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1. 发明授权

US09180307B2 Method of reducing the occurrence of arrhythmias via photobiomodulation and apparatus for same 有权
标题翻译：通过光生物调节法减少心律失常发生的方法及其设备
公开(公告)号：US09180307B2
公开(公告)日：2015-11-10
申请号：US13047983
申请日：2011-03-15
申请人： Karin Järverud , Cecilia Emanuelsson , Anders Björling , Kjell Noren
发明人： Karin Järverud , Cecilia Emanuelsson , Anders Björling , Kjell Noren
IPC分类号： A61N5/06 , A61B5/05 , A61N1/39 , A61B5/103 , A61B18/18 , A61N1/00 , A61B5/117 , A61N1/30
CPC分类号： A61N5/0613 , A61B5/0408 , A61B5/05 , A61B5/103 , A61B5/117 , A61B18/18 , A61B18/20 , A61B2018/00577 , A61N1/00 , A61N1/056 , A61N1/30 , A61N1/362 , A61N1/39 , A61N5/06 , A61N5/0603 , A61N2005/0602 , A61N2005/0609 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0659 , A61N2005/0662
摘要： In response to local or systemic inflammation in a patient, photobiomodulation therapy is applied to a cardiac location to reduce the risk and/or occurrence of cardiac arrhythmia. Once inflammation is identified, photobiomodulation therapy can be applied in any suitable fashion (e.g., via a catheter- or transesophageal probe-mounted photoemitter, via an externally-applied photoemitter, or via photoemitter incorporated into an implantable medical device). Photobiomodulation therapy can also be employed to good advantage in conjunction with non-photobiomodulation therapy (e.g., traditional cardiac rhythm management therapies).
摘要翻译：响应于患者的局部或全身炎症，将光生物调节治疗应用于心脏位置以降低心律失常的风险和/或发生。一旦发现炎症，可以以任何合适的方式（例如经由经导管或经食管探针安装的光发射器，经由外部施加的光电探测器，或通过并入可植入医疗装置中的光电发生器）应用光生物调节治疗。结合非光生物调节治疗（例如传统的心律管理疗法）也可以利用光生物调节治疗来获得良好的优点。

2. 发明授权

US08060203B2 Method and apparatus for determining variation over time of a medical parameter of a human being 有权
标题翻译：用于确定人的医学参数随时间变化的方法和装置
公开(公告)号：US08060203B2
公开(公告)日：2011-11-15
申请号：US12438397
申请日：2006-08-28
申请人： Karin Järverud , Kjell Noren
发明人： Karin Järverud , Kjell Noren
IPC分类号： A61N1/00
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/1116 , A61B5/686 , A61B5/7239 , A61N1/36564 , A61N1/3702
摘要： An apparatus for determining variation over time of a medical parameter of a human being obtained from a sensed signal has a sensor implantable in the human being for sensing the signal. A comparator compares at least one characteristic property, derived from the sensed signal obtained for at least one predetermined first level of activity of the human being, with corresponding reference property of a sensed reference signal, obtained for a predetermined reference level of activity of the human being, for determining a relation between the characteristic property of the sensed signal and the reference property. A trend determining unit determines trends in the medical parameter by analyzing the relation between the characteristic property of the sensed signal obtained at different times and the reference property. A corresponding method also function an implant for heart failure diagnostics also function as described. A sensor is then arranged to pick up dynamic mechanical information from the heart of the human being and generate a corresponding signal. A heart stimulator includes such an implant and a control unit arranged to control stimulation of the heart depending on determined trends in the medical parameter.
摘要翻译：用于确定从感测信号获得的人的医学参数随时间变化的装置具有可植入人体的用于感测信号的传感器。比较器比较从针对人的至少一个预定的第一活动水平获得的感测信号导出的至少一个特征属性与针对人的预定参考活动水平获得的感测参考信号的相应参考特性用于确定感测信号的特性与参考属性之间的关系。趋势确定单元通过分析在不同时间获得的感测信号的特性与参考属性之间的关系来确定医疗参数的趋势。相应的方法也可以用于心力衰竭诊断的植入物也起到所述的作用。然后设置传感器以从人的心脏拾取动态机械信息并产生相应的信号。心脏刺激器包括这样的植入物和控制单元，其被布置成根据医学参数中确定的趋势来控制心脏的刺激。

3. 发明授权

US08000790B2 Device for adjusting the sensitivity level of an implantable medical device 有权
标题翻译：用于调节植入式医疗装置的灵敏度水平的装置
公开(公告)号：US08000790B2
公开(公告)日：2011-08-16
申请号：US10576178
申请日：2003-10-27
申请人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
发明人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3704 , A61B5/0452 , A61N1/368
摘要： An implantable cardiac stimulation device has an atrial detector that detects atrial events of a patient's heart, and a memory in which sequences of IEGM signals are stored, having a predetermined length, and an analyzing unit that analyzes the sequences to determine if the stored sequences contain atrial events having a lower amplitude than the current sensitivity setting of the atrial detector. A control unit is connected to the atrial detector to adjust the sensitivity setting thereof to a threshold that is determined based on the aforementioned analysis of the IEGM signals.
摘要翻译：可植入心脏刺激装置具有心房检测器，其检测患者心脏的心房事件，以及存储具有预定长度的IEGM信号序列的存储器，以及分析单元，其分析序列以确定所存储的序列是否包含心房事件的振幅低于心房检测器的当前灵敏度设置。控制单元连接到心房检测器以将其灵敏度设置调整到基于上述对IEGM信号的分析确定的阈值。

4. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

5. 发明授权

US08755874B2 Implantable medical device and method for classifying arrhythmia events 有权
标题翻译：植入式医疗器械和心律失常事件分类方法
公开(公告)号：US08755874B2
公开(公告)日：2014-06-17
申请号：US12989581
申请日：2008-05-07
申请人： Anders Björling , Rupinder Bharmi , Michael Broomé , Karin Järverud
发明人： Anders Björling , Rupinder Bharmi , Michael Broomé , Karin Järverud
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/0809 , A61B5/7264 , A61N1/3622 , A61N1/36585 , A61N1/395 , A61N1/3987
摘要： In an implantable medical device such as an implantable cardiac defibrillator, and a method for classifying arrhythmia events, IEGM signals are analyzed to detect an arrhythmia event and a respiratory pattern of the patient is sensed. At least one respiratory parameter reflecting characteristics of the respiratory pattern of the patient is determined based on the sensed respiratory pattern and a respiratory measure corresponding to a change of a rate of change of the at least one respiratory parameter is calculated. The detected arrhythmia event is classified based on the respiratory measure and the IEGM signals, wherein arrhythmia events that satisfy at least a first criterion is classified as an arrhythmia event requiring therapy.
摘要翻译：在诸如可植入心脏除颤器的可植入医疗装置和用于分类心律失常事件的方法中，分析IEGM信号以检测心律失常事件并感测患者的呼吸模式。基于感测到的呼吸模式来确定反映患者呼吸模式特征的至少一个呼吸参数，并且计算与至少一个呼吸参数的变化率的变化相对应的呼吸测量。基于呼吸测量和IEGM信号对所检测到的心律失常事件进行分类，其中满足至少第一标准的心律失常事件被分类为需要治疗的心律失常事件。

6. 发明授权

US08738120B2 Implantable medical device and method comprising means for detecting and classifying an arrhythmia 有权
标题翻译：可植入医疗装置和方法包括用于检测和分类心律失常的装置
公开(公告)号：US08738120B2
公开(公告)日：2014-05-27
申请号：US13696261
申请日：2010-05-12
申请人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
发明人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
IPC分类号： A61B5/0468
CPC分类号： A61N1/3621 , A61N1/3622 , A61N1/36521 , A61N1/3704 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during at least a portion of cardiac cycle. A moment processor (132) calculates a moment parameter value based on the cardiogenic impedance signal. The moment parameter is representative of a weighted sum of impedance amplitudes within a time window centered at defined time instance within the cardiac cycle. The weights of the impedance amplitudes are further dependent on the length in time between the defined time instance and the point of time of the associated impedance amplitude. The moment parameter is of high diagnostic value and is employed by an arrhythmia classifier (132) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在心脏周期的至少一部分期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源性阻抗信号。时刻处理器（132）基于心源阻抗信号计算力矩参数值。力矩参数代表以心动周期内规定时间范围为中心的时间窗内的阻抗振幅加权和。阻抗幅度的权重进一步取决于所定义的时间实例和相关联的阻抗幅度的时间点之间的时间长度。时刻参数具有很高的诊断价值，并被心律失常分类器（132）采用，以便将检测到的心脏（10）的心律失常进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

7. 发明申请

US20110112419A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR CLASSIFYING ARRHYTHMIA EVENTS 有权
标题翻译：可植入医疗装置和分类ARRHYTHMIA事件的方法
公开(公告)号：US20110112419A1
公开(公告)日：2011-05-12
申请号：US12989581
申请日：2008-05-07
申请人： Anders Björling , Rupinder Bharmi , Michael Broomé , Karin Järverud
发明人： Anders Björling , Rupinder Bharmi , Michael Broomé , Karin Järverud
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/0809 , A61B5/7264 , A61N1/3622 , A61N1/36585 , A61N1/395 , A61N1/3987
摘要： In an implantable medical device such as an implantable cardiac defibrillator, and a method for classifying arrhythmia events, IEGM signals are analyzed to detect an arrhythmia event and a respiratory pattern of the patient is sensed. At least one respiratory parameter reflecting characteristics of the respiratory pattern of the patient is determined based on the sensed respiratory pattern and a respiratory measure corresponding to a change of a rate of change of the at least one respiratory parameter is calculated. The detected arrhythmia event is classified based on the respiratory measure and the IEGM signals, wherein arrhythmia events that satisfy at least a first criterion is classified as an arrhythmia event requiring therapy.
摘要翻译：在诸如可植入心脏除颤器的可植入医疗装置和用于分类心律失常事件的方法中，分析IEGM信号以检测心律失常事件并感测患者的呼吸模式。基于感测到的呼吸模式来确定反映患者呼吸模式特征的至少一个呼吸参数，并且计算与至少一个呼吸参数的变化率的变化相对应的呼吸测量。基于呼吸测量和IEGM信号对所检测到的心律失常事件进行分类，其中满足至少第一标准的心律失常事件被分类为需要治疗的心律失常事件。

8. 发明申请

US20110046691A1 IMPLANTABLE HEART STIMULATOR DETERMINING LEFT VENTRICULAR SYSTOLIC PRESSURE 审中-公开
标题翻译：可植入心脏刺激器确定左心室舒张压
公开(公告)号：US20110046691A1
公开(公告)日：2011-02-24
申请号：US12990136
申请日：2008-06-18
申请人： Anders Björling , Andreas Blomqvist , Karin Järverud
发明人： Anders Björling , Andreas Blomqvist , Karin Järverud
IPC分类号： A61N1/36
CPC分类号： A61B5/0215 , A61B5/053 , A61N1/36521
摘要： An implantable heart stimulator has an impedance measurement a cardiogenic impedance waveform using an impedance configuration arranged to measure myocardial contractility of the heart. The heart stimulator further has a calculating unit that calculates an estimate value being related to at least two impedance values of the waveform, or of an average waveform of several consecutive waveforms, during a predetermined time period of the waveform, or average waveform, the calculated estimate value being an estimate of the left ventricular (LV) systolic pressure.
摘要翻译：可植入心脏刺激器具有使用布置成测量心脏的心肌收缩力的阻抗配置的心源阻抗波形的阻抗测量。心脏刺激器还具有计算单元，该计算单元在波形的预定时间段期间，计算与波形的至少两个阻抗值或几个连续波形的平均波形有关的估计值，或者计算出平均波形估计值是左心室（LV）收缩压的估计值。

9. 发明授权

US07181279B2 Implantable heart stimulating device, system and method 有权
标题翻译：植入式心脏刺激装置，系统及方法
公开(公告)号：US07181279B2
公开(公告)日：2007-02-20
申请号：US10781171
申请日：2004-02-18
申请人： Anders Björling , Nils Holmström , Karin Järverud
发明人： Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device and system operate, within a time cycle, to deliver pacing pulses with both a first and a second pacing circuit with a first time delay between these pacing pulses. The device employs a criterion with which a signal typical for a premature ventricular contraction is detected. The device also operates with a second time delay and/or with a third time delay, and, if a predefined pacing rule is fulfilled, to deliver a pacing pulse with the second time delay or said third time delay. The risk for arrhythmia in connection with a PVC is reduced.
摘要翻译：一种可植入的双心室心脏刺激装置和系统在一个时间周期内操作，以便在这些起搏脉冲之间具有第一和第二起搏电路与第一时间延迟之间输送起搏脉冲。该装置采用标准，通过该标准可以检测出早期心室收缩的典型信号。该装置还以第二时间延迟和/或第三时间延迟进行操作，并且如果满足预定的起搏规则，则以第二时间延迟或所述第三时间延迟递送起搏脉冲。与PVC相关的心律失常风险降低。

10. 发明授权

US07089058B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07089058B2
公开(公告)日：2006-08-08
申请号：US10813776
申请日：2004-03-31
申请人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
发明人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart. Evoked response detectors having blanking intervals following the delivery of pacing pulses include sensing elements for sensing IEGM-signals from each of the heart chambers and an integrating unit that integrates the IEGM-signal within evoked response detection time windows after delivery of pacing pulses for detecting evoked response. The evoked response detection time window for a heart chamber contain at least one blanking interval resulting from delivery of a pacing pulse to another chamber and each of the sensed IEGM signals having a generally known morphology. An integral reconstructing unit reconstructs the time integral of the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲。在递送起搏脉冲之后具有消隐间隔的诱发响应检测器包括用于感测来自每个心室的IEGM信号的感测元件和在递送用于检测诱发的起搏脉冲之后的诱发响应检测时间窗口内积分IEGM信号的积分单元响应。心室的诱发反应检测时间窗口包含至少一个消隐间隔，其由将起搏脉冲递送到另一个腔室而产生，每个感测的IEGM信号具有通常已知的形态。整体重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号的时间积分。

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