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1. 发明授权

US06811971B2 Method for the detection of influenza A/B viruses 有权
标题翻译：检测甲型流感病毒的方法
公开(公告)号：US06811971B2
公开(公告)日：2004-11-02
申请号：US10311523
申请日：2002-12-13
申请人： Juergen Klepp , Reiner Schlipfenbacher
发明人： Juergen Klepp , Reiner Schlipfenbacher
IPC分类号： C12Q170
CPC分类号： C12Q1/701 , G01N33/56983 , Y10S435/81
摘要： The invention concerns a method for the detection of an infection with influenza A and/or influenza B virus comprising the steps: i) obtaining a saliva sample, ii) preparing the saliva sample for a detection reaction and iii) detecting the influenza A and/or influenza B virus in the saliva sample. The invention in addition concerns a test kit for the detection of an infection by the influenza A and/or influenza B virus containing: i) a device for the collection of a saliva sample and ii) reagents and auxiliary agents for the detection of influenza A and/or influenza B viruses. Furthermore the invention concerns the use of saliva as a sample material for the detection of an infection with the influenza A and/or influenza B virus.
摘要翻译：本发明涉及用于检测A型流感和/或B型流感病毒感染的方法，包括以下步骤：i）获得唾液样品，ii）制备用于检测反应的唾液样品，以及iii）检测A型流感和/ 或乙型流感病毒。本发明另外涉及用于检测甲型流感病毒和/或乙型流感病毒感染的检测试剂盒，其包含：i）用于收集唾液样品的装置和ii）用于检测流感A的试剂和辅助剂和/或乙型流感病毒。此外，本发明涉及使用唾液作为检测A型流感和/或B型流感病毒感染的样品材料。

2. 发明申请

US20050202487A1 Methods for isolation of bacteria from biological samples 审中-公开
标题翻译：从生物样品中分离细菌的方法
公开(公告)号：US20050202487A1
公开(公告)日：2005-09-15
申请号：US11069667
申请日：2005-03-01
申请人： Juergen Klepp , Peter Kaspar , Ralf Zielenski , Reiner Schlipfenbacher
发明人： Juergen Klepp , Peter Kaspar , Ralf Zielenski , Reiner Schlipfenbacher
IPC分类号： G01N33/53 , C12N1/00 , C12N1/02 , C12N1/20 , C12N15/09 , C12Q1/02 , C12Q1/04 , C12Q1/24 , C12Q1/68 , G01N33/554 , G01N33/569
CPC分类号： C12N1/02
摘要： The present invention is directed to methods and kits for isolation of bacteria from biological samples. In such methods antibodies specific for eukaryotic cells, which are deficient in a bacteria-binding Fc-terminus, are used for separating eukaryotic cells from biological samples.
摘要翻译：本发明涉及从生物样品中分离细菌的方法和试剂盒。在这些方法中，对细菌结合的Fc末端缺陷的真核细胞特异的抗体用于从真菌样品中分离真核细胞。

3. 发明授权

US08202490B2 Membranes and methods for coating membranes 有权
标题翻译：膜和膜的涂覆方法
公开(公告)号：US08202490B2
公开(公告)日：2012-06-19
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： B01L3/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

4. 发明授权

US08951806B2 Immunological test element with improved control zone 有权
标题翻译：具有改善控制区的免疫测试元件
公开(公告)号：US08951806B2
公开(公告)日：2015-02-10
申请号：US12881651
申请日：2010-09-14
申请人： Juergen Klepp
发明人： Juergen Klepp
IPC分类号： G01N33/558 , G01N33/563 , G01N33/543
CPC分类号： G01N33/54386 , G01N33/54306 , G01N33/54366
摘要： The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
摘要翻译：本发明涉及一种用于进行免疫学夹心测试的测试元件，用于确定含有试剂区域或共轭区域的液体样品的分析物，该试剂区域或共轭区域含有分析物结合配偶体和可通过视觉直接或间接检测的标记物的缀合物，光学或电化学手段（例如，酶，荧光或直接标记等），其中缀合物可以被液体样品溶解，包含永久固定的（即不能被液体样品分离）的检测区域结合分析物的合作伙伴或含有分析物的复合物; 以及控制区，其包含用于分析物结合配偶体和标记物的缀合物的永久固定的结合配偶体，其特征在于所述对照区域另外含有一种或多种用于分析物的永久固定的结合配偶体或含有所述分析物的复合物。

5. 发明申请

US20110091914A1 Immunological Test Element with Improved Control Zone 审中-公开
标题翻译：具有改进控制区的免疫测试元件
公开(公告)号：US20110091914A1
公开(公告)日：2011-04-21
申请号：US12917124
申请日：2010-11-01
申请人： Juergen Klepp
发明人： Juergen Klepp
IPC分类号： G01N33/53 , C12M1/40
CPC分类号： G01N33/54386 , B01L2300/0825 , B01L2400/0406 , G01N33/54306 , G01N33/54366 , G01N33/558
摘要： The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
摘要翻译：本发明涉及一种用于进行免疫学夹心测试的测试元件，用于确定含有试剂区域或共轭区域的液体样品的分析物，该试剂区域或共轭区域含有分析物结合配偶体和可通过视觉直接或间接检测的标记物的缀合物，光学或电化学手段（例如，酶，荧光或直接标记等），其中缀合物可以被液体样品溶解，包含永久固定的（即不能被液体样品分离）的检测区域结合分析物的合作伙伴或含有分析物的复合物; 以及控制区，其包含用于分析物结合配偶体和标记的缀合物的永久固定的结合配偶体，其特征在于所述对照区域另外含有用于分析物的一个或多个永久固定的结合配偶体或含有所述分析物的复合物。

6. 发明授权

US07955563B2 Methods for applying reactive films containing solids to microporous membranes and membranes produced therefrom 有权
标题翻译：将含有固体的活性膜施加到微孔膜的方法和由其制备的膜
公开(公告)号：US07955563B2
公开(公告)日：2011-06-07
申请号：US11758804
申请日：2007-06-06
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N27/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式制备的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

7. 发明申请

US20070274861A1 MEMBRANES AND METHODS FOR COATING MEMBRANES 有权
标题翻译：膜和涂膜方法
公开(公告)号：US20070274861A1
公开(公告)日：2007-11-29
申请号：US11758804
申请日：2007-06-06
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N31/22
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluid.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式制备的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

8. 发明申请

US20100330705A1 Immunological Test Element with Improved Control Zone 有权
标题翻译：具有改进控制区的免疫测试元件
公开(公告)号：US20100330705A1
公开(公告)日：2010-12-30
申请号：US12881651
申请日：2010-09-14
申请人： Juergen Klepp
发明人： Juergen Klepp
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , G01N33/54306 , G01N33/54366
摘要： The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
摘要翻译：本发明涉及一种用于进行免疫学夹心测试的测试元件，用于确定含有试剂区域或共轭区域的液体样品的分析物，该试剂区域或共轭区域含有分析物结合配偶体和可通过视觉直接或间接检测的标记物的缀合物，光学或电化学手段（例如，酶，荧光或直接标记等），其中缀合物可以被液体样品溶解，包含永久固定的（即不能被液体样品分离）的检测区域结合分析物的合作伙伴或含有分析物的复合物; 以及控制区，其包含用于分析物结合配偶体和标记的缀合物的永久固定的结合配偶体，其特征在于所述对照区域另外含有用于分析物的一个或多个永久固定的结合配偶体或含有所述分析物的复合物。

9. 发明申请

US20110194980A1 Process For Hydrophilizing Surfaces Of Fluidic Components And Systems 有权
标题翻译：流体组分和系统的亲水化表面的方法
公开(公告)号：US20110194980A1
公开(公告)日：2011-08-11
申请号：US13089721
申请日：2011-04-19
申请人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
发明人： Juergen Klepp , Thomas Fischer , Rolf Lerch , Dieter Mangold , Juergen Schaeffler
IPC分类号： G01N30/00
CPC分类号： B01D69/12 , B01D67/0088 , G01N33/521 , Y10T436/2575
摘要： A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
摘要翻译：提供了一种将含有固体的反应性膜施加到微孔膜的方法，其中首先润湿膜，并且将含有固体的反应性膜施加到膜上，同时其仍然是潮湿的。以这种方式生产的膜可以含有具有高比例的开膜剂的反应性膜，并且可以有利地用于检测成分的诊断元件，特别是用于体液中的大的疏水性分析物。

10. 发明申请

US20070184506A1 IMMUNOLOGICAL TEST ELEMENT WITH IMPROVED CONTROL ZONE 审中-公开
标题翻译：具有改进控制区的免疫测试单元
公开(公告)号：US20070184506A1
公开(公告)日：2007-08-09
申请号：US11622515
申请日：2007-01-12
申请人： Juergen Klepp
发明人： Juergen Klepp
IPC分类号： G01N33/558
CPC分类号： G01N33/54386 , B01L2300/0825 , B01L2400/0406 , G01N33/54306 , G01N33/54366 , G01N33/558
摘要： The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g., an enzyme, fluorescent or direct label, etc.) wherein the conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e., which cannot be detached by the liquid sample) binding partner for the analyte or for complexes containing the analyte; and a control zone which contains a permanently immobilized binding partner for the conjugate of analyte binding partner and label characterized in that the control zone additionally contains one or more permanently immobilized binding partner(s) for the analyte or for complexes containing the analyte.
摘要翻译：本发明涉及一种用于进行免疫学夹心测试的测试元件，用于确定含有试剂区域或共轭区域的液体样品的分析物，该试剂区域或共轭区域含有分析物结合配偶体和可通过视觉直接或间接检测的标记物的缀合物，光学或电化学手段（例如，酶，荧光或直接标记等），其中缀合物可以被液体样品溶解，包含永久固定的（即不能被液体样品分离）的检测区域结合分析物的合作伙伴或含有分析物的复合物; 以及控制区，其包含用于分析物结合配偶体和标记的缀合物的永久固定的结合配偶体，其特征在于所述对照区域另外含有用于分析物的一个或多个永久固定的结合配偶体或含有所述分析物的复合物。

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