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1. 发明申请

US20070009960A1 Characterising polypeptides 审中-公开
标题翻译：表征多肽
公开(公告)号：US20070009960A1
公开(公告)日：2007-01-11
申请号：US10565563
申请日：2004-07-22
申请人： Jurgen Schafer , Christian Hamon , Josef Schwarz , Christopher Pearce
发明人： Jurgen Schafer , Christian Hamon , Josef Schwarz , Christopher Pearce
IPC分类号： G01N33/53 , C12Q1/37 , G01N33/00
CPC分类号： G01N33/6851 , C07D403/14 , C07D413/14 , C07K1/13 , G01N33/533 , G01N33/6848
摘要： Provided is a method for characterising an analyte by matrix assisted laser desorption ionisation (MALDI) mass spectrometry, which method comprises: (a) labelling the analyte with a light-absorbing label that absorbs light at a pre-determined frequency, to form a labelled analyte; (b) embedding the labelled analyte in a matrix formed from at least one compound that absorbs light, to form an embedded labelled analyte; (c) desorbing the embedded labelled analyte by exposing it to light having the pre-determined frequency, to form a desorbed analyte; and (d) detecting the desorbed analyte by mass spectrometry to characterise the analyte; wherein the light absorbing label comprises a fluorophore moiety, and wherein prior to detecting by mass spectrometry, the analyte is selected for detection on the basis of its fluorophore moiety.
摘要翻译：提供了一种通过基质辅助激光解吸电离（MALDI）质谱鉴定分析物的方法，该方法包括：（a）用预吸收光的光吸收标记物以预定的频率标记分析物，形成标记的分析物; （b）将标记的分析物包埋在由吸收光的至少一种化合物形成的基质中，以形成嵌入的标记分析物; （c）通过将嵌入的标记分析物暴露于具有预定频率的光来解吸，形成解吸附的分析物; 和（d）通过质谱检测解吸附的分析物来表征分析物; 其中所述光吸收标签包含荧光团部分，并且其中在通过质谱法检测之前，根据其荧光团部分选择所述分析物进行检测。

2. 发明申请

US20050048489A1 Mass labels 有权
标题翻译：批量标签
公开(公告)号：US20050048489A1
公开(公告)日：2005-03-03
申请号：US10489341
申请日：2002-09-16
申请人： Andrew Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
发明人： Andrew Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
IPC分类号： G01N27/62 , B01J20/281 , G01N30/04 , G01N30/72 , G01N30/88 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/58 , G01N33/68 , H01J49/04 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6851 , G01N2458/15 , H01J49/04
摘要： Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalisation moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectromety, and wherein the mass marker moiety comprises an amino acid and the mass normalisation moiety comprises an amino acid.
摘要翻译：提供了一组两个或更多个质量标签，该组中的每个标签包含通过具有至少一个酰胺键与质量标准化部分连接的质量标记部分，其中该组中每个标签的总质量可以是相同或不同，组中每个标记物的质量标记物部分的质量可以相同或不同，并且其中在具有共同质量的质量标记物部分的组中的任何标签组中，每个标签具有总体质量不同于该组中的所有其它标记，并且其中在组中具有共同聚集体的任何标签组中，每个标记具有与该组中所有其他质量标记部分的质量不同的质量标记部分，使得全部组中的质量标记物通过质谱可以彼此区分，并且其中质量标记物部分包含氨基酸，质量标准化部分包含氨基酸。

3. 发明授权

US07732378B2 Mass labels 有权
标题翻译：批量标签
公开(公告)号：US07732378B2
公开(公告)日：2010-06-08
申请号：US10489341
申请日：2002-09-16
申请人： Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
发明人： Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
IPC分类号： C40B40/00
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6851 , G01N2458/15 , H01J49/04
摘要： Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalization moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectrometry, and wherein the mass marker moiety comprises an amino acid and the mass normalization moiety comprises an amino acid.
摘要翻译：提供了一组两个或更多个质量标签，该组中的每个标签包含通过具有至少一个酰胺键与质量标准化部分连接的质量标记部分，其中该组中每个标签的总质量可以是相同或不同，组中每个标记物的质量标记物部分的质量可以相同或不同，并且其中在具有共同质量的质量标记物部分的组中的任何标签组中，每个标签具有总体质量不同于该组中的所有其它标记，并且其中在组中具有共同聚集体的任何标签组中，每个标记具有与该组中所有其他质量标记部分的质量不同的质量标记部分，使得全部组中的质量标记物通过质谱法彼此区分，并且其中质量标记物部分包含氨基酸，质量标准化部分包含氨基酸。

4. 发明申请

US20100178710A1 Mass Labels 有权
标题翻译：批量标签
公开(公告)号：US20100178710A1
公开(公告)日：2010-07-15
申请号：US11996910
申请日：2006-07-26
申请人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
发明人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
IPC分类号： G01N24/00 , C07D401/12 , C07D239/04
CPC分类号： C07D403/12 , C07D207/404 , C07D401/12 , C07K5/06139 , G01N33/6848 , G01N2458/00 , Y10T436/24
摘要： A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R1), C(R1), CO, CO(R1), C(R1)2, O or S; X is N, C or C(R1); each R1 is independently H, a substituted or unsubstituted straight or branched C1-C6 alkyl group, a substituted or unsubstituted aliphatic cyclic group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; and y is an integer from 0-10, L is a cleavable linker comprising an amide bond and M is a mass normalization moiety.
摘要翻译：用于通过质谱法标记和检测生物分子的质量标签，该标签包含以下结构：XLM，其中X是包含以下基团的质量标记物部分：式（I），其中所述环状单元是芳族或脂族的，并且包含 0-3双键独立地在任意两个相邻的原子之间; 每个Z独立地为N，N（R1），C（R1），CO，CO（R1），C（R1）2，O或S; X为N，C或C（R1）; 每个R 1独立地为H，取代或未取代的直链或支链C 1 -C 6烷基，取代或未取代的脂族环基，取代或未取代的芳基或取代或未取代的杂环基; y是0-10的整数，L是包含酰胺键的可切割连接物，M是质量归一化部分。

5. 发明授权

US09023656B2 Reactive mass labels 有权
标题翻译：反应性质量标签
公开(公告)号：US09023656B2
公开(公告)日：2015-05-05
申请号：US11996910
申请日：2006-07-26
申请人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
发明人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
IPC分类号： G01N33/68 , C07D401/12 , C07D239/04 , C07D403/12 , C07D207/404 , C07K5/078
CPC分类号： C07D403/12 , C07D207/404 , C07D401/12 , C07K5/06139 , G01N33/6848 , G01N2458/00 , Y10T436/24
摘要： A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R1), C(R1), CO, CO(R1), C(R1)2, O or S; X is N, C or C(R1); each R1 is independently H, a substituted or unsubstituted straight or branched C1-C6 alkyl group, a substituted or unsubstituted aliphatic cyclic group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; and y is an integer from 0-10, L is a cleavable linker comprising an amide bond and M is a mass normalization moiety.
摘要翻译：用于通过质谱法标记和检测生物分子的质量标签，该标签包含以下结构：XLM，其中X是包含以下基团的质量标记物部分：式（I），其中所述环状单元是芳族或脂族的，并且包含 0-3双键独立地在任意两个相邻的原子之间; 每个Z独立为N，N（R1），C（R1），CO，CO（R1），C（R1）2，O或S; X为N，C或C（R1）; 每个R 1独立地为H，取代或未取代的直链或支链C 1 -C 6烷基，取代或未取代的脂族环基，取代或未取代的芳基或取代或未取代的杂环基; y是0-10的整数，L是包含酰胺键的可切割连接物，M是质量归一化部分。

6. 发明授权

US08697604B2 Labeling agents for mass spectrometry comprising tertiary amines 失效
标题翻译：用于质谱的标记试剂包括叔胺
公开(公告)号：US08697604B2
公开(公告)日：2014-04-15
申请号：US10550558
申请日：2004-03-18
申请人： Christian Hamon , Karsten Kuhn , Andrew Thompson , Dieter Reuschling , Juergen Schaefer
发明人： Christian Hamon , Karsten Kuhn , Andrew Thompson , Dieter Reuschling , Juergen Schaefer
IPC分类号： C40B40/00 , G01N33/68
CPC分类号： G01N33/68 , C07B2200/05 , C07C229/12 , C07D207/46 , C07D211/14 , C07D295/15 , C07D401/12 , C07K1/13 , C40B40/04 , C40B70/00 , G01N33/6848 , G01N2458/15 , Y10T436/24
摘要： Provided is a method for characterizing a molecule by mass spectrometry, which molecule comprises one or more free amino groups, which method comprises: (a) reacting one or more free amino groups in the molecule with a mass tag reagent comprising a reactive functionality capable of reacting with an amino group, and a tertiary amino group linked to the reactive functionality; and (b) characterizing the molecule by mass spectrometry.
摘要翻译：本发明提供了一种通过质谱鉴定分子的方法，该分子包含一个或多个游离氨基，该方法包括：（a）使分子中的一个或多个游离氨基与包含能够与氨基反应，和与反应性官能团连接的叔氨基; 和（b）通过质谱鉴定分子。

7. 发明授权

US07163803B2 Method for characterizing polypeptides 失效
标题翻译：表征多肽的方法
公开(公告)号：US07163803B2
公开(公告)日：2007-01-16
申请号：US10479843
申请日：2002-06-07
申请人： Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Abed Mohammed
发明人： Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Abed Mohammed
IPC分类号： C12Q1/37
CPC分类号： G01N33/6848 , C07K1/12 , G01N33/6821
摘要： Provided is a method for characterizing a polypeptide, which method comprises the steps of: (a) optionally reducing cysteine disulphide bridges in the polypeptide to form free thiols, and capping the free thiols; (b) cleaving the polypeptide with a sequence specific cleavage reagent to form peptide fragments; (c) optionally deactivating the cleavage reagent; (d) capping one or more ε-amino groups that are present with a lysine reactive agent; (e) analyzing peptide fragments by mass spectrometry to form a mass fingerprint for the polypeptide; and (f) determining the identity of the polypeptide from the mass fingerprint.
摘要翻译：提供了表征多肽的方法，该方法包括以下步骤：（a）任选地减少多肽中的半胱氨酸二硫键形成游离硫醇，并封端游离硫醇; （b）用序列特异性切割试剂切割多肽以形成肽片段; （c）任选地使切割试剂失活; （d）封端与赖氨酸反应剂一起存在的一个或多个ε-氨基; （e）通过质谱分析肽片段以形成多肽的质量指纹图谱; 和（f）从质量指纹图谱确定多肽的身份。

8. 发明授权

US06682710B1 Catalytic reduction of nitrous oxide content in gases 有权
标题翻译：催化还原气体中的一氧化二氮含量
公开(公告)号：US06682710B1
公开(公告)日：2004-01-27
申请号：US09582622
申请日：2001-03-05
申请人： Christian Hamon , Karine Malefant , Geneviève Neveu
发明人： Christian Hamon , Karine Malefant , Geneviève Neveu
IPC分类号： B01J800
CPC分类号： C01B21/265 , B01D53/8628 , B01D2257/402 , B01J29/88 , Y02C20/10 , Y02P20/153
摘要： A process and catalyst for reducing the nitrous oxide content in gas, which operates at relatively low temperatures, the activity of which is relatively insensitive to the presence of water vapour and which is highly resistant to hydrothermal degradation, is prepared from ferrierite exchanged with iron. Application to the treatment of gases with a low N2O content, such as gases resulting from plants for the manufacture of nitric acid, and of gases with a high N2O content, which are emitted during oxidations of organic compounds by nitric acid.
摘要翻译：一种用于降低气体中的一氧化二氮含量的方法和催化剂，其在相对低的温度下操作，其活性对于水蒸汽的存在相对不敏感，并且高度耐水热降解，由与铁交换的镁碱沸石制备。用于处理具有低N 2 O含量的气体的处理，例如由用于制造硝酸的植物产生的气体和在硝酸有机化合物氧化期间排出的具有高N 2 O含量的气体。

9. 发明授权

US5536483A Zeolite Y-based catalytic composition for use in the treatment of oxygenated effluents containing nitrogen oxides, its preparation and process for use 失效
标题翻译：用于处理含氮氧化物的含氧废水的沸石Y型催化剂组合物，其制备方法和使用方法
公开(公告)号：US5536483A
公开(公告)日：1996-07-16
申请号：US297934
申请日：1994-08-31
申请人： Gilles Descat , Christian Hamon
发明人： Gilles Descat , Christian Hamon
IPC分类号： B01D53/86 , B01J29/14 , B01J8/00
CPC分类号： B01J29/146 , B01D53/8628
摘要： The invention concerns novel zeolite Y containing catalyst compositions and the use thereof for the treatment of oxygenated effluents containing nitrogen oxides. The invention further concerns the preparation of such novel zeolite Y containing catalyst compositions.
摘要翻译：本发明涉及新型含Y沸石的催化剂组合物及其用于处理含氮氧化物的含氧流出物的用途。本发明还涉及这种新型含Y沸石催化剂组合物的制备。

10. 发明授权

US4910004A Process for selective reduction of nitrogen oxides contained in oxygenated gaseous effluents 失效
标题翻译：用于选择性还原含氧气体流出物中所含的氮氧化物的方法
公开(公告)号：US4910004A
公开(公告)日：1990-03-20
申请号：US177461
申请日：1988-04-04
申请人： Christian Hamon , Yannick Le Goff
发明人： Christian Hamon , Yannick Le Goff
IPC分类号： B01D53/94 , B01D53/86 , B01J29/18
CPC分类号： B01J29/18 , B01D53/8628
摘要： A catalytic composition for selective reduction of nitrogen oxides comprising, as active material, mordenite in ammonium or acid form, with a residual sodium content less than 1000 ppmw, representing 70 to 95% of the total weight of the catalytic composition, the remainder comprising a binder. The active material can also be in the form of small-pore mordenite exchanged with copper ions.The catalytic composition can be used for the purification of effluents with containing any nitrogen oxide, in particular for depolluting residual gases rejected into the atmosphere during the production of nitric acid.
摘要翻译：用于选择性还原氮氧化物的催化组合物，其包含作为活性材料的铵或酸形式的丝光沸石，残余钠含量小于1000ppmw，占催化组合物总重量的70-95％，其余包括粘合剂活性材料也可以是与铜离子交换的小孔丝光沸石的形式。催化剂组合物可用于净化含有任何氮氧化物的流出物，尤其用于在硝酸生产过程中污染残留气体的污染物。

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