专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5776929A Benzodiazepine derivative 失效
标题翻译：苯二氮卓衍生物
公开(公告)号：US5776929A
公开(公告)日：1998-07-07
申请号：US663304
申请日：1996-06-25
申请人： Sanji Hagishita , Susumu Kamata , Kaoru Seno , Nobuhiro Haga , Yasunobu Ishihara
发明人： Sanji Hagishita , Susumu Kamata , Kaoru Seno , Nobuhiro Haga , Yasunobu Ishihara
IPC分类号： C07D243/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , A61K31/55
CPC分类号： C07D403/12 , C07D243/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： A benzodiazepine derivative of the formula (I): ##STR1## wherein R.sub.1 is a bond, --CH.sub.2 --, --CH.sub.2 O--, --SCH.sub.2 -- or a group of the formula: ##STR2## R.sub.2 is a lower alkyl, --COOR.sub.5, --CONH(CH.sub.2).sub.n COOR.sub.5, --CONHSO.sub.2 R.sub.5, --SO.sub.2 NHCOR.sub.5, or an optionally substituted heterocyclic group (R.sub.5 is a hydrogen atom, lower alkyl or benzyl and n is an integer of 1 to 5); R.sub.3 is a bond, --CO-- or --CONH--; and R.sub.4 is an optionally substituted heterocyclic group, optionally substituted lower alkyl, optionally substituted lower cycloalkyl, optionally substituted aryl, or lower alkoxycarbonyl group, or a pharmaceutically acceptable salt thereof, which has a high affinity for gastrin receptors and/or CCK-B receptors but not for CCK-A receptors, and is useful for treating diseases associated with gastrin receptors and/or CCK-B receptors without inducing the side effects associated with CCK-A receptors.
摘要翻译： PCT No.PCT / JP94 / 02132 Sec。 371日期1996年6月25日第 102（e）日期1996年6月25日PCT 1994年12月19日PCT PCT。公开号WO95 / 18110 日期：1995年7月6日一种式（I）的苯并二氮杂衍生物：其中R 1是一个键，-CH 2 - ， - CH 2 O-，-SCH 2 - 或下式的基团：低级烷基，-COOR 5，-CONH（CH 2）n COOR 5，-CONHSO 2 R 5，-SO 2 NHCOR 5或任选取代的杂环基（R 5为氢原子，低级烷基或苄基，n为1至5的整数）。 R3是键，-CO-或-CONH-; 并且R4是任选取代的杂环基，任选取代的低级烷基，任选取代的低级环烷基，任选取代的芳基或低级烷氧基羰基或其药学上可接受的盐，其对胃泌素受体和/或CCK-B受体具有高亲和力但不适用于CCK-A受体，并且可用于治疗与胃泌素受体和/或CCK-B受体相关的疾病，而不诱导与CCK-A受体相关的副作用。

2. 发明授权

US5739162A Carbamoylmethylurea derivatives 失效
标题翻译：氨基甲酰基甲基脲衍生物
公开(公告)号：US5739162A
公开(公告)日：1998-04-14
申请号：US687433
申请日：1996-08-09
申请人： Sanji Hagishita , Susumu Kamata , Yasushi Murakami , Nobuhiro Haga , Yasunobu Ishihara , Toshiro Konoike
发明人： Sanji Hagishita , Susumu Kamata , Yasushi Murakami , Nobuhiro Haga , Yasunobu Ishihara , Toshiro Konoike
IPC分类号： A61K31/17 , A61K38/00 , A61K38/05 , A61P1/04 , C07C275/28 , C07K5/06 , C07K5/062 , A61K31/24
CPC分类号： C07K5/0606 , C07C275/28 , C07K5/06026 , C07K5/06139 , A61K38/00
摘要： A compound of the formula (I): ##STR1## wherein R.sub.1 is a hydrogen atom or lower alkyl; R.sub.2 is a lower alkoxy, lower alkylamino, lower cycloalkyl, optionally substituted phenyl or optionally substituted heterocyclic group; R.sub.3 is an optionally substituted phenyl; R.sub.4 is an optionally substituted phenyl, optionally substituted cycloalkyl, optionally substituted alkyl or optionally substituted heterocyclic group, or a pharmaceutically acceptable salt thereof, which has a high affinity for gastrin receptors and/or CCK-B receptors but not for CCK-A receptors, and is useful for treating diseases associated with gastrin receptors and/or CCK-B receptors without inducing the side effects associated with CCK-A receptors.
摘要翻译： PCT No.PCT / JP95 / 00161 Sec。 371日期：1996年8月9日 102（e）日期1996年8月9日PCT提交1995年2月7日PCT公布。 WO95 / 21856 PCT公开日期：1995年8月17日一种式（I）化合物：其中R 1是氢原子或低级烷基; R2是低级烷氧基，低级烷基氨基，低级环烷基，任意取代的苯基或任意取代的杂环基; R3是任选取代的苯基; R4是任选取代的苯基，任选取代的环烷基，任选取代的烷基或任选取代的杂环基，或其药学上可接受的盐，其对胃泌素受体和/或CCK-B受体具有高亲和力，但不对CCK-A受体具有高亲和力，并且可用于治疗与胃泌素受体和/或CCK-B受体相关的疾病，而不诱导与CCK-A受体相关的副作用。

3. 发明申请

US20090069363A1 Therapeutic Agent for Constipation 审中-公开
标题翻译：便秘治疗剂
公开(公告)号：US20090069363A1
公开(公告)日：2009-03-12
申请号：US11792893
申请日：2005-12-13
申请人： Tsutomu Suzuki , Takuko Sawada , Yasunobu Ishihara
发明人： Tsutomu Suzuki , Takuko Sawada , Yasunobu Ishihara
IPC分类号： A61K31/485 , C07D489/00 , A61P1/10
CPC分类号： A61K31/485 , A61K45/06
摘要： A therapeutic and/or prophylactic agent for constipation induced by a compound having an opioid μ receptor agonist activity, which agent comprises as an effective ingredient a compound having an opioid δ receptor antagonist activity, e.g., a compound of Formula (I): (wherein R1 represents hydrogen, lower alkyl, cycloalkyl lower alkyl or the like; R2 and R3 independently represent hydrogen, hydroxy or the like; R4 is hydrogen, hydroxy or the like; R5 is hydrogen; R4 and R5 may optionally form —O— or the like; R6 represents hydrogen, lower alkyl or the like (wherein X represents —O— or —N(R10)— or the like; R7, R8, R9a and R9b independently represent hydrogen, lower alkyl, lower alkoxycarbonyl or the like; r represents an integer of 0 to 5; Y represents —CH— or the like; Z represents a crosslinkage composed of 2 to 5 atoms) or a pharmaceutically acceptable salt thereof or a solvate of either.
摘要翻译：一种由具有阿片样物质α受体激动剂活性的化合物诱导的便秘的治疗和/或预防剂，该药物包含作为有效成分的具有阿片样物质δ受体拮抗剂活性的化合物，例如式（I）的化合物：其中 R1代表氢，低级烷基，环烷基低级烷基等; R2和R3独立地表示氢，羟基等; R4是氢，羟基等; R5是氢; R4和R5可以任选地形成-O-或 R6表示氢，低级烷基等（其中X表示-O-或-N（R10） - 等; R7，R8，R9a和R9b独立地表示氢，低级烷基，低级烷氧基羰基等; r 表示0〜5的整数，Y表示-CH-等; Z表示2〜5个原子的交联键）或其药学上可接受的盐或其溶剂合物。

4. 发明授权

US4840953A 9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivatives 失效
标题翻译： 9-（取代的硫代）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物
公开(公告)号：US4840953A
公开(公告)日：1989-06-20
申请号：US206665
申请日：1988-06-15
申请人： Shigeru Matsutani , Yukio Mizushima , Masami Doteuchi , Yasunobu Ishihara
发明人： Shigeru Matsutani , Yukio Mizushima , Masami Doteuchi , Yasunobu Ishihara
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: ##STR1## wherein n is 0 or 1, R is --COR.sup.1, --CONR.sup.4 R.sup.5 or --CH.sub.2 R.sup.6, R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C.sub.6 -C.sub.10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R.sup.2 and R.sup.3 each is hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R.sup.4 and R.sup.5 each is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl optionally substituted, and R.sup.8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.
摘要翻译： 9-（取代的硫代）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物其中n为0或1，R为-COR 1，-CONR 4 R 5或-CH 2 R 6 R1是C1-C5烷基，C3-C7环烷基，烯硫基，苯乙烯基，苯氧基甲基，噻吩基甲基，任选取代的C 6 -C 10芳基，任选取代的苄基，或任选被取代的5或6元杂环基，R 2和R 3各自是氢， C 1 -C 5烷基，羧基，C 2 -C 5烷氧基羰基或任选取代的苄氧基羰基，R 4和R 5各自为氢，C 1 -C 5烷基，C 3 -C 7环烷基或任选取代的苯基，R 8为任选取代的吡啶基或苯基）可用作抗溃疡剂代理商通过几条路线提供。

5. 发明申请

US20090292124A1 Therapeutic Agent for Nausea and/or Vomiting 审中-公开
标题翻译：用于恶心和/或呕吐的治疗剂
公开(公告)号：US20090292124A1
公开(公告)日：2009-11-26
申请号：US12083367
申请日：2006-10-10
申请人： Tsutomu Suzuki , Yasunobu Ishihara
发明人： Tsutomu Suzuki , Yasunobu Ishihara
IPC分类号： C07D491/18 , C07D491/08
CPC分类号： C07D491/18 , A61K31/485
摘要： A therapeutic and/or prophylactic agent for nausea and/or vomiting is provided. A therapeutic and/or prophylactic agent for nausea and/or vomiting, comprising a compound of the Formula (I) or a pharmaceutically acceptable salt or solvate thereof: R1 and R2 are each independently hydrogen or lower alkyl; R3 is hydrogen or lower alkoxycarbonyl; and R4 is hydrogen or lower alkyl; with the proviso that all of R1 to R3 are not simultaneously hydrogen; and R1 and R4 are not simultaneously hydrogen).
摘要翻译：提供了用于恶心和/或呕吐的治疗和/或预防剂。用于恶心和/或呕吐的治疗和/或预防剂，其包含式（I）化合物或其药学上可接受的盐或溶剂合物：R 1和R 2各自独立地为氢或低级烷基; R3是氢或低级烷氧基羰基; R4为氢或低级烷基; 条件是R1至R3全部不同时为氢; 且R1和R4不同时为氢）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式