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1. 发明申请

US20070055300A1 Methods and devices for treating fractured and/or diseased bone using an expandable balloon structure that remains within the bone 审中-公开
$Methods and devices for treating fractured and/or diseased bone using an expandable balloon structure that remains within the bone$
标题翻译：使用保留在骨内的可膨胀气囊结构来治疗骨折和/或患病骨的方法和装置
公开(公告)号：US20070055300A1
公开(公告)日：2007-03-08
申请号：US11527859
申请日：2006-09-27
申请人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista , Mark Reiley , Arie Scholten , Karen Talmadge , Robert Scribner
发明人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista , Mark Reiley , Arie Scholten , Karen Talmadge , Robert Scribner
IPC分类号： A61M29/00
CPC分类号： A61F2/4601 , A61B17/1604 , A61B17/1671 , A61B17/3472 , A61B17/8805 , A61B17/8855 , A61B50/33 , A61B90/39 , A61B2017/00261 , A61B2017/00464 , A61B2017/00539 , A61B2017/00557 , A61B2017/00867 , A61B2050/0065 , A61B2090/062 , A61F2/44 , A61F2002/2835 , A61F2002/3008 , A61F2002/30581 , A61F2002/4602 , A61F2002/4624 , A61F2002/4635 , A61F2002/4662 , A61F2250/0098 , A61F2310/00353
摘要： A percutaneous path is created into a bone having an interior volume occupied, at least in part, by a cancellous bone, e.g., a vertebral body. An expandable balloon structure is introduced into the cancellous bone by deployment of a tool through the percutaneous path into the cancellous bone. The expandable balloon structure is expanded and the tool withdrawn, leaving the expandable balloon structure expanded inside the cancellous bone. Expansion of the expandable balloon structure within cancellous bone can, e.g., compact cancellous bone, and/or create a cavity in cancellous bone, and/or move fractured cortical bone.
摘要翻译：将经皮通路产生到具有至少部分由松质骨例如椎体占据的内部体积的骨中。通过将穿过经皮途径的工具部署到松质骨中，将可膨胀气囊结构引入松质骨。可膨胀气囊结构膨胀并且工具被取出，留下可膨胀气囊结构在松质骨内部扩张。松质骨内的可膨胀气囊结构的扩张可以例如紧实的松质骨，和/或在松质骨中产生空腔，和/或移动骨折的皮质骨。

2. 发明申请

US20080065087A1 Methods for treating a fractured and/or diseased and/or weakened bone 有权
$Methods for treating a fractured and/or diseased and/or weakened bone$
标题翻译：用于治疗骨折和/或患病和/或减弱的骨的方法
公开(公告)号：US20080065087A1
公开(公告)日：2008-03-13
申请号：US11978271
申请日：2007-10-29
申请人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista
发明人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista
IPC分类号： A61B17/58
CPC分类号： A61F2/4601 , A61B17/1604 , A61B17/1671 , A61B17/3472 , A61B17/8805 , A61B17/8855 , A61B50/33 , A61B90/39 , A61B2017/00261 , A61B2017/00464 , A61B2017/00539 , A61B2017/00557 , A61B2017/00867 , A61B2050/0065 , A61B2090/062 , A61F2/44 , A61F2002/2835 , A61F2002/3008 , A61F2002/30581 , A61F2002/4602 , A61F2002/4624 , A61F2002/4635 , A61F2002/4662 , A61F2250/0098 , A61F2310/00353
摘要： Introduction of a bone filler material into at least a portion of the cancellous bone volume pressurizes the bone filler material and compresses the cancellous bone volume within the bone structure.
摘要翻译：将骨填充材料引入松质骨体积的至少一部分中，对骨填充材料进行加压并压缩骨结构内的松质骨体积。

3. 发明申请

US20080027554A1 KIT AND METHODS OF TREATMENT OF AN INTERVERTEBRAL DISC 审中-公开
标题翻译：治疗椎间盘的药盒和方法
公开(公告)号：US20080027554A1
公开(公告)日：2008-01-31
申请号：US11830294
申请日：2007-07-30
申请人： Karen Talmadge
发明人： Karen Talmadge
IPC分类号： A61F2/44
CPC分类号： A61L27/50 , A61F2002/444 , A61L27/227
摘要： Methods and kits for performing minimally invasive medical procedures are disclosed herein. In one embodiment, a method includes injecting an enzyme that is less immunogenic than chymopapain into an interior portion of an intervertebral disc. The enzyme can be mixed with a buffer prior to, during or after the injecting. The enzyme is configured to dissolve tissue within the interior portion of the intervertebral disc. Tissue that is dissolved by the enzyme can be removed from the interior portion of the intervertebral disc after the injecting. In some embodiments, the enzyme is a serine protease having an ability to sensitize that is less than chymopapain's ability to sensitize.
摘要翻译：本文公开了用于执行微创医疗程序的方法和试剂盒。在一个实施方案中，一种方法包括将比木瓜凝乳蛋白酶低的免疫原性的酶注射到椎间盘的内部。该酶可以在注射之前，期间或之后与缓冲液混合。该酶被配置成在椎间盘的内部部分内溶解组织。在注射后可以从椎间盘的内部去除由酶溶解的组织。在一些实施方案中，酶是具有敏化能力小于木瓜凝乳蛋白酶敏化能力的丝氨酸蛋白酶。

4. 发明申请

US20070060941A1 Systems and methods for removing tissue from a cancellous bone volume 审中-公开
标题翻译：从松质骨体积中去除组织的系统和方法
公开(公告)号：US20070060941A1
公开(公告)日：2007-03-15
申请号：US11528163
申请日：2006-09-27
申请人： Mark Reiley , Arie Scholten , Karen Talmadge , Robert Scribner
发明人： Mark Reiley , Arie Scholten , Karen Talmadge , Robert Scribner
IPC分类号： A61M29/00
CPC分类号： A61B17/8855 , A61B10/025 , A61B10/0283 , A61B17/00234 , A61B17/7061 , A61B17/7097 , A61B17/7098 , A61B17/7258 , A61B17/7291 , A61B17/742 , A61B17/744 , A61B17/8805 , A61B17/8811 , A61B17/8816 , A61B50/33 , A61B90/39 , A61B90/94 , A61B2010/0258 , A61B2017/00539 , A61B2017/00544 , A61B2017/0256 , A61B2050/0065 , A61B2050/3015 , A61F2/28 , A61F2/2846 , A61F2/44 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/2825 , A61F2002/2828 , A61F2002/2832 , A61F2002/2835 , A61F2002/2853 , A61F2002/2871 , A61F2002/2892 , A61F2002/30113 , A61F2002/30115 , A61F2002/30125 , A61F2002/30133 , A61F2002/30225 , A61F2002/30228 , A61F2002/30242 , A61F2002/30247 , A61F2002/30253 , A61F2002/30285 , A61F2002/30288 , A61F2002/30308 , A61F2002/30311 , A61F2002/30313 , A61F2002/30448 , A61F2002/30462 , A61F2002/30464 , A61F2002/30581 , A61F2002/30586 , A61F2002/30599 , A61F2002/30677 , A61F2002/30909 , A61F2002/4217 , A61F2002/4602 , A61F2002/4627 , A61F2002/4635 , A61F2002/4636 , A61F2002/4685 , A61F2220/005 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61F2230/0015 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076 , A61F2250/0063 , A61F2310/00293 , A61F2310/00353 , A61F2310/0097 , A61M25/10 , A61M25/1002 , A61M29/00 , A61M29/02 , A61M2210/02 , A61M2210/1003
摘要： A cavity forming structure is introduced through a percutaneous access path into a selected bone having an interior volume occupied, at least in part, by cancellous bone, e.g., a vertebral body. A cavity is formed in the cancellous bone volume by manipulation of the cavity forming structure. Tissue is removed from within the cavity through the percutaneous access path.
摘要翻译：空腔形成结构通过经皮进入路径被引入到具有至少部分由松质骨例如椎体占据的内部体积的选定的骨中。通过操作空腔形成结构在松质骨体积中形成空腔。组织通过经皮进入路径从腔内移除。

5. 发明申请

US20070055285A1 Methods and devices for treating fractured and/or diseased bone using an expandable stent structure 有权
$Methods and devices for treating fractured and/or diseased bone using an expandable stent structure$
标题翻译：使用可扩张支架结构治疗骨折和/或患病骨的方法和装置
公开(公告)号：US20070055285A1
公开(公告)日：2007-03-08
申请号：US11528146
申请日：2006-09-27
申请人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista
发明人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista
IPC分类号： A61F2/00
CPC分类号： A61F2/4601 , A61B17/1604 , A61B17/1671 , A61B17/3472 , A61B17/8805 , A61B17/8855 , A61B50/33 , A61B90/39 , A61B2017/00261 , A61B2017/00464 , A61B2017/00539 , A61B2017/00557 , A61B2017/00867 , A61B2050/0065 , A61B2090/062 , A61F2/44 , A61F2002/2835 , A61F2002/3008 , A61F2002/30581 , A61F2002/4602 , A61F2002/4624 , A61F2002/4635 , A61F2002/4662 , A61F2250/0098 , A61F2310/00353
摘要： A percutaneous path is established into a selected bone having an interior volume occupied, at least in part, by a cancellous bone, e.g., a vertebral body. An expandable stent structure is introduced into the cancellous bone by deployment of a tool through the percutaneous path into the cancellous bone. The expandable stent structure is expanded within cancellous bone.
摘要翻译：经皮途径被建立到具有至少部分由松质骨例如椎体占据的内部体积的选定的骨中。通过将穿过经皮途径的工具部署到松质骨中，将可扩张支架结构引入松质骨。可膨胀支架结构在松质骨内扩张。

6. 发明申请

US20070055278A1 Method and devices for treating fractured and/or diseased bone using an expandable mesh structure that remains within the bone 审中-公开
$Method and devices for treating fractured and/or diseased bone using an expandable mesh structure that remains within the bone$
标题翻译：使用保留在骨内的可扩张网状结构来治疗骨折和/或患病骨的方法和装置
公开(公告)号：US20070055278A1
公开(公告)日：2007-03-08
申请号：US11527952
申请日：2006-09-27
申请人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista , Mark Reiley , Arie Scholten , Robert Scribner
发明人： Reynaldo Osorio , Marialulu Follmer , Richard Layne , Ryan Boucher , Karen Talmadge , Joseph Basista , Mark Reiley , Arie Scholten , Robert Scribner
IPC分类号： A61F2/00
CPC分类号： A61F2/4601 , A61B17/1604 , A61B17/1671 , A61B17/3472 , A61B17/8805 , A61B17/8855 , A61B50/33 , A61B90/39 , A61B2017/00261 , A61B2017/00464 , A61B2017/00539 , A61B2017/00557 , A61B2017/00867 , A61B2050/0065 , A61B2090/062 , A61F2/44 , A61F2002/2835 , A61F2002/3008 , A61F2002/30581 , A61F2002/4602 , A61F2002/4624 , A61F2002/4635 , A61F2002/4662 , A61F2250/0098 , A61F2310/00353
摘要： A percutaneous path is created into a bone having an interior volume occupied, at least in part, by a cancellous bone, e.g., a vertebral body. An expandable mesh structure is introduced into the cancellous bone by deployment of a tool through the percutaneous path into the cancellous bone. The expandable mesh structure is expanded and the tool withdrawn, leaving the expandable mesh structure expanded inside the cancellous bone. Expansion of the expandable mesh structure within cancellous bone can, e.g., compact cancellous bone, and/or create a cavity in cancellous bone, and/or move fractured cortical bone.
摘要翻译：将经皮通路产生到具有至少部分由松质骨例如椎体占据的内部体积的骨中。通过将穿过经皮途径的工具部署到松质骨中，将可扩张网状结构引入松质骨。可膨胀网状结构膨胀并且工具被取出，留下可膨胀网状结构在松质骨内部扩张。松质骨内的可膨胀网状结构的扩张可以例如紧实的松质骨，和/或在松质骨中产生空腔，和/或移动骨折的皮质骨。

7. 发明申请

US20060235460A1 Cavity formation device 审中-公开
标题翻译：腔形成装置
公开(公告)号：US20060235460A1
公开(公告)日：2006-10-19
申请号：US11450337
申请日：2006-06-12
申请人： Mark Reiley , Arie Scholten , Karen Talmadge
发明人： Mark Reiley , Arie Scholten , Karen Talmadge
IPC分类号： A61M29/00
CPC分类号： A61F2/4601 , A61B17/7258 , A61B17/8855 , A61B2017/00557 , A61B2017/0256 , A61F2/3601 , A61F2/389 , A61F2/441 , A61F2002/2828 , A61F2002/2832 , A61F2002/2853 , A61F2002/2871 , A61F2002/2892 , A61F2002/30131 , A61F2002/30133 , A61F2002/30204 , A61F2002/30225 , A61F2002/30228 , A61F2002/30242 , A61F2002/30581 , A61F2002/30586 , A61F2002/30599 , A61F2002/30677 , A61F2002/30686 , A61F2002/3611 , A61F2002/3625 , A61F2002/4062 , A61F2002/4602 , A61F2230/0013 , A61F2230/0015 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2250/0063 , A61M25/10 , A61M25/1002 , A61M25/1011 , A61M2025/1072 , A61M2210/02 , A61M2210/1003
摘要： A balloon for use in compressing cancellous bone and marrow (also known as medullary bone or trabecular bone) against the inner cortex of bones whether the bones are fractured or not. The balloon comprises an inflatable, non-expandable balloon body for insertion into said bone. The body has a shape and size to compress at least a portion of the cancellous bone to form a cavity in the cancellous bone and to restore the original position of the outer cortical bone, if fractured or collapsed. The balloon is prevented from applying excessive pressure to the outer cortical bone. The wall or walls of the balloon are such that proper inflation the balloon body is achieved to provide for optimum compression of all the bone marrow. The balloon is able to be folded so that it can be inserted quickly into a bone. The balloon can be made to have a suction catheter. It can also be coated with therapeutic substances. The main purpose of the balloon is the forming or enlarging of a cavity or passage in a bone, especially in, but not limited to, vertebral bodies. Another important purpose is to deliver therapeutic substances to bone in an improved way.
摘要翻译：一种用于压缩松质骨和骨髓（也称为髓质骨或小梁骨）的球囊，无论骨头是否断裂，均可抵抗骨内皮质。气球包括用于插入所述骨中的可膨胀的，不可膨胀的气囊体。身体具有形状和尺寸以压缩松质骨的至少一部分以在松质骨中形成空腔，并且如果骨折或塌陷则恢复外皮质骨的原始位置。防止气囊对外皮质骨施加过大的压力。球囊的壁或壁使得实现气囊体的适当充气以提供所有骨髓的最佳压缩。气囊能够被折叠，使得其可以快速插入骨骼。可以使气囊具有吸引导管。它也可以涂上治疗物质。气囊的主要目的是形成或扩大骨骼中的腔或通道，特别是但不限于椎体。另一个重要的目的是以一种改进的方式将治疗物质递送到骨骼。

8. 发明申请

US20060095064A1 Expandable preformed structures for deployment in interior body regions 审中-公开
公开(公告)号：US20060095064A1
公开(公告)日：2006-05-04
申请号：US11299172
申请日：2005-12-09
申请人： Robert Scribner , Karen Talmadge
发明人： Robert Scribner , Karen Talmadge
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61B17/3472 , A61B17/7097 , A61B17/8855 , A61B90/39 , A61B2017/00526 , A61B2017/00539 , A61B2017/00544 , A61B2017/00557 , A61B2017/0256 , A61M25/002 , A61M25/1011 , A61M29/02 , A61M2210/02 , A61M2210/1003 , Y10S606/91
摘要： An expandable structure made from an elastomer material is preformed to a desired geometry by exposure to heat and pressure. The structure undergoes controlled expansion and further distention in cancellous bone, with controlled deformation and without stress failure.

9. 发明授权

US06423083B1 Inflatable device for use in surgical protocol relating to fixation of bone 失效
公开(公告)号：US06423083B1
公开(公告)日：2002-07-23
申请号：US09059796
申请日：1998-04-13
申请人： Mark A. Reiley , Arie Scholten , Karen Talmadge
发明人： Mark A. Reiley , Arie Scholten , Karen Talmadge
IPC分类号： A61B1756
摘要： A balloon for use in compressing cancellous bone and marrow (also known as medullary bone or trabecular bone) against the inner cortex of bones whether the bones are fractured or not. The balloon comprises an inflatable, non-expandable balloon body for insertion into said bone. The body has a shape and size to compress at least a portion of the cancellous bone to form a cavity in the cancellous bone and to restore the original position of the outer cortical bone, if fractured or collapsed. The balloon is prevented from applying excessive pressure to the outer cortical bone. The wall or walls of the balloon are such that proper inflation the balloon body is achieved to provide for optimum compression of all the bone marrow. The balloon is able to be folded so that it can be inserted quickly into a bone. The balloon can be made to have a suction catheter. The main purpose of the balloon is the forming or enlarging of a cavity or passage in a bone, especially in, but not limited to, vertebral bodies.

10. 发明申请

US20080132934A1 Systems and methods treating a vertebral body related applications 审中-公开
标题翻译：治疗椎体相关应用的系统和方法
公开(公告)号：US20080132934A1
公开(公告)日：2008-06-05
申请号：US11977608
申请日：2007-10-25
申请人： Mark A. Reiley , Arie Scholten , Karen Talmadge
发明人： Mark A. Reiley , Arie Scholten , Karen Talmadge
IPC分类号： A61M29/00 , A61F2/44
CPC分类号： A61B17/8855 , A61B2017/0256 , A61F2/28 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/30535 , A61F2250/0058 , A61M25/10 , A61M25/1002 , A61M29/02 , A61M2210/02 , A61M2210/1003
摘要： A vertebral body is selected for treatment. The vertebral body has a cortical wall enclosing a cancellous bone volume. The vertebral body has at least one cortical plate that is depressed due to fracture. At least one maximum dimension for the cancellous bone volume is ascertained. An expandable device is provided having an expanded configuration and an unexpanded configuration. The expandable device has a predefined dimension when substantially expanded that is less than the maximum dimension. The expandable device is introduced into the vertebral body through a percutaneous access path while in the unexpanded condition. The expandable device is expanded while disposed within the cancellous bone volume from the unexpanded configuration toward the expanded configuration to move the fractured cortical plate toward a desired anatomic position.
摘要翻译：选择椎体进行治疗。椎体具有包围松质骨体积的皮质壁。椎体具有由于骨折而被压下的至少一个皮质板。确定松质骨体积的至少一个最大尺寸。提供具有扩展配置和未扩展配置的可扩展设备。当基本上扩展时，可扩展装置具有小于最大尺寸的预定尺寸。可膨胀装置在未膨胀状态下通过经皮通路进入椎体。扩张装置在从未膨胀构型朝扩展构型放置在松质骨容积内的同时被扩张，从而将断裂的皮质板移动到期望的解剖位置。

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