专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5160486A Test carrier utilizing reaction of two bioaffine binding partners 失效
标题翻译：使用两个生物伙伴合作伙伴的测试携带者反应
公开(公告)号：US5160486A
公开(公告)日：1992-11-03
申请号：US450557
申请日：1989-12-14
申请人： Reiner Schlipfenbacher , Dieter Mangold , Rolf Lerch , Joachim Steinbiss
发明人： Reiner Schlipfenbacher , Dieter Mangold , Rolf Lerch , Joachim Steinbiss
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/805
摘要： Test carrier for analysis of a sample liquid with the help of a specific binding reaction of two bioaffine binding partners, one of which is contained in the sample and one in the reagent system of the test carrier, with several capillary-active test zones (11-16; 21-25) arranged substantially next to one another on a base layer (2). The test zones are in liquid contact with one another so that they form a liquid transport path (20, 30) along which a liquid flows, driven by capillary forces, from a start zone (11, 21), a reaction thereby taking place between the first binding partner and the reagent system containing the second reaction partner, which reaction leads to a labelled species characteristic for the desired analysis. A third binding partner specific for the first binding partner sets as capturing reagent which is so arranged in a zone of the liquid transport path (20, 30) and is so measured with regard to the amount used that it binds a part of the first binding partner and thereby removes it from the reaction leading to the characteristic labelled species. A process for the analysis of a liquid sample with the above test carrier is also provided.
摘要翻译：借助于两个生物亚硫酸结合配偶体的特异性结合反应（其中一个包含在样品中，一个在测试载体的试剂系统中）与样品液体分离的测试载体，具有几个毛细管活性测试区（11 -16; 21-25），其基本上彼此相邻布置在基底层（2）上。测试区彼此液体接触，使得它们形成液体输送路径（20,30），液体沿着该液体输送路径（20,30）从毛细作用力从起始区域（11,21）流动，由此发生反应第一结合配偶体和含有第二反应伴侣的试剂系统，该反应导致所需分析的标记物质特征。特定于第一结合伴侣的第三结合配偶体设置为捕获试剂，其被布置在液体输送路径（20,30）的区域中，并且相对于所使用的量如此测量，其结合了第一结合物的一部分从而将其从导致特征标记物种的反应中除去。还提供了使用上述测试载体分析液体样品的方法。

2. 发明授权

US07026002B1 Element, method and kit for the determination of an analyte in a liquid 失效
标题翻译：用于测定液体中分析物的元素，方法和试剂盒
公开(公告)号：US07026002B1
公开(公告)日：2006-04-11
申请号：US09594972
申请日：2000-06-15
申请人： Ada Goerlach-Graw , Reiner Schlipfenbacher
发明人： Ada Goerlach-Graw , Reiner Schlipfenbacher
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10S435/969 , Y10S435/97 , Y10S435/975 , Y10S436/81
摘要： The invention concerns an element for the determination of an analyte in a liquid by means of a specific binding reaction of two bioaffine binding partners containing in or on material which enables liquid transport between the zones. The element comprises a sample application zone; a detection zone located downstream thereof that is devoid of binding reagents and is the last zone on the element that allows liquid transport; a zone containing immobilized analyte or analyte analogue between the sample application zone and the detection zone; and impregnated conjugate that can be detached by liquid located in the sample application zone or upstream or downstream thereof composed of a bioaffine binding partner capable of a specific binding reaction with the analyte to be determined and a detectable label.
摘要翻译：本发明涉及一种用于通过两种生物亚胺结合配偶体的特异性结合反应来测定液体中的分析物的元件，所述两种生物石蜡结合配对物质包含在能够在区域之间进行液体输送的材料中或材料上。元件包括样品施加区域; 位于其下游的没有结合试剂的检测区，并且是允许液体输送的元件上的最后一个区域; 在样品施用区域和检测区域之间含有固定化分析物或分析物类似物的区域; 以及可以通过位于样品施用区域中的液体或其上游或下游由能够与待测定的分析物进行特异性结合反应的生物熔解结合对象组成的浸渍的共轭物和可检测标记物。

3. 发明授权

US6153192A Peptides with a characteristic antigenic determinant of .alpha.1-microglobulin 失效
标题翻译：具有α1-微球蛋白特征抗原决定簇的肽
公开(公告)号：US6153192A
公开(公告)日：2000-11-28
申请号：US96044
申请日：1993-07-22
申请人： Erhard Kopetzki , Christian Klein , Dieter Mangold , Werner Stock , Reiner Schlipfenbacher
发明人： Erhard Kopetzki , Christian Klein , Dieter Mangold , Werner Stock , Reiner Schlipfenbacher
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , C07K16/00 , C07K16/06 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N31/22 , G01N33/53 , A61K39/00 , A61K38/00 , G01N33/566
CPC分类号： C07K16/18 , C07K16/06 , Y10S530/81 , Y10S530/812
摘要： A peptide according to the present invention is not more than 40 amino acids long and contains a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 144 and 183 of human .alpha.1-microglobulin or/and a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 1 and 20 of human .alpha.1-microglobulin.An antibody according to the present invention is capable of specific binding to a peptide according to the present invention as well as to human .alpha.1-microglobulin.In order to determine human .alpha.1-microglobulin in a sample liquid by an immunoassay, the sample liquid is brought into contact simultaneously or sequentially with defined amounts of the components antibody and peptide whereby one of the components is labelled and the determination is carried out by means of this label.
摘要翻译：根据本发明的肽不超过40个氨基酸长，并且含有与人α1-微球蛋白的氨基酸144和183之间的氨基酸部分序列至少6个氨基酸长的序列或/和该序列与人α1-微球蛋白的氨基酸1和20之间的氨基酸部分序列至少6个氨基酸长。根据本发明的抗体能够与根据本发明的肽以及人α1-微球蛋白特异性结合。为了通过免疫测定法在样品液体中测定人α1-微球蛋白，将样品液体与定义量的组分抗体和肽同时或依次接触，由此其中一种组分被标记，并且测定由该标签的手段。

4. 发明授权

US06811971B2 Method for the detection of influenza A/B viruses 有权
标题翻译：检测甲型流感病毒的方法
公开(公告)号：US06811971B2
公开(公告)日：2004-11-02
申请号：US10311523
申请日：2002-12-13
申请人： Juergen Klepp , Reiner Schlipfenbacher
发明人： Juergen Klepp , Reiner Schlipfenbacher
IPC分类号： C12Q170
CPC分类号： C12Q1/701 , G01N33/56983 , Y10S435/81
摘要： The invention concerns a method for the detection of an infection with influenza A and/or influenza B virus comprising the steps: i) obtaining a saliva sample, ii) preparing the saliva sample for a detection reaction and iii) detecting the influenza A and/or influenza B virus in the saliva sample. The invention in addition concerns a test kit for the detection of an infection by the influenza A and/or influenza B virus containing: i) a device for the collection of a saliva sample and ii) reagents and auxiliary agents for the detection of influenza A and/or influenza B viruses. Furthermore the invention concerns the use of saliva as a sample material for the detection of an infection with the influenza A and/or influenza B virus.
摘要翻译：本发明涉及用于检测A型流感和/或B型流感病毒感染的方法，包括以下步骤：i）获得唾液样品，ii）制备用于检测反应的唾液样品，以及iii）检测A型流感和/ 或乙型流感病毒。本发明另外涉及用于检测甲型流感病毒和/或乙型流感病毒感染的检测试剂盒，其包含：i）用于收集唾液样品的装置和ii）用于检测流感A的试剂和辅助剂和/或乙型流感病毒。此外，本发明涉及使用唾液作为检测A型流感和/或B型流感病毒感染的样品材料。

5. 发明授权

US06485915B1 Analytical element for species-specific detection of nucleic acids 有权
标题翻译：核酸物种特异性检测的分析要素
公开(公告)号：US06485915B1
公开(公告)日：2002-11-26
申请号：US09716013
申请日：2000-11-17
申请人： Volker Keller , Andreas Rauscher , Joachim Steinbiss , Reiner Schlipfenbacher , Jurgen Klepp
发明人： Volker Keller , Andreas Rauscher , Joachim Steinbiss , Reiner Schlipfenbacher , Jurgen Klepp
IPC分类号： C12Q168
CPC分类号： C12Q1/6813 , Y10T436/143333
摘要： The present invention concerns a method for the detection of nucleic acids on an analytical element which contains a sample application zone and a detection zone, the analytical element enabling liquid transport from the sample application zone to the detection zone, wherein a sample is applied to the sample application zone of the analytical element and the nucleic acids contained in the sample are denatured and can be detected qualitatively in the detection zone by hybridization with a detection probe and also quantitatively, preferably by means of marker groups. In addition new analytical elements and reagent kits for the detection of nucleic acids are provided.
摘要翻译：本发明涉及一种用于检测分析元件上的核酸的方法，所述分析元件包含样品施用区和检测区，所述分析元件使液体从样品施用区转移到检测区，其中将样品施加到分析元件的样品应用区域和样品中包含的核酸变性，并且可以在检测区域中通过与检测探针杂交并定量地优选通过标记物质量定性检测。此外，还提供了用于检测核酸的新的分析元件和试剂盒。

6. 发明授权

US5188939A Displacement immunoassay utilizing an oligavalent labelled antibody 失效
标题翻译：使用免疫反应标签的免疫球蛋白
公开(公告)号：US5188939A
公开(公告)日：1993-02-23
申请号：US549893
申请日：1990-07-09
申请人： Dieter Mangold , Reiner Schlipfenbacher
发明人： Dieter Mangold , Reiner Schlipfenbacher
IPC分类号： G01N33/53 , G01N33/532 , G01N33/535 , G01N33/543 , G01N33/68
CPC分类号： G01N33/54386 , G01N33/535 , G01N33/6857 , Y10S436/819
摘要： A method for carrying out competitive displacement immunoassays which entails the use of an oligovalent labelled antibody having at least 4 binding sites for the analyte to be determined per label.
摘要翻译：用于进行竞争性置换免疫测定的方法，其需要使用具有至少4个结合位点的寡核苷酸标记抗体来分析每个标签。

7. 发明授权

US07267992B2 Method for the determination of an analyte in a liquid 失效
标题翻译：用于测定液体中分析物的方法
公开(公告)号：US07267992B2
公开(公告)日：2007-09-11
申请号：US11348705
申请日：2006-02-07
申请人： Ada Goerlach-Graw , Reiner Schlipfenbacher
发明人： Ada Goerlach-Graw , Reiner Schlipfenbacher
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10S435/969 , Y10S435/97 , Y10S435/975 , Y10S436/81
摘要： A method is provided to determine the presence of an analyte in a sample. The method provides an element with a sample application zone, a detection zone, a zone containing immobilized analyte or analyte analogue, a conjugate that has a first bioaffine binding partner capable of a specific binding reaction with the analyte and a first detectable label, and a universal conjugate, which can be detached by liquid and comprises a second bioaffine binding partner and a visually detectable label. The second bioaffine binding partner is capable of a specific binding reaction with the first detectable label. The method also includes contacting the sample application zone with the sample, contacting the sample with the conjugate and the universal conjugate to react the analyte with the and the universal conjugate to form a detection complex, and determining the presence of the detection complex in the detection zone of the element.
摘要翻译：提供了一种确定样品中分析物的存在的方法。该方法提供了具有样品施用区域，检测区域，含有固定化分析物或分析物类似物的区域的元件，具有能够与分析物和第一可检测标记物进行特异性结合反应的第一生物亚烷结合配偶体的缀合物，以及通用缀合物，其可以通过液体分离并且包含第二生物碱结合配偶体和视觉上可检测的标记。第二生物石墨结合配偶体能够与第一可检测标记物进行特异性结合反应。该方法还包括使样品施用区与样品接触，使样品与缀合物和通用缀合物接触以使分析物与通用缀合物反应以形成检测复合物，并确定检测复合物在检测中的存在元素的区域。

8. 发明申请

US20060128029A1 Method for the determination of an analyte in a liquid 失效
标题翻译：用于测定液体中分析物的方法
公开(公告)号：US20060128029A1
公开(公告)日：2006-06-15
申请号：US11348705
申请日：2006-02-07
申请人： Ada Goerlach-Graw , Reiner Schlipfenbacher
发明人： Ada Goerlach-Graw , Reiner Schlipfenbacher
IPC分类号： G01N33/558 , G01N33/551
CPC分类号： G01N33/558 , Y10S435/969 , Y10S435/97 , Y10S435/975 , Y10S436/81
摘要： A method is provided to determine the presence of an analyte in a sample. The method provides an element with a sample application zone, a detection zone, a zone containing immobilized analyte or analyte analogue, a conjugate that has a first bioaffine binding partner capable of a specific binding reaction with the analyte and a first detectable label, and a universal conjugate, which can be detached by liquid and comprises a second bioaffine binding partner and a visually detectable label. The second bioaffine binding partner is capable of a specific binding reaction with the first detectable label. The method also includes contacting the sample application zone with the sample, contacting the sample with the conjugate and the universal conjugate to react the analyte with the and the universal conjugate to form a detection complex, and determining the presence of the detection complex in the detection zone of the element.
摘要翻译：提供了一种确定样品中分析物的存在的方法。该方法提供了具有样品施用区域，检测区域，含有固定化分析物或分析物类似物的区域的元件，具有能够与分析物和第一可检测标记物进行特异性结合反应的第一生物亚烷结合配偶体的缀合物，以及通用缀合物，其可以通过液体分离并且包含第二生物碱结合配偶体和视觉上可检测的标记。第二生物石墨结合配偶体能够与第一可检测标记物进行特异性结合反应。该方法还包括使样品施用区与样品接触，使样品与缀合物和通用缀合物接触以使分析物与通用缀合物反应以形成检测复合物，并确定检测复合物在检测中的存在元素的区域。

9. 发明申请

US20050202487A1 Methods for isolation of bacteria from biological samples 审中-公开
标题翻译：从生物样品中分离细菌的方法
公开(公告)号：US20050202487A1
公开(公告)日：2005-09-15
申请号：US11069667
申请日：2005-03-01
申请人： Juergen Klepp , Peter Kaspar , Ralf Zielenski , Reiner Schlipfenbacher
发明人： Juergen Klepp , Peter Kaspar , Ralf Zielenski , Reiner Schlipfenbacher
IPC分类号： G01N33/53 , C12N1/00 , C12N1/02 , C12N1/20 , C12N15/09 , C12Q1/02 , C12Q1/04 , C12Q1/24 , C12Q1/68 , G01N33/554 , G01N33/569
CPC分类号： C12N1/02
摘要： The present invention is directed to methods and kits for isolation of bacteria from biological samples. In such methods antibodies specific for eukaryotic cells, which are deficient in a bacteria-binding Fc-terminus, are used for separating eukaryotic cells from biological samples.
摘要翻译：本发明涉及从生物样品中分离细菌的方法和试剂盒。在这些方法中，对细菌结合的Fc末端缺陷的真核细胞特异的抗体用于从真菌样品中分离真核细胞。

10. 发明授权

US5690529A Adsorber material, apparatus and process for concentrating and recovering trace materials from the gaseous phase 失效
标题翻译：用于从气相中浓缩和回收痕量物质的吸附剂材料，设备和方法
公开(公告)号：US5690529A
公开(公告)日：1997-11-25
申请号：US748618
申请日：1996-11-13
申请人： Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter , Harald Ertl , Rolf Lerch , Reiner Schlipfenbacher , Ludwig Angermaier , Christian Klein
发明人： Helmut Oberpriller , Reinhold Hilpert , Florian Binder , Josef Ritter , Harald Ertl , Rolf Lerch , Reiner Schlipfenbacher , Ludwig Angermaier , Christian Klein
IPC分类号： B01J20/24 , B01J20/26 , B01J20/28 , G01N1/22 , G01N1/34 , G01N13/00 , D04H3/00 , D04H3/12
CPC分类号： B01J20/28023 , B01J20/2803 , B01J20/28033 , G01N1/405 , G01N1/2214 , Y10T442/696 , Y10T442/697 , Y10T442/698
摘要： An adsorber material for collecting, concentrating and/or recovering gaseous and/or particle-shaped trace substances from an air or gas flow, in which the adsorber material is composed of fibrous elements made of natural and/or synthetic, organic, textile fibers which are worked into a nonwoven web having a planar geometry, the nonwoven web having a thickness of between 100 .mu.m and 2 mm and a weight per unit area of between 20 and 200 g/m.sup.2. Preferably the fibers have a fiber size between 1 and 10 dtex and are composed of cellulose and/or polyester, and if desired, the fibers may be provided with a binding agent and/or a moisture resistance agent. In preferred embodiments the nonwoven adsorber web is a fiber mixture of 80 parts polyester fibers, 20 parts viscose rayon staple fibers, and 20 parts polyvinyl alcohol fibers or a fiber mixture of 50 parts viscose rayon staple fibers and 50 parts linters, which are provided with an epichlorohydrin resin binder. The adsorber webs can be used to detect gaseous or particulate trace contaminants in air or another gas stream.
摘要翻译：用于从空气或气体流中收集，浓缩和/或回收气态和/或颗粒状痕量物质的吸附剂材料，其中吸附材料由天然和/或合成的有机纺织纤维制成的纤维元素组成，被加工成具有平面几何形状的非织造纤维网，非织造纤维网的厚度在100μm和2mm之间，每单位面积的重量在20和200g / m 2之间。优选地，纤维的纤维尺寸在1和10分特之间并且由纤维素和/或聚酯组成，如果需要，纤维可以具有粘合剂和/或防潮剂。在优选的实施方案中，非织造物吸附剂纤维网是80份聚酯纤维，20份粘胶人造丝短纤维和20份聚乙烯醇纤维或50份粘胶人造丝短纤维和50份绒毛的纤维混合物的纤维混合物，它们具有表氯醇树脂粘合剂。吸附器腹板可用于检测空气或其他气体流中的气态或微量痕量污染物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式