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1. 发明授权

US07100600B2 Fluid filled ampoules and methods for their use in aerosolizers 有权
公开(公告)号：US07100600B2
公开(公告)日：2006-09-05
申请号：US09812755
申请日：2001-03-20
申请人： Joseph P. Loeffler , Richard Q. Poynter , David Rapp , Michael Klimowicz
发明人： Joseph P. Loeffler , Richard Q. Poynter , David Rapp , Michael Klimowicz
IPC分类号： A61M11/00
CPC分类号： A61M15/0085 , A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/0028 , A61M15/0031 , A61M15/009 , A61M2205/6045 , A61M2205/6054 , B05B17/0607 , B65D1/095 , B65D2203/00 , Y10S206/828 , Y10S215/03
摘要： A fluid filled ampoule comprises an ampoule body having a top end, a bottom end and a sealed interior containing a liquid. A top tab is coupled to the top end and is removable to create a drain vent in the top end. A bottom tab is coupled to the bottom end and is removable to create a drain opening in the bottom end. A movable shroud is coupled to the top end and is disposed about the top tab. The shroud is movable to permit access to the top tab.

2. 发明授权

US07032590B2 Fluid filled ampoules and methods for their use in aerosolizers 有权
公开(公告)号：US07032590B2
公开(公告)日：2006-04-25
申请号：US10752330
申请日：2004-01-05
申请人： Joseph P. Loeffler , Richard Q. Poynter , David Rapp , Michael Klimowicz
发明人： Joseph P. Loeffler , Richard Q. Poynter , David Rapp , Michael Klimowicz
IPC分类号： B65D1/09 , B65D83/04 , B65D85/42 , A61M15/00
CPC分类号： A61M15/0085 , A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/0028 , A61M15/0031 , A61M15/009 , A61M2205/6045 , A61M2205/6054 , B05B17/0607 , B65D1/095 , B65D2203/00 , Y10S206/828 , Y10S215/03
摘要： A fluid filled ampoule comprises an ampoule body having a top end, a bottom end and a sealed interior containing a liquid. A top tab is coupled to the top end and is removable to create a drain vent in the top end. A bottom tab is coupled to the bottom end and is removable to create a drain opening in the bottom end. A movable shroud is coupled to the top end and is disposed about the top tab. The shroud is movable to permit access to the top tab.

3. 发明授权

US07195011B2 Convertible fluid feed system with comformable reservoir and methods 有权
标题翻译：具有可变形油藏的可转换流体进料系统和方法
公开(公告)号：US07195011B2
公开(公告)日：2007-03-27
申请号：US10882888
申请日：2004-06-30
申请人： Joseph P. Loeffler , David Rapp , Victor Briones , Ralf Bitdinger , Michael Klimowicz
发明人： Joseph P. Loeffler , David Rapp , Victor Briones , Ralf Bitdinger , Michael Klimowicz
IPC分类号： A61M11/00 , A61M15/00 , B05B7/26
CPC分类号： A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , B05B17/0646 , Y10S206/828
摘要： A feed system for an aerosolizer utilizes an ampoule containing a liquid and includes a housing having an ampoule region into which the ampoule is held, and a liquid receiving region that is adapted to receive liquid dispensed from the ampoule. An interface is used to couple the liquid receiving region to an aerosol generator, whereby liquid from the liquid receiving region is permitted to flow to the aerosol generator for aerosolization.
摘要翻译：用于气雾化器的进料系统利用含有液体的安瓿，并且包括具有安瓿保藏在其中的安瓿区域的壳体和适于接收从安瓿分配的液体的液体接收区域。接口用于将液体接收区域耦合到气溶胶发生器，由此来自液体接收区域的液体被允许流到气溶胶发生器用于雾化。

4. 发明授权

US06948491B2 Convertible fluid feed system with comformable reservoir and methods 有权
标题翻译：具有可变形油藏的可转换流体进料系统和方法
公开(公告)号：US06948491B2
公开(公告)日：2005-09-27
申请号：US09812987
申请日：2001-03-20
申请人： Joseph P. Loeffler , David Rapp , Victor Briones , Ralf Bitdinger , Michael Klimowicz
发明人： Joseph P. Loeffler , David Rapp , Victor Briones , Ralf Bitdinger , Michael Klimowicz
IPC分类号： A61M15/00 , B05B17/06 , A61M11/00
CPC分类号： A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , B05B17/0646 , Y10S206/828
摘要： A feed system for an aerosolizer utilizes an ampoule containing a liquid and includes a housing having an ampoule region into which the ampoule is held, and a liquid receiving region that is adapted to receive liquid dispensed from the ampoule. An interface is used to couple the liquid receiving region to an aerosol generator, whereby liquid from the liquid receiving region is permitted to flow to the aerosol generator for aerosolization.
摘要翻译：用于气雾化器的进料系统利用含有液体的安瓿，并且包括具有安瓿保藏在其中的安瓿区域的壳体和适于接收从安瓿分配的液体的液体接收区域。接口用于将液体接收区域耦合到气溶胶发生器，由此来自液体接收区域的液体被允许流到气溶胶发生器用于雾化。

5. 发明授权

US5700286A Polymer film for wrapping a stent structure 失效
标题翻译：用于包裹支架结构的聚合物膜
公开(公告)号：US5700286A
公开(公告)日：1997-12-23
申请号：US701405
申请日：1996-08-22
申请人： Joseph M. Tartaglia , Joseph P. Loeffler , Todd H. Turnlund
发明人： Joseph M. Tartaglia , Joseph P. Loeffler , Todd H. Turnlund
IPC分类号： A61M31/00 , A61F2/00 , A61F2/82 , A61F2/92 , A61L27/00 , A61L31/00 , A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61F2/92 , A61F2/915 , A61F2002/075 , A61F2220/005 , A61F2250/0067
摘要： The drug loaded stent includes an expandable stent structural member, and a planar sheet of polymeric material attached to the outside of the expandable stent structural member. The polymeric material is preferably bioabsorbable, and loaded or coated with a therapeutic agent or drug to reduce or prevent restenosis in the vessel being treated. The polymer material can be attached to the metal stent at one or more points, and wrapped in a coil around the stent in an unexpanded state, to uncoil and expand in diameter to substantially match the expanded diameter of the metal stent; or can be wrapped tightly around the stent structural member and attached to itself, to stretch radially when the stent structural member is expanded. In another currently preferred embodiment, a combination of a stent structural member and a polymeric film wrapping can be provided with a coating of lubricious material. The lubricious material can be polyethylene oxide, polyethylene glycol, polyethylene acetate, polyvinyl pyrrolidone, polyvinyl alcohol, polyacrylamide, hydrophilic soft segment urethanes, some natural gums, polyanhydrides or other similar hydrophilic polymers, and combinations thereof. The layer of lubricious material protects the stent from the guide or the body lumen in which the stent is inserted by providing a low friction surface over the stents.
摘要翻译：药物负载支架包括可扩张的支架结构构件和附接到可扩张支架结构构件的外侧的聚合物材料的平面片。聚合物材料优选是生物可吸收的，并且加载或涂覆有治疗剂或药物以减少或预防待治疗血管中的再狭窄。聚合物材料可以以一个或多个点附着到金属支架上，并且以未膨胀的状态包裹在支架周围的线圈中，以直径展开和膨胀以与金属支架的扩张直径基本匹配; 或者可以紧紧地包裹在支架结构构件上并且附接到其自身，以在支架结构构件膨胀时径向拉伸。在另一个目前优选的实施方案中，支架结构构件和聚合物膜包裹物的组合可以提供有润滑材料的涂层。润滑材料可以是聚环氧乙烷，聚乙二醇，聚乙酸乙烯酯，聚乙烯吡咯烷酮，聚乙烯醇，聚丙烯酰胺，亲水性软链段聚氨酯，一些天然树胶，聚酐或其它类似的亲水聚合物，及其组合。光滑材料层通过在支架上提供低摩擦表面来保护支架免于插入支架的引导件或体腔。

6. 发明授权

US5637113A Polymer film for wrapping a stent structure 失效
标题翻译：用于包裹支架结构的聚合物膜
公开(公告)号：US5637113A
公开(公告)日：1997-06-10
申请号：US355402
申请日：1994-12-13
申请人： Joseph M. Tartaglia , Joseph P. Loeffler , Todd H. Turnlund
发明人： Joseph M. Tartaglia , Joseph P. Loeffler , Todd H. Turnlund
IPC分类号： A61M31/00 , A61F2/00 , A61F2/82 , A61F2/92 , A61L27/00 , A61L31/00 , A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61F2/92 , A61F2/915 , A61F2002/075 , A61F2220/005 , A61F2250/0067
摘要： The drug loaded stent includes an expandable stent structural member, and a planar sheet of polymeric material attached to the outside of the expandable stent structural member. The polymeric material is preferably bioabsorbable, and loaded or coated with a therapeutic agent or drug to reduce or prevent restenosis in the vessel being treated. The polymer material can be attached to the metal stent at one or more points, and wrapped in a coil around the stent in an unexpanded state, to uncoil and expand in diameter to substantially match the expanded diameter of the metal stent; or can be wrapped tightly around the stent structural member and attached to itself, to stretch radially when the stent structural member is expanded. In another currently preferred embodiment, a combination of a stent structural member and a polymeric film wrapping can be provided with a coating of lubricious material. The lubricious material can be polyethylene oxide, polyethylene glycol, polyethylene acetate, polyvinyl pyrrolidone, polyvinyl alcohol, polyacrylamide, hydrophilic soft segment urethanes, some natural gums, polyanhydrides or other similar hydrophilic polymers, and combinations thereof. The layer of lubricious material protects the stent from the guide or the body lumen in which the stent is inserted by providing a low friction surface over the stent.
摘要翻译：药物负载支架包括可扩张的支架结构构件和附接到可扩张支架结构构件的外侧的聚合物材料的平面片。聚合物材料优选是生物可吸收的，并且加载或涂覆有治疗剂或药物以减少或预防待治疗血管中的再狭窄。聚合物材料可以以一个或多个点附着到金属支架上，并且以未膨胀的状态包裹在支架周围的线圈中，以直径展开和膨胀以与金属支架的扩张直径基本匹配; 或者可以紧紧地包裹在支架结构构件上并且附接到其自身，以在支架结构构件膨胀时径向拉伸。在另一个目前优选的实施方案中，支架结构构件和聚合物膜包裹物的组合可以提供有润滑材料的涂层。润滑材料可以是聚环氧乙烷，聚乙二醇，聚乙酸乙烯酯，聚乙烯吡咯烷酮，聚乙烯醇，聚丙烯酰胺，亲水性软链段聚氨酯，一些天然树胶，聚酐或其它类似的亲水聚合物，及其组合。光滑材料层通过在支架上提供低摩擦表面来保护支架免于插入支架的引导件或体腔。

7. 发明授权

US5897911A Polymer-coated stent structure 失效
标题翻译：聚合物涂层支架结构
公开(公告)号：US5897911A
公开(公告)日：1999-04-27
申请号：US909399
申请日：1997-08-11
申请人： Joseph P. Loeffler
发明人： Joseph P. Loeffler
IPC分类号： A61F2/00 , A61F2/82 , A61F2/86 , A61L31/10 , B29C33/30 , B29C39/10 , B29C41/14 , B29C41/20 , B29C63/00 , B05D3/12 , B05D7/22
CPC分类号： A61F2/82 , A61L31/10 , B29C39/10 , B29C41/20 , A61F2/07 , A61F2/86 , A61F2240/001 , A61F2250/0067 , B29C33/304 , B29C41/14 , B29C63/00 , B29C70/52 , B29K2995/0097
摘要： The thickness of a polymer coating applied to the interior surface of a stent is precisely controlled by fitting a mandrel within its interior. Fitment of an exterior mold serves to additionally control the thickness of polymer on the exterior surface of the stent. Alternatively, a preformed sheath of polymer is fitted to the interior of the stent whereby the subsequent application of polymer not only causes the exterior to become coated but also causes the sheath to become adhered to the stent.
摘要翻译：施加到支架内表面的聚合物涂层的厚度通过在其内部安装心轴来精确地控制。外部模具的装配用于另外控制支架外表面上聚合物的厚度。或者，预先形成的聚合物护套安装在支架的内部，由此随后应用聚合物不仅使得外部变得被涂覆，而且还导致护套粘附到支架上。

8. 发明授权

US6159140A Radiation shielded catheter for delivering a radioactive source and method of use 失效
标题翻译：用于放射源的放射屏蔽导管及其使用方法
公开(公告)号：US6159140A
公开(公告)日：2000-12-12
申请号：US24669
申请日：1998-02-17
申请人： Joseph P. Loeffler , Eric D. Peterson , Jon A. Becker
发明人： Joseph P. Loeffler , Eric D. Peterson , Jon A. Becker
IPC分类号： A61F2/958 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61M25/10 , A61N2005/1004 , A61N2005/1021
摘要： A radiation delivery catheter which increases the margin of safety and reduces unintended exposure to radiation dosage during delivery thereof to a target area to reduce the likelihood of the development of restenosis. The catheter includes a shaft comprised of radiation shielding material, to shield the patient and staff from unintended radiation exposure. The catheter further includes a treatment section including a reservoir balloon comprised of radiation trans-parent material, which enables predetermined concentrations of radioactivity in the radiation source to permeate therethrough into the target area in a substantially uniform dosage pattern.
摘要翻译：一种辐射输送导管，其增加安全边缘，并减少在将其递送至目标区域期间辐射剂量的意外暴露以减少再狭窄发展的可能性。导管包括由辐射屏蔽材料组成的轴，以屏蔽患者和工作人员免受非预期的辐射照射。导管还包括处理部分，其包括由辐射反式材料组成的储存器气囊，其使辐射源中的预定浓度的放射性以基本上均匀的剂量模式渗透到目标区域中。

9. 发明授权

US5891154A Passive perfusion stent delivery system 失效
标题翻译：被动灌注支架输送系统
公开(公告)号：US5891154A
公开(公告)日：1999-04-06
申请号：US851111
申请日：1997-05-06
申请人： Joseph P. Loeffler
发明人： Joseph P. Loeffler
IPC分类号： A61M25/00 , A61F2/06 , A61F2/82 , A61F2/84 , A61M25/01 , A61M29/02 , A61F11/00 , A61M29/00
CPC分类号： A61F2/958 , A61F2002/9517 , A61M2025/1097
摘要： A stent delivery method and system are disclosed. The system generally includes an elongated delivery sheath and a perfusion catheter disposed within a sheath lumen of the sheath having an expandable member on its distal extremity. The sheath includes perfusion ports to maintain blood flow to perfusion ports in the catheter during delivery of the stent. A manipulating device is provided at the proximal end of the delivery system to effect relative axial movement between the sheath and the catheter so as to expose the stent mounted on the expandable member on the catheter within a body lumen such as a coronary artery and allow the expansion of the stent by the expansion of the expandable member.
摘要翻译：公开了一种支架输送方法和系统。该系统通常包括细长的输送护套和设置在鞘的鞘腔内的灌注导管，其在其远端具有可扩张构件。护套包括灌注端口，以在输送支架期间维持血液流入导管中的灌注端口。操纵装置设置在输送系统的近端处以实现护套和导管之间的相对轴向运动，以便将安装在可扩张构件上的支架暴露在诸如冠状动脉的体腔内的导管上，并允许通过可扩张构件的膨胀来扩张支架。

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