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1. 发明申请

US20100330149A1 Solid Drug Tablets for Implantable Drug Delivery Devices 有权
标题翻译：可植入药物输送装置的固体药片
公开(公告)号：US20100330149A1
公开(公告)日：2010-12-30
申请号：US12825238
申请日：2010-06-28
申请人： Karen Danielle Daniel , Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee
发明人： Karen Danielle Daniel , Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee
IPC分类号： A61K31/167 , A61K9/00 , A61P13/10
CPC分类号： A61K9/0004 , A61K9/0034 , A61K9/2004 , A61K9/2027 , A61K9/2031 , A61K9/2072 , A61K9/2095 , A61K31/16 , A61K31/165 , A61K31/167 , A61M31/002 , A61M31/007 , A61M2202/06 , B65B1/16
摘要： A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another.
摘要翻译：以固体片剂的形式提供药物剂型，其大于当量麻醉剂的50重量％。局部麻醉剂可以选自氨基酰胺，氨基酯及其组合。药片可以是大于70重量％的药物的微型片剂，其余为赋形剂。例如，麻醉剂可以包括盐或碱形式的利多卡因，与粘合剂和润滑剂赋形剂组合。还提供了包括片剂在内的可植入药物递送装置，例如药物片剂中的一种或多种可以包含在生物相容的壳体中。药物片剂可以是具有平坦端面的大致圆柱形，并且该装置可以具有在壳体中对齐的10至100个药物片剂，相邻片剂的平坦端面彼此邻接。

2. 发明授权

US08343516B2 Solid drug tablets for implantable drug delivery devices 有权
标题翻译：用于可植入药物递送装置的固体药物片剂
公开(公告)号：US08343516B2
公开(公告)日：2013-01-01
申请号：US12825238
申请日：2010-06-28
申请人： Karen Danielle Daniel , Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee
发明人： Karen Danielle Daniel , Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee
IPC分类号： A61F13/00 , A61F2/02
CPC分类号： A61K9/0004 , A61K9/0034 , A61K9/2004 , A61K9/2027 , A61K9/2031 , A61K9/2072 , A61K9/2095 , A61K31/16 , A61K31/165 , A61K31/167 , A61M31/002 , A61M31/007 , A61M2202/06 , B65B1/16
摘要： A drug dosage form is provided in the form of a solid tablet which is greater than 50% by weight the local anesthetic agent. The local anesthetic agent may be selected from the group consisting of an aminoamide, an aminoester, and a combination thereof. The drug tablet may be in the form of a mini-tablet which is greater than 70 wt % drug, with the balance being excipient. For example, the anesethetic agent may include lidocaine, in a salt or base form, combined with binder and lubricant excipients. Implantable drug delivery devices including the tablets are also provided, e.g., one or more of the drug tablets may be contained in a biocompatible housing. The drug tablets may be substantially cylindrical with flat end faces, and the device may have from 10 to 100 drug tablets aligned in the housing with the flat end faces of adjacent tablets abutting one another.
摘要翻译：以固体片剂的形式提供药物剂型，其大于当量麻醉剂的50重量％。局部麻醉剂可以选自氨基酰胺，氨基酯及其组合。药片可以是大于70重量％的药物的微型片剂，其余为赋形剂。例如，麻醉剂可以包括盐或碱形式的利多卡因，与粘合剂和润滑剂赋形剂组合。还提供了包括片剂在内的可植入药物递送装置，例如药物片剂中的一种或多种可以包含在生物相容的壳体中。药物片剂可以是具有平坦端面的大致圆柱形，并且该装置可以具有在壳体中对齐的10至100个药物片剂，相邻片剂的平坦端面彼此邻接。

3. 发明申请

US20130158675A1 URETERAL STENT DRUG DELIVERY DEVICE, KIT, AND METHOD 有权
标题翻译：急性手术药物递送装置，套件和方法
公开(公告)号：US20130158675A1
公开(公告)日：2013-06-20
申请号：US13813973
申请日：2011-08-05
申请人： Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee , Jim Boyko
发明人： Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee , Jim Boyko
IPC分类号： A61F2/04
CPC分类号： A61M31/002 , A61F2/04 , A61F2002/048 , A61M25/0017 , A61M25/0041 , A61M25/0108 , A61M25/09 , A61M27/008 , A61M2025/0057 , Y10T29/49826
摘要： Ureteral stent devices having improved drug delivery capabilities are provided. The ureteral stent device includes a ureteral stent comprising two opposed ends, and a drug delivery component associated with at least one end of the ureteral stent. The drug delivery component includes a drug housing defining a drug reservoir containing a drug, wherein the drug housing is configured to release the drug in-vivo.
摘要翻译：提供具有改善的药物递送能力的输尿管支架装置。输尿管支架装置包括输尿管支架，其包括两个相对的端部，以及与输尿管支架的至少一端相关联的药物输送部件。药物递送组分包括限定含有药物的药物储存器的药物外壳，其中药物壳体构造成在体内释放药物。

4. 发明授权

US09492266B2 Ureteral stent drug delivery device, kit, and method 有权
标题翻译：输尿管支架药物输送装置，试剂盒和方法
公开(公告)号：US09492266B2
公开(公告)日：2016-11-15
申请号：US13813973
申请日：2011-08-05
申请人： Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee , Jim Boyko
发明人： Burleigh M. Hutchins, III , Cheryl Larrivee-Elkins , Heejin Lee , Jim Boyko
IPC分类号： A61F2/04 , A61F2/06 , A61M27/00 , A61M25/00
CPC分类号： A61M31/002 , A61F2/04 , A61F2002/048 , A61M25/0017 , A61M25/0041 , A61M25/0108 , A61M25/09 , A61M27/008 , A61M2025/0057 , Y10T29/49826
摘要： Ureteral stent devices having improved drug delivery capabilities are provided. The ureteral stent device includes a ureteral stent comprising two opposed ends, and a drug delivery component associated with at least one end of the ureteral stent. The drug delivery component includes a drug housing defining a drug reservoir containing a drug, wherein the drug housing is configured to release the drug in-vivo.
摘要翻译：提供具有改善的药物递送能力的输尿管支架装置。输尿管支架装置包括输尿管支架，其包括两个相对的端部，以及与输尿管支架的至少一端相关联的药物输送部件。药物递送组分包括限定含有药物的药物储存器的药物外壳，其中药物壳体构造成在体内释放药物。

5. 发明授权

US10543166B2 Implantable drug delivery devices and methods of making the same 有权
公开(公告)号：US10543166B2
公开(公告)日：2020-01-28
申请号：US12825215
申请日：2010-06-28
申请人： Heejin Lee , Cheryl Larrivee-Elkins
发明人： Heejin Lee , Cheryl Larrivee-Elkins
IPC分类号： A61K9/00 , A61K9/20 , A61K31/167 , A61M31/00 , A61K31/165 , B65B1/16 , A61K31/16
摘要： A drug delivery device is provided that includes a device body, a number of solid, compressed drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The number of solid, compressed drug tablets are positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen. The drug tablets may be mini-tablets aligned in the drug reservoir lumen, with an interstice formed between any two adjacent drug tablets facilitating deformation of the device body. Systems and method are also provided for loading a drug delivery device. In one embodiment, the method includes positioning one or more solid drug units upstream of the drug delivery device; and driving the drug units into the drug delivery device with a flow of pressurized gas.

6. 发明申请

US20110218488A1 Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites 审中-公开
标题翻译：膀胱和其他泌尿生殖部位植入装置的系统和方法
公开(公告)号：US20110218488A1
公开(公告)日：2011-09-08
申请号：US13042200
申请日：2011-03-07
申请人： Jim Boyko , Heejin Lee , Cheryl Larrivee-Elkins
发明人： Jim Boyko , Heejin Lee , Cheryl Larrivee-Elkins
IPC分类号： A61M31/00
CPC分类号： A61M31/00
摘要： An implantable drug delivery device includes a drug reservoir portion, a retention frame portion, and a guide wire portion. The drug reservoir portion houses a drug. The retention frame portion houses a retention frame. The guide wire portion defines a hollow bore for receiving a guide wire.
摘要翻译：可植入药物输送装置包括药物储存部分，保持框架部分和导丝部分。药物储存部分容纳药物。保持框架部分容纳保持框架。引导线部分限定用于接收导丝的中空孔。

7. 发明申请

US20110060309A1 Implantable Device for Controlled Drug Delivery 有权
标题翻译：用于控制药物输送的可植入装置
公开(公告)号：US20110060309A1
公开(公告)日：2011-03-10
申请号：US12851494
申请日：2010-08-05
申请人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
发明人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
IPC分类号： A61M25/00 , A61F2/00 , A61K31/16
CPC分类号： A61K9/0092 , A61K9/0004 , A61K9/0034 , A61K31/167 , A61M31/002
摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.
摘要翻译：提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

8. 发明申请

US20100331770A1 Implantable Drug Delivery Devices and Methods of Making the Same 审中-公开
标题翻译：可植入药物输送装置及其制作方法
公开(公告)号：US20100331770A1
公开(公告)日：2010-12-30
申请号：US12825215
申请日：2010-06-28
申请人： Heejin Lee , Cheryl Larrivee-Elkins
发明人： Heejin Lee , Cheryl Larrivee-Elkins
IPC分类号： A61M31/00 , B65D83/04
CPC分类号： A61K9/0004 , A61K9/0034 , A61K9/2004 , A61K9/2027 , A61K9/2031 , A61K9/2072 , A61K9/2095 , A61K31/16 , A61K31/165 , A61K31/167 , A61M31/002 , A61M31/007 , A61M2202/06 , B65B1/16
摘要： A drug delivery device is provided that includes a device body, a number of solid, compressed drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The number of solid, compressed drug tablets are positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen. The drug tablets may be mini-tablets aligned in the drug reservoir lumen, with an interstice formed between any two adjacent drug tablets facilitating deformation of the device body. Systems and method are also provided for loading a drug delivery device. In one embodiment, the method includes positioning one or more solid drug units upstream of the drug delivery device; and driving the drug units into the drug delivery device with a flow of pressurized gas.
摘要翻译：提供了一种药物递送装置，其包括装置主体，多个固体，压缩药片和保留框架。装置主体包括药物储存器腔和保持框架内腔。固体压缩药片的数量位于药物储存器腔中，并且保持框架位于保持框架腔中。药物片剂可以是在药物储存器腔中排列的微型药片，在任何两个相邻的药物片剂之间形成有促进器官体变形的间隙。还提供了用于装载药物递送装置的系统和方法。在一个实施方案中，该方法包括将药物递送装置上游的一个或多个固体药物单元定位; 并用加压气体流将药物单元驱入药物输送装置。

9. 发明授权

US08167836B2 Tissue expander configured for drug delivery 有权
标题翻译：组织扩张器配置用于药物递送
公开(公告)号：US08167836B2
公开(公告)日：2012-05-01
申请号：US12963621
申请日：2010-12-08
申请人： Heejin Lee , Karen Daniel , Grace Kim , Cheryl Larrivee-Elkins , Michael J. Cima
发明人： Heejin Lee , Karen Daniel , Grace Kim , Cheryl Larrivee-Elkins , Michael J. Cima
IPC分类号： A61M29/00 , A61L31/16 , A61F2/12
CPC分类号： A61L31/16 , A61B90/02 , A61F2/12 , A61L31/10 , A61L2300/402 , A61L2430/04 , A61M2025/105 , C08L83/04
摘要： A device includes a tissue expanding portion and an enclosure positioned on a surface of the tissue expanding portion. The enclosure includes an enclosure wall and a drug formulation pocket defined by the enclosure wall. A solid drug formulation that includes a drug is housed within the drug formulation pocket.
摘要翻译：一种装置包括组织扩张部分和位于组织扩张部分的表面上的外壳。外壳包括外壳壁和由外壳壁限定的药物制剂口袋。包含药物的固体药物制剂容纳在药物制剂口袋内。

10. 发明申请

US20120089122A1 TIME-SELECTIVE BIORESORBABLE OR COLLAPSIBLE DRUG DELIVERY SYSTEMS AND METHODS 有权
标题翻译：时间选择性生物可降解或可溶性药物递送系统和方法
公开(公告)号：US20120089122A1
公开(公告)日：2012-04-12
申请号：US13267560
申请日：2011-10-06
申请人： Heejin Lee , Michael J. Cima , Cheryl Larrivee-Elkins , Dennis Geising , Jessica K. Anderson , Sarma Duddu
发明人： Heejin Lee , Michael J. Cima , Cheryl Larrivee-Elkins , Dennis Geising , Jessica K. Anderson , Sarma Duddu
IPC分类号： A61M25/00
CPC分类号： A61M31/002 , A61K9/0034 , A61K9/0039 , A61L29/148 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/00
摘要： Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.
摘要翻译：提供了可植入的医疗装置和治疗方法，特别用于膀胱。该装置构造成在膀胱中保留药物递送期的至少一部分，并且包括至少一种可生物降解的组分，使得在选定时间内经过生物降解后，保留功能丧失并且其装置或部分被吸收， /或排泄。该方法可以包括向患者的膀胱中部署具有容纳包含药物的药物制剂的装置结构的装置; 将药物从装置结构释放到膀胱中; 然后，例如通过改变pH来改变膀胱中尿液的组成，以触发装置结构的至少一部分的降解，使装置结构或其部分能够从膀胱排出。

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