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1. 发明授权

US07732378B2 Mass labels 有权
标题翻译：批量标签
公开(公告)号：US07732378B2
公开(公告)日：2010-06-08
申请号：US10489341
申请日：2002-09-16
申请人： Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
发明人： Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
IPC分类号： C40B40/00
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6851 , G01N2458/15 , H01J49/04
摘要： Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalization moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectrometry, and wherein the mass marker moiety comprises an amino acid and the mass normalization moiety comprises an amino acid.
摘要翻译：提供了一组两个或更多个质量标签，该组中的每个标签包含通过具有至少一个酰胺键与质量标准化部分连接的质量标记部分，其中该组中每个标签的总质量可以是相同或不同，组中每个标记物的质量标记物部分的质量可以相同或不同，并且其中在具有共同质量的质量标记物部分的组中的任何标签组中，每个标签具有总体质量不同于该组中的所有其它标记，并且其中在组中具有共同聚集体的任何标签组中，每个标记具有与该组中所有其他质量标记部分的质量不同的质量标记部分，使得全部组中的质量标记物通过质谱法彼此区分，并且其中质量标记物部分包含氨基酸，质量标准化部分包含氨基酸。

2. 发明申请

US20050048489A1 Mass labels 有权
标题翻译：批量标签
公开(公告)号：US20050048489A1
公开(公告)日：2005-03-03
申请号：US10489341
申请日：2002-09-16
申请人： Andrew Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
发明人： Andrew Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
IPC分类号： G01N27/62 , B01J20/281 , G01N30/04 , G01N30/72 , G01N30/88 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/58 , G01N33/68 , H01J49/04 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6851 , G01N2458/15 , H01J49/04
摘要： Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalisation moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectromety, and wherein the mass marker moiety comprises an amino acid and the mass normalisation moiety comprises an amino acid.
摘要翻译：提供了一组两个或更多个质量标签，该组中的每个标签包含通过具有至少一个酰胺键与质量标准化部分连接的质量标记部分，其中该组中每个标签的总质量可以是相同或不同，组中每个标记物的质量标记物部分的质量可以相同或不同，并且其中在具有共同质量的质量标记物部分的组中的任何标签组中，每个标签具有总体质量不同于该组中的所有其它标记，并且其中在组中具有共同聚集体的任何标签组中，每个标记具有与该组中所有其他质量标记部分的质量不同的质量标记部分，使得全部组中的质量标记物通过质谱可以彼此区分，并且其中质量标记物部分包含氨基酸，质量标准化部分包含氨基酸。

3. 发明授权

US07700306B2 Method for charcterising analytes 失效
标题翻译：分析物识别方法
公开(公告)号：US07700306B2
公开(公告)日：2010-04-20
申请号：US10510246
申请日：2003-04-04
申请人： Andrew H. Thompson , Christian Hamon , Karsten Kuhn , Markus Meyer , Schafer Juergen , Thomas Neumann
发明人： Andrew H. Thompson , Christian Hamon , Karsten Kuhn , Markus Meyer , Schafer Juergen , Thomas Neumann
IPC分类号： G01N33/00
CPC分类号： G01N33/6848 , C07K1/13 , G01N33/6851
摘要： Provided is a method for characterizing an analyte by matrix assisted laser desorption ionization (MALDI) mass spectrometry, which method comprises: (a) labelling the analyte with a light-absorbing label that absorbs light at a pre-determined frequency, to form a labelled analyte; (b) embedding the labelled analyte in a matrix formed from at least one compound that absorbs light, to form an embedded labelled analyte; (c) desorbing the embedded labelled analyte by exposing it to light having the pre-determined frequency, to form a desorbed analyte; and (d) detecting the desorbed analyte by mass spectrometry to characterize the analyte.
摘要翻译：本发明提供了一种通过基质辅助激光解吸电离（MALDI）质谱法分析分析物的方法，该方法包括：（a）用预吸收光量的光吸收标记标记分析物，以形成标记的分析物; （b）将标记的分析物包埋在由吸收光的至少一种化合物形成的基质中，以形成嵌入的标记分析物; （c）通过将嵌入的标记分析物暴露于具有预定频率的光来解吸，形成解吸附的分析物; 和（d）通过质谱检测解吸附的分析物来表征分析物。

4. 发明申请

US20050042676A1 Characterising polypeptides 审中-公开
标题翻译：表征多肽
公开(公告)号：US20050042676A1
公开(公告)日：2005-02-24
申请号：US10479855
申请日：2002-06-07
申请人： Christian Hamon , Andrew Thompson , Karsten Kuhn , Thomas Neumann , Richard Joubert , Robert Johnstone , Gunier Schmidt
发明人： Christian Hamon , Andrew Thompson , Karsten Kuhn , Thomas Neumann , Richard Joubert , Robert Johnstone , Gunier Schmidt
IPC分类号： C07D213/71 , C07D215/36 , C07D239/38 , C07D241/18 , C07D251/58 , C07K1/107 , C07K1/12 , C12Q1/02 , C12Q1/37 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6848 , C07K1/12 , G01N33/6821
摘要： Provided is a method for characterising a polypeptide or a population of polypeptides, which method comprises the steps of: (a) contacting a sample comprising one or more polypeptides with a lysine reactive agent to cap ε-amino groups; (b) optionally reacting the sample of polypeptides with an amine reactive reagent to block α-amino groups; (c) digesting the sample of polypeptides with a cleavage reagent to produce peptide fragments; (d) optionally deactivating the cleavage reagent; (e) removing those peptides having uncapped or unblocked amino groups; and (f) recovering the N-terminal peptides.
摘要翻译：提供了表征多肽或多肽群体的方法，该方法包括以下步骤：（a）将包含一种或多种多肽的样品与赖氨酸反应剂接触以将ε-氨基封端; （b）任选地使多肽样品与胺反应试剂反应以阻断α-氨基; （c）用裂解试剂消化多肽样品以产生肽片段; （d）任选地使切割试剂失活; （e）除去具有未封端或未封闭的氨基的那些肽; 和（f）回收N-末端肽。

5. 发明授权

US09023656B2 Reactive mass labels 有权
标题翻译：反应性质量标签
公开(公告)号：US09023656B2
公开(公告)日：2015-05-05
申请号：US11996910
申请日：2006-07-26
申请人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
发明人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
IPC分类号： G01N33/68 , C07D401/12 , C07D239/04 , C07D403/12 , C07D207/404 , C07K5/078
CPC分类号： C07D403/12 , C07D207/404 , C07D401/12 , C07K5/06139 , G01N33/6848 , G01N2458/00 , Y10T436/24
摘要： A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R1), C(R1), CO, CO(R1), C(R1)2, O or S; X is N, C or C(R1); each R1 is independently H, a substituted or unsubstituted straight or branched C1-C6 alkyl group, a substituted or unsubstituted aliphatic cyclic group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; and y is an integer from 0-10, L is a cleavable linker comprising an amide bond and M is a mass normalization moiety.
摘要翻译：用于通过质谱法标记和检测生物分子的质量标签，该标签包含以下结构：XLM，其中X是包含以下基团的质量标记物部分：式（I），其中所述环状单元是芳族或脂族的，并且包含 0-3双键独立地在任意两个相邻的原子之间; 每个Z独立为N，N（R1），C（R1），CO，CO（R1），C（R1）2，O或S; X为N，C或C（R1）; 每个R 1独立地为H，取代或未取代的直链或支链C 1 -C 6烷基，取代或未取代的脂族环基，取代或未取代的芳基或取代或未取代的杂环基; y是0-10的整数，L是包含酰胺键的可切割连接物，M是质量归一化部分。

6. 发明申请

US20070023628A1 Labeling agents for mass spectrometry comprising tertiary amines 失效
标题翻译：用于质谱的标记试剂包括叔胺
公开(公告)号：US20070023628A1
公开(公告)日：2007-02-01
申请号：US10550558
申请日：2004-03-18
申请人： Christian Hamon , Karsten Kuhn , Andrew Thompson , Dieter Reuschling , Juergen Schaefer
发明人： Christian Hamon , Karsten Kuhn , Andrew Thompson , Dieter Reuschling , Juergen Schaefer
IPC分类号： B01D59/44
CPC分类号： G01N33/68 , C07B2200/05 , C07C229/12 , C07D207/46 , C07D211/14 , C07D295/15 , C07D401/12 , C07K1/13 , C40B40/04 , C40B70/00 , G01N33/6848 , G01N2458/15 , Y10T436/24
摘要： Provided is a method for characterising a molecule by mass spectrometry, which molecule comprises one or more free amino groups, which method comprises: (a) reacting one or more free amino groups in the molecule with a mass tag reagent comprising a reactive functionality capable of reacting with an amino group, and a tertiary amino group linked to the reactive functionality; and (b) characterising the molecule by mass spectrometry.
摘要翻译：本发明提供了一种通过质谱鉴定分子的方法，该分子包含一个或多个游离氨基，该方法包括：（a）使分子中的一个或多个游离氨基与包含能够与氨基反应，和与反应性官能团连接的叔氨基; 和（b）通过质谱鉴定分子。

7. 发明授权

US08697604B2 Labeling agents for mass spectrometry comprising tertiary amines 失效
标题翻译：用于质谱的标记试剂包括叔胺
公开(公告)号：US08697604B2
公开(公告)日：2014-04-15
申请号：US10550558
申请日：2004-03-18
申请人： Christian Hamon , Karsten Kuhn , Andrew Thompson , Dieter Reuschling , Juergen Schaefer
发明人： Christian Hamon , Karsten Kuhn , Andrew Thompson , Dieter Reuschling , Juergen Schaefer
IPC分类号： C40B40/00 , G01N33/68
CPC分类号： G01N33/68 , C07B2200/05 , C07C229/12 , C07D207/46 , C07D211/14 , C07D295/15 , C07D401/12 , C07K1/13 , C40B40/04 , C40B70/00 , G01N33/6848 , G01N2458/15 , Y10T436/24
摘要： Provided is a method for characterizing a molecule by mass spectrometry, which molecule comprises one or more free amino groups, which method comprises: (a) reacting one or more free amino groups in the molecule with a mass tag reagent comprising a reactive functionality capable of reacting with an amino group, and a tertiary amino group linked to the reactive functionality; and (b) characterizing the molecule by mass spectrometry.
摘要翻译：本发明提供了一种通过质谱鉴定分子的方法，该分子包含一个或多个游离氨基，该方法包括：（a）使分子中的一个或多个游离氨基与包含能够与氨基反应，和与反应性官能团连接的叔氨基; 和（b）通过质谱鉴定分子。

8. 发明申请

US20100178710A1 Mass Labels 有权
标题翻译：批量标签
公开(公告)号：US20100178710A1
公开(公告)日：2010-07-15
申请号：US11996910
申请日：2006-07-26
申请人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
发明人： Christian Hamon , Josef Schwarz , Wolfgang Becker , Stefan Kienle , Karsten Kuhn , Juergen Schaefer
IPC分类号： G01N24/00 , C07D401/12 , C07D239/04
CPC分类号： C07D403/12 , C07D207/404 , C07D401/12 , C07K5/06139 , G01N33/6848 , G01N2458/00 , Y10T436/24
摘要： A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R1), C(R1), CO, CO(R1), C(R1)2, O or S; X is N, C or C(R1); each R1 is independently H, a substituted or unsubstituted straight or branched C1-C6 alkyl group, a substituted or unsubstituted aliphatic cyclic group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; and y is an integer from 0-10, L is a cleavable linker comprising an amide bond and M is a mass normalization moiety.
摘要翻译：用于通过质谱法标记和检测生物分子的质量标签，该标签包含以下结构：XLM，其中X是包含以下基团的质量标记物部分：式（I），其中所述环状单元是芳族或脂族的，并且包含 0-3双键独立地在任意两个相邻的原子之间; 每个Z独立地为N，N（R1），C（R1），CO，CO（R1），C（R1）2，O或S; X为N，C或C（R1）; 每个R 1独立地为H，取代或未取代的直链或支链C 1 -C 6烷基，取代或未取代的脂族环基，取代或未取代的芳基或取代或未取代的杂环基; y是0-10的整数，L是包含酰胺键的可切割连接物，M是质量归一化部分。

9. 发明授权

US09341635B2 Mass labels 有权
标题翻译：批量标签
公开(公告)号：US09341635B2
公开(公告)日：2016-05-17
申请号：US13497875
申请日：2010-09-08
申请人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
发明人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
IPC分类号： C40B30/10 , C40B40/04 , C07D401/12 , G01N33/74 , C07B59/00 , C07D211/14 , G01N33/58
CPC分类号： G01N33/743 , C07B59/002 , C07D211/14 , C07D401/12 , G01N33/58 , G01N2458/15 , G01N2560/00 , Y10T436/196666 , Y10T436/200833 , Y10T436/24
摘要： A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure: X-L-M-S—Re wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: wherein J is C═O, K is NH, and n is 2 or J and K are both CH2 and n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.
摘要翻译：用于通过质谱法标记用于检测的生物分子的反应性质量标签，该标记包括用于标记巯基或羰基的反应性官能团。还提供了用于通过质谱法标记用于检测的生物分子的反应性质量标签，其中所述质量标签包含以下结构：XLMS-Re，其中X是质量标记物部分，L是可切割接头，M是质量归一化部分 S是包含以下基团的质量系列改性基团：其中J为C = O，K为NH，n为2或J和K均为CH 2，n为1，m为至少1; 并且Re是用于将质量标签附着到生物分子的反应性官能团。

10. 发明申请

US20120283137A1 MASS LABELS 有权
标题翻译：质量标签
公开(公告)号：US20120283137A1
公开(公告)日：2012-11-08
申请号：US13497875
申请日：2010-09-08
申请人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
发明人： Christian Baumann , Stefan Kienle , Karsten Kuhn , Harald Legner
IPC分类号： C07D401/12 , C40B30/10 , C40B40/04 , C07D211/14 , G01N27/72
CPC分类号： G01N33/743 , C07B59/002 , C07D211/14 , C07D401/12 , G01N33/58 , G01N2458/15 , G01N2560/00 , Y10T436/196666 , Y10T436/200833 , Y10T436/24
摘要： A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure: X-L-M-S-Re wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: wherein J is C═O, K is NH, and n is 2 or J and K are both CH2 and n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.
摘要翻译：用于通过质谱法标记用于检测的生物分子的反应性质量标签，该标记包括用于标记巯基或羰基的反应性官能团。还提供了用于通过质谱法标记用于检测的生物分子的反应性质量标签，其中所述质量标签包含以下结构：XLMS-Re，其中X是质量标记物部分，L是可切割接头，M是质量归一化部分 S是包含以下基团的质量系列改性基团：其中J为C = O，K为NH，n为2或J和K均为CH 2，n为1，m为至少1; 并且Re是用于将质量标签附着到生物分子的反应性官能团。

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