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1. 发明授权

US07880154B2 Methods and apparatus for the planning and delivery of radiation treatments 有权
公开(公告)号：US07880154B2
公开(公告)日：2011-02-01
申请号：US12132597
申请日：2008-06-03
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/10 , A61N5/00 , G21K1/02
CPC分类号： A61B5/4836 , A61B5/08 , A61B5/113 , A61B34/10 , A61B2034/101 , A61N5/103 , A61N5/1031 , A61N5/1036 , A61N5/1037 , A61N5/1039 , A61N5/1042 , A61N5/1045 , A61N5/1047 , A61N5/1049 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1032 , A61N2005/1034 , A61N2005/1035
摘要： Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

2. 发明授权

US08696538B2 Methods and apparatus for the planning and delivery of radiation treatments 有权
标题翻译：辐射治疗计划和运送的方法和装置
公开(公告)号：US08696538B2
公开(公告)日：2014-04-15
申请号：US12986420
申请日：2011-01-07
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/10
CPC分类号： A61B5/4836 , A61B5/08 , A61B5/113 , A61B34/10 , A61B2034/101 , A61N5/103 , A61N5/1031 , A61N5/1036 , A61N5/1037 , A61N5/1039 , A61N5/1042 , A61N5/1045 , A61N5/1047 , A61N5/1049 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1032 , A61N2005/1034 , A61N2005/1035
摘要： Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.
摘要翻译：提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

3. 发明授权

US08658992B2 Methods and apparatus for the planning and delivery of radiation treatments 有权
公开(公告)号：US08658992B2
公开(公告)日：2014-02-25
申请号：US13043892
申请日：2011-03-09
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/00
CPC分类号： A61N5/1031 , A61B6/032 , A61B6/4085 , A61N5/1047 , A61N5/1049 , A61N5/1064 , A61N2005/1032 , A61N2005/1034 , A61N2005/1035
摘要： Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

4. 发明申请

US20130102830A1 SYSTEM AND METHOD FOR ESTIMATING AND MANIPULATING ESTIMATED RADIATION DOSE 有权
标题翻译：用于估计和操作估计辐射剂量的系统和方法
公开(公告)号：US20130102830A1
公开(公告)日：2013-04-25
申请号：US13806677
申请日：2011-06-22
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/00 , A61N5/10 , G01T1/29 , H05K999/00
摘要： Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.
摘要翻译：提供了用于允许操纵由辐射递送装置输送的用于建议的受试者治疗的可实现的剂量分布估计的方法。一种这样的方法包括：确定期望修饰剂量值的剂量修饰体素和所需剂量修饰的相应量级; 对于多个波束中的每一个：（i）将波束表征为子波束的二维阵列，其中每个子波束与对应的强度值相关联，并且射线代表子束进入空间的投影; 和（ii）识别具有与剂量修改体素相交的相关联的射线的一个或多个剂量变化子束; 修改至少一个剂量变化子束的强度值; 以及更新所述可实现的剂量分布估计以考虑所述剂量变化子束中的至少一个的修改的强度值。

5. 发明授权

US07906770B2 Methods and apparatus for the planning and delivery of radiation treatments 有权
标题翻译：辐射治疗计划和运送的方法和装置
公开(公告)号：US07906770B2
公开(公告)日：2011-03-15
申请号：US11996932
申请日：2006-07-25
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1031 , A61B6/032 , A61B6/4085 , A61N5/1047 , A61N5/1049 , A61N5/1064 , A61N2005/1032 , A61N2005/1034 , A61N2005/1035
摘要： Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.
摘要翻译：提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

6. 发明申请

US20080226030A1 Methods and Apparatus For the Planning and Delivery of Radiation Treatments 有权
标题翻译：辐射治疗的规划和运送方法和装置
公开(公告)号：US20080226030A1
公开(公告)日：2008-09-18
申请号：US11996932
申请日：2006-07-25
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/00
CPC分类号： A61N5/1031 , A61B6/032 , A61B6/4085 , A61N5/1047 , A61N5/1049 , A61N5/1064 , A61N2005/1032 , A61N2005/1034 , A61N2005/1035
摘要： Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.
摘要翻译：提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

7. 发明申请

US20060256915A1 METHOD AND APPARATUS FOR PLANNING AND DELIVERING RADIATION TREATMENT 有权
标题翻译：用于规划和提供辐射治疗的方法和装置
公开(公告)号：US20060256915A1
公开(公告)日：2006-11-16
申请号：US11383188
申请日：2006-05-12
申请人： Karl Otto , Marie-Pierre Milette
发明人： Karl Otto , Marie-Pierre Milette
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1036 , A61N5/1042 , A61N2005/1032 , A61N2005/1035
摘要： Radiation may be delivered in a number of segments shaped by a multi-leaf collimator. The collimator may be at different angles of rotation for the different segments. A method for planning radiation treatment involves obtaining an optimized set of collimator configurations by a direct aperture optimization method that takes into account collimator rotation. In some embodiments, area constraints are applied to the optimization. Methods according to embodiments of the invention can generate efficient treatment plans.
摘要翻译：辐射可以在由多叶准直器成形的多个片段中传送。对于不同的段，准直器可以处于不同的旋转角度。一种用于规划辐射治疗的方法包括通过考虑到准直器旋转的直接孔径优化方法来获得优化的准直器配置集合。在一些实施例中，面积约束被应用于优化。根据本发明的实施例的方法可以产生有效的治疗计划。

8. 发明授权

US09050459B2 Methods and apparatus for the planning and delivery of radiation treatments 有权
标题翻译：辐射治疗计划和运送的方法和装置
公开(公告)号：US09050459B2
公开(公告)日：2015-06-09
申请号：US14202305
申请日：2014-03-10
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/10
CPC分类号： A61B5/4836 , A61B5/08 , A61B5/113 , A61B34/10 , A61B2034/101 , A61N5/103 , A61N5/1031 , A61N5/1036 , A61N5/1037 , A61N5/1039 , A61N5/1042 , A61N5/1045 , A61N5/1047 , A61N5/1049 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1032 , A61N2005/1034 , A61N2005/1035
摘要： Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.
摘要翻译：提供了方法和装置，用于通过模式来规划和传送辐射治疗，所述模式涉及沿着相对于受试者的轨迹移动辐射源，同时向受试者传送辐射。在一些实施例中，辐射源沿轨迹连续移动，而在一些实施例中，辐射源间歇地移动。一些实施例涉及辐射递送计划的优化以满足各种优化目标，同时满足许多约束。对于沿着轨迹的多个控制点中的每一个，辐射递送计划可以包括：一组运动轴参数，一组波束形状参数和波束强度。

9. 发明授权

US08073103B2 Systems and methods for optimization of on-line adaptive radiation therapy 有权
标题翻译：在线自适应放射治疗优化的系统和方法
公开(公告)号：US08073103B2
公开(公告)日：2011-12-06
申请号：US12374788
申请日：2007-07-27
申请人： Karl Otto , Ante Mestrovic
发明人： Karl Otto , Ante Mestrovic
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61B6/022 , A61B6/5241 , A61N5/1038 , A61N5/1067
摘要： Methods and systems are disclosed for radiation treatment of a subject involving one or more fractional treatments. A fractional treatment comprises: obtaining fractional image data pertaining to a region of interest of the subject; performing a fractional optimization of a radiation treatment plan to determine optimized values of one or more radiation delivery variables based at least in part on the fractional image data; and delivering a fraction of the radiation treatment plan to the region of interest using the optimized values of the one or more radiation delivery variables as one or more corresponding parameters of the radiation treatment plan. A portion of performing the fractional optimization overlaps temporally with a portion of at least one of: obtaining the fractional image data and delivering the fraction of the radiation treatment plan.
摘要翻译：公开了涉及一个或多个分数处理的受试者的放射治疗的方法和系统。分数处理包括：获得与受试者的感兴趣区域有关的分数图像数据; 执行辐射治疗计划的分数优化以至少部分地基于分数图像数据来确定一个或多个辐射递送变量的优化值; 以及使用所述一个或多个辐射递送变量的优化值作为所述辐射治疗计划的一个或多个对应参数将所述辐射治疗计划的一部分递送到感兴趣区域。执行分数优化的一部分与以下至少一个的一部分在时间上重叠：获得分数图像数据并递送辐射处理计划的分数。

10. 发明授权

US06907105B2 Methods and apparatus for planning and delivering intensity modulated radiation fields with a rotating multileaf collimator 有权
标题翻译：用旋转多叶准直器规划和传递强度调制辐射场的方法和装置
公开(公告)号：US06907105B2
公开(公告)日：2005-06-14
申请号：US10253781
申请日：2002-09-25
申请人： Karl Otto
发明人： Karl Otto
IPC分类号： A61N5/10 , G21K1/04
CPC分类号： G21K1/046 , A61N5/103 , A61N5/1036 , A61N5/1042
摘要： A method and system for controlling the spatial distribution of radiation produced by a radiation device having a multi-leaf collimator can generate arbitrary intensity-modulated radiation fields. The methods control both angles and leaf configuration of the multi-leaf collimator for each of multiple sub-fields. The leaf positions, collimator angles, and individual sub-field contributions may be derived by optimization techniques.
摘要翻译：用于控制由具有多叶准直器的辐射装置产生的辐射的空间分布的方法和系统可以产生任意强度调制的辐射场。该方法控制多个子场中的每一个的多叶准直器的角度和叶子配置。叶位置，准直器角度和单个子场贡献可以通过优化技术得到。

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