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1. 发明授权

US08167836B2 Tissue expander configured for drug delivery 有权
标题翻译：组织扩张器配置用于药物递送
公开(公告)号：US08167836B2
公开(公告)日：2012-05-01
申请号：US12963621
申请日：2010-12-08
申请人： Heejin Lee , Karen Daniel , Grace Kim , Cheryl Larrivee-Elkins , Michael J. Cima
发明人： Heejin Lee , Karen Daniel , Grace Kim , Cheryl Larrivee-Elkins , Michael J. Cima
IPC分类号： A61M29/00 , A61L31/16 , A61F2/12
CPC分类号： A61L31/16 , A61B90/02 , A61F2/12 , A61L31/10 , A61L2300/402 , A61L2430/04 , A61M2025/105 , C08L83/04
摘要： A device includes a tissue expanding portion and an enclosure positioned on a surface of the tissue expanding portion. The enclosure includes an enclosure wall and a drug formulation pocket defined by the enclosure wall. A solid drug formulation that includes a drug is housed within the drug formulation pocket.
摘要翻译：一种装置包括组织扩张部分和位于组织扩张部分的表面上的外壳。外壳包括外壳壁和由外壳壁限定的药物制剂口袋。包含药物的固体药物制剂容纳在药物制剂口袋内。

2. 发明申请

US20110137244A1 Tissue Expander Configured for Drug Delivery 有权
标题翻译：组织扩张剂配置用于药物输送
公开(公告)号：US20110137244A1
公开(公告)日：2011-06-09
申请号：US12963621
申请日：2010-12-08
申请人： Heejin Lee , Karen Daniel , Grace Kim , Cheryl Larrivee-Elkins , Michael J. Cima
发明人： Heejin Lee , Karen Daniel , Grace Kim , Cheryl Larrivee-Elkins , Michael J. Cima
IPC分类号： A61M29/00 , A61L31/16 , A61F2/12
CPC分类号： A61L31/16 , A61B90/02 , A61F2/12 , A61L31/10 , A61L2300/402 , A61L2430/04 , A61M2025/105 , C08L83/04
摘要： A device includes a tissue expanding portion and an enclosure positioned on a surface of the tissue expanding portion. The enclosure includes an enclosure wall and a drug formulation pocket defined by the enclosure wall. A solid drug formulation that includes a drug is housed within the drug formulation pocket
摘要翻译：一种装置包括组织扩张部分和位于组织扩张部分的表面上的外壳。外壳包括外壳壁和由外壳壁限定的药物制剂口袋。包含药物的固体药物制剂容纳在药物制剂口袋内

3. 发明申请

US20110060309A1 Implantable Device for Controlled Drug Delivery 有权
标题翻译：用于控制药物输送的可植入装置
公开(公告)号：US20110060309A1
公开(公告)日：2011-03-10
申请号：US12851494
申请日：2010-08-05
申请人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
发明人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
IPC分类号： A61M25/00 , A61F2/00 , A61K31/16
CPC分类号： A61K9/0092 , A61K9/0004 , A61K9/0034 , A61K31/167 , A61M31/002
摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.
摘要翻译：提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

4. 发明授权

US09017312B2 Implantable device for controlled drug delivery 有权
标题翻译：用于受控药物输送的可植入装置
公开(公告)号：US09017312B2
公开(公告)日：2015-04-28
申请号：US12851494
申请日：2010-08-05
申请人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
发明人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
IPC分类号： A61K9/22 , A61M31/00 , A61K9/00 , A61K31/167
CPC分类号： A61K9/0092 , A61K9/0004 , A61K9/0034 , A61K31/167 , A61M31/002
摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.
摘要翻译：提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

5. 发明申请

US20100152704A1 Method for Intravesical Drug Delivery 有权
标题翻译：膀胱内给药方法
公开(公告)号：US20100152704A1
公开(公告)日：2010-06-17
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M25/00 , A61K31/167 , A61K33/04 , A61K31/737 , A61K31/24 , A61K31/407
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

6. 发明授权

US08801694B2 Intravesical drug delivery device 有权
标题翻译：膀胱内药物输送装置
公开(公告)号：US08801694B2
公开(公告)日：2014-08-12
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61F2/00 , A61M31/00 , A61L29/16 , A61K9/00 , A61L29/06
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

7. 发明申请

US20070202151A1 INTRAVESICAL DRUG DELIVERY DEVICE AND METHOD 有权
标题翻译：内窥镜药物递送装置及方法
公开(公告)号：US20070202151A1
公开(公告)日：2007-08-30
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Ho Duc , Michael Cima , Mario Casillo-Ortiz , Steven Floelich , Jordan Dimitrakov
发明人： Heejin Lee , Karen Daniel , Hong Ho Duc , Michael Cima , Mario Casillo-Ortiz , Steven Floelich , Jordan Dimitrakov
IPC分类号： A61F2/02
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

8. 发明授权

US07421857B1 Process for fabricating glass art 失效
标题翻译：制作玻璃艺术的工艺
公开(公告)号：US07421857B1
公开(公告)日：2008-09-09
申请号：US11092365
申请日：2005-03-29
申请人： Karen Daniel
发明人： Karen Daniel
IPC分类号： C03C27/02 , C03C27/08
CPC分类号： C03C27/08 , B44C5/00
摘要： A process for fabricating glass art, comprising the steps of: (a) providing a first substrate and a second substrate, wherein each of the first and second substrates comprises an upper surface and a lower surface; (b) providing at least one wire, wherein the at least one wire comprises a first end, a second end, and a length therebetween; (c) associating the first end of the at least one wire with the lower surface of the first substrate and the upper surface of the second substrate; (d) heating the first and second substrates and the at least one wire from ambient temperature to an elevated temperature ranging from approximately 1,000 degrees Fahrenheit to approximately 2,000 degrees Fahrenheit over a period of time ranging from approximately 0.5 hours to approximately 10 hours; (e) maintaining the elevated temperature for a period of time ranging from approximately 1 minute to approximately 30 minutes; and (f) cooling the first and second substrates and the at least one wire from the elevated temperature to ambient temperature over a period of time ranging from approximately 0.5 hours to approximately 30 hours.
摘要翻译：一种制造玻璃艺术的方法，包括以下步骤：（a）提供第一基底和第二基底，其中第一和第二基底中的每一个包括上表面和下表面; （b）提供至少一根线，其中所述至少一根线包括第一端，第二端和其间的长度; （c）将所述至少一根导线的第一端与所述第一基板的下表面和所述第二基板的上表面相关联; （d）在约0.5小时至约10小时的时间段内将第一和第二基底和至少一根丝线从环境温度加热到约1000华氏度至约2000华氏度的升高温度; （e）将高温维持约1分钟至约30分钟的时间; 以及（f）在约0.5小时至约30小时的时间段内将第一和第二基底和至少一根丝线从升高的温度冷却至环境温度。

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