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1. 发明授权

US5883350A Crisla process 失效
标题翻译： Crisla过程
公开(公告)号：US5883350A
公开(公告)日：1999-03-16
申请号：US834095
申请日：1997-04-14
申请人： Jozef W. Eerkens , Dennis G. Garratt , Brian C. Olson , Ken J. Falk , John H. Wang
发明人： Jozef W. Eerkens , Dennis G. Garratt , Brian C. Olson , Ken J. Falk , John H. Wang
IPC分类号： B01D59/18 , B01D59/34 , B01D59/50 , B01D3/00
CPC分类号： B01D59/18 , B01D59/34 , B01D59/50
摘要： Nozzle cooling and wall contact prevention control are included in a gaseous CRISLA apparatus, along with removable collectors, and the efficient use of one or more currently available high power lasers to produce a commercially economic isotope separation process. The wall contact prevention is accomplished with gaseous boundary layers, and a supersonic nozzle normally is used to cool and separate excitation bands of the isotopic material. Non-intermixing gaseous streams with different isotopic assays can be created in a single nozzle chamber and segmented collection chamber, which along with recirculation loops and compressors, allows a single laser system and a single nozzle system to be used to selectively excite the isotopic material while it makes multiple passes through the laser beams of the laser system until only a small fraction of the desired isotope remains to be separated. The process is especially effective in separating .sup.235 UF.sub.6 from a gaseous mixture of .sup.235 UF.sub.6 and .sup.238 UF.sub.6.
摘要翻译：气体冷却和壁接触预防控制包括在气体CRISLA设备中，以及可移除的收集器，以及有效地使用一个或多个当前可用的大功率激光器以产生商业经济的同位素分离过程。通过气体边界层实现壁接触预防，通常使用超音速喷嘴来冷却和分离同位素材料的激发带。可以在单个喷嘴室和分段收集室中产生具有不同同位素测定的非混合气流，其与循环回路和压缩机一起可以使用单个激光系统和单个喷嘴系统来选择性地激发同位素材料，同时它使得多次通过激光系统的激光束，直到只有一小部分所需的同位素保持分离。该方法在将235UF6与235UF6和238UF6的气体混合物分离时特别有效。

2. 发明授权

US5666639A CRISLA process and apparatus 失效
标题翻译： CRISLA工艺和设备
公开(公告)号：US5666639A
公开(公告)日：1997-09-09
申请号：US255331
申请日：1994-06-07
申请人： Jozef W. Eerkens , Dennis G. Garratt , Brian C. Olson , Ken J. Falk , John H. Wang
发明人： Jozef W. Eerkens , Dennis G. Garratt , Brian C. Olson , Ken J. Falk , John H. Wang
IPC分类号： B01D59/18 , B01D59/34 , B01D59/50 , B01J19/08
CPC分类号： B01D59/34 , B01D59/18 , B01D59/50
摘要： Nozzle cooling and wall contact prevention control are included in a gaseous CRISLA apparatus, along with removable collectors, and the efficient use of one or more currently available high power lasers to produce a commercially economic isotope separation process. The wall contact prevention is accomplished with gaseous boundary layers, and a supersonic nozzle normally is used to cool and separate excitation bands of the isotopic material. Non-intermixing gaseous streams with different isotopic assays can be created in a single nozzle chamber and segmented collection chamber, which along with recirculation loops and compressors, allows a single laser system and a single nozzle system to be used to selectively excite the isotopic material while it makes multiple passes through the laser beams of the laser system until only a small fraction of the desired isotope remains to be separated. The process is especially effective in separating .sup.235 UF.sub.6 from a gaseous mixture of .sup.235 UF.sub.6 and .sup.238 UF.sub.6.
摘要翻译：气体冷却和壁接触预防控制包括在气体CRISLA设备中，以及可移除的收集器，以及有效地使用一个或多个当前可用的大功率激光器以产生商业经济的同位素分离过程。通过气体边界层实现壁接触预防，通常使用超音速喷嘴来冷却和分离同位素材料的激发带。可以在单个喷嘴室和分段收集室中产生具有不同同位素测定的非混合气流，其与循环回路和压缩机一起可以使用单个激光系统和单个喷嘴系统来选择性地激发同位素材料，同时它使得多次通过激光系统的激光束，直到只有一小部分所需的同位素保持分离。该方法在将235UF6与235UF6和238UF6的气体混合物分离时特别有效。

3. 发明授权

US5744116A Reaction of uranium fluorides with mineral acids to recover hydrogen fluoride 失效
标题翻译：氟化铀与无机酸的反应以回收氟化氢
公开(公告)号：US5744116A
公开(公告)日：1998-04-28
申请号：US354161
申请日：1994-12-08
申请人： Brian C. Olson , John H. Wang , Dennis W. Prediger , Marlo S. Savoie , Dennis G. Garratt
发明人： Brian C. Olson , John H. Wang , Dennis W. Prediger , Marlo S. Savoie , Dennis G. Garratt
IPC分类号： C01B7/19 , C01G43/01 , C01G43/025
CPC分类号： C01G43/01 , C01B7/191 , C01G43/025 , C01P2006/60 , C01P2006/80 , C01P2006/82
摘要： Uranium fluoride compounds, in which the uranium is preferably present in the tetravalent or higher valency state, are reacted with a strong mineral acid, to yield a gaseous phase of hydrogen fluoride and a precipitate that is a uranium salt of the mineral acid. The precipitate can be subjected to thermal decomposition to recover the mineral acid and to obtain an oxide of uranium. The process provides an economical way of obtaining hydrogen fluoride from byproduct depleted UF.sub.6.
摘要翻译：其中铀优选以四价或更高价态存在的氟化铪化合物与强无机酸反应，产生氟化氢的气相和作为无机酸的铀盐的沉淀物。可以将沉淀物进行热分解以回收无机酸并获得铀氧化物。该方法提供了从副产物消耗的UF6获得氟化氢的经济方法。

4. 发明授权

US06929637B2 Device and method for intra-bronchial provision of a therapeutic agent 有权
标题翻译：用于支气管内给药治疗剂的装置和方法
公开(公告)号：US06929637B2
公开(公告)日：2005-08-16
申请号：US10317667
申请日：2002-12-11
申请人： Hugo X. Gonzalez , Steven Chase Springmeyer , Richard O. Shea , John H. Wang , Lauri J. DeVore
发明人： Hugo X. Gonzalez , Steven Chase Springmeyer , Richard O. Shea , John H. Wang , Lauri J. DeVore
IPC分类号： A61B17/12 , A61B17/22 , A61F2/04 , A61M1/00 , A61M25/00 , A61M25/04 , A61M31/00 , A61N5/10 , A61K9/22
CPC分类号： A61M31/002 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61B2017/242 , A61B2217/005 , A61F2002/043 , A61M1/0023 , A61M25/04 , A61M31/00 , A61M2025/0076 , A61M2210/1035 , A61N5/1027 , A61N2005/1021
摘要： The present invention includes an intra-bronchial device, system, and method for providing a therapeutic agent to a patient. A device includes a flow control member for placement in an air passageway communicating with a lung portion, and when deployed in the air passageway inhibits a therapeutic agent distal of the control member from moving proximal of the control member, and includes the therapeutic agent associated with the flow control member. The control member may inhibit movement of the therapeutic agent by limiting airflow, and may include a one-way valve limiting exhalation of air from the lung portion. The control member may include a flexible membrane impervious to air flow, or a separator arranged to inhibit the movement of the therapeutic agent. The control member may include at least one anchor, and the anchor may be releasable from the air passageway for removal of the intra-bronchial device.
摘要翻译：本发明包括用于向患者提供治疗剂的支气管内装置，系统和方法。一种装置包括用于放置在与肺部连通的空气通道中的流量控制构件，并且当部署在空气通道中时，阻止远离控制构件的治疗剂移动到控制构件的近侧，并且包括与流量控制构件。控制构件可以通过限制气流来抑制治疗剂的移动，并且可以包括限制从肺部呼出空气的单向阀。控制构件可以包括不透气体的柔性膜，或者设置成抑制治疗剂运动的隔膜。控制构件可以包括至少一个锚固件，并且锚固件可以从空气通道释放以去除支气管内装置。

5. 发明授权

US06679870B1 Methods and kits for locking and disinfecting implanted catheters 有权
标题翻译：用于锁定和消毒植入导管的方法和套件
公开(公告)号：US06679870B1
公开(公告)日：2004-01-20
申请号：US09611421
申请日：2000-07-07
申请人： Charles D. Finch , John H. Wang , Paul F. Marad , James M. Brugger
发明人： Charles D. Finch , John H. Wang , Paul F. Marad , James M. Brugger
IPC分类号： A61M3100
CPC分类号： A61M25/00 , A61L2/18 , A61L29/14 , A61L29/16 , A61L2300/404 , A61L2300/42 , A61L2300/45 , A61M2025/0019 , A61M2025/0056
摘要： Implanted catheters are locked with a solution comprising a lower alcohol, typically ethanol, propanol, or butanol, most preferably isopropanol, and an additive, the additive comprising an anti-microbial, typically taurolidine or triclosan, or an anti-coagulant, typically riboflavin, sodium citrate, ethylene diamine tetraacetic acid, or citric acid. The use of an alcohol and additive solution can effectively reduce fouling of the catheter, particularly clotting and thrombus in intravascular catheters, as well as reduce the risk of infection. The risk of infection can be further reduced by employing a catheter body which is sufficiently porous to permit the anti-microbial solution of a lower alcohol and another anti-microbial or anti-coagulant compound to penetrate into the catheter body and preferably through the catheter into tissue surrounding the implanted catheter.
摘要翻译：植入的导管用包含低级醇（通常为乙醇，丙醇或丁醇），最优选异丙醇和添加剂的溶液锁定，所述添加剂包含抗微生物剂，通常为taurolidine或三氯生，或抗凝血剂，通常为核黄素，柠檬酸钠，乙二胺四乙酸或柠檬酸。使用酒精和添加剂溶液可有效减少导管的结垢，特别是血管内导管中的凝血和血栓，以及降低感染的风险。可以通过使用足够多孔的导管体来进一步降低感染的风险，该导管体允许低级醇和其它抗微生物剂或抗凝血剂化合物的抗微生物溶液渗入导管体内，优选通过导管进入围绕植入导管的组织。

6. 发明授权

US06299610B1 Methods and apparatus for disinfecting subcutaneously implanted devices 失效
标题翻译：用于消毒皮下植入装置的方法和装置
公开(公告)号：US06299610B1
公开(公告)日：2001-10-09
申请号：US09003772
申请日：1998-01-07
申请人： Charles D. Finch , Jeffrey H. Burbank , James M. Brugger , John H. Wang
发明人： Charles D. Finch , Jeffrey H. Burbank , James M. Brugger , John H. Wang
IPC分类号： A61M3100
CPC分类号： A61M39/0208 , A61M39/16 , A61M2039/0226
摘要： Implantable ports and other devices are disinfected by the injection of an anti-microbial agent into a tissue pocket surrounding the device. In a first embodiment, the anti-microbial agent is injected through an aperture in the device to flush internal regions of the device before infusing the tissue pocket. In other embodiments, the anti-microbial agent is injected directly to a target site on the exterior of the device. Implantable devices may include special, usually hardened, target regions for receiving the sharpened end of a needle used to inject the anti-microbial agent.
摘要翻译：通过将抗微生物剂注入装置周围的组织袋中，可植入端口和其它装置被消毒。在第一实施方案中，抗微生物剂通过装置中的孔注入，以在灌注组织袋之前冲洗装置的内部区域。在其它实施方案中，将抗微生物剂直接注射到装置外部的靶位点。可植入装置可以包括用于接收用于注射抗微生物剂的针的尖端的特殊的，通常硬化的靶区域。

7. 发明授权

US06299609B1 Methods and apparatus for inhibiting infection of subcutaneously implanted devices 失效
标题翻译：用于抑制皮下植入装置感染的方法和装置
公开(公告)号：US06299609B1
公开(公告)日：2001-10-09
申请号：US09333827
申请日：1999-06-15
申请人： Charles D. Finch , Jeffrey H. Burbank , James M. Brugger , John H. Wang
发明人： Charles D. Finch , Jeffrey H. Burbank , James M. Brugger , John H. Wang
IPC分类号： A61M3100
CPC分类号： A61M39/0208 , A61M25/0017 , A61M39/16 , A61M2005/1403 , A61M2039/0226 , A61M2209/04
摘要： Implantable ports and other devices are cleansed by the injection of a washing solution into a region in the device or in a tissue pocket surrounding the device. In a first embodiment, the washing solution is injected through an aperture in the device to flush internal regions of the device before infusing the tissue pocket and flushing outwardly through a tissue tract leading to the device. In other embodiments, the washing solution is injected directly to a target site on the exterior of the device. Implantable devices may include special, usually hardened, target regions for receiving the sharpened end of a needle used to inject the washing solution. Kits will include devices, syringes, access devices, and instructions for cleansing according to the methods of the present invention.
摘要翻译：可植入端口和其它装置通过将洗涤溶液注入装置中的区域或围绕该装置的组织袋中来清洁。在第一实施例中，洗涤溶液通过装置中的孔注入，以在注入组织袋之前冲洗装置的内部区域并向外冲洗通过通向该装置的组织通道。在其他实施例中，将洗涤溶液直接注入到装置外部的目标部位。可植入装置可以包括用于接收用于注射洗涤溶液的针的尖端的特殊的，通常硬化的目标区域。试剂盒将包括根据本发明的方法的装置，注射器，进入装置和用于清洁的说明书。

8. 发明授权

US6042569A Subcutaneously implanted cannula and methods for vascular access 失效
标题翻译：皮下植入插管和血管通路的方法
公开(公告)号：US6042569A
公开(公告)日：2000-03-28
申请号：US9758
申请日：1998-01-20
申请人： Charles D. Finch, Jr. , Hendrik K. Kuiper , Jeffrey H. Burbank , James M. Brugger , John H. Wang
发明人： Charles D. Finch, Jr. , Hendrik K. Kuiper , Jeffrey H. Burbank , James M. Brugger , John H. Wang
IPC分类号： A61F2/06 , A61M39/02 , A61M5/32
CPC分类号： A61F2/064 , A61M39/0208 , A61M2039/0211
摘要： A catheter with valve for implantation in a vascular structure of a living being. The catheter is in the general shape of a "T" with the top of the "T" implanted within the lumen of or anastomotically attached to a vascular structure. The lumen of the implanted portion of the catheter completely occupies or may be aligned with the lumen of the vascular structure, causing all blood flow through the vascular structure to be directed through the implanted portion of the catheter. A valve is placed in the wall of the implanted portion of the catheter which opens into the lumen of the leg of the "T" of the catheter upon application of sufficient differential pressure between the lumens of the two portions of the catheter. The leg of the "T" may be connected to the side wall of the implant portion of the catheter at an angle, such that the axis of the lumen of the leg of the "T" intersects the axis of the lumen of the implanted portion of the catheter at approximately a 45.degree. angle.
摘要翻译：具有用于植入生活的血管结构的瓣膜的导管。导管是“T”的一般形状，其中“T”的顶部植入内腔内或与血管结构吻合。导管的植入部分的内腔完全占据或可以与血管结构的内腔对准，导致通过血管结构的所有血液流动通过导管的植入部分。在导管的两个部分的腔之间施加足够的压差之后，将阀放置在导管的植入部分的壁中，该导管开口进入导管的“T”的腿的内腔。 “T”的腿可以以一定的角度连接到导管的植入部分的侧壁，使得“T”的腿的管腔的轴线与植入部分的内腔的轴线相交的导管在大约45度的角度。

9. 发明授权

US07942931B2 Device and method for intra-bronchial provision of a therapeutic agent 有权
标题翻译：用于支气管内给药治疗剂的装置和方法
公开(公告)号：US07942931B2
公开(公告)日：2011-05-17
申请号：US11204383
申请日：2005-08-15
申请人： Hugo X. Gonzalez , Steven Chase Springmeyer , Richard O. Shea , John H. Wang , Lauri J. DeVore
发明人： Hugo X. Gonzalez , Steven Chase Springmeyer , Richard O. Shea , John H. Wang , Lauri J. DeVore
IPC分类号： A61F2/20 , A61M31/00
CPC分类号： A61M31/002 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61B2017/242 , A61B2217/005 , A61F2002/043 , A61M1/0023 , A61M25/04 , A61M31/00 , A61M2025/0076 , A61M2210/1035 , A61N5/1027 , A61N2005/1021
摘要： The present invention includes an intra-bronchial device, system, and method for providing a therapeutic agent to a patient. A device includes a flow control member for placement in an air passageway communicating with a lung portion, and when deployed in the air passageway inhibits a therapeutic agent distal of the control member from moving proximal of the control member, and includes the therapeutic agent associated with the flow control member. The control member may inhibit movement of the therapeutic agent by limiting airflow, and may include a one-way valve limiting exhalation of air from the lung portion. The control member may include a flexible membrane impervious to air flow, or a separator arranged to inhibit the movement of the therapeutic agent. The control member may include at least one anchor, and the anchor may be releasable from the air passageway for removal of the intra-bronchial device.
摘要翻译：本发明包括用于向患者提供治疗剂的支气管内装置，系统和方法。一种装置包括用于放置在与肺部连通的空气通道中的流量控制构件，并且当部署在空气通道中时，阻止远离控制构件的治疗剂移动到控制构件的近侧，并且包括与流量控制构件。控制构件可以通过限制气流来抑制治疗剂的移动，并且可以包括限制从肺部呼出空气的单向阀。控制构件可以包括不透气体的柔性膜，或者设置成抑制治疗剂运动的隔膜。控制构件可以包括至少一个锚固件，并且锚固件可以从空气通道释放以去除支气管内装置。

10. 发明授权

US06592564B2 Methods and kits for locking and disinfecting implanted catheters 有权
标题翻译：用于锁定和消毒植入导管的方法和套件
公开(公告)号：US06592564B2
公开(公告)日：2003-07-15
申请号：US09359842
申请日：1999-07-23
申请人： Charles D. Finch , John H. Wang
发明人： Charles D. Finch , John H. Wang
IPC分类号： A61M2500
CPC分类号： A61M25/00 , A61L29/14 , A61L29/16 , A61L2300/216 , A61L2300/404 , A61M2025/0019 , A61M2025/0056
摘要： Implanted catheters are locked with a solution comprising a lower alcohol, typically ethanol, propanol, or butanol, most preferably isopropanol. The use of an alcohol can both reduce fouling of the catheter, particularly clotting and thrombus in intravascular catheters, as well as reducing the risk of infection. The risk of infection can be further reduced by employing a catheter body which is sufficiently porous to permit the lower alcohol or other anti-microbial solution to penetrate into the catheter body and preferably through the catheter into tissue surrounding the implanted catheter.
摘要翻译：植入的导管用包含低级醇（通常为乙醇，丙醇或丁醇），最优选异丙醇的溶液锁定。使用酒精可以减少导管的结垢，特别是血管内导管中的凝血和血栓，以及降低感染的风险。可以通过使用足够多孔的导管主体来进一步降低感染的风险，所述导管主体允许低级醇或其它抗微生物溶液渗透到导管体中，优选地通过导管进入围绕植入的导管的组织中。

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