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1. 发明授权

US07662826B2 Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same 失效
标题翻译：吡唑并[1,5-a]嘧啶衍生物和含有它们的nad（p）h氧化酶抑制剂
公开(公告)号：US07662826B2
公开(公告)日：2010-02-16
申请号：US10511840
申请日：2003-04-18
申请人： Kaoru Seno , Koichi Nishi , Yoshiyuki Matsuo , Toshio Fujishita
发明人： Kaoru Seno , Koichi Nishi , Yoshiyuki Matsuo , Toshio Fujishita
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P27/02 , A61P29/00 , A61P43/00
CPC分类号： C07D519/00 , A61K31/519 , A61K31/5377 , C07D487/04
摘要： A compound represented by the formula (Ia) (wherein R1a, R2a, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or solvate thereof. The compounds are useful in the prevention of or treatment for diseases relating to NAD(P)H.
摘要翻译：由式（Ia）表示的化合物（其中R1a，R2a和R3至R5与说明书中定义相同），其前药，其药学上可接受的盐或其溶剂化物。该化合物可用于预防或治疗与NAD（P）H有关的疾病。

2. 发明申请

US20060089362A1 Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same 失效
标题翻译：吡唑并[1,5-a]嘧啶衍生物和含有它们的nad（p）h氧化酶抑制剂
公开(公告)号：US20060089362A1
公开(公告)日：2006-04-27
申请号：US10511840
申请日：2003-04-18
申请人： Kaoru Seno , Koichi Nishi , Yoshiyuki Matsuo , Toshio Fujishita
发明人： Kaoru Seno , Koichi Nishi , Yoshiyuki Matsuo , Toshio Fujishita
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D519/00 , A61K31/519 , A61K31/5377 , C07D487/04
摘要： A compound represented by the formula (Ia) (wherein R1a, R2a, and R3 to R5 are the same as defined in the description), a prodrug thereof, a pharmaceutically acceptable salt thereof, or solvate thereof. The compounds are useful in the prevention of or treatment for diseases relating to NAD(P)H.
摘要翻译：由式（Ia）表示的化合物（其中R1a，R2a和R3至R5与说明书中定义相同），其前药，其药学上可接受的盐或其溶剂化物。该化合物可用于预防或治疗与NAD（P）H相关的疾病。

3. 发明申请

US20090286796A1 Compounds exhibiting type X sPLA2 inhibiting effect 审中-公开
标题翻译：表现出X型sPLA2抑制作用的化合物
公开(公告)号：US20090286796A1
公开(公告)日：2009-11-19
申请号：US12458846
申请日：2009-07-24
申请人： Tomoyuki Ogawa , Kaoru Seno , Kohji Hanasaki , Minoru Ikeda , Takashi Ono
发明人： Tomoyuki Ogawa , Kaoru Seno , Kohji Hanasaki , Minoru Ikeda , Takashi Ono
IPC分类号： A61K31/5025 , C07D487/02 , A61P43/00
CPC分类号： C07D403/12 , C07D209/12 , C07D209/22 , C07D209/24 , C07D209/42 , C07D487/04
摘要： A compound represented by the general formula: wherein R20 is —CH2COOH and the like; R21 is —COCONH2 and the like; R22 is C4-C6 alkyl; and the like; R23 is —CH2—R18 wherein R18 is aryl and the like; R24 is hydrogen or C1-C6 alkyl and the like; an optical active compound, a prodrug thereof, or a pharmaceutically acceptable salt, or a solvate having type X sPLA2 inhibitory effect was found.
摘要翻译：由通式表示的化合物：其中R 20是-CH 2 COOH等; R 21是-COCONH 2等; R 22是C 4 -C 6烷基; 等等; R 23是-CH 2 -R 18，其中R 18是芳基等; R 24是氢或C 1 -C 6烷基等; 发现光学活性化合物，其前药，或其药学上可接受的盐，或具有X sPLA2型抑制作用的溶剂化物。

4. 发明申请

US20080167347A1 Ctgf Expression Inhibitor 审中-公开
标题翻译： Ctgf表达抑制剂
公开(公告)号：US20080167347A1
公开(公告)日：2008-07-10
申请号：US11795533
申请日：2006-01-19
申请人： Kaoru Seno , Toshihiro Shinosaki , Satoshi Hata , Isamu Yamada , Hiroki Sato , Mikayo Hayashi
发明人： Kaoru Seno , Toshihiro Shinosaki , Satoshi Hata , Isamu Yamada , Hiroki Sato , Mikayo Hayashi
IPC分类号： A61K31/45 , C07C235/68 , A61K31/167 , C07D211/96
CPC分类号： A61K31/167 , A61K31/45 , C07C235/64 , C07C255/57 , C07C305/24 , C07C309/76 , C07C311/04 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/12 , C07C323/62 , C07D207/323 , C07D207/48 , C07D211/96 , C07D213/30 , C07D213/40 , C07D215/48 , C07D233/64 , C07D235/08 , C07D239/34 , C07D239/42 , C07D243/08 , C07D279/02 , C07D295/088 , C07D295/135 , C07D295/155 , C07D295/185 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/42 , C07D307/52 , C07D307/79 , C07D307/81 , C07D317/60 , C07D333/22 , C07D333/54 , C07D333/58 , C07D335/02 , C07D401/12
摘要： A CTGF expression inhibitor comprising a compound of the formula I: a pharmaceutically acceptable salt or solvate thereof as an active ingredient, (wherein Y is hydroxy or a group of the formula: —NH—SO2—Y′ (wherein Y′ is optionally substituted aryl or optionally substituted alkyl), and R1 to R9 are each independently hydrogen, halogen, optionally substituted alkyl, optionally substituted alkoxy or the like).
摘要翻译：一种CTGF表达抑制剂，其包含式I化合物：其药学上可接受的盐或溶剂化物作为活性成分（其中Y为羟基或式-NH-SO 2 -Y '（其中Y'为任选取代的芳基或任选取代的烷基），R 1至R 9各自独立地为氢，卤素，任选取代的烷基，任选取代的烷氧基或类似）。

5. 发明授权

US5776929A Benzodiazepine derivative 失效
标题翻译：苯二氮卓衍生物
公开(公告)号：US5776929A
公开(公告)日：1998-07-07
申请号：US663304
申请日：1996-06-25
申请人： Sanji Hagishita , Susumu Kamata , Kaoru Seno , Nobuhiro Haga , Yasunobu Ishihara
发明人： Sanji Hagishita , Susumu Kamata , Kaoru Seno , Nobuhiro Haga , Yasunobu Ishihara
IPC分类号： C07D243/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , A61K31/55
CPC分类号： C07D403/12 , C07D243/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： A benzodiazepine derivative of the formula (I): ##STR1## wherein R.sub.1 is a bond, --CH.sub.2 --, --CH.sub.2 O--, --SCH.sub.2 -- or a group of the formula: ##STR2## R.sub.2 is a lower alkyl, --COOR.sub.5, --CONH(CH.sub.2).sub.n COOR.sub.5, --CONHSO.sub.2 R.sub.5, --SO.sub.2 NHCOR.sub.5, or an optionally substituted heterocyclic group (R.sub.5 is a hydrogen atom, lower alkyl or benzyl and n is an integer of 1 to 5); R.sub.3 is a bond, --CO-- or --CONH--; and R.sub.4 is an optionally substituted heterocyclic group, optionally substituted lower alkyl, optionally substituted lower cycloalkyl, optionally substituted aryl, or lower alkoxycarbonyl group, or a pharmaceutically acceptable salt thereof, which has a high affinity for gastrin receptors and/or CCK-B receptors but not for CCK-A receptors, and is useful for treating diseases associated with gastrin receptors and/or CCK-B receptors without inducing the side effects associated with CCK-A receptors.
摘要翻译： PCT No.PCT / JP94 / 02132 Sec。 371日期1996年6月25日第 102（e）日期1996年6月25日PCT 1994年12月19日PCT PCT。公开号WO95 / 18110 日期：1995年7月6日一种式（I）的苯并二氮杂衍生物：其中R 1是一个键，-CH 2 - ， - CH 2 O-，-SCH 2 - 或下式的基团：低级烷基，-COOR 5，-CONH（CH 2）n COOR 5，-CONHSO 2 R 5，-SO 2 NHCOR 5或任选取代的杂环基（R 5为氢原子，低级烷基或苄基，n为1至5的整数）。 R3是键，-CO-或-CONH-; 并且R4是任选取代的杂环基，任选取代的低级烷基，任选取代的低级环烷基，任选取代的芳基或低级烷氧基羰基或其药学上可接受的盐，其对胃泌素受体和/或CCK-B受体具有高亲和力但不适用于CCK-A受体，并且可用于治疗与胃泌素受体和/或CCK-B受体相关的疾病，而不诱导与CCK-A受体相关的副作用。

6. 发明授权

US4976891A Bicyclic sulfonamide derivatives 失效
标题翻译：双环磺酰胺衍生物
公开(公告)号：US4976891A
公开(公告)日：1990-12-11
申请号：US327778
申请日：1989-03-23
申请人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Sanji Hagishita , Kaoru Seno , Susumu Kamata
发明人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Sanji Hagishita , Kaoru Seno , Susumu Kamata
IPC分类号： C07D493/08 , A61K31/00 , A61K31/335 , A61K31/336 , A61K31/34 , A61K31/557 , A61P7/02 , A61P9/08 , A61P11/08 , C07C20060101 , C07C67/00 , C07C301/00 , C07C311/00 , C07C311/02 , C07C311/07 , C07C311/10 , C07C311/13 , C07C311/15 , C07C311/20 , C07C311/37 , C07C313/00 , C07C323/52 , C07D209/52 , C07D209/56 , C07D213/34 , C07D213/71 , C07D221/22 , C07D303/40 , C07D303/46 , C07D331/02 , C07D491/044 , C07D493/04 , C07D495/04
CPC分类号： C07D493/08 , C07D213/34 , Y02P20/55
摘要： Bicyclic sulfonamido derivatives represented by the formula: ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl; R.sub.2 is an alkyl, substituted or unsubstituted arly, aralkyl or hetelocycle; R.sub.3 is hydrogen or methyl; X is an alkylene or alkenylene which may be substituted by a fluorine atom or atoms and may contain an oxygen, sulfur and/or phenylene in the chain; Y is straight or branched alkylene or alkeneylene, oxygen, or sulfur; m is 0 or 1; and n is 0, 1 or 2, or their salt, said derivatives being useful as antithrombotic, anti-vasoconstricting, and anti-bronchoconstricting drugs.

7. 发明授权

US06924301B1 Composition for treating or preventing arrhythmia 失效
标题翻译：用于治疗或预防心律失常的组合物
公开(公告)号：US06924301B1
公开(公告)日：2005-08-02
申请号：US10111090
申请日：2000-10-16
申请人： Kaoru Seno , Yozo Hori
发明人： Kaoru Seno , Yozo Hori
IPC分类号： A61K31/422 , A61K31/427 , A61P9/06 , A61P43/00 , C07D213/61 , C07D417/12 , C07D417/14 , A61K31/42 , C07D413/00 , C07F3/14
CPC分类号： C07D417/12 , A61K31/422 , A61K31/427 , C07D213/61 , C07D417/14
摘要： A composition for treating or preventing arrhythmia containing as an active ingredient a cPLA2 inhibitor, for example a compound represented by formula (I): wherein R1 is optionally substituted aralkyl or the like; Z is —S— or the like; X1 is —(CH2)s-N(R18)—CO— (wherein R18 is hydrogen atom or the like, s is an integer of 0 to 3) or the like; X2 is optionally substituted arylene or the like; X3 is a bond or the like; A, B, and E are each independently oxygen atom or sulfur atom; D is hydrogen atom or the like; Y1 is —(CH2)mCO— (m is an integer of 0 to 3) or the like; Y2 is optionally substituted aryl or the like.
摘要翻译：用于治疗或预防心律失常的组合物，其包含cPLA 2 N抑制剂作为活性成分，例如由式（I）表示的化合物：其中R 1是任选取代的芳烷基或类似; Z是-S-等; X 1是 - （CH 2 2）s N（R 18）-CO-（其中R 18是氢原子等，s为0〜3的整数）等; X 2是任选取代的亚芳基等; X 3是键或类似物; A，B和E各自独立地为氧原子或硫原子; D是氢原子等; Y 1是 - （CH 2 2）mCO-（m是0至3的整数）等; Y 2是任选取代的芳基等。

8. 发明授权

US5047540A Lipid derivatives 失效
标题翻译：脂质衍生物
公开(公告)号：US5047540A
公开(公告)日：1991-09-10
申请号：US284590
申请日：1988-11-29
申请人： Susumu Kamata , Tatsuo Tsuri , Nobuhiro Haga , Takeaki Matsui , Morio Kishi , Kimio Takahashi , Sanji Hagashita , Kaoru Seno
发明人： Susumu Kamata , Tatsuo Tsuri , Nobuhiro Haga , Takeaki Matsui , Morio Kishi , Kimio Takahashi , Sanji Hagashita , Kaoru Seno
IPC分类号： C07C311/32 , C07C311/46 , C07C323/49 , C07C391/00 , C07D213/20 , C07D215/10 , C07D217/10 , C07D241/12 , C07D249/14 , C07D261/12 , C07D277/22 , C07D277/62 , C07D295/088 , C07D413/12 , C07D521/00
CPC分类号： C07D213/20 , C07C311/32 , C07C311/46 , C07C323/49 , C07C391/00 , C07D215/10 , C07D217/10 , C07D231/12 , C07D233/56 , C07D241/12 , C07D249/08 , C07D261/12 , C07D277/22 , C07D277/62 , C07D295/088 , C07D413/12
摘要： Lipid derivatives represented by the formula: ##STR1## wherein R.sub.1 is alkyl or alkylcarbamoyl; R.sub.2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, heterocyclic group, or he0 terocyclyloxy; R.sub.2 ' is hydrogen or R.sub.2 and R.sub.2 ' taken together form --O(CH.sub.2).sub.m -- wherein m is an integer of 1 to 5; R.sub.3, R.sub.4, and R.sub.5 each is hydrogen or lower alkyl or two or three of R.sub.3, R.sub.4, and R.sub.5 taken together with the adjacent nitrogen atom form cyclic ammonio; R.sub.6 is hydrogen or lower alkylcarbonyl; X.sup.- is a counter anion; Y is oxygen or sulfur; and n is an integer of 1 to 10, being useful as PAF antagonists, e.g., as antithrombotic, antivasoconstricting, antibronchoconstricting agent or antitumor agent.

9. 发明授权

US4916231A Alkenyltetrazole derivatives 失效
标题翻译：链烯基四唑衍生物
公开(公告)号：US4916231A
公开(公告)日：1990-04-10
申请号：US377409
申请日：1989-07-10
申请人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Takaharu Matsuura , Sanji Hagishita , Kaoru Seno
发明人： Masayuki Narisada , Mitsuaki Ohtani , Fumihiko Watanabe , Takaharu Matsuura , Sanji Hagishita , Kaoru Seno
IPC分类号： C07D257/04 , C07D493/08
CPC分类号： C07D257/04 , C07D493/08
摘要： Tetrazole derivatives represented by the formula: ##STR1## wherein R is naphthyl or phenyl optionally substituted by phenyl, lower alkyo, halogen, lower alkoxy, hydroxy or acetoxy; X is methylene, dimethylmethylene or oxygen; n is an integer of 0 or 1; and p and r each is an integer of 0 or 1 and q is an integer of 1 or 2 provided that p+q+r=2; or a tautomer in tetrazole ring and a pharmaceutically acceptable salt thereof, which are useful as TXA.sub.2 receptor antagonist.

10. 发明授权

US5955616A Pyrrolidine derivatives having phospholipase A.sub.2 inhibitory activity 失效
标题翻译：具有磷脂酶A2抑制活性的吡咯烷衍生物及其组成
公开(公告)号：US5955616A
公开(公告)日：1999-09-21
申请号：US11404
申请日：1998-01-28
申请人： Mitsuaki Ohtani , Toshiyuki Kato , Fumihiko Watanabe , Kaoru Seno
发明人： Mitsuaki Ohtani , Toshiyuki Kato , Fumihiko Watanabe , Kaoru Seno
IPC分类号： C07D417/12 , C07D417/14 , A61K31/42 , A61K31/425 , A61K31/44 , C07D413/12
CPC分类号： C07D417/12 , C07D417/14
摘要： A compound of the formula I: ##STR1## or a pharmaceutically acceptable salt or a hydrate thereof, which has the activity of inhibiting the production of prostaglandin E.sub.2 by inhibiting cytosolic phospholipase.sub.2.
摘要翻译： PCT No.PCT / JP96 / 02079 Sec。 371日期1998年1月28日 102（e）1998年1月28日PCT PCT 1996年7月25日PCT公布。出版物WO97 / 05135 日期1997年2月13日通过抑制细胞溶质磷脂酶2具有抑制前列腺素E2产生的活性的式I化合物或其药学上可接受的盐或水合物。

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