; and applying the protectant coating on surfaces of both the keypad and also the body to prevent sticking between the mating surfaces. A system and method is added in accordance with the present invention utilizing a protectant on critical surfaces which serves to prevent the residual buildup of contaminants following spills. In so doing the sticky key problem associated with the contaminated buildup is substantially eliminated.

10. 发明授权

US06689614B1 Method of identifying and treating invasive carcinomas 失效
标题翻译：识别和治疗侵袭性癌的方法
公开(公告)号：US06689614B1
公开(公告)日：2004-02-10
申请号：US10369032
申请日：2003-02-18
申请人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
发明人： Karl X. Chai , Li-Mei Chen , Lee Chao , Julie Chao
IPC分类号： G01N3350
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/154 , C12Q2600/158
摘要： Prostasin protein has been found to be a useful marker for determination of the invasiveness of and as a means to treat human carcinomas. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in normal human prostate epithelial cells and the human prostate cancer cell line LNCaP, but not in the highly invasive human prostate cancer cell lines DU-145 and PC-3. Imunohistochemistry studies of human prostate cancer specimens revealed a down-regulation of prostasin in high-grade tumors. Using RT-PCR and western blot analyses, prostasin protein and mRNA expression were found in a non-invasive human breast cancer cell line, MCF-7, while invasive human breast cancer cell lines MDA-MB-231 and MDA-MB-435s were found not to express either the prostasin protein or the mRNA. A non-invasive human breast cancer cell line, MDA-MB-453, was shown to express prostasin mRNA but not prostasin protein. Transfection of DU-145 and PC-3 cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 68% and 42%, respectively. Transfection of MDA-MB-231 and MDA-MB-435s cells with a full-length human prostasin cDNA restored prostasin expression and reduced the in vitro invasiveness by 50% for either cell line.
摘要翻译：已经发现前列腺素蛋白是用于测定人类癌的侵袭性和作为手段治疗人类癌症的有用标志物。使用RT-PCR和蛋白质印迹分析，在正常人前列腺上皮细胞和人前列腺癌细胞系LNCaP中发现前列腺素蛋白和mRNA表达，但不存在于高侵袭性人前列腺癌细胞系DU-145和PC-3中。人类前列腺癌标本的免疫组织化学研究显示高级肿瘤中前列腺素的下调。使用RT-PCR和蛋白质印迹分析，在非侵入性人乳腺癌细胞系MCF-7中发现前列腺素蛋白和mRNA表达，而侵袭性人乳腺癌细胞系MDA-MB-231和MDA-MB-435s分别为发现不表达前列腺素蛋白或mRNA。非侵入性人乳腺癌细胞系MDA-MB-453显示表达前列腺素mRNA而不是前列腺素蛋白。 DU-145和PC-3细胞用全长人前列腺素cDNA的转染能够恢复前列腺素的表达，体外侵袭能力分别降低了68％和42％。用全长人前列腺素cDNA转染MDA-MB-231和MDA-MB-435s细胞恢复前列腺素的表达，并将任何细胞系的体外侵袭力降低50％。

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