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1. 发明授权

US5871694A Device for providing a substituate 失效
标题翻译：用于提供取代基的装置
公开(公告)号：US5871694A
公开(公告)日：1999-02-16
申请号：US762472
申请日：1996-12-09
申请人： Josef Beden , Hans-Jurgen Flaig , Bernd Steinbach
发明人： Josef Beden , Hans-Jurgen Flaig , Bernd Steinbach
IPC分类号： A61M1/14 , A61M1/34 , B01D63/00
CPC分类号： A61M1/3441 , A61M1/3444 , A61M2205/3389 , A61M2205/3396 , Y10S210/929
摘要： In a device for providing a substituate to a device for removing toxic substances from the blood which employs volumetric balancing of the fluid, an equalization chamber (11, 20) communicates with first and second inlet lines (9, 18) respectively, of a balancing chamber (14). Moreover, a buffer chamber (23) communicates with the first and/or second outlet line (15, 22) of the balancing chamber (14). The volume prevailing in the buffer chamber (23) that communicates with the first or second outlet line (15 or 22) can be so varied that the volume expands when the second or first equalization chamber (20 or 11) is emptied, and is reduced when the second or first equalization chamber is filled. As a result, the discontinuous pulse is smoothed on the outlet side of the balancing chamber.
摘要翻译：在用于从血液中提取取代物以从血液中除去有毒物质的装置中，均衡室（11,20）分别与第一和第二入口管线（9,18）连通，平衡室室（14）。此外，缓冲室（23）与平衡室（14）的第一和/或第二出口管线（15,22）连通。在与第一或第二出口管线（15或22）连通的缓冲室（23）中的体积可以变化，使得当第二或第一平衡室（20或11）被排空时体积膨胀并且减小当第二或第一均衡室被填充时。结果，不平衡脉冲在平衡室的出口侧平滑。

2. 发明授权

US5836908A Disposable balancing unit for balancing fluids, and related medical treatment device 失效
标题翻译：用于平衡流体的一次性平衡装置和相关的医疗装置
公开(公告)号：US5836908A
公开(公告)日：1998-11-17
申请号：US762084
申请日：1996-12-09
申请人： Josef Beden , Hans-Jurgen Flaig , Bernd Steinbach
发明人： Josef Beden , Hans-Jurgen Flaig , Bernd Steinbach
IPC分类号： A61M1/14 , A61J1/10 , A61M1/16 , A61M1/28 , A61M1/34 , A61M1/36 , A61M5/44
CPC分类号： A61M1/3441 , A61M1/1664 , A61M1/281 , A61M1/3444 , A61M1/28 , A61M1/369 , A61M2205/123 , A61M2205/127 , A61M2205/3396 , A61M2205/3653 , A61M5/44
摘要： A disposable balancing unit designed as a sheet bag includes two sheets (1, 2), which are heat-sealed together, forming a balancing chamber (4) that is divided by a flexible wall (8) into the two chamber halves (9, 10), and forming two equalization chambers (5, 6), as well as the channels (15 through 18) connecting the individual chambers. The flexible wall (8), which separates the first chamber half (9) of the balancing chamber (4) from the second chamber half (10), is formed by an intermediate sheet, which is inserted between the first and second sheet (1, 2) in the area of the balancing volume and is heat-sealed in a pressure-tight manner to the outer sheets, forming the first and second chamber half (9, 10). The fixed volume of the balancing chamber halves (9, 10) is specified by a corresponding system insert unit, into which the disposable unit is fittingly inserted. The system insert unit has two rigid receiving bodies (25, 26) with trough-shaped depressions (27) to grasp above or below the balancing chamber (4) of the disposable unit. The disposable balancing unit can be manufactured cost-effectively in a single heat-sealing operation and is easy to handle.
摘要翻译：设计为片材袋的一次性平衡单元包括两个热封在一起的片材（1,2），形成由柔性壁（8）分成两个室半部（9）的平衡室（4） 10），以及形成两个均衡室（5,6）以及连接各个室的通道（15至18）。将平衡室（4）的第一室半部（9）与第二室半部（10）分离的柔性壁（8）由中间片形成，中间片插入在第一和第二片，2）在平衡容积的区域中，并以压力密封的方式热封到外部片材上，形成第一和第二室半部（9,10）。平衡室半部（9,10）的固定体积由相应的系统插入单元指定，一次性单元被适配地插入其中。系统插入单元具有两个具有槽形凹陷（27）的刚性接收体（25,26），以抓住一次性单元的平衡室（4）的上方或下方。一次性平衡单元可以在单个热封操作中成本有效地制造并且易于处理。

3. 发明申请

US20120061310A1 Dialysis Fluid Cassettes and Related Systems and Methods 有权
标题翻译：透析液盒及相关系统及方法
公开(公告)号：US20120061310A1
公开(公告)日：2012-03-15
申请号：US13237149
申请日：2011-09-20
申请人： Josef Beden , Uwe Hahmann , Martin Herklotz , Martin Lauer , Joachim Manke , Peter Scheunert , Manfred Weis
发明人： Josef Beden , Uwe Hahmann , Martin Herklotz , Martin Lauer , Joachim Manke , Peter Scheunert , Manfred Weis
IPC分类号： B01D61/28
CPC分类号： A61M1/16 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1601 , A61M1/1621 , A61M1/3496 , A61M1/3621 , A61M1/367 , A61M2202/0413 , A61M2205/12 , A61M2205/122 , A61M2205/126 , A61M2205/128 , A61M2205/3331
摘要： A dialysis fluid cassette that includes a base and a flexible membrane attached to the base. The flexible membrane and the base cooperate to at least partially define a venting chamber and a fluid channel fluidly connected to the venting chamber.
摘要翻译：一种透析液盒，其包括基部和附接到基部的柔性膜。柔性膜和基部配合以至少部分地限定通气室和流体连接到排气室的流体通道。

4. 发明授权

US07488301B2 Method for returning blood from a blood treatment device, and device for carrying out this method 有权
标题翻译：用于从血液处理装置返回血液的方法，以及用于执行该方法的装置
公开(公告)号：US07488301B2
公开(公告)日：2009-02-10
申请号：US10527460
申请日：2003-07-22
申请人： Josef Beden , Joachim Manke
发明人： Josef Beden , Joachim Manke
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3643 , A61M1/16 , A61M1/3434 , A61M1/3437 , A61M1/3639 , A61M1/3644 , A61M1/3646 , A61M1/3649 , A61M1/3652 , A61M2205/12
摘要： A method for the return of blood from a blood treatment apparatus, preferably from a dialysis apparatus, uses a pumped substituate fluid to displace the blood. A substituate pump contained in the treatment apparatus displaces the blood by means of the correspondingly transported substituate fluid until it is detected in corresponding detectors that substituate fluid is flowing back in the line instead of blood. Once the transported substituate fluid has been detected, the blood volume is further displaced in a controlled manner until it has reached the line outlet of the corresponding line.
摘要翻译：用于从血液处理装置返回血液的方法，优选从透析装置使用泵送的取代液来置换血液。包含在治疗设备中的替代泵通过相应转运的取代液体移除血液，直到在对应的检测器中检测到，其中液体在管线中代替血液而流回。一旦检测到转运的取代液体，血液体积就以受控的方式进一步移动，直到其达到相应线路的出口。

5. 发明授权

US08852135B2 Method and device for monitoring the introduction of substitution fluids upstream of downstream of a dialyzer of filter 有权
标题翻译：用于监测过滤器透析器下游上游引入替代液的方法和装置
公开(公告)号：US08852135B2
公开(公告)日：2014-10-07
申请号：US13124353
申请日：2009-10-08
申请人： Josef Beden , Itka Bado , Georg Verch
发明人： Josef Beden , Itka Bado , Georg Verch
IPC分类号： A61M1/34
CPC分类号： A61M1/342 , A61M1/16 , A61M1/3434 , A61M1/3437 , A61M1/3627 , A61M2205/3386
摘要： A method is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing device with an extra-corporeal blood circuit, comprising an arterial blood line, running from an arterial patient connection to a first chamber of a dialyzer or filter divided into said first chamber and a second chamber by a membrane and a venous blood line, running from the first chamber of the dialyzer or filter to a venous patient connection. A device is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing unit with an extra-corporeal blood circuit and an extra-corporeal blood processing device with a device for monitoring the introduction of substitution fluids. The method and the device for monitoring the introduction of substitution fluids are based on monitoring the fluid level in the bubble trap, arranged in the venous blood line of the extra-corporeal blood circuit. The method and the device require that fluid is added to fill the extra-corporeal blood circuit, for example, for a rinsing procedure of the extra-corporeal blood circuit by means of the substitution fluid supply line arranged upstream or downstream of the dialyzer. A pre-dilution can be commanded when, after initiating the rinsing process the fill level in the bubble trap does not drop below a certain level. When by contrast the fill level drops below a given level a post-dilution can be commanded.
摘要翻译：提供了一种用于监测引入具有体外血液回路的体外血液处理装置的替代流体的方法，其包括动脉血液管线，从动脉患者连接到透析器或过滤器的第一腔室分为所述第一腔室和通过膜和静脉血液管线的第二腔室，其从透析器或过滤器的第一腔室延伸到静脉患者连接。提供了一种装置，用于监测引入具有体外血液回路的体外血液处理装置的替代液体和具有用于监测引入取代流体的装置的体外血液处理装置。用于监测引入替代液体的方法和装置是基于监测排列在体外血液回路的静脉血管中的气泡阱中的液位。该方法和装置要求添加流体以填充超体内血液回路，例如通过布置在透析器上游或下游的替代流体供应管线来进行体外血液回路的漂洗程序。在开始漂洗处理之后，可以命令预稀释，气泡阱中的填充水平不会下降到一定水平以下。当相反，填充水平降低到给定水平以下时，可以命令后稀释。

6. 发明授权

US08375797B2 Method for operating a pressure measuring unit, apparatus having at least one pressure measuring unit, device having such an apparatus, and use of a measuring chamber 有权
标题翻译：用于操作压力测量单元的方法，具有至少一个压力测量单元的设备，具有这种设备的设备以及测量室的使用
公开(公告)号：US08375797B2
公开(公告)日：2013-02-19
申请号：US13055558
申请日：2009-07-21
申请人： Josef Beden , Itka Bado , Patrick Spalt
发明人： Josef Beden , Itka Bado , Patrick Spalt
IPC分类号： G01L9/00 , A61B8/00
CPC分类号： A61M1/3639 , A61M1/3641 , A61M2205/3331 , A61M2205/702
摘要： The present invention relates to a method for the operation of a pressure measuring device for the measurement of the pressure in a system through which fluid flows, in particular in an extracorporeal circuit of a medical unit, with the pressure measuring device having a measuring chamber which is bounded by a flexible membrane, through which fluid flows in the operation of the system or which is filled with fluid and also having a pressure sensor connected to the membrane for the purpose of pressure measurement, with the method including the following steps not requiring any intervention of the staff: a. increasing the pressure in the measuring chamber (12) to a pressure value at which the membrane (13) is at least slightly outwardly curved relative to the measuring chamber (12) in the state not connected to the pressure sensor (14) or determining such a pressure value; b: separating the membrane (13) of the measuring chamber (12) from the pressure sensor (14); c. joining together the membrane (13) of the measuring chamber (12) and of the pressure sensor (14) such that the membrane (13) of the measuring chamber (12) contacts the pressure sensor (14); and d. repeating the steps a. to c. at predetermined intervals and/or on the occurrence of an error case.
摘要翻译：本发明涉及一种压力测量装置的操作方法，该压力测量装置用于测量流体流动的系统中的压力，特别是在医疗单元的体外回路中，压力测量装置具有测量室，由柔性膜界定，流体在系统操作中流动，或者填充有流体，并且还具有连接到膜的压力传感器用于压力测量，该方法包括以下步骤，不需要任何工作人员干预：a。在不连接到压力传感器（14）的状态下，将测量室（12）中的压力增加到压力值，在该压力值膜（13）相对于测量室（12）至少稍微向外弯曲，或者确定压力值 b：将测量室（12）的膜（13）与压力传感器（14）分离; C。将测量室（12）的膜（13）和压力传感器（14）接合在一起，使得测量室（12）的膜（13）接触压力传感器（14）; 和d。重复步骤a。到c。以预定间隔和/或出现错误情况。

7. 发明申请

US20100133153A1 Medical Fluid Cassettes and Related Systems 有权
标题翻译：医用流体盒和相关系统
公开(公告)号：US20100133153A1
公开(公告)日：2010-06-03
申请号：US12627043
申请日：2009-11-30
申请人： Josef Beden , Uwe Hahmann , Martin Herklotz , Martin Lauer , Joachim Manke , Peter Scheunert , Manfred Weis , Alexander Bongers
发明人： Josef Beden , Uwe Hahmann , Martin Herklotz , Martin Lauer , Joachim Manke , Peter Scheunert , Manfred Weis , Alexander Bongers
IPC分类号： B01D61/28 , B01D61/24
CPC分类号： A61M1/16 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1601 , A61M1/1621 , A61M1/3496 , A61M1/3621 , A61M1/367 , A61M2202/0413 , A61M2205/12 , A61M2205/122 , A61M2205/126 , A61M2205/128 , A61M2205/3331
摘要： The invention relates to an apparatus for the treatment of a medical liquid comprising a liquid treatment machine and a cassette insertable therein substantially made of a rigid base body of the cassette with fitted chambers and passages and a foil covering them.
摘要翻译：本发明涉及一种用于处理医用液体的设备，其包括液体处理机和可插入的盒，其基本由具有装配的室和通道的盒的刚性基体和覆盖它们的箔组成。

8. 发明授权

US07044432B2 Fluid channel valve for use with a disposable cartridge in extracorporeal circulations 有权
标题翻译：流体通道阀，用于体外循环中的一次性药筒
公开(公告)号：US07044432B2
公开(公告)日：2006-05-16
申请号：US10363703
申请日：2001-08-17
申请人： Josef Beden , Juergen Braun , Hans-Peter Schneider
发明人： Josef Beden , Juergen Braun , Hans-Peter Schneider
IPC分类号： F16K7/10
CPC分类号： A61M1/367 , A61M5/16813 , A61M2205/128 , F16K7/10
摘要： A valve for the closure of fluid channels, in particular for use in disposable cartridges for extracorporeal circulations, having a valve body with a pressure channel, and a sealing cap, which can cooperate with the valve body in such a way that it closes off the end of the pressure channel on the valve body side against the surroundings. The valve is designed in such a way that a pressure chamber can be formed between the pressure channel and the sealing cap, and the sealing cap has a deformable sealing area for entry into a fluid channel in order to close the latter. The valve may be incorporated within a device for use with a disposable cartridge for at least one fluid channel.
摘要翻译：用于封闭流体通道的阀，特别是用于体外循环的一次性药筒中，具有带有压力通道的阀体和密封帽，该阀可以与阀体配合，以使阀体闭合阀体侧的压力通道的端部抵靠周围。阀被设计成使得压力室可以形成在压力通道和密封盖之间，并且密封盖具有用于进入流体通道的可变形的密封区域，以便关闭阀。阀可以结合在与用于至少一个流体通道的一次性盒的装置中。

9. 发明授权

US08875748B2 Device for filling a filter, and method therefor 有权
标题翻译：用于填充过滤器的装置及其方法
公开(公告)号：US08875748B2
公开(公告)日：2014-11-04
申请号：US13061782
申请日：2009-09-02
申请人： Josef Beden , Itka Bado , Georg Verch
发明人： Josef Beden , Itka Bado , Georg Verch
IPC分类号： A61M1/16 , B01D61/30 , A61M1/36 , B01D65/00
CPC分类号： A61M1/3643 , A61M1/1607 , A61M1/1658 , A61M1/3644 , A61M1/365 , A61M2205/3393 , B01D61/30 , B01D65/00 , B01D2313/16
摘要： An apparatus for the filling of a medical filter has at least one first space and one second space which are semipermeably separated by one or more membranes, with the spaces each having at least one inflow and outflow. The apparatus includes a detection unit having a first element and a second element, with a liquid discharge from at least one of the first and second spaces being detectable by the first element, and the state of the filling of the filter being determinable by the second element with reference to the detected liquid discharge. A method of filling a medical filter employs the apparatus.
摘要翻译：用于填充医疗过滤器的装置具有至少一个第一空间和一个第二空间，该第一空间和第二空间被一个或多个膜半透明地分开，空间各自具有至少一个流入和流出。该装置包括具有第一元件和第二元件的检测单元，其中第一和第二空间中的至少一个的液体排放可由第一元件检测，并且过滤器的填充状态可由第二元件确定参考检测到的液体排出。填充医疗过滤器的方法采用该装置。

10. 发明授权

US08366921B2 Dialysis systems and related methods 有权
标题翻译：透析系统及相关方法
公开(公告)号：US08366921B2
公开(公告)日：2013-02-05
申请号：US13401429
申请日：2012-02-21
申请人： Josef Beden , Juergen Braun , Hans-Peter Schneider
发明人： Josef Beden , Juergen Braun , Hans-Peter Schneider
IPC分类号： A61M1/14
CPC分类号： A61M1/16 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1601 , A61M1/1621 , A61M1/3496 , A61M1/3621 , A61M1/367 , A61M2202/0413 , A61M2205/12 , A61M2205/122 , A61M2205/126 , A61M2205/128 , A61M2205/3331
摘要： A dialysis machine that includes a valve body defining a pressure passage and a sealing cap disposed at a first end of the valve body such that the sealing cap closes off the pressure passage at the first end of the valve body. The sealing cap has a deformable area configured to deform outwardly away from the valve body when pressurized fluid is introduced into the pressure passage of the valve body. The sealing cap is configured so that, when a dialysis fluid cassette is disposed in a cassette compartment of the dialysis machine and pressurized fluid is introduced into the pressure passage of the valve body, the deformable area obstructs a fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough.
摘要翻译：一种透析机，其包括限定压力通道的阀体和设置在所述阀体的第一端处的密封盖，使得所述密封盖封闭所述阀体的第一端处的压力通道。当加压流体被引入阀体的压力通道中时，密封帽具有构造成向外远离阀体变形的变形区域。密封帽被构造成使得当透析流体盒设置在透析机的盒室中并且加压流体被引入到阀体的压力通道中时，可变形区域阻碍透析流体盒的流体通道控制透析液流过其中。

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