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1. 发明授权

US4515789A .beta.-Lactam antibiotics 失效
标题翻译： β-内酰胺抗生素
公开(公告)号：US4515789A
公开(公告)日：1985-05-07
申请号：US483062
申请日：1983-04-07
申请人： Karl G. Metzger , Wilfried Schrock , Dieter Habich , Paul Naab , Hans-Joachim Zeiler
发明人： Karl G. Metzger , Wilfried Schrock , Dieter Habich , Paul Naab , Hans-Joachim Zeiler
IPC分类号： C07D499/66 , A61K31/397 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , C07D205/08 , C07D205/085 , C07D233/32 , C07D233/36 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D417/14 , C07D463/00 , C07D499/00 , C07D499/44 , C07D499/64 , C07D499/68 , C07D499/70 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/38 , C07D501/57 , C07D505/00 , C07F7/18 , C07D501/56
CPC分类号： C07D403/12 , C07D233/32 , C07D233/36 , C07D403/14 , C07D405/14 , C07D409/12 , C07D417/14 , C07D499/00 , C07D505/00 , C07F7/184
摘要： A 3-.beta.-(vic-dihydroxyphenylmethyleneamino-2-oxo-imidazolidine)- or 3-.beta.-(vic-dihydroxyphenyl-methyleneamino-2,3-dioxo-piperazine)-1-carbonylamino-acetamidoazetidin-2-one having an acidic grouping on .sub.1 N, e.g. of the formula ##STR1## The compounds are antibiotically active, especially against Pseudomonas bacteria and can be used in combating bacterial infection, as a preservative and as a growth promoting agent in animal feeds.
摘要翻译： 3β-（咔唑 - 二羟基苯基亚甲基氨基-2-氧代 - 咪唑烷） - 或3β-（咔 - 二羟基苯基 - 亚甲基氨基-2,3-二氧代 - 哌嗪）-1-羰基乙酰氨基吖丁啶-2-酮在1N上酸性分组，例如该化合物具有抗菌活性，特别是针对假单胞菌属细菌，可用于防治细菌感染，作为防腐剂和作为动物饲料中的生长促进剂。

2. 发明授权

US4863916A Substituted 6-hydroxymethyl-carbapenem antibiotics 失效
标题翻译：取代的6-羟甲基 - 碳青霉烯类抗生素
公开(公告)号：US4863916A
公开(公告)日：1989-09-05
申请号：US47371
申请日：1987-05-06
申请人： Dieter Habich , Wolfgang Hartwig , Karl G. Metzger , Hans-Joachim Zeiler
发明人： Dieter Habich , Wolfgang Hartwig , Karl G. Metzger , Hans-Joachim Zeiler
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20
CPC分类号： C07D477/20
摘要： Substituted 6-hydroxymethyl-carbapenem antibiotics of the formula ##STR1## in which R.sup.1 is --OR.sup.4, ##STR2## A is a direct bond, or an alkylene and/or cycloalkylene radical, R.sup.2 is a group of the formula ##STR3## an aryl or heterocyclic radical, ##STR4## R.sup.3 is a COOH radical, or salt or ester thereof.
摘要翻译：取代的式“IMAGE”的6-羟甲基 - 碳青霉烯类抗生素，其中R 1为-OR 4，A为直接键，或亚烷基和/或亚环烷基，R 2为下式基团：或杂环基，R 3是COOH基团，或其盐或酯。

3. 发明授权

US4840946A Benzazolythio-carbapenem antibiotics 失效
标题翻译：苯扎硫代碳青霉烯类抗生素
公开(公告)号：US4840946A
公开(公告)日：1989-06-20
申请号：US119752
申请日：1987-11-12
申请人： Dieter Habich , Wolfgang Hartwig , Karl G. Metzger , Hans-Joachim Zeiler
发明人： Dieter Habich , Wolfgang Hartwig , Karl G. Metzger , Hans-Joachim Zeiler
IPC分类号： C07D477/00 , A61K31/397 , A61K31/41 , A61P31/04 , C07D477/20
CPC分类号： C07D477/20 , Y02P20/55
摘要： Antibiotically active benzazolylthio-carbapenems of the formula ##STR1## in which R.sup.1 represents hydrogen or a hydroxyl-protecting group,R.sup.2 represents hydrogen or a carboxyl-protecting group or an ester radical which can be cleaved off in vivo,R.sup.3 represents hydrogen or C.sub.1 -C.sub.10 -alkyl, C.sub.6 -C.sub.12 -aryl or C.sub.7 -C.sub.14 -aralkyl,R.sup.4 represents hydrogen or represents C.sub.1 -C.sub.10 -alkyl, C.sub.6 -C.sub.12 -aryl or C.sub.7 -C.sub.14 aralkyl, or represents C.sub.1 -C.sub.10 -alkylsulphonyl, C.sub.6 -C.sub.12 -arylsulphonyl or C.sub.7 -C.sub.14 -aralkylsulphonyl, or represents an amino-protecting group, or represents a group of the formula ##STR2## in which R.sup.5, R.sup.6 and R.sup.8 are indentical or different and denote hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.6 -C.sub.12 -aryl or C.sub.7 -C.sub.14 -aralkyl,andX represents O, S, NH or NCH.sub.3,or salts thereof.
摘要翻译：其中R 1表示氢或羟基保护基，R 2表示氢或羧基保护基或可在体内被切割的酯基的式为“IMAGE”的抗生素活性苯并唑基硫代碳青霉烯类，R3表示氢或C1- C 1 -C 12 - 芳基或C 7 -C 14 - 芳烷基，R 4表示氢或C 1 -C 10 - 烷基，C 6 -C 12 - 芳基或C 7 -C 14芳烷基，或表示C 1 -C 10 - 烷基磺酰基，C 6 -C 12 - 或芳基磺酰基或C 7 -C 14 - 芳烷基磺酰基，或表示氨基保护基，或表示其中R 5，R 6和R 8表示氢，C 1 -C 10 - 烷基，C 6 -C 12 芳基或C 7 -C 14 - 芳烷基，X表示O，S，NH或NCH 3或其盐。

4. 发明授权

US4631275A 1-Oxadethiacephalosporin derivatives and antibacterial use thereof 失效
标题翻译： 1-硫代十八烷基醚衍生物及其抗菌用途
公开(公告)号：US4631275A
公开(公告)日：1986-12-23
申请号：US696275
申请日：1985-01-30
申请人： Wolfgang Hartwig , Dieter Habich , Karl G. Metzger , Hans-Joachim Zeiler
发明人： Wolfgang Hartwig , Dieter Habich , Karl G. Metzger , Hans-Joachim Zeiler
IPC分类号： A61K31/535 , A61P31/04 , C07D498/04 , C07D505/00 , A01N43/90
CPC分类号： C07D505/00
摘要： 1-Oxadethiacephalosporin derivatives of the formula ##STR1## in which R.sup.1 denotes hydrogen or halogen,R.sup.2 denotes hydrogen or methoxy,A is a nitrogen-containing positively charged N-containing heterocyclic 5-membered to 7-membered ring which in total can contain up to 4 heteroatoms from the group of N, O and S, to which ring up to two further rings can be fused and which ring may optionally be substituted, the ring being bonded via N,B denotes optionally substituted alkoxy or amino, and the remaining radicals are more or less conventional,which are antibacterially active.
摘要翻译：式中，R1表示氢或卤素，R2表示氢或甲氧基的式“IMAGE”的1-硫代十八烷基醚衍生物，A是含氮带正电荷的含氮杂环的5元至7元环，其总共可含有至4个来自N，O和S的杂原子，其中多达两个另外的环可以被稠合并且哪个环可以被任选取代，该环通过N键合，B表示任选取代的烷氧基或氨基，剩余的自由基或多或少是常规的，其具有抗菌活性。

5. 发明授权

US4438114A .beta.-Lactam antibiotics 失效
标题翻译： β-内酰胺抗生素
公开(公告)号：US4438114A
公开(公告)日：1984-03-20
申请号：US415632
申请日：1982-09-07
申请人： Michael Boberg , Dieter Habich , Karl G. Metzger , Paul Naab
发明人： Michael Boberg , Dieter Habich , Karl G. Metzger , Paul Naab
IPC分类号： A23L29/00 , A23L2/44 , A61K31/535 , A61P31/04 , C07D505/00 , C07D498/04
CPC分类号： C07D505/00 , Y02P20/55
摘要： A .beta.-lactam of the formula ##STR1## or a hydrate thereof, in whichR represents a hydrogen atom or a methoxy group,n is 1 or 2,Z represents a group of the formula ##STR2## wherein R.sup.1 denotes an optionally substituted aryl group or an optionally substituted heterocyclyl group;or, when n is 1,Z can also represent an optionally substituted cycloalkyl group or an optionally substituted pseudoaromatic heterocyclic 5-membered or 6-membered ring,B represents an optionally substituted phenyl or cyclohexadienyl group, or an unsaturated optionally subtituted heterocyclic ring,T denotes an alkyl--CO--O--, pyridinium, aminopyridinium, carbamoylpyridinium or carbamoyloxy group, an --S--phenyl group which can be substituted, or an --S--Het group in which Het represents an optionally substituted heterocyclic 5-membered or 6-membered ring; andE represents a hydrogen atom, a pharmaceutically acceptable ester grouping a salt-forming cation or a protective group, or represents a negative charge when T contains a quaternary nitrogen,which possesses antibacterial activity rendering it useful as an antibiotic and animal feed supplement.
摘要翻译：其中R表示氢原子或甲氧基，其中n表示1或2，Z表示下式的基团：其中R 1，R 2，R 3，表示任选取代的芳基或任选取代的杂环基; 或者当n为1时，Z还可以表示任选取代的环烷基或任选取代的假芳香杂环5元或6元环，B表示任选取代的苯基或环己二烯基，或不饱和任选取代的杂环，T 表示烷基-CO-O-，吡啶鎓，氨基吡啶鎓，氨基甲酰基吡啶鎓或氨基甲酰氧基，可被取代的-S-苯基或其中Het表示任选取代的杂环5元或6-元烷基的-S-Het基团，元环并且E表示氢原子，成盐阳离子或保护基的药学上可接受的酯基，或当T含有季氮时具有负电荷，其具有抗菌活性，使其可用作抗生素和动物饲料添加剂。

6. 发明授权

US5480879A Quinolonecarboxylic acids 失效
标题翻译：喹诺酮羧酸
公开(公告)号：US5480879A
公开(公告)日：1996-01-02
申请号：US131253
申请日：1993-10-01
申请人： Uwe Petersen , Wilfried Schrock , Dieter Habich , Andreas Krebs , Thomas Schenke , Thomas Philipps , Klaus Grohe , Rainer Endermann , Klaus-Dieter Bremm , Karl-Georg Metzger
发明人： Uwe Petersen , Wilfried Schrock , Dieter Habich , Andreas Krebs , Thomas Schenke , Thomas Philipps , Klaus Grohe , Rainer Endermann , Klaus-Dieter Bremm , Karl-Georg Metzger
IPC分类号： A61K31/43 , A61K31/435 , A61K31/47 , A61K31/535 , A61K31/545 , A61P31/04 , C07D417/12 , C07D463/00 , C07D477/00 , C07D477/14 , C07D498/04 , C07D499/88 , C07D501/00 , C07D501/16 , C07D513/06 , C07D519/00 , C07D519/06 , C07D487/04
CPC分类号： C07D477/14 , C07D499/88 , C07D501/00
摘要： The invention relates to novel derivatives of quinolonecarboxylic acid and naphthyridonecarboxylic acid which are linked to a .beta.-lactam antibiotic, to their salts, to processes for their preparation and to antibacterial agents containing these derivatives.
摘要翻译：本发明涉及与β-内酰胺抗生素连接的喹诺酮羧酸和萘啶酮羧酸的新型衍生物，其盐，其制备方法和含有这些衍生物的抗菌剂。

7. 发明授权

US6069160A Heteroatom-containing benzocyclopentane-oxazolidinones 失效
标题翻译：含杂原子的苯并环戊烷 - 恶唑烷酮
公开(公告)号：US6069160A
公开(公告)日：2000-05-30
申请号：US631516
申请日：1996-04-12
申请人： Andreas Stolle , Dieter Habich , Stephan Bartel , Bernd Riedl , Martin Ruppelt , Hanno Wild , Rainer Endermann , Klaus-Dieter Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
发明人： Andreas Stolle , Dieter Habich , Stephan Bartel , Bernd Riedl , Martin Ruppelt , Hanno Wild , Rainer Endermann , Klaus-Dieter Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
IPC分类号： A61K31/40 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/655 , A61K31/66 , A61P31/04 , C07D263/58 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/04 , C07F9/6558 , C07F9/6584 , A61K31/428 , C07D263/54 , C07D277/62
CPC分类号： C07D263/58 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/04 , C07F9/6558 , C07F9/65842
摘要： The invention relates to heteroatom-containing benzocyclopentaneoxazolidinones, to processes for their preparation and their use as medicaments, especially as antibacterial medicaments.
摘要翻译：本发明涉及含杂原子的苯并环戊恶唑烷酮，其制备方法及其作为药物的用途，特别是作为抗菌药物。

8. 发明授权

US5529998A Benzoxazolyl- and benzothiazolyloxazolidinones 失效
标题翻译：苯并恶唑基和苯并噻唑基恶唑烷酮
公开(公告)号：US5529998A
公开(公告)日：1996-06-25
申请号：US508245
申请日：1995-07-27
申请人： Dieter Habich , Bernd Riedl , Martin Ruppelt , Andreas Stolle , Hanno Wild , Rainer Endermann , Klaus D. Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
发明人： Dieter Habich , Bernd Riedl , Martin Ruppelt , Andreas Stolle , Hanno Wild , Rainer Endermann , Klaus D. Bremm , Hein-Peter Kroll , Harald Labischinski , Klaus Schaller , Hans-Otto Werling
IPC分类号： C07D491/113 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5377 , A61K31/55 , A61P31/04 , C07D247/02 , C07D263/38 , C07D263/56 , C07D263/58 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/12 , C07D491/10 , C07D413/02 , C07D417/02
CPC分类号： C07D263/58 , C07D417/04 , C07D417/14 , C07D491/10
摘要： The invention relates to benzoxazolyl- and benzothiazolyloxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
摘要翻译：本发明涉及苯并恶唑基和苯并噻唑基恶唑烷酮，其制备方法及其作为药物的用途，特别是抗菌药物。

9. 发明授权

US5492918A Use of substituted chromans, some of which are known, as medicaments, new active compounds and processes for their preparation 失效
标题翻译：取代的苯并二氢吡喃酮（其中一些已知的）用作药物，新的活性化合物及其制备方法
公开(公告)号：US5492918A
公开(公告)日：1996-02-20
申请号：US251986
申请日：1994-06-01
申请人： Hanno Wild , Wolfgang Bender , Dieter Habich , Hans-Georg Heine , Siegfried Raddatz , Wolfgang Roben , Jutta Hansen , Arnold Paessens
发明人： Hanno Wild , Wolfgang Bender , Dieter Habich , Hans-Georg Heine , Siegfried Raddatz , Wolfgang Roben , Jutta Hansen , Arnold Paessens
IPC分类号： A61K31/443 , A61K31/445 , A61P31/12 , C07D405/06 , C07D405/14
CPC分类号： C07D405/06 , C07D405/14
摘要： The present invention relates to the use of substituted chromans of the general formula (I) ##STR1## in which the substituents have the meaning indicated in the description, for the production of medicaments, in particular as HIV protease-inhibiting agents, new active compounds and processes for their preparation.
摘要翻译：本发明涉及通式（I）的取代苯并二氢吡喃的用途，其中取代基具有说明书中指出的含义，用于生产药物，特别是作为HIV蛋白酶抑制剂，新的活性化合物及其制备方法。

10. 发明授权

US5147865A Phosphonopyrrolidine- and piperidine-containing pseudopeptides of the statin type, a process for their preparation and their use as medicaments against retroviruses 失效
标题翻译：苯妥英类和苯哌啶类药物的类型，其制备方法及其作为抗逆转录病毒药物使用的方法
公开(公告)号：US5147865A
公开(公告)日：1992-09-15
申请号：US746272
申请日：1991-08-15
申请人： Dieter Habich , Jutta Hansen , Arnold Paessens
发明人： Dieter Habich , Jutta Hansen , Arnold Paessens
IPC分类号： A61K31/675 , A61K38/00 , A61P31/12 , A61P31/18 , C07F9/572 , C07F9/59 , C07K5/02 , C07K5/06 , C07K5/08
CPC分类号： C07K5/0205 , C07F9/5726 , A61K38/00
摘要： The invention relates to new phosphonopyrrolidine- and piperidine-containing pseudopeptides, to a process for their preparation and to their use as medicaments, in particular as antiviral agents in human and veterinary medicine.
摘要翻译：本发明涉及新的膦酰基吡咯烷和哌啶的伪肽，涉及其制备方法和用作药物，特别是作为人和兽医学中的抗病毒剂。

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