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1. 发明授权

US06267983B1 Dermatological patch and process for producing thereof 有权
标题翻译：皮肤贴片及其制造方法
公开(公告)号：US06267983B1
公开(公告)日：2001-07-31
申请号：US09319577
申请日：1999-08-11
申请人： Kimihiro Fujii , Kazuo Tanaka , Kazuya Ikawa , Yasuhiro Ikeura , Shinji Yamasoto
发明人： Kimihiro Fujii , Kazuo Tanaka , Kazuya Ikawa , Yasuhiro Ikeura , Shinji Yamasoto
IPC分类号： A61F1300
CPC分类号： B32B27/08 , A61K9/7053 , B32B7/12 , B32B27/302 , B32B27/304 , B32B27/32 , B32B27/36 , B32B27/40 , B32B2327/06 , B32B2367/00 , B32B2375/00 , B32B2556/00
摘要： A transdermal patch which comprises: a substrate sheet comprises a composite film formed of a resin composition comprising 100 parts by weight of a polyvinyl chloride-polyurethane composite and 2-10 parts by weight of a styrene-ethylene-butylene-styrene copolymer, a first adhesive layer on the one side of the composite film, and a polyalkylene terephthalate film adhered to the one side of the composite film by means of the first adhesive layer, a primer layer which comprises a saturated polyester resin and is formed on the surface of the polyalkylene terephthalate film; and a second adhesive layer comprising a styrene-diene-styrene block copolymer containing a pharmaceutical agent layered on the primer layer. A method for the manufacture of the above-mentioned substrate sheet comprises preparing the above resin composition molding the resin composition into a composite film by a calendar process, and then adhering a polyalkylene terephthalate film on one side of the composite film by means of an adhesive layer thereby forming the substrate sheet, and forming a primer layer comprising a saturated polyester resin on the outer surface of the polyalkylene terephthalate film.
摘要翻译：一种透皮贴片，其特征在于，包括：基材片，由包含100重量份聚氯乙烯 - 聚氨酯复合物和2-10重量份苯乙烯 - 乙烯 - 丁烯 - 苯乙烯共聚物的树脂组合物形成的复合膜，第一在复合膜的一侧上的粘合剂层和通过第一粘合剂层粘附到复合膜的一侧的聚对苯二甲酸亚烷基酯膜，底漆层，其包含饱和聚酯树脂，并形成在复合膜的表面上聚对苯二甲酸亚烷基酯膜; 以及第二粘合剂层，其包含含有在底漆层上层叠的药剂的苯乙烯 - 二烯 - 苯乙烯嵌段共聚物。一种制造上述基材片的方法包括制备将树脂组合物模塑成复合膜的上述树脂组合物通过日历处理，然后通过粘合剂层将聚对苯二甲酸亚烷基酯膜粘合在一起，从而形成基材片，并且在聚对苯二甲酸亚烷基酯膜的外表面上形成包含饱和聚酯树脂的底漆层。

2. 发明授权

US06991095B1 Packaging bag for plaster and packaged plaster 有权
标题翻译：包装袋为石膏和包装石膏
公开(公告)号：US06991095B1
公开(公告)日：2006-01-31
申请号：US10019400
申请日：2000-06-30
申请人： Shinji Yamasoto , Yasuhiro Ikeura
发明人： Shinji Yamasoto , Yasuhiro Ikeura
IPC分类号： A61B17/06 , B65D73/00 , B65D85/84 , B65D81/26
CPC分类号： B32B27/08 , A61K9/7053 , A61K9/7076 , B32B15/08 , B32B15/085 , B32B15/20 , B32B27/20 , B32B27/32 , B32B2307/724 , B32B2307/726 , B32B2311/24 , B32B2323/043 , B32B2323/046 , B32B2439/80
摘要： Packaged patch (10) according to the invention comprises patch (2) situated in space (4) inside patch package (3) composed of laminated packaging material (1), and its edges are sealed. Laminated packaging material (1) comprises hygroscopic material layer (13) made of LDPE containing 20–40 wt % of an inorganic filler, situated between moisture-permeable material layer (14) made of LDPE and having a moisture permeability of 40–120 g/m2/day and a screen material layer which blocks penetration of moisture, etc. and is composed of HDPE layer (12) and aluminum foil (11). The saturation hygroscopicity of laminated packaging material (1) is 2–30 g/m2 under atmosphere conditions with a temperature of 25° C. and a relative humidity of 75%. This construction sufficiently reduces the effect of moisture on a drug in patch (2) and allows patch (2) to be held in a stable state for prolonged periods, while also improving the economy and handleability of patch package (3).
摘要翻译：根据本发明的包装贴片（10）包括位于由层压包装材料（1）组成的贴片包装（3）内的空间（4）中的贴片（2），并且其边缘被密封。层压包装材料（1）包括由含有20-40重量％无机填料的LDPE制成的吸湿材料层（13），其位于由LDPE制成的透湿材料层（14）之间，具有40-120g的透湿性 /天/天，以及阻挡水分渗透等的屏幕材料层，并且由HDPE层（12）和铝箔（11）组成。层压包装材料（1）的饱和吸湿性在25℃，相对湿度为75％的气氛条件下为2-30g / m 2。这种结构充分降低了水分对斑块（2）中药物的影响，并使斑块（2）长时间保持在稳定状态，同时也提高了贴片包装（3）的经济性和可操作性。

3. 发明申请

US20090149794A1 Adhesive Preparation 有权
标题翻译：胶粘剂制备
公开(公告)号：US20090149794A1
公开(公告)日：2009-06-11
申请号：US12227066
申请日：2007-08-01
申请人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
发明人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
IPC分类号： A61F13/02
CPC分类号： A61L15/44 , A61F13/00 , A61F15/00 , A61K9/7053 , A61K9/7076 , A61K31/045 , A61K31/618 , A61K31/695 , A61L15/24 , A61L15/58 , A61L2300/216 , B32B7/12 , Y10T428/28 , Y10T428/2852 , Y10T442/2738 , Y10T442/3561
摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.
摘要翻译：一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯，相对于该层的总质量，整个粘合剂制剂在40℃的温度和90％的相对湿度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24范围为3.0至60.0ng.hr/mL，以平均值±标准偏差计，水杨酸作为水杨酸甲酯的代谢物具有5000至13000ng.hr/mL的血浆AUC 0-24，以当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

4. 发明授权

US08809615B2 Adhesive preparation 有权
标题翻译：粘合剂制备
公开(公告)号：US08809615B2
公开(公告)日：2014-08-19
申请号：US12588721
申请日：2009-10-26
申请人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
发明人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
IPC分类号： B32B7/12 , B32B15/04 , C08G61/02 , C08J3/00 , A61K6/083 , A61K8/72 , C08L15/00 , A61K6/00 , C09J4/00 , C09J101/00 , C09J201/00 , A61F13/00 , A61F15/00 , A61L15/16 , A61K9/70 , B32B25/02
CPC分类号： A61L15/44 , A61F13/00 , A61F15/00 , A61K9/7053 , A61K9/7076 , A61K31/045 , A61K31/618 , A61K31/695 , A61L15/24 , A61L15/58 , A61L2300/216 , B32B7/12 , Y10T428/28 , Y10T428/2852 , Y10T442/2738 , Y10T442/3561
摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.
摘要翻译：一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯，相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

5. 发明授权

US08455376B2 Adhesive preparation 有权
标题翻译：粘合剂制备
公开(公告)号：US08455376B2
公开(公告)日：2013-06-04
申请号：US12227066
申请日：2007-08-01
申请人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
发明人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
IPC分类号： B32B25/02 , A61F13/00 , A61L15/16 , A61K9/70
CPC分类号： A61L15/44 , A61F13/00 , A61F15/00 , A61K9/7053 , A61K9/7076 , A61K31/045 , A61K31/618 , A61K31/695 , A61L15/24 , A61L15/58 , A61L2300/216 , B32B7/12 , Y10T428/28 , Y10T428/2852 , Y10T442/2738 , Y10T442/3561
摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.
摘要翻译：一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯，相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

6. 外观设计

USD512509S1 Medical patch 失效
标题翻译：医疗补丁
公开(公告)号：USD512509S1
公开(公告)日：2005-12-06
申请号：US29202019
申请日：2004-03-25
申请人： Shinji Yamasoto , Nobuo Tsutsumi , Masakazu Shigiishi
设计人： Shinji Yamasoto , Nobuo Tsutsumi , Masakazu Shigiishi

7. 发明申请

US20100047328A1 Adhesive preparation 有权
标题翻译：粘合剂制备
公开(公告)号：US20100047328A1
公开(公告)日：2010-02-25
申请号：US12588721
申请日：2009-10-26
申请人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
发明人： Kiyomi Tsuruda , Shinji Yamasoto , Kouki Shoho , Masaru Nakanishi
IPC分类号： A61K9/70 , A61K31/60 , A61P17/02
CPC分类号： A61L15/44 , A61F13/00 , A61F15/00 , A61K9/7053 , A61K9/7076 , A61K31/045 , A61K31/618 , A61K31/695 , A61L15/24 , A61L15/58 , A61L2300/216 , B32B7/12 , Y10T428/28 , Y10T428/2852 , Y10T442/2738 , Y10T442/3561
摘要： An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.
摘要翻译：一种粘合剂制剂，其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层，其中所述可拉伸载体包括进行压接加工的互锁织物，所述粘合剂层包含10质量％以上的水杨酸甲酯，相对于该层的总质量，整个粘合剂在40℃，相对湿度90％的温度下测得的透湿度为1〜350g / m 2·24小时，水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL，以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL，以当将粘合剂制剂施用于人类皮肤8小时，使得施加的粘合剂层的施用量为50至300g / m 2，接触面积为280cm 2时，其平均值为±标准偏差。

8. 发明授权

US08920831B2 Lidocaine-containing hydrogel patch 有权
标题翻译：含利多卡因的水凝胶贴片
公开(公告)号：US08920831B2
公开(公告)日：2014-12-30
申请号：US14127322
申请日：2012-06-13
申请人： Junichi Kubo , Seiichiro Tsuru , Keiichiro Tsurushima , Shinji Yamasoto
发明人： Junichi Kubo , Seiichiro Tsuru , Keiichiro Tsurushima , Shinji Yamasoto
IPC分类号： A61K9/70 , A61K31/167 , A61K47/42 , A61K47/12
CPC分类号： A61K9/7046 , A61K9/7023 , A61K9/7038 , A61K9/7061 , A61K31/167 , A61K47/12 , A61K47/42
摘要： A lidocaine-containing hydrogel patch comprising: a support layer; and a adhesive layer stacked on a surface of the support layer, wherein the adhesive layer comprises at least one selected from the group consisting of lidocaine and pharmaceutically acceptable salts thereof, a total content of the lidocaine and the pharmaceutically acceptable salts thereof is 3 to 8% by mass relative to an entire mass of the adhesive layer, the adhesive layer further comprises oleic acid in an amount of 0.3 to 1% by mass relative to the entire mass of the adhesive layer, and a pH of the adhesive layer is 6.8 to 7.4.
摘要翻译：一种含利多卡因的水凝胶贴片，包括：支撑层; 以及层叠在所述支撑层的表面上的粘合剂层，其中，所述粘合剂层包含选自利多卡因及其药学上可接受的盐中的至少一种，所述利多卡因及其药学上可接受的盐的总含量为3〜8 相对于粘合剂层的整个质量的质量％，粘合剂层还包含相对于粘合剂层的整个质量为0.3〜1质量％的油酸，粘合剂层的pH为6.8〜 7.4。

9. 发明申请

US20140141056A1 LIDOCAINE-CONTAINING HYDROGEL PATCH 有权
标题翻译：含LIDOCAINE的水凝胶
公开(公告)号：US20140141056A1
公开(公告)日：2014-05-22
申请号：US14127322
申请日：2012-06-13
申请人： Junichi Kubo , Seiichiro Tsuru , Keiichiro Tsurushima , Shinji Yamasoto
发明人： Junichi Kubo , Seiichiro Tsuru , Keiichiro Tsurushima , Shinji Yamasoto
IPC分类号： A61K9/70 , A61K31/167
CPC分类号： A61K9/7046 , A61K9/7023 , A61K9/7038 , A61K9/7061 , A61K31/167 , A61K47/12 , A61K47/42
摘要： A lidocaine-containing hydrogel patch comprising: a support layer; and a adhesive layer stacked on a surface of the support layer, wherein the adhesive layer comprises at least one selected from the group consisting of lidocaine and pharmaceutically acceptable salts thereof, a total content of the lidocaine and the pharmaceutically acceptable salts thereof is 3 to 8% by mass relative to an entire mass of the adhesive layer, the adhesive layer further comprises oleic acid in an amount of 0.3 to 1% by mass relative to the entire mass of the adhesive layer, and a pH of the adhesive layer is 6.8 to 7.4.
摘要翻译：一种含利多卡因的水凝胶贴片，包括：支撑层; 以及层叠在所述支撑层的表面上的粘合剂层，其中，所述粘合剂层包含选自利多卡因及其药学上可接受的盐中的至少一种，所述利多卡因及其药学上可接受的盐的总含量为3〜8 相对于粘合剂层的整个质量的质量％，粘合剂层还包含相对于粘合剂层的整个质量为0.3〜1质量％的油酸，粘合剂层的pH为6.8〜 7.4。

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