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1. 发明授权

US08241680B2 Nutraceutical product containing anatabine and yerba maté 有权
标题翻译：含有数据和yerbamaté的营养品
公开(公告)号：US08241680B2
公开(公告)日：2012-08-14
申请号：US12826985
申请日：2010-06-30
申请人： Jonnie R. Williams , Curtis Wright
发明人： Jonnie R. Williams , Curtis Wright
IPC分类号： A01N65/38 , A01N65/00 , C07D401/04 , A24B15/00
CPC分类号： A61K36/185 , A61K31/444 , A61K45/06 , A61K2300/00
摘要： Nutraceutical compositions containing anatabine and Yerba maté extract are efficacious for temporarily reducing the desire to smoke, reducing nicotine cravings, the treatment of smoking cessation, tobacco withdrawal symptoms, tobacco dependence, weight loss, and/or related disorders.
摘要翻译：含有数据库和耶尔巴提取物的营养组合物有效地暂时降低吸烟欲望，减少尼古丁的渴望，治疗戒烟，戒烟症状，烟草依赖，体重减轻和/或相关疾病。

2. 发明申请

US20120003341A1 Nutraceutical Product Containing Anatabine And Yerba Maté 有权
标题翻译：含营养品的营养品和YerbaMaté
公开(公告)号：US20120003341A1
公开(公告)日：2012-01-05
申请号：US12826985
申请日：2010-06-30
申请人： Jonnie R. Williams , Curtis Wright
发明人： Jonnie R. Williams , Curtis Wright
IPC分类号： A61K36/00 , A61P25/34
CPC分类号： A61K36/185 , A61K31/444 , A61K45/06 , A61K2300/00
摘要： Nutraceutical compositions containing anatabine and Yerba maté extract are efficacious for temporarily reducing the desire to smoke, reducing nicotine cravings, the treatment of smoking cessation, tobacco withdrawal symptoms, tobacco dependence, weight loss, and/or related disorders.
摘要翻译：含有数据库和耶尔巴提取物的营养组合物有效地暂时降低吸烟欲望，减少尼古丁的渴望，治疗戒烟，戒烟症状，烟草依赖，体重减轻和/或相关疾病。

3. 发明申请

US20160050968A1 Alkaloid Composition for E-Cigarette 审中-公开
标题翻译：电子烟的生物碱组合物
公开(公告)号：US20160050968A1
公开(公告)日：2016-02-25
申请号：US14672716
申请日：2015-03-30
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A24B15/16 , A24F47/00
CPC分类号： A24B15/16 , A24B15/167 , A24F47/002
摘要： An alkaloid composition for an e-cigarette contains a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition. The alkaloid composition may be contained in a refilling cartridge for an e-cigarette, or in a container as part of a kit for refilling an e-cigarette. The alkaloid compositions disclosed herein feature a balanced form of alkaloids to provide an attractive alternative to smoking tobacco, in which nicotine makes up about 90 wt. % of the total alkaloid content. The alkaloid compositions are characterized by a significant quantity of anatabine, which has lower toxicity than other alkaloids such as nicotine. The alkaloid compositions enable individuals to experience the pleasure-enhancing attributes of conventional cigarette smoking, while avoiding exposure to combusted materials and other potentially hazardous components present in tobacco.
摘要翻译：用于电子烟的生物碱组合物含有溶剂和至少约25重量％基于组合物的总生物碱重量的％数据。生物碱组合物可以包含在用于电子香烟的再填充筒中，或作为用于重新填充电子香烟的试剂盒的一部分的容器中。本文公开的生物碱组合物特征在于平衡形式的生物碱，以提供吸烟烟草的有吸引力的替代品，其中尼古丁占约90wt。总生物碱含量的百分比。生物碱组合物的特征在于大量的数据库，其毒性比其他生物碱如尼古丁低。生物碱组合物使得个体能够体验常规吸烟的快乐增强属性，同时避免暴露于存在于烟草中的燃烧材料和其它潜在危险组分。

4. 发明申请

US20120325228A1 ALKALOID COMPOSITION FOR E-CIGARETTE 审中-公开
标题翻译：用于电子烟的碱性组合物
公开(公告)号：US20120325228A1
公开(公告)日：2012-12-27
申请号：US13493132
申请日：2012-06-11
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A24B15/10 , A24F47/00
CPC分类号： A24B15/16 , A24B15/167 , A24F47/002
摘要： An alkaloid composition for an e-cigarette contains a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition. The alkaloid composition may be contained in a refilling cartridge for an e-cigarette, or in a container as part of a kit for refilling an e-cigarette. The alkaloid compositions disclosed herein feature a balanced form of alkaloids to provide an attractive alternative to smoking tobacco, in which nicotine makes up about 90 wt. % of the total alkaloid content. The alkaloid compositions are characterized by a significant quantity of anatabine, which has lower toxicity than other alkaloids such as nicotine. The alkaloid compositions enable individuals to experience the pleasure-enhancing attributes of conventional cigarette smoking, while avoiding exposure to combusted materials and other potentially hazardous components present in tobacco.
摘要翻译：用于电子烟的生物碱组合物含有溶剂和至少约25重量％基于组合物的总生物碱重量的％数据。生物碱组合物可以包含在用于电子香烟的再填充筒中，或作为用于重新填充电子香烟的试剂盒的一部分的容器中。本文公开的生物碱组合物特征在于平衡形式的生物碱，以提供吸烟烟草的有吸引力的替代品，其中尼古丁占约90wt。总生物碱含量的百分比。生物碱组合物的特征在于大量的数据库，其毒性比其他生物碱如尼古丁低。生物碱组合物使得个体能够体验常规吸烟的快乐增强属性，同时避免暴露于存在于烟草中的燃烧材料和其它潜在危险组分。

5. 发明授权

US06668839B2 Smokeless tobacco product 失效
标题翻译：无烟烟草制品
公开(公告)号：US06668839B2
公开(公告)日：2003-12-30
申请号：US09845249
申请日：2001-05-01
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A24B1500
CPC分类号： A24B15/30 , A24B15/14 , A24B15/16 , A24B15/22
摘要： A smokeless tobacco product suitable for human consumption can be prepared from an aqueous extract of cured tobacco. In one embodiment, the smokeless tobacco product comprises a solid tablet having at least 50 wt % powdered tobacco. The powdered tobacco preferably consists essentially of Virginia flue tobacco stems. The smokeless tobacco product optionally includes eucalyptus and/or propolis in an amount effective to remove bitterness from said powdered tobacco. The smokeless tobacco product preferably contains powdered tobacco having a collective content of N′-nitrosonornicotine (NNN), 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK), N′-nitrosoanatabine (NAT) and N′-nitrosoanabasine (NAB) which is 0.1 &mgr;g/g or less, preferably 0.05 &mgr;g/g or less, more preferably 0.03 &mgr;g/g or less. The powdered tobacco preferably has a content of 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) which is 0.002 &mgr;g/g or less, preferably 0.001 &mgr;g/g or less.
摘要翻译：适合人类消费的无烟烟草制品可以由固化烟草的水提取物制备。在一个实施方案中，无烟烟草制品包含具有至少50重量％粉末烟草的固体片剂。粉状烟草最好基本上由弗吉尼亚烟草烟梗组成。无烟烟草制品任选地包括有效去除所述粉末状烟草中的苦味的桉树和/或蜂胶。无烟烟草制品优选含有具有N' - 亚硝基烟碱（NNN），4-（N-亚硝基甲基氨基）-1-（3-吡啶基）-1-丁酮（NNK），N'-亚硝基胍（NAT））和N-N-亚硝基三亚胺（NAB），其为0.1mug / g以下，优选为0.05mug / g以下，更优选为0.03mug / g以下。粉末状烟草的含量优选为0.002mug / g以下，优选为0.001mug / g以下的4-（N-亚硝基甲基氨基）-1-（3-吡啶基）-1-丁酮（NNK）。

6. 发明授权

US06425401B1 Method of treating tobacco to reduce nitrosamine content, and products produced thereby 有权
标题翻译：处理烟草以减少亚硝胺含量的方法，以及由此产生的产品
公开(公告)号：US06425401B1
公开(公告)日：2002-07-30
申请号：US09668144
申请日：2000-09-25
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A24B102
CPC分类号： A24B15/245 , A24B3/18 , A24B15/18 , A24B15/22
摘要： A method of treating tobacco to reduce the content of, or prevent formation of, harmful nitrosamines which are normally found in tobacco is disclosed. The method includes the step of subjecting at least a portion of the plant, while the portion is uncured and in a state susceptible to having the amount of nitrosamines reduced or formation of nitrosamines arrested, to a controlled environment capable of providing a reduction in the amount of nitrosamines or prevention of the formation of nitrosamines, for a time sufficient to reduce the amount of or substantially prevent the formation of at least one nitrosamine, wherein the controlled environment is provided by controlling at least one of humidity, rate of temperature change, temperature, airflow, CO level, CO2 level, O2 level, and arrangement of the tobacco plant. Tobacco products and an apparatus for producing such tobacco products are also disclosed.
摘要翻译：公开了一种处理烟草以减少烟草中通常存在的有害亚硝胺含量或阻止其形成的方法。该方法包括以下步骤：使植物的至少一部分未被固化，并且在易于使亚硝胺的量减少或形成亚硝胺被捕获的状态下，在能够提供量减少的受控环境中亚硝胺或防止形成亚硝胺的时间足以减少或基本上防止形成至少一种亚硝胺，其中受控环境通过控制湿度，温度变化率，温度，气流，CO水平，CO2水平，O2水平和烟草植物的布置。烟草制品和生产这种烟草制品的设备也被公开。

7. 发明授权

US06311695B1 Method of treating tobacco to reduce nitrosamine content, and products produced thereby 有权
标题翻译：处理烟草以减少亚硝胺含量的方法，以及由此产生的产品
公开(公告)号：US06311695B1
公开(公告)日：2001-11-06
申请号：US09272191
申请日：1999-03-18
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A24B1522
CPC分类号： A23G4/068 , A24B15/18 , A24B15/22 , Y10S432/50
摘要： Methods of reducing the content of and preventing formation of carcinogenic nitrosamines in harvested leafy plants such as tobacco and marijuana, are disclosed. The methods are directed to subjecting the plant to microwave and/or higher frequency radiation, at appropriate times in the cure cycle. With tobacco, products suitable for human consumption, such as cigarettes, cigars, etc., can be made in accordance with the present invention, having contents of tobacco-specific nitrosamines on a par with fresh-cut, green tobacco. In preferred embodiments, the resultant tobacco products are dried, golden-yellow leaves having almost negligible amounts of the known carcinogens NNN and NNK, in comparison to conventionally cured tobacco.
摘要翻译：公开了减少收获的叶片植物如烟草和大麻中致癌亚硝胺形成的含量和预防方法。该方法涉及在固化周期的适当时间对植物进行微波和/或更高频率辐射。对于烟草来说，可以根据本发明制造适合人类消费的产品，例如香烟，雪茄等，其中含有与鲜切绿色烟草相当的烟草特异性亚硝胺。在优选实施方案中，与常规固化的烟草相比，所得烟草产品被干燥，具有几乎可忽略量的已知致癌物NNN和NNK的金黄色叶子。

8. 发明申请

US20180184704A1 Alkaloid Composition for E-Cigarette 审中-公开
公开(公告)号：US20180184704A1
公开(公告)日：2018-07-05
申请号：US15679731
申请日：2017-08-17
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A24B15/16 , A24F47/00
CPC分类号： A24B15/16 , A24B15/167 , A24F47/002
摘要： An alkaloid composition for an e-cigarette contains a solvent and at least about 25 wt. % anatabine based on the total alkaloid weight of the composition. The alkaloid composition may be contained in a refilling cartridge for an e-cigarette, or in a container as part of a kit for refilling an e-cigarette. The alkaloid compositions disclosed herein feature a balanced form of alkaloids to provide an attractive alternative to smoking tobacco, in which nicotine makes up about 90 wt. % of the total alkaloid content. The alkaloid compositions are characterized by a significant quantity of anatabine, which has lower toxicity than other alkaloids such as nicotine. The alkaloid compositions enable individuals to experience the pleasure-enhancing attributes of conventional cigarette smoking, while avoiding exposure to combusted materials and other potentially hazardous components present in tobacco.

9. 发明申请

US20130053355A1 PRODUCTS FOR ANTI-INFLAMMATION SUPPORT 审中-公开
标题翻译：抗炎消炎支持产品
公开(公告)号：US20130053355A1
公开(公告)日：2013-02-28
申请号：US13494237
申请日：2012-06-12
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A61K31/444 , A61P29/00 , A61K31/593
CPC分类号： A61K31/444 , A23L29/03 , A23L33/10 , A23L33/105 , A23L33/155 , A23P10/20 , A23V2002/00 , A61K31/07 , A61K31/4545 , A61K31/593 , A61K36/81 , A61K47/22 , A61K2300/00 , A23V2200/324
摘要： This disclosure provides products, including pharmaceutical compositions and dietary supplements, which are useful for anti-inflammatory support.
摘要翻译：本公开提供了可用于抗炎支持的产品，包括药物组合物和膳食补充剂。

10. 发明申请

US20120245202A1 METHODS AND PRODUCTS FOR TREATING INFLAMMATION 审中-公开
标题翻译：治疗炎症的方法和产品
公开(公告)号：US20120245202A1
公开(公告)日：2012-09-27
申请号：US13235860
申请日：2011-09-19
申请人： Jonnie R. Williams
发明人： Jonnie R. Williams
IPC分类号： A61K31/444 , A61P37/00 , A61P25/28 , A61P35/00 , A61P11/00 , A61P25/16 , A61P25/08 , A61P25/00 , A61P5/16 , A61P3/10 , A61P9/10 , A61P29/00 , A61P19/02
CPC分类号： A61K31/444 , A23L33/105 , A23V2002/00 , A61K9/0043 , A61K9/0073 , A61K31/4545 , A61K31/465 , C07D401/04 , A23V2200/322 , A23V2200/326 , A23V2250/21 , A61K2300/00
摘要： Pharmaceutical compositions comprising an isolated form of a compound of Formula I or IA (e.g., anatabine or S-(−)-anatabine) or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low-level inflammation. Compounds of Formula I also can be provided, for example, in other vehicles such as beverage products and consumer products such as lotions and creams.
摘要翻译：可以使用包含分离形式的式I或IA化合物（例如，数据库或S - （ - ） - 配体）或其盐的药物组合物来治疗包含慢性，低水平炎症的炎症成分的疾病。式I化合物也可以例如在其它载体如饮料产品和消费品如洗剂和乳膏中提供。

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