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1. 发明申请

US20120143513A1 BIO-SENSOR CHIP AND READER THEREOF 审中-公开
标题翻译：生物传感器芯片和读取器
公开(公告)号：US20120143513A1
公开(公告)日：2012-06-07
申请号：US13219197
申请日：2011-08-26
申请人： Jong-Heon YANG , Chang-Geun Ahn , Chan Woo Park , Chil Seong Ah , Wan Joong Kim , Kwang Hyo Chung , Yo Han Choi , Gun Yong Sung
发明人： Jong-Heon YANG , Chang-Geun Ahn , Chan Woo Park , Chil Seong Ah , Wan Joong Kim , Kwang Hyo Chung , Yo Han Choi , Gun Yong Sung
IPC分类号： G06F19/10
CPC分类号： G01N21/6454 , G01N21/01 , G01N2021/0106
摘要： Provided are a bio sensor chip and a reader thereof. The bio-sensor chip is optically addressed. The bio-sensor chip includes a word line control circuit and a bit line control circuit controlled by light provided from the bio-sensor chip reader. The bio-sensor chip does not require a peripheral circuit for driving word lines and bit lines, simplifying a fabrication process and reducing the area of the chip.
摘要翻译：提供了一种生物传感器芯片及其读取器。生物传感器芯片被光学寻址。生物传感器芯片包括由生物传感器芯片读取器提供的光控制的字线控制电路和位线控制电路。生物传感器芯片不需要用于驱动字线和位线的外围电路，简化制造工艺并减少芯片的面积。

2. 发明授权

US08834811B2 Device for storing reagent and method of discharging reagent thereof 有权
标题翻译：储存试剂的装置及其试剂的排出方法
公开(公告)号：US08834811B2
公开(公告)日：2014-09-16
申请号：US13528777
申请日：2012-06-20
申请人： Kwang Hyo Chung , Yo Han Choi , Jong Heon Yang , Chan Woo Park , Chil Seong Ah , Wan Joong Kim , Gun Yong Sung
发明人： Kwang Hyo Chung , Yo Han Choi , Jong Heon Yang , Chan Woo Park , Chil Seong Ah , Wan Joong Kim , Gun Yong Sung
IPC分类号： B01L3/00 , B01J19/00 , F04B19/00
CPC分类号： B01L3/0268 , B01L3/502715 , B01L3/52 , B01L2200/16 , B01L2300/0816 , B01L2400/0481 , F04B43/043
摘要： Provided are a device for storing a reagent capable of being adhered to a biochip and supplying the stored reagent to the biochip, and a method of discharging a reagent thereof. The device for storing a reagent includes an elastic film pressurizing part configured to pressurize an elastic film by magnetic force, and a reagent discharging part configured to store the reagent and discharge the reagent through an outlet by using the deformation in the elastic film due to the pressurization. According to the present invention, a magnetic force controlling device can be small-sized and the reagent can be automatically, high-precisely, and reproducibly supplied through the magnetic force control.
摘要翻译：提供了一种用于存储能够粘附到生物芯片并将储存的试剂供应到生物芯片的试剂的装置及其试剂的排出方法。用于存储试剂的装置包括：弹性膜加压部，其被配置为通过磁力对弹性膜加压;以及试剂排出部，其构造成存储试剂，并且通过使用弹性膜中的变形通过出口排出试剂，加压。根据本发明，磁力控制装置可以小型化，并且可以通过磁力控制自动，高精度地且可再现地供给试剂。

3. 发明申请

US20130137182A1 BLOOD PRE-TREATMENT APPARATUS AND PRE-TREATMENT METHOD USING THE SAME 审中-公开
标题翻译：血液预处理装置和使用该方法的预处理方法
公开(公告)号：US20130137182A1
公开(公告)日：2013-05-30
申请号：US13544931
申请日：2012-07-09
申请人： Yo Han CHOI , Chan Woo Park , Wan Joong Kim , Chil Seong Ah , Kwang Hyo Chung , Jong-Heon Yang , Gun Yong Sung
发明人： Yo Han CHOI , Chan Woo Park , Wan Joong Kim , Chil Seong Ah , Kwang Hyo Chung , Jong-Heon Yang , Gun Yong Sung
IPC分类号： G01N33/48 , B01D21/00
CPC分类号： B01D15/08 , A61K35/14 , B01L3/502753 , B01L2300/0681 , B01L2300/0825
摘要： Provided is a blood pre-treating apparatus including an injecting part for injecting a blood sample, an albumin-removing part including albumin adsorption beads for removing albumins from the blood sample, and an agglutination part including an agglutination reactant, by which blood corpuscles in the blood sample may be agglutinated to form a hemagglutination reactant.
摘要翻译：本发明提供一种血液预处理装置，包括：用于注射血液试样的注射部，含有从血液试样中除去白蛋白的白蛋白吸附珠的白蛋白除去部，以及含有凝集反应物的凝集部，血液样品可能被凝集形成血凝反应物。

4. 发明授权

US08728312B2 Method and device for filtering blood using magnetic force 有权
标题翻译：使用磁力过滤血液的方法和装置
公开(公告)号：US08728312B2
公开(公告)日：2014-05-20
申请号：US13285236
申请日：2011-10-31
申请人： Kwang Hyo Chung , Yo Han Choi , Chang-Geun Ahn , Gun Yong Sung
发明人： Kwang Hyo Chung , Yo Han Choi , Chang-Geun Ahn , Gun Yong Sung
IPC分类号： B03C1/30 , B01D35/06
CPC分类号： B03C1/288 , B03C1/0332 , B03C1/0335 , B03C2201/18 , B03C2201/26
摘要： Disclosed are a method and an apparatus for filtering plasma using magnetic force. The apparatus for filtering plasma using magnetic force includes: an inlet into which blood is injected; a filter unit filtering plasma in the blood passing through the inlet by capillary force; a magnetic force receiving part made of magnetizable materials and assisting plasma filtering by applying pressure to the filter unit by movement due to magnetic force generated from the outside; an outlet discharging plasma filtered from blood; and a filter outer body surrounding the inlet, the filter unit, the magnetic receiving part, and the outlet.
摘要翻译：公开了一种使用磁力对等离子体进行过滤的方法和装置。使用磁力对血浆进行过滤的装置包括：注入血液的入口; 过滤器单元通过毛细管力对通过入口的血液中的血浆进行过滤; 由可磁化材料制成的磁力接收部分，并通过由于从外部产生的磁力的移动而对过滤器单元施加压力来辅助等离子体过滤; 排出从血液中过滤的血浆的出口; 以及围绕入口，过滤器单元，磁接收部分和出口的过滤器外体。

5. 发明授权

US08585013B2 Magnetic microvalve using metal ball and method of manufacturing the same 有权
标题翻译：使用金属球的磁性微型阀及其制造方法
公开(公告)号：US08585013B2
公开(公告)日：2013-11-19
申请号：US12872289
申请日：2010-08-31
申请人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Young Jun Kim , Moon Youn Jung , Seon Hee Park
发明人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Young Jun Kim , Moon Youn Jung , Seon Hee Park
IPC分类号： F16K31/08
CPC分类号： F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0034 , F16K99/0046 , F16K2099/0078
摘要： There is provided a magnetic microvalve using a metal ball and a method of manufacturing the same. A magnetic microvalve using a metal ball according to an aspect of the invention may include: an upper substrate having a microchannel serving as a passage through which a fluid moves, a fluid inlet through which the fluid flows into the microchannel, and a fluid outlet through which the fluid, having passed through the microchannel, flows out of the microchannel; a lower substrate having a trench locally provided therein; a PDMS/metal ball combination having a metal ball and PDMS surrounding the metal ball so that the metal ball is located in a central portion thereof, the PDMS/metal ball combination being inserted into the trench provided in the lower substrate; and a magnet located above the microchannel, provided in the upper substrate, and generating magnetic force.
摘要翻译：提供了使用金属球的磁性微型阀及其制造方法。使用根据本发明的一个方面的金属球的磁性微型阀可以包括：具有作为流体移动通道的微通道的上基板，流体流入微通道的流体入口，以及流体出口通过已经通过微通道的流体流出微通道; 具有局部设置在其中的沟槽的下基板; 具有围绕金属球的金属球和PDMS的PDMS /金属球组合，使得金属球位于其中心部分，PDMS /金属球组合插入设置在下基板中的沟槽中; 以及设置在上基板上的微通道上方的磁体，并产生磁力。

6. 发明授权

US08057672B2 Disposable multi-layered filtration device for the separation of blood plasma 有权
标题翻译：一次性多层过滤装置，用于分离血浆
公开(公告)号：US08057672B2
公开(公告)日：2011-11-15
申请号：US12133295
申请日：2008-06-04
申请人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
发明人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
IPC分类号： B01D69/06 , B01D63/08 , B01D29/00
CPC分类号： G01N33/491 , B01L3/502753 , B01L2300/043 , B01L2300/0645 , B01L2300/0681 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B33Y80/00
摘要： Provided is a disposable multi-layered filtration device for the separation of blood plasma which can be applied to a biochip and appropriate for disposal uses. The filtration device for the separation of blood plasma includes: an upper substrate including a blood inlet; an intermediate substrate including a filtering unit for extracting blood plasma from blood flowing through the blood inlet; and a lower substrate including an air outlet, wherein the upper substrate, the intermediate substrate, and the lower substrate are stacked and adhered.
摘要翻译：提供了一种用于分离血浆的一次性多层过滤装置，其可以应用于生物芯片并适合于处置用途。用于分离血浆的过滤装置包括：包括血液入口的上基板; 中间基板，包括用于从流过血液入口的血液中提取血浆的过滤单元; 以及包括空气出口的下基板，其中所述上基板，所述中间基板和所述下基板被堆叠和粘附。

7. 发明申请

US20090120865A1 DISPOSABLE MULTI-LAYERED FILTRATION DEVICE FOR THE SEPARATION OF BLOOD PLASMA 有权
标题翻译：用于分离血浆等离子体的多层过滤装置
公开(公告)号：US20090120865A1
公开(公告)日：2009-05-14
申请号：US12133295
申请日：2008-06-04
申请人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
发明人： Kwang Hyo Chung , Yo Han Choi , Dae Sik Lee , Ju Hyun Jeon , Moon Youn Jung , Seon Hee Park
IPC分类号： B01D25/12 , B01D27/08 , B01D35/30
CPC分类号： G01N33/491 , B01L3/502753 , B01L2300/043 , B01L2300/0645 , B01L2300/0681 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B33Y80/00
摘要： Provided is a disposable multi-layered filtration device for the separation of blood plasma which can be applied to a biochip and appropriate for disposal uses. The filtration device for the separation of blood plasma includes: an upper substrate including a blood inlet; an intermediate substrate including a filtering unit for extracting blood plasma from blood flowing through the blood inlet; and a lower substrate including an air outlet, wherein the upper substrate, the intermediate substrate, and the lower substrate are stacked and adhered.
摘要翻译：提供了一种用于分离血浆的一次性多层过滤装置，其可以应用于生物芯片并适合于处置用途。用于分离血浆的过滤装置包括：包括血液入口的上基板; 中间基板，包括用于从流过血液入口的血液中提取血浆的过滤单元; 以及包括空气出口的下基板，其中所述上基板，所述中间基板和所述下基板被堆叠和粘附。

8. 发明授权

US08309040B2 Microfluidic control apparatus and method of assembling the same 有权
标题翻译：微流控制装置及其组装方法
公开(公告)号：US08309040B2
公开(公告)日：2012-11-13
申请号：US12542627
申请日：2009-08-17
申请人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
发明人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
IPC分类号： B01J8/00 , B01L3/00
CPC分类号： B01J19/0093 , B01J2219/00373 , B01J2219/00376 , B01J2219/00891 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0457 , B01L2400/0487 , B01L2400/06 , Y10T29/494 , Y10T29/49826
摘要： Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.
摘要翻译：提供了一种微流控制装置，其包括至少一个控制装置和微流控制芯片。当将微流控制芯片装载到控制装置时，将提供给控制装置的针插入到微流控制芯片的反应溶液储存室中，其中反应溶液储存室用密封胶带密封。因此，在微流控制芯片和控制装置之间容易形成流体连接而没有泄漏。

9. 发明申请

US20100279396A1 MICRO-SCALED ANIMAL CELL INCUBATOR AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：微量级动物细胞培养物及其生产方法
公开(公告)号：US20100279396A1
公开(公告)日：2010-11-04
申请号：US12746093
申请日：2008-06-27
申请人： Yo Han Choi , Kwang Hyo Chung , Dae Sik Lee , Sang Hee Kim , Min Suk Jeong , Chi Hoon Jun , Moon Youn Jung , Seon Hee Park
发明人： Yo Han Choi , Kwang Hyo Chung , Dae Sik Lee , Sang Hee Kim , Min Suk Jeong , Chi Hoon Jun , Moon Youn Jung , Seon Hee Park
IPC分类号： C12M3/00 , H05K3/00
CPC分类号： C12M23/20 , B01L3/5027 , B01L7/00 , C12M23/16 , C12M41/12 , Y10T29/49124
摘要： There is provided a cell culture technology for culturing an animal cell in a separate microstructure. The micro-scaled animal cell incubator includes a lower glass substrate having fine hot wires processed with a metal and formed in an upper surface thereof; a first PDMS film attached onto the lower glass substrate to form two or more liquid and solid storage spaces in a position corresponding to the fine hot wires of the lower glass substrate and gas flow channels coupled respectively to the liquid and solid storage spaces to allow generated gases to flow therethrough; a gas-permeable PDMS thin film attached onto the gas flow channels of the PDMS film to pass the generated gases therethrough; a second PDMS film attached onto the PDMS thin film and having a culture medium storage space for storing a culture medium; and an upper glass substrate attached onto the second PDMS film and having fine hot wires formed in a lower surface thereof, the fine hot wires being covered by the PDMS film. The micro-scaled animal cell incubator may be useful to control a temperature of a culture medium to a suitable temperature level, as well as to self-supply gases required for the animal cell culture in a microstructure.
摘要翻译：提供了用于在单独的微结构中培养动物细胞的细胞培养技术。微型动物细胞培养箱包括具有用金属加工并形成在其上表面的细微热丝的下玻璃基板; 附着在下玻璃基板上的第一PDMS膜，以形成两个或多个液体和固体存储空间，该液体和固体储存空间位于对应于分别与液体和固体储存空间相连的下玻璃基板和气流通道的细热线的位置，以允许产生气体流过其中; 透气的PDMS薄膜，附着在PDMS薄膜的气流通道上，以使产生的气体通过; 附着在PDMS薄膜上并具有用于储存培养基的培养基储存空间的第二PDMS膜; 以及附着在第二PDMS膜上并具有形成在其下表面上的精细热丝的上玻璃基板，细的热丝被PDMS膜覆盖。微量级动物细胞培养箱可用于将培养基的温度控制到合适的温度水平，以及自动供应在微结构中动物细胞培养所需的气体。

10. 发明申请

US20100158761A1 MICROFLUIDIC CONTROL APPARATUS AND METHOD OF ASSEMBLING THE SAME 有权
标题翻译：微流控制装置及其装配方法
公开(公告)号：US20100158761A1
公开(公告)日：2010-06-24
申请号：US12542627
申请日：2009-08-17
申请人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
发明人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
IPC分类号： B01J19/00 , B23P11/00 , B81C1/00
CPC分类号： B01J19/0093 , B01J2219/00373 , B01J2219/00376 , B01J2219/00891 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0457 , B01L2400/0487 , B01L2400/06 , Y10T29/494 , Y10T29/49826
摘要： Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.
摘要翻译：提供了一种微流控制装置，其包括至少一个控制装置和微流控制芯片。当将微流控制芯片装载到控制装置时，将提供给控制装置的针插入到微流控制芯片的反应溶液储存室中，其中反应溶液储存室用密封胶带密封。因此，在微流控制芯片和控制装置之间容易形成流体连接而没有泄漏。

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