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    • 10. 发明授权
    • Dermatological patch and process for producing thereof
    • 皮肤贴片及其制造方法
    • US06267983B1
    • 2001-07-31
    • US09319577
    • 1999-08-11
    • Kimihiro FujiiKazuo TanakaKazuya IkawaYasuhiro IkeuraShinji Yamasoto
    • Kimihiro FujiiKazuo TanakaKazuya IkawaYasuhiro IkeuraShinji Yamasoto
    • A61F1300
    • B32B27/08A61K9/7053B32B7/12B32B27/302B32B27/304B32B27/32B32B27/36B32B27/40B32B2327/06B32B2367/00B32B2375/00B32B2556/00
    • A transdermal patch which comprises: a substrate sheet comprises a composite film formed of a resin composition comprising 100 parts by weight of a polyvinyl chloride-polyurethane composite and 2-10 parts by weight of a styrene-ethylene-butylene-styrene copolymer, a first adhesive layer on the one side of the composite film, and a polyalkylene terephthalate film adhered to the one side of the composite film by means of the first adhesive layer, a primer layer which comprises a saturated polyester resin and is formed on the surface of the polyalkylene terephthalate film; and a second adhesive layer comprising a styrene-diene-styrene block copolymer containing a pharmaceutical agent layered on the primer layer. A method for the manufacture of the above-mentioned substrate sheet comprises preparing the above resin composition molding the resin composition into a composite film by a calendar process, and then adhering a polyalkylene terephthalate film on one side of the composite film by means of an adhesive layer thereby forming the substrate sheet, and forming a primer layer comprising a saturated polyester resin on the outer surface of the polyalkylene terephthalate film.
    • 一种透皮贴片,其特征在于,包括:基材片,由包含100重量份聚氯乙烯 - 聚氨酯复合物和2-10重量份苯乙烯 - 乙烯 - 丁烯 - 苯乙烯共聚物的树脂组合物形成的复合膜,第一 在复合膜的一侧上的粘合剂层和通过第一粘合剂层粘附到复合膜的一侧的聚对苯二甲酸亚烷基酯膜,底漆层,其包含饱和聚酯树脂,并形成在复合膜的表面上 聚对苯二甲酸亚烷基酯膜; 以及第二粘合剂层,其包含含有在底漆层上层叠的药剂的苯乙烯 - 二烯 - 苯乙烯嵌段共聚物。一种制造上述基材片的方法包括制备将树脂组合物模塑成复合膜的上述树脂组合物 通过日历处理,然后通过粘合剂层将聚对苯二甲酸亚烷基酯膜粘合在一起,从而形成基材片,并且在聚对苯二甲酸亚烷基酯膜的外表面上形成包含饱和聚酯树脂的底漆层 。