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    • 3. 发明授权
    • Radiation centering catheters
    • 辐射定心导管
    • US06224535B1
    • 2001-05-01
    • US09024666
    • 1998-02-17
    • Jessica G. ChiuEric D. Peterson
    • Jessica G. ChiuEric D. Peterson
    • A61N500
    • A61N5/1002A61M25/10A61N2005/1003
    • The invention is directed to a radiation delivery catheter assembly for maintaining patency of a body lumen for a period of time sufficient to allow delivery of a radiation source to the body lumen. The catheter utilizes an inflatable region which maintains and centers the catheter in the body lumen. The catheter may include a perfusion lumen for supplying oxygenated blood to tissue located downstream from the catheter when the inflatable region is expanded in the body lumen. The inflatable region can be made up of a plurality of balloon segments which help center the radiation source, even if placed on a curved section of the body lumen. Embodiments of the invention include a catheter design which utilizes “rapid exchange” features and a dual therapeutic catheter which is capable of dilating a stenosed region of the body lumen prior to the administration of the radiation treatment. A two-piece protective sheath is used to protect the radiation source from bodily fluids.
    • 本发明涉及一种辐射递送导管组件,用于维持体腔通畅一段足以使辐射源传送至体腔的时间。 该导管使用可将导管保持并居中在体腔内的可充气区域。 当可膨胀区域在体腔内扩张时,导管可包括用于将氧合血液供应到位于导管下游的组织的灌注腔。 可膨胀区域可以由多个气囊段组成,即使放置在体腔的弯曲部分上也有助于使辐射源居中。 本发明的实施例包括利用“快速交换”特征的导管设计和能够在施用放射治疗之前扩张体腔的狭窄区域的双重治疗导管。 使用两片保护套来保护辐射源免受体液的伤害。
    • 4. 发明授权
    • Speeding learning in neural networks
    • 加速神经网络学习
    • US4912651A
    • 1990-03-27
    • US284148
    • 1988-12-14
    • Laurence F. WoodMichael J. GrimaldiEric D. Peterson
    • Laurence F. WoodMichael J. GrimaldiEric D. Peterson
    • G06N3/08
    • G06N3/084
    • A method of accelerating the training of an artificial neural network uses a computer configured as an artificial neural network with a network input and a network output, and having a plurality of interconnected units arranged in layers including an input layer and an output layer. Each unit has a multiplicity of unit inputs and a set of variables for operating upon a unit inputs to provide a unit output. A plurality of examples are serially provided to the network input and the network output is observed. The computer is programmed with a back propagation algorithm for adjusting each set of variables in response to feedback representing differences between the network output for each example and the desired output. The examples are iterated until the signs of the outputs of the units of the output layer converge. Then each set of variables is multiplied by a multiplier. The examples are reiterated until the magnitude of the outputs of the units of the output layer converge.
    • 一种加速人工神经网络的训练的方法使用配置为具有网络输入和网络输出的人造神经网络的计算机,并且具有布置成包括输入层和输出层的层的多个互连单元。 每个单元具有多个单位输入和一组用于在单位输入上运行以提供单位输出的变量。 将多个示例串行提供给网络输入,并且观察网络输出。 计算机被编程有反向传播算法,用于响应于表示每个示例的网络输出与期望输出之间的差异的反馈来调整每组变量。 迭代示例,直到输出层的单位输出的符号收敛。 然后每组变量乘以乘数。 重复这些示例,直到输出层的单位的输出的大小收敛。
    • 10. 发明授权
    • Stepped centering balloon for optimal radiation delivery
    • 步进的定心气球,以获得最佳的辐射输送
    • US06605031B1
    • 2003-08-12
    • US09505340
    • 2000-02-16
    • Firas MourtadaEric D. Peterson
    • Firas MourtadaEric D. Peterson
    • A61M3604
    • A61M25/1002A61M2025/1047A61N5/1002A61N2005/1003
    • A stepped centering catheter for delivery of intravascular radiation therapy including a central segment of a first effective diameter and smaller, offset segments of second effective diameters to each side of the central segment. The first effective diameter of the central segment substantially centers a portion of a radiation source within the lumen of a vessel along a therapeutic treatment length. The second effective diameters of the offset segments constrain portions of the radioactive source that extend beyond the therapeutic treatment length within a region having a minimum offset distance from the vessel wall. The first effective diameter of the central segment is gradually tapered to the second effective diameter of the offset segments across first steps. The second effective diameters of the offset segments are gradually tapered to the diameter of the catheter shaft across second steps. The smaller diameter offset segments and tapered change in diameters mitigates further injury to vessel walls located outside the therapeutic treatment length.
    • 一种用于递送血管内放射治疗的阶梯式定心导管,包括第一有效直径的中心段和较小的第二有效直径的偏移段到中心段的每一侧。 中心段的第一有效直径基本上使辐射源的一部分沿着治疗处理长度居中在容器的腔内。 偏移段的第二有效直径将放射源的部分限制在距离血管壁最小偏移距离的区域内延伸超过治疗处理长度。 中心段的第一有效直径在第一步骤中逐渐变细到偏移段的第二有效直径。 偏移段的第二有效直径在第二步骤中逐渐变细到导管轴的直径。 较小的直径偏移段和直径的锥形变化减轻了位于治疗治疗长度之外的血管壁的进一步损伤。